메뉴 건너뛰기




Volumn 6, Issue 5, 2012, Pages 185-199

Efficacy and tolerability of nebivolol: Does age matter? A retrospective analysis of three randomized, placebo-controlled trials in stage I–II hypertension

Author keywords

age groups; hypertension; nebivolol

Indexed keywords

NEBIVOLOL; PLACEBO;

EID: 84867301940     PISSN: 17539447     EISSN: 17539455     Source Type: Journal    
DOI: 10.1177/1753944712459593     Document Type: Article
Times cited : (10)

References (39)
  • 1
    • 22744438831 scopus 로고    scopus 로고
    • Tolerability of nebivolol in head-to-head clinical trials versus other cardioselective beta-blockers in the treatment of hypertension: A meta-analysis
    • Ambrosioni E. Borghi C. (2005) Tolerability of nebivolol in head-to-head clinical trials versus other cardioselective beta-blockers in the treatment of hypertension: A meta-analysis. High Blood Press Cardiovasc Prev 12: 27–35.
    • (2005) High Blood Press Cardiovasc Prev , vol.12 , pp. 27-35
    • Ambrosioni, E.1    Borghi, C.2
  • 2
    • 22544466994 scopus 로고    scopus 로고
    • A randomised comparison of the effects of nebivolol and atenolol with and without chlorthalidone on the sexual function of hypertensive men
    • Boydak B. Nalbantgil S. Fici F. Nalbantgil I. Zoghi M. Ozerkan F. et al. (2005) A randomised comparison of the effects of nebivolol and atenolol with and without chlorthalidone on the sexual function of hypertensive men. Clin Drug Investig 25: 409–416.
    • (2005) Clin Drug Investig , vol.25 , pp. 409-416
    • Boydak, B.1    Nalbantgil, S.2    Fici, F.3    Nalbantgil, I.4    Zoghi, M.5    Ozerkan, F.6
  • 3
    • 41549145797 scopus 로고    scopus 로고
    • Comparison of drug adherence rates among patients with seven different medical conditions
    • Briesacher B. Andrade S. Fouayzi H. Chan K. (2008) Comparison of drug adherence rates among patients with seven different medical conditions. Pharmacotherapy 28: 437–443.
    • (2008) Pharmacotherapy , vol.28 , pp. 437-443
    • Briesacher, B.1    Andrade, S.2    Fouayzi, H.3    Chan, K.4
  • 4
    • 33846951170 scopus 로고    scopus 로고
    • Nitric oxide, erectile dysfunction and beta-blocker treatment (MR NOED study): benefit of nebivolol versus metoprolol in hypertensive men
    • Brixius K. Middeke M. Lichtenthal A. Jahn E. Schwinger R. (2007) Nitric oxide, erectile dysfunction and beta-blocker treatment (MR NOED study): benefit of nebivolol versus metoprolol in hypertensive men. Clin Exp Pharmacol Physiol 34: 327–331.
    • (2007) Clin Exp Pharmacol Physiol , vol.34 , pp. 327-331
    • Brixius, K.1    Middeke, M.2    Lichtenthal, A.3    Jahn, E.4    Schwinger, R.5
  • 5
    • 77958481106 scopus 로고    scopus 로고
    • Hypertension in the elderly: what is the goal blood pressure target and how can this be attained?
    • Carlberg B. Nilsson P. (2010) Hypertension in the elderly: what is the goal blood pressure target and how can this be attained? Curr Hypertens Rep 12: 331–334.
    • (2010) Curr Hypertens Rep , vol.12 , pp. 331-334
    • Carlberg, B.1    Nilsson, P.2
  • 6
    • 0037046206 scopus 로고    scopus 로고
    • Paradoxical pressor effects of beta-blockers in standing elderly patients with mild hypertension: a beneficial side effect
