Arterial aging-hemodynamic changes and therapeutic options

Nature Reviews Cardiology

Volumn 7, Issue 8, 2010, Pages 442-449

  Safar, Michel E ^a  

^a HÔTEL DIEU   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIOVASCULAR AGENT; ALDOSTERONE ANTAGONIST; AMLODIPINE; ANGIOTENSIN II ANTAGONIST; ANTIFIBROTIC AGENT; ATENOLOL; AZELNIDIPINE; BENDROFLUMETHIAZIDE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM CHANNEL BLOCKING AGENT; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; HYDROCHLOROTHIAZIDE; INDAPAMIDE; OLMESARTAN; PERINDOPRIL;

ADULT; AGE; AGED; AGING; ARTERY; CARDIOVASCULAR DISEASE; DRUG EFFECT; FEMALE; HEMODYNAMICS; HUMAN; MALE; MIDDLE AGED; PATHOLOGY; PATHOPHYSIOLOGY; REVIEW; AORTA; ARTERIAL STIFFNESS; ARTERY WALL; CARDIOVASCULAR RISK; CLINICAL RESEARCH; CLINICAL TRIAL; HEART VENTRICLE EJECTION; HEART VENTRICLE REMODELING; HYPERTENSION; MORBIDITY; MORTALITY; PRIORITY JOURNAL; PULSATILE FLOW; PULSE PRESSURE; PULSE WAVE; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; SYSTOLIC BLOOD PRESSURE; THERAPY EFFECT;

ADULT; AGE FACTORS; AGED; AGING; ARTERIES; CARDIOVASCULAR AGENTS; CARDIOVASCULAR DISEASES; FEMALE; HEMODYNAMICS; HUMANS; MALE; MIDDLE AGED;

EID: 77955004042     PISSN: 17595002     EISSN: 17595010     Source Type: Journal    
DOI: 10.1038/nrcardio.2010.96     Document Type: Review

References (57)

