GH levels and insulin sensitivity are differently associated with biomarkers of cardiovascular disease in active acromegaly

Clinical Endocrinology

Volumn 77, Issue 4, 2012, Pages 579-585

  Boero, L ^a   Manavela, M ^a   Merono T ^a   Maidana, P ^a   Rosso, L Gómez ^a   Brites, F ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

APOLIPOPROTEIN A1; APOLIPOPROTEIN B; BIOLOGICAL MARKER; C REACTIVE PROTEIN; CHOLESTEROL ESTER TRANSFER PROTEIN; ENDOTHELIN 1; FATTY ACID; GROWTH HORMONE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; INSULIN; LOW DENSITY LIPOPROTEIN CHOLESTEROL; OXIDIZED LOW DENSITY LIPOPROTEIN; RESISTIN; TRIACYLGLYCEROL; VASCULAR CELL ADHESION MOLECULE 1;

ACROMEGALY; ADULT; ANTHROPOMETRIC PARAMETERS; ARTHRALGIA; ARTICLE; ATHEROGENESIS; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE DURATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEADACHE; HORMONE DETERMINATION; HUMAN; INSULIN SENSITIVITY; LIPID ANALYSIS; MALE; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; SLEEP DISORDERED BREATHING; SOFT TISSUE DISEASE; SOFT TISSUE SWELLING; SWEATING;

ACROMEGALY; ADULT; BIOLOGICAL MARKERS; CARDIOVASCULAR DISEASES; CROSS-SECTIONAL STUDIES; FEMALE; GROWTH HORMONE; HUMANS; INSULIN RESISTANCE; MALE; MIDDLE AGED;

EID: 84867287661     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2012.04414.x     Document Type: Article

References (34)

1. Bengtsson, B.A., Eden, S., Ernest, I. et al. (1988) Epidemiology and long-term survival in acromegaly. A study of 166 cases diagnosed between 1955 and 1984. Acta Medica Scandinavica, 223, 327-335.
2. Boero, L., Manavela, M., Gomez Rosso, L. et al. (2009) Alterations in biomarkers of cardiovascular disease (CVD) in active acromegaly. Clinical Endocrinology, 70, 88-95.
3. Beentjes, J.A., van Tol, A., Sluiter, W.J. et al. (2000) Low plasma lecithin:cholesterol acyltransferase and lipid transfer protein activities in growth hormone deficient and acromegalic men: role in altered high density lipoproteins. Atherosclerosis, 153, 491-498.
4. Colao, A., Ferone, D., Marzullo, P. et al. (2004) Systemic complications of acromegaly: epidemiology, pathogenesis, and management. Endocrine Reviews, 25, 102-152.
5. Moller, N., Schmitz, O., Joorgensen, J.O. et al. (1992) Basal- and insulin-stimulated substrate metabolism in patients with active acromegaly before and after adenomectomy. Journal of Clinical Endocrinology and Metabolism, 74, 1012-1019.
6. Theuma, P. & Fonseca, V.A. (2004) Inflammation, insulin resistance, and atherosclerosis. Metabolic Syndrome and Related Disorders, 2, 105-113.
7. Holland, W.L., Knotts, T.A., Chavez, J.A. et al. (2007) Lipid mediators of insulin resistance. Nutrition Reviews, 65, S39-S46.
8. Jung, H.S., Park, K.H., Cho, Y.M. et al. (2006) Resistin is secreted from macrophages in atheromas and promotes atherosclerosis. Cardiovascular Research, 69, 76-85.
9. Nagaev, I. & Smith, U. (2001) Insulin resistance and type 2 diabetes are not related to resistin expression in human fat cells or skeletal muscle. Biochemical and Biophysical Research Communications, 285, 561-564.
10. Assmann, G., Jabs, H.U., Kohnert, U. et al. (1984) LDL-cholesterol determination in blood serum following precipitation of LDL with polyvinylsulfate. Clinica Chimica Acta, 140, 77-83.
11. Warnick, G.R., Benderson, J. & Albers, J.J. (1982) Dextran sulfate- Mg2+ precipitation procedure for quantitation of high-density- lipoprotein cholesterol. Clinical Chemistry, 28, 1379-1388.
12. Lagrost, L., Gandjini, H., Athias, A. et al. (1993) Influence of plasma cholesteryl ester transfer activity on the LDL and HDL distribution profiles in normolipidemic subjects. Arteriosclerosis and Thrombosis, 13, 815-825.
13. Boero, L., Cuniberti, L., Magnani, N. et al. (2010) Increased oxidized low density lipoprotein associated with high ceruloplasmin activity in patients with active acromegaly. Clinical Endocrinology, 72, 654-660.
14. Hansen, I., Tsalikian, E., Beaufrere, B. et al. (1986) Insulin resistance in acromegaly: defects in both hepatic and extrahepatic insulin action. American Journal of Physiology, 250, E269-E273.
15. Moller, N. & Jorgensen, J.O. (2009) Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocrine Reviews, 30, 152-177.
16. Chen, X.L., Lee, K., Hartzell, D.L. et al. (2001) Adipocyte insensitivity to insulin in growth hormone-transgenic mice. Biochemical and Biophysical Research Communications, 283, 933-937.
17. Vijayakumar, A., Novosyadlyy, R., Wu, Y. et al. (2010) Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Hormone and IGF Research, 20, 1-7.
18. Silha, J.V., Krsek, M., Hana, V. et al. (2003) Perturbations in adiponectin, leptin and resistin levels in acromegaly: lack of correlation with insulin resistance. Clinical Endocrinology, 58, 736-742.
19. Antuna-Puente, B., Feve, B., Fellahi, S. et al. (2008) Adipokines: the missing link between insulin resistance and obesity. Diabetes and Metabolism, 34, 2-11.
20. Krag, M.B., Gormsen, L.C., Guo, Z. et al. (2007) Growth hormone-induced insulin resistance is associated with increased intramyocellular triglyceride content but unaltered VLDLtriglyceride kinetics. American Journal of Physiology. Endocrinology and Metabolism, 292, E920-E927.
21. Coculescu, M., Niculescu, D., Lichiardopol, R. et al. (2007) Insulin resistance and insulin secretion in non-diabetic acromegalic patients. Experimental and Clinical Endocrinology&Diabetes, 115, 308-316.
22. Resmini, E., Minuto, F., Colao, A. et al. (2009) Secondary diabetes associated with principal endocrinopathies: the impact of new treatment modalities. Acta Diabetologica, 46, 85-95.
23. Grundy, S.M. (2006) Atherogenic dyslipidemia associated with metabolic syndrome and insulin resistance. Clinical Cornerstone, 8(Suppl 1), S21-S27.
24. Verges, B. (2