    • Cleophas T. Grabowsky I. Niemeyer M. Makel W. van der Wall E. (2002) Paradoxical pressor effects of beta-blockers in standing elderly patients with mild hypertension: a beneficial side effect. Circulation 105: 1669–1671.
    • (2002) Circulation , vol.105 , pp. 1669-1671
    • Cleophas, T.1    Grabowsky, I.2    Niemeyer, M.3    Makel, W.4    van der Wall, E.5
  • 7
    • 0037273675 scopus 로고    scopus 로고
    • Age-related decline in autonomic control of blood pressure: implications for the pharmacological management of hypertension in the elderly
    • Cleophas T. van Marum R. (2003) Age-related decline in autonomic control of blood pressure: implications for the pharmacological management of hypertension in the elderly. Drugs Aging 20: 313–319.
    • (2003) Drugs Aging , vol.20 , pp. 313-319
    • Cleophas, T.1    van Marum, R.2
  • 9
    • 0036863587 scopus 로고    scopus 로고
    • Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT)
    • Cushman W. Ford C. Cutler J. Margolis K. Davis B. Grimm R. et al. (2002) Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). J Clin Hypertens (Greenwich) 4: 393–404.
    • (2002) J Clin Hypertens (Greenwich) , vol.4 , pp. 393-404
    • Cushman, W.1    Ford, C.2    Cutler, J.3    Margolis, K.4    Davis, B.5    Grimm, R.6
  • 10
    • 33644793403 scopus 로고    scopus 로고
    • Beneficial effects of switching from beta-blockers to nebivolol on the erectile function of hypertensive patients
    • Doumas M. Tsakiris A. Douma S. Grigorakis A. Papadopoulos A. Hounta A. et al. (2006) Beneficial effects of switching from beta-blockers to nebivolol on the erectile function of hypertensive patients. Asian J Androl 8: 177–182.
    • (2006) Asian J Androl , vol.8 , pp. 177-182
    • Doumas, M.1    Tsakiris, A.2    Douma, S.3    Grigorakis, A.4    Papadopoulos, A.5    Hounta, A.6
  • 11
    • 17844396904 scopus 로고    scopus 로고
    • Sexual dysfunction in male patients with hypertension: influence of antihypertensive drugs
    • Düsing R. (2005) Sexual dysfunction in male patients with hypertension: influence of antihypertensive drugs. Drugs 65: 773–786.
    • (2005) Drugs , vol.65 , pp. 773-786
    • Düsing, R.1
  • 12
    • 77952750659 scopus 로고    scopus 로고
    • US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008
    • Egan B. Zhao Y. Axon R. (2010) US trends in prevalence, awareness, treatment, and control of hypertension, 1988–2008. JAMA 303: 2043–2050.
    • (2010) JAMA , vol.303 , pp. 2043-2050
    • Egan, B.1    Zhao, Y.2    Axon, R.3
  • 13
    • 77951102841 scopus 로고    scopus 로고
    • Primary medication non-adherence: analysis of 195,930 electronic prescriptions
    • Fischer M. Stedman M. Lii J. Vogeli C. Shrank W. Brookhart M. et al. (2010) Primary medication non-adherence: analysis of 195,930 electronic prescriptions. J Gen Intern Med 25: 284–290.
    • (2010) J Gen Intern Med , vol.25 , pp. 284-290
    • Fischer, M.1    Stedman, M.2    Lii, J.3    Vogeli, C.4    Shrank, W.5    Brookhart, M.6
  • 14
    • 2342631217 scopus 로고    scopus 로고
    • Effect of antihypertensive agents on quality of life in the elderly
    • Fogari R. Zoppi A. (2004) Effect of antihypertensive agents on quality of life in the elderly. Drugs Aging 21: 377–393.
    • (2004) Drugs Aging , vol.21 , pp. 377-393
    • Fogari, R.1    Zoppi, A.2
  • 15
    • 76949103329 scopus 로고    scopus 로고