1. Staessen, J. E., Li, Y., Thijs, L. & Wang, J. G. in Handbook of Hypertension: Arterial Stiffness in Hypertension Vol. 23 Ch. 29 (eds Safar, M. E. & O’Rourke, M. F.) 459-484 (Elsevier, Edinburgh, 2006).
2. Nichols, W. W. & O’Rourke, M. F. McDonald’s Blood Flow in Arteries: Theoretical, Experimental and Clinical Principles, 5th edn (Hodder Arnold, London, 2005).
3. Safar, M. E. & O’Rourke, M. F. (eds) Handbook of Hypertension: Arterial Stiffness in Hypertension Vol. 23 (Elsevier, Edinburgh, 2006).
4. Black, H. R. The paradigm has shifted, to systolic blood pressure. Hypertension 34, 386-387 (1999).
5. Langille, B. L. Remodeling of developing and mature arteries: endothelium, smooth muscle, and matrix. J. Cardiovasc. Pharmacol. 21 (Suppl. 1), S11-S17 (1993).
6. Levy, B. I., Ambrosio, G., Pries, A. R. & Struijker- Boudier, H. A. Microcirculation in hypertension: a new target for treatment? Circulation 104, 735-740 (2001).
7. Gibbons, G. H. & Dzau, V. J. The emerging concept of vascular remodeling. N. Engl. J. Med. 330, 1431-1438 (1994).
8. Levy, B. I. et al. Effects of chronic inhibition of converting enzyme on mechanical and structural properties of arteries in rat renovascular hypertension. Circ. Res. 63, 227-239 (1988).
9. Levy, B. I., Benessiano, J., Poitevin, P. & Safar, M. E. Endothelium-dependent mechanical properties of the carotid artery in WKY and SHR Role of angiotensin converting enzyme inhibition. Circ. Res. 66, 321-328 (1990).
10. Schiffrin, E. L. Remodeling of resistance arteries in essential hypertension and effects of antihypertensive treatment. Am. J. Hypertens. 17, 1192-1200 (2004).
11. London, G. M., Asmar, R. G., O’Rourke, M. F. & Safar, M. E. Mechanism(s) of selective systolic blood pressure reduction after a low-dose combination of perindopril/indapamide in hypertensive subjects: comparison with atenolol. J.Am. Coll. Cardiol. 43, 92-99 (2004).
12. Safar, M. E., Rizzoni, D., Blacher, J., Muiesan, M. L. & Agabiti-Rosei, E. Macro and microvasculature in hypertension: therapeutic aspects. J. Hum. Hypertens. 22, 590-595 (2008).
13. Williams, B. Mechanical influences on vascular smooth muscle cell function. J. Hypertens. 16, 1921-1929 (1998).
14. Agabiti-Rosei, E., Heagerty, A. M. & Rizzoni, D. Effects of antihypertensive treatment on small artery remodelling. J. Hypertens. 27, 1107-1114 (2009).
15. Franklin, S. S. et al. Hemodynamic patterns of age-related changes in blood pressure. The Framingham Heart Study. Circulation 96, 308-315 (1997).
16. Safar, M. E. et al. The Data from an Epidemiologic Study on the Insulin Resistance Syndrome Study: the change and the rate of change of the age-blood pressure relationship. J. Hypertens. 26, 1903-1911 (2008).
17. Baksi, A. J. et al. A meta-analysis of the mechanism of blood pressure change with aging. J.Am. Coll. Cardiol. 54, 2087-2092 (2009).
18. Lieber, A. et al. Aortic wave reflection in women and men. Am. J. Physiol. Heart Circ. Physiol. doi:10.1152/ajpheart.00985.2009.
19. Darne, B., Girerd, X., Safar, M., Cambien, F & Guize, L. Pulsatile versus steady component of blood pressure: a cross-sectional analysis and a prospective analysis on cardiovascular mortality. Hypertension 13, 392-400 (1989).
20. Madhavan, S., Ooi, W. L., Cohen, H. & Alderman, M. H. Relation of pulse pressure and blood pressure reduction to the incidence of myocardial infarction. Hypertension 23, 395-401 (1994).
21. Blacher, J., Asmar, R., Djane, S., London, G. M. & Safar, M. E. Aortic pulse wave velocity as a marker of cardiovascular risk in hypertensive patients. Hypertension 33, 1111-1117 (1999).
22. Meaume, S., Benetos, A., Henry, O. F., Rudnichi, A. & Safar, M. E. Aortic pulse wave velocity predicts cardiovascular mortality in subjects >70 years of age. Arterioscler. Thromb. Vasc. Biol. 21, 2046-2050 (2001).
23. Avolio, A. P et al. Role of pulse pressure amplification in arterial hypertension: experts’ opinion and review of the data. Hypertension 54, 375-383 (2009).
24. Westerhof, N., Stergiopulos, N. & Noble, M. I. M. Snapshots of Hemodynamics. An Aid for Clinical Research and Graduate Education (Springer, New York, 2005).
25. London, G. M. et al. Arterial wave reflections and survival in end-stage renal failure. Hypertension 38, 434-438 (2001).
26. Westerbacka, J., Seppälä-Lindroos, A. & Yki-Järvinen, H. Resistance to acute insulin induced decreases in large artery stiffness accompanies the insulin resistance syndrome. J. Clin. Endocrinol. Metab. 86, 5262-5268 (2001).
27. Lacolley, P, Safar, M. E., Regnault, V. & Frohlich, E. D. Angiotensin II, mechanotransduction, and pulsatile arterial hemodynamics in hypertension. Am. J. Physiol. Heart Circ. Physiol. 297, H1567-H1575 (2009).
28. Hirai, T., Sasayama, S., Kawasaki, T & Yagi, S. Stiffness of systemic arteries in patients with myocardial infarction. A noninvasive method to predict severity of coronary atherosclerosis. Circulation 80, 78-86 (1989).
29. Gatzka, C. D., Cameron, J. D., Kingwell, B. A. & Dart, A. M. Relation between coronary artery disease, aortic stiffness, and left ventricular structure in a population sample. Hypertension 32, 575-578 (1998).
