Nonalcoholic fatty liver disease is associated with increased GHBP and reduced GH/IGF-I levels

Clinical Endocrinology

Volumn 77, Issue 4, 2012, Pages 531-536

  Fusco, Alessandra ^a   D'Uonnolo, Annalisa ^a   Forgione, Alessandra ^a   Riccardi, Laura ^a   Cefalo, Consuelo ^a   Barini, Angela ^a   Bianchi, Antonio ^a   Giampietro, Antonella ^a   Cimino, Vincenzo ^a   Landolfi, Raffaele ^a   Grieco, Antonio ^a   De Marinis, Laura ^a  

^a CATHOLIC UNIVERSITY   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCOSE; GROWTH HORMONE; GROWTH HORMONE BINDING PROTEIN; GROWTH HORMONE RELEASING FACTOR; INSULIN; SOMATOMEDIN BINDING PROTEIN 3; SOMATOMEDIN C;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DISEASE ASSOCIATION; DISEASE COURSE; FEMALE; GLUCOSE BLOOD LEVEL; GROWTH HORMONE BLOOD LEVEL; HORMONE BLOOD LEVEL; HORMONE RELEASE; HUMAN; INSULIN BLOOD LEVEL; INSULIN RESISTANCE; LIVER FUNCTION; MAJOR CLINICAL STUDY; MALE; NONALCOHOLIC FATTY LIVER; OBESITY; PRIORITY JOURNAL;

ADULT; BLOOD GLUCOSE; CARRIER PROTEINS; CROSS-SECTIONAL STUDIES; FATTY LIVER; FEMALE; GLYCOPROTEINS; GROWTH HORMONE; HUMANS; INSULIN-LIKE GROWTH FACTOR BINDING PROTEINS; INSULIN-LIKE GROWTH FACTOR I; MALE; MIDDLE AGED; OBESITY;

EID: 84867290809     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2011.04291.x     Document Type: Article

References (36)