    • Effects of beta-blockers on glucose and lipid metabolism
    • Fonseca V. (2010) Effects of beta-blockers on glucose and lipid metabolism. Curr Med Res Opin 26: 615–629.
    • (2010) Curr Med Res Opin , vol.26 , pp. 615-629
    • Fonseca, V.1
  • 16
    • 34249908675 scopus 로고    scopus 로고
    • Bystolic: Full Prescribing Information
    • Forest Laboratories St Louis, MO: Forest Laboratories, Inc. Available at
    • Forest Laboratories (2011) Bystolic: Full Prescribing Information. St Louis, MO: Forest Laboratories, Inc. Available at: http://www.frx.com/pi/Bystolic_pi.pdf.
    • (2011)
  • 17
    • 0030838005 scopus 로고    scopus 로고
    • Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study
    • Franklin S. Gustin W. Wong N. Larson M. Weber M. Kannel W. et al. (1997) Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation 96: 308–315.
    • (1997) Circulation , vol.96 , pp. 308-315
    • Franklin, S.1    Gustin, W.2    Wong, N.3    Larson, M.4    Weber, M.5    Kannel, W.6
  • 18
    • 0035105181 scopus 로고    scopus 로고
    • Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III
    • Franklin S. Jacobs M. Wong N. L'Italien G. Lapuerta P. (2001) Predominance of isolated systolic hypertension among middle-aged and elderly US hypertensives: analysis based on National Health and Nutrition Examination Survey (NHANES) III. Hypertension 37: 869–874.
    • (2001) Hypertension , vol.37 , pp. 869-874
    • Franklin, S.1    Jacobs, M.2    Wong, N.3    L'Italien, G.4    Lapuerta, P.5
  • 19
    • 77950814414 scopus 로고    scopus 로고
    • Nebivolol efficacy and safety in patients with stage I-II hypertension
    • Greathouse M. (2010) Nebivolol efficacy and safety in patients with stage I-II hypertension. Clin Cardiol 33 (4): E20–E27.
    • (2010) Clin Cardiol , vol.33 , Issue.4 , pp. E20-E27
    • Greathouse, M.1
  • 20
    • 80053940592 scopus 로고    scopus 로고
    • 2010 Census briefs: Age and sex composition: 2010
    • Report no. C2010BR-03 US Census Bureau; US Department of Commerce Available at
    • Howden L. Meyer J. (2011) 2010 Census briefs: Age and sex composition: 2010. Report no. C2010BR-03, US Census Bureau; US Department of Commerce. Available at: http://www.census.gov/prod/cen2010/briefs/c2010br-03.pdf.
    • (2011)
    • Howden, L.1    Meyer, J.2
  • 21
    • 0033970994 scopus 로고    scopus 로고
    • Elevated systolic blood pressure as a cardiovascular risk factor
    • Kannel W. (2000) Elevated systolic blood pressure as a cardiovascular risk factor. Am J Cardiol 85: 251–255.
    • (2000) Am J Cardiol , vol.85 , pp. 251-255
    • Kannel, W.1
  • 22
    • 33744970717 scopus 로고    scopus 로고
    • Re-examining the efficacy of beta-blockers for the treatment of hypertension: a meta-analysis
    • Khan N. McAlister F. (2006) Re-examining the efficacy of beta-blockers for the treatment of hypertension: a meta-analysis. CMAJ 174: 1737–1742.
    • (2006) CMAJ , vol.174 , pp. 1737-1742
    • Khan, N.1    McAlister, F.2
  • 23
    • 0037125378 scopus 로고    scopus 로고
    • Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction
    • Ko D. Hebert P. Coffey C. Sedrakyan A. Curtis J. Krumholz H. (2002) Beta-blocker therapy and symptoms of depression, fatigue, and sexual dysfunction. JAMA 288: 351–357.
    • (2002) JAMA , vol.288 , pp. 351-357