30. Stefanadis, C., Wooley, C. F., Bush, C. A., Kolibash, A. J. & Boudoulas, H. Aortic distensibility abnormalities in coronary artery disease. Am. J. Cardiol. 59, 1300-1304 (1987).
31. Jankowski, P et al. Pulsatile but not steady component of blood pressure predicts cardiovascular events in coronary patients. Hypertension 51, 848-855 (2008).
32. Agabiti-Rosei, E. et al. Central blood pressure measurements and antihypertensive therapy: a consensus document. Hypertension 50, 154-160 (2007).
33. Weber, T. et al. Arterial stiffness, wave reflections, and the risk of coronary artery disease. Circulation 109, 184-189 (2004).
34. Safar, M. E. et al. Central pulse pressure and mortality in end-stage renal disease. Hypertension 39, 735-738 (2002).
35. Roman, M. J. et al. Central pressure more strongly relates to vascular disease and outcome than does brachial pressure: the Strong Heart Study. Hypertension 50, 197-203 (2007).
36. Van Bortel, L. M., Struijker-Boudier, H. A. & Safar, M. E. Pulse pressure, arterial stiffness, and drug treatment of hypertension. Hypertension 38, 914-921 (2001).
37. Ingber, D. Integrins as mechanochemical transducers. Curr. Opin. Cell Biol. 3, 841-848 (1991).
38. Wilson, E., Sudhir, K. & Ives, H. E. Mechanical strain of rat vascular smooth muscle cells is sensed by specific extracellular matrix/integrin interactions. J. Clin. Invest. 96, 2364-2372 (1995).
39. Louis, H. et al. Role of alpha1beta1-integrin in arterial stiffness and angiotensin-induced arterial wall hypertrophy in mice. Am. J. Physiol. Heart Circ. Physiol. 293, H2597-H2604 (2007).
40. Bézie, Y. et al. Fibronectin expression and aortic wall elastic modulus in spontaneously hypertensive rats. Arterioscler. Thromb. Vasc. Biol. 18, 1027-1034 (1998).
41. Kakou, A. et al. Selective reduction of central pulse pressure under angiotensin blockage in SHR: role of the fibronectin-alpha5beta1 integrin complex. Am. J. Hypertens. 22, 711-717 (2009).
42. Labat, C. et al. Effects of valsartan on mechanical properties of the carotid artery in spontaneously hypertensive rats under high-salt diet. Hypertension 38, 439-43 (2001).
43. Lacolley, P. et al. Increased carotid wall elastic modulus and fibronectin in aldosterone- salt-treated rats: effects of eplerenone. Circulation 106, 2848-2853 (2002).
44. Bezie, Y, Lacolley, P, Laurent, S. & Gabella, G. Connection of smooth muscle cells to elastic lamellae in aorta of spontaneously hypertensive rats. Hypertension 32, 166-169 (1998).
45. Koffi, I. et al. Prevention of arterial structural alterations with verapamil and trandolapril and consequences for mechanical properties in spontaneously hypertensive rats. Eur. J. Pharmacol. 361, 51-60 (1998).
46. Safar, M. E. et al. Peripheral arterial disease and isolated systolic hypertension: the ATTEST study. J. Hum. Hypertens. 23, 182-187 (2009).
47. de Luca, N., Asmar, R. G., London, G. M., O’Rourke, M. F. & Safar, M. E. Selective reduction of cardiac mass and central blood pressure on low-dose combination perindopril/ indapamide in hypertensive subjects. J. Hypertens. 22, 1623-1630 (2004).
48. Protogerou, A., Blacher, J., Stergiou, G. S., Achimastos, A. & Safar, M. E. Blood pressure response under chronic antihypertensive drug therapy: the role of aortic stiffness in the REASON (Preterax in Regression of Arterial Stiffness in a Controlled Double-Blind) study. J. Am. Coll. Cardiol. 53, 445-451 (2009).
49. Dhakam, Z. et al. A comparison of atenolol and nebivolol in isolated systolic hypertension. J. Hypertens. 26, 351-356 (2008).
50. Guerin, A. P et al. Impact of aortic stiffness attenuation on survival of patients in end-stage renal failure. Circulation 103, 987-992 (2001).
51. Kengne, A. P et al. Blood pressure variables and cardiovascular risk: new findings from ADVANCE. Hypertension 54, 399-404 (2009).
52. Williams, B. et al. Differential impact of blood pressure-lowering drugs on central aortic pressure and clinical outcomes: principal results of the Conduit Artery Function Evaluation (CAFE) study. Circulation 113, 1213-1225 (2006).
53. Matsui, Y et al. Differential effects between a calcium channel blocker and a diuretic when used in combination with angiotensin II receptor blocker on central aortic pressure in hypertensive patients. Hypertension 54, 716-723 (2009).
54. Dengo, A. L. et al. Arterial destiffening with weight loss in overweight and obese middle-aged and older adults. Hypertension 55, 855-861 (2010).
55. Ferrario, C. M., Trask, A. J. & Jessup, J. A. Advances in biochemical and functional roles of angiotensin-converting enzyme 2 and angiotensin-(1-7) in regulation of cardiovascular function. Am. J. Physiol. Heart Circ. Physiol. 289, H2281-H2290 (2005).
56. Gueyffier, F. et al. Antihypertensive drugs in very old people: a subgroup meta-analysis of randomised controlled trials. INDANA Group. Lancet 353, 793-796 (1999).
57. Asmar, R. G., London, G. M., O’Rourke, M. E. & Safar, M. E. Improvement in blood pressure, arterial stiffness and wave reflections with a very-low-dose perindopril/indapamide combination in hypertensive patient: a comparison with atenolol. Hypertension 38, 922-926 (2001).