1. Vijayakumar, A., Novosyadlyy, R., Wu, Y. et al. (2010) Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Hormone and IGF Research, 20, 1-7.
2. Baumann, G. (2002) Growth hormone binding protein. The soluble growth hormone receptor. Minerva Endocrinologica, 27, 265-276.
3. Baumann, G., Shaw, M.A. & Amburn, K. (1994) Circulating growth hormone binding proteins. Journal of Endocrinological Investigation, 17, 67-81.
4. Rasmussen, M.H., Ho, K.K.Y., Kjems, L. et al. (1996) Serum growth hormone-binding protein in obesity: effect of short-term, very low calorie diet and diet-induced weight loss. Journal of Clinical Endocrinology and Metabolism, 81, 1519-1524.
5. Nam, S.Y., Lee, E.J., Kim, K.R. et al. (1997) Effect of obesity on total and free insulin-like growth factor (IGF)-1 and their relationship to IGF-binding protein (BP)-1, IGFBP-2, IGFBP-3, insulin and growth hormone. International Journal of Obesity and Related Metabolic Disorders, 21, 355-359.
6. Argente, J., Caballo, N., Barrios, V. et al. (1997) Multiple endocrine abnormalities of the growth hormone and insulin-like growth factor axis in prepubertal children with exogenous obesity: effect of short and long-term weight reduction. Journal of Clinical Endocrinology and Metabolism, 82, 2076-2083.
7. Rasmussen, M.H., Jull, A., Kjems, L.L. et al. (2006) Effects of shortterm caloric restriction on circulating free IGF-I, acid-labile subunit, IGF-binding proteins (IGFBPs)-1-4, and IGFBPs-1-3 protease activity in obese subjects. European Journal of Endocrinology, 155, 575-581.
8. Willner, I.R., Waters, B., Patil, S.R. et al. (2001) Ninety patients with nonalcoholic steatohepatitis: insulin resistance, familial tendency, and severity of disease. American Journal of Gastroenterology, 96, 2957-2961.
9. Fan, Y., Menon, R.K., Cohen, P. et al. (2009) Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signalling in hepatic lipid metabolism. The Journal of Biological Chemistry, 284, 19937-19944.
10. Hong, J.W., Kim, J.Y., Kim, Y.E. et al. (2011) Metabolic parameters and non-alcoholic fatty liver disease in hypopituitary men. Hormone and Metabolic Research, 43, 48-54.
11. Corneli, G., Di Somma, C., Baldelli, R. et al. (2005) The cut-off limits of the GH response to GH-releasing hormone-arginine test related to body mass index. European Journal of Endocrinology, 153, 257-264.
12. Mercado, M., Davila, N., McLeod, J.F. et al. (1994) Distribution of growth hormone receptor messenger ribonucleic acid containing and lacking exon 3 in human tissues. Journal of Clinical Endocrinology and Metabolism, 78, 731-735.
13. Massa, G., Bouillon, R. & Vanderschueren-Lodeweyckx, M. (1992) Serum levels of growth hormone-binding protein and insulin-like growth factor-I during puberty. Clinical Endocrinology (Oxford), 37, 175-180.
14. Nam, S.Y., Kim, K.R., Song, Y.D. et al. (1999) GH-binding protein in obese men with varying glucose tolerance: relationship to body fat distribution, insulin secretion and the GH-IGF-I axis. European Journal of Endocrinology, 140, 159-163.
15. Fernandez-Real, J.M., Granada, M.L., Ruzafa, A. et al. (2000) Insulin sensitivity and secretion influence the relationship between growth hormone-binding protein and leptin. Clinical Endocrinology (Oxford), 52, 159-164.
16. Fisker, S., Vahl, N., Hansen, T.B. et al. (1998) Growth hormone (GH) substitution for one year normalizes elevated GH-binding protein levels in GH-deficient adults secondary to a reduction in body fat. A placebo-controlled trial. Growth Hormone and IGF Research, 8, 105-112.
17. Clasey, J.L., Weltman, A., Patrie, J. et al. (2001) Abdominal visceral fat and fasting insulin are important predictors of 24-hour GH release independent of age, gender and other physiological factors. Journal of Clinical Endocrinology and Metabolism, 86, 3845-3852.
18. Leung, K.C., Doyle, N., Ballesteros, M. et al. (2000) Insulin regulation of human hepatic growth hormone receptors: divergent effects on biosynthesis and surface translocation. Journal of Clinical Endocrinology and Metabolism, 85, 4712-4720.
19. Edge, J.A., Matthews, D.R. & Dunger, D.B. (1990) The dawn phenomenon is related to overnight GH release in adolescent diabetics. Clinical Endocrinology (Oxford), 33, 729-737.
20. Zachrisson, I., Brismar, K., Hall, K. et al. (1997) Determinants of growth in diabetic pubertal subjects. Diabetes Care, 20, 1261-1265.
21. Dastot, F., Sobrier, M.L., Duquesnoy, P. et al. (1996) Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein. Proceedings of the National Academy of Sciences of the United States of America, 93, 10723-10728.
22. Dastot, F., Duquesnoy, P., Sobrier, M.L. et al. (1998) Evolutionary divergence of the truncated growth hormone receptor isoform in its ability to generate a soluble growth hormone binding protein. Molecular and Cellular Endocrinology, 137, 79-84.
23. Ross, R.J., Esposito, N., Shen, X.Y. et al. (1997) A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein. Molecular Endocrinology, 11, 265-273.
24. Shen, X.Y., Holt, R.I., Miell, J.P. et al. (1998) Cirrhotic liver expresses low levels of the full-length and truncated growth hormone receptors. Journal of Clinical Endocrinology and Metabolism, 83, 2532-2538.
25. Williams, T., Berelowitz, M., Joffe, S.N. et al. (1984) Impaired growth hormone responses to growth hormone-releasing factor in obesity. A pituitary defect reversed with weight reduction. New England Journal of Medicine, 311, 1403-1407.
26. Mingrone, G., De Gaetano, A., Greco, A.V. et al. (1997) Reversibility of insulin resistance in obese diabetic patients: role of plasma lipids. Diabetologia, 40, 599-605.
27. Melmed, S. (1984) Insulin suppresses growth hormone secretion by rat pituitary cells. Journal of Clinical Investigation, 73, 1425-1433.
28. De Marinis, L., Bianchi, A., Mancini, A. et al. (2004) Growth hormone secretion and leptin in morbid obesity before and after biliopancreatic diversion: relationship with insulin and body composition. Journal of Clinical Endocrinology and Metabolism, 89, 174-180.
29. Lee, E.J., Nam, S.Y., Kim, K.R. et al. (1995) Acipimox potentiates growth hormone (GH) responses to GH-releasing hormone with or without pyridostigmine by lowering serum free fatty acid in normal and obese subjects. Journal of Clinical Endocrinology and Metabolism, 80, 2495-2498.
30. Crespo, J., Cayon, A., Fernandez-Gil, P. et al. (2001) Gene expression of tumour necrosis factor alpha and TNF-receptors, p55 and p75, in non-alcoholic steatohepatitis patients. Hepatology, 34, 1158-1163.
31. Qin, Y. & Tian, Y. (2010) Preventive effects of chronic exogenous growth hormone levels in diet-induced hepatic steatosis in rats. Lipids in Health and Disease, 9, 78.
32. Bredella, M.A., Torriani, M., Thomas, B.J. et al. (2009) Peak growth hormone-releasing hormone-arginine-stimulated growth hormone is inversely associated with intramyocellular and intrahepatic lipid content in premenopausal women with obesity. Journal of Clinical Endocrinology and Metabolism, 94, 3995-4002.
33. Franco, C., Brandberg, J., Lönn, L. et al. (2005) Growth hormone treatment reduces abdominal visceral fat in postmenopausal women with abdominal obesity: a 12-month placebo-controlled trial. Journal of Clinical Endocrinology and Metabolism, 90, 1466-1474.
34. Takahashi, Y., Iida, K., Takahashi, K. et al. (2007) Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency. Gastroenterology, 132, 938-943.
35. Ichikava, T., Nakao, K., Hamasaki, K. et al. (2007) Role of growth hormone, insulin-like growth factor 1 and insulin-like growth factor-binding protein 3 in development of non-alcoholic fatty liver disease. Hepatology International, 1, 287-294.
36. Ney, D.M., Yang, H., Smith, S.M. et al. (1995) High-calorie total parenteral nutrition reduces hepatic insulin-like growth factor-I mRNA and alters serum levels of insulin-like growth factorbinding protein-1, -3, -5, and -6 in the rat. Metabolism, 44, 152-160.