    • Ko, D.1    Hebert, P.2    Coffey, C.3    Sedrakyan, A.4    Curtis, J.5    Krumholz, H.6
  • 24
    • 77957559010 scopus 로고    scopus 로고
    • Nebivolol lowers blood pressure and increases weight loss in patients with hypertension and diabetes in regard to age
    • Ladage D. Reidenbach C. Rieckeheer E. Graf C. Schwinger R. Brixius K. (2010) Nebivolol lowers blood pressure and increases weight loss in patients with hypertension and diabetes in regard to age. J Cardiovasc Pharmacol 56: 275–281.
    • (2010) J Cardiovasc Pharmacol , vol.56 , pp. 275-281
    • Ladage, D.1    Reidenbach, C.2    Rieckeheer, E.3    Graf, C.4    Schwinger, R.5    Brixius, K.6
  • 25
    • 0042971853 scopus 로고    scopus 로고
    • Nitric oxide production and intensity of free radical processes in young men with high normal and hypertensive blood pressure
    • Lyamina N. Dolotovskaya P. Lyamina S. Malyshev I. Manukhina E. (2003) Nitric oxide production and intensity of free radical processes in young men with high normal and hypertensive blood pressure. Med Sci Monit 9: 304–310.
    • (2003) Med Sci Monit , vol.9 , pp. 304-310
    • Lyamina, N.1    Dolotovskaya, P.2    Lyamina, S.3    Malyshev, I.4    Manukhina, E.5
  • 27
    • 0032540714 scopus 로고    scopus 로고
    • Are beta-blockers efficacious as first-line therapy for hypertension in the elderly? A systematic review
    • Messerli F. Grossman E. Goldbourt U. (1998) Are beta-blockers efficacious as first-line therapy for hypertension in the elderly? A systematic review. JAMA 279: 1903–1907.
    • (1998) JAMA , vol.279 , pp. 1903-1907
    • Messerli, F.1    Grossman, E.2    Goldbourt, U.3
  • 28
    • 70350445237 scopus 로고    scopus 로고
    • Nebivolol: the somewhat-different beta-adrenergic receptor blocker
    • Münzel T. Gori T. (2009) Nebivolol: the somewhat-different beta-adrenergic receptor blocker. J Am Coll Cardiol 54: 1491–1499.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 1491-1499
    • Münzel, T.1    Gori, T.2
  • 29
    • 47749134827 scopus 로고    scopus 로고
    • Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study
    • Paiva H. Kahonen M. Lehtimaki T. Raitakari O. Jula A. Viikari J. et al. (2008) Asymmetric dimethylarginine (ADMA) has a role in regulating systemic vascular tone in young healthy subjects: the cardiovascular risk in young Finns study. Am J Hypertens 21: 873–878.
    • (2008) Am J Hypertens , vol.21 , pp. 873-878
    • Paiva, H.1    Kahonen, M.2    Lehtimaki, T.3    Raitakari, O.4    Jula, A.5    Viikari, J.6
  • 30
    • 24944503881 scopus 로고    scopus 로고
    • Prevalence and trends of prehypertension and hypertension in United States: National Health and Nutrition Examination Surveys 1976 to 2000
    • Qureshi A. Suri M. Kirmani J. Divani A. (2005) Prevalence and trends of prehypertension and hypertension in United States: National Health and Nutrition Examination Surveys 1976 to 2000. Med Sci Monit 11: 403–409.
    • (2005) Med Sci Monit , vol.11 , pp. 403-409
    • Qureshi, A.1    Suri, M.2    Kirmani, J.3    Divani, A.4
  • 31
    • 77955004042 scopus 로고    scopus 로고
    • Arterial aging - hemodynamic changes and therapeutic options
    • Safar M. (2010) Arterial aging - hemodynamic changes and therapeutic options. Nat Rev Cardiol 7: 442–449.
    • (2010) Nat Rev Cardiol , vol.7 , pp. 442-449
    • Safar, M.1
  • 32
    • 38449115960 scopus 로고    scopus 로고
    • The efficacy and tolerability of nebivolol in hypertensive African American patients
    • Saunders E. Smith W. de Salvo K. Sullivan W. (2007) The efficacy and tolerability of nebivolol in hypertensive African American patients. J Clin Hypertens (Greenwich) 9: 866–875.
    • (2007) J Clin Hypertens (Greenwich) , vol.9 , pp. 866-875
    • Saunders, E.1    Smith, W.2    de Salvo, K.3    Sullivan, W.4
  • 34
    • 39749168348 scopus 로고    scopus 로고
    • Efficacy and tolerability of nebivolol compared with other antihypertensive drugs: a meta-analysis
    • van Bortel L. Fici F. Mascagni F. (2008) Efficacy and tolerability of nebivolol compared with other antihypertensive drugs: a meta-analysis. Am J Cardiovasc Drugs 8: 35–44.
    • (2008) Am J Cardiovasc Drugs , vol.8 , pp. 35-44
    • van Bortel, L.1    Fici, F.2    Mascagni, F.3
  • 35
    • 0037181148 scopus 로고    scopus 로고
    • Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study
    • Vasan R. Beiser A. Seshadri S. Larson M. Kannel W. D'Agostino R. et al. (2002) Residual lifetime risk for developing hypertension in middle-aged women and men: The Framingham Heart Study. JAMA 287: 1003–1010.
    • (2002) JAMA , vol.287 , pp. 1003-1010
    • Vasan, R.1    Beiser, A.2    Seshadri, S.3    Larson, M.4    Kannel, W.5    D'Agostino, R.6
  • 36
    • 0030824039 scopus 로고    scopus 로고
    • Drug-induced orthostatic hypotension in the elderly: avoiding its onset
    • Verhaeverbeke I. Mets T. (1997) Drug-induced orthostatic hypotension in the elderly: avoiding its onset. Drug Saf 17: 105–118.
    • (1997) Drug Saf , vol.17 , pp. 105-118
    • Verhaeverbeke, I.1    Mets, T.2
  • 37
    • 80052991604 scopus 로고    scopus 로고
    • Efficacy and tolerability of nebivolol in stage I–II hypertension: a pooled analysis of data from three randomized, placebo-controlled monotherapy trials
    • Weiss R. Saunders E. Greathouse M. (2011) Efficacy and tolerability of nebivolol in stage I–II hypertension: a pooled analysis of data from three randomized, placebo-controlled monotherapy trials. Clin Ther 33: 1150–1161.
    • (2011) Clin Ther , vol.33 , pp. 1150-1161
    • Weiss, R.1    Saunders, E.2    Greathouse, M.3
  • 38
    • 38449118283 scopus 로고    scopus 로고
    • A randomized, double-blind, placebo-controlled parallel-group study to assess the efficacy and safety of nebivolol, a novel beta-blocker, in patients with mild to moderate hypertension
    • Weiss R. Weber M. Carr A. Sullivan W. (2007) A randomized, double-blind, placebo-controlled parallel-group study to assess the efficacy and safety of nebivolol, a novel beta-blocker, in patients with mild to moderate hypertension. J Clin Hypertens (Greenwich) 9: 667–676.
    • (2007) J Clin Hypertens (Greenwich) , vol.9 , pp. 667-676
    • Weiss, R.1    Weber, M.2    Carr, A.3    Sullivan, W.4
  • 39
    • 77951927068 scopus 로고    scopus 로고
    • Cardiovascular Diseases (CVDs)
    • World Health Organization Fact Sheet No 317. Available at
    • World Health Organization (2009) Cardiovascular Diseases (CVDs). Fact Sheet No 317. Available at: http://www.who.int/mediacentre/factsheets/fs317/en/print.html.
    • (2009)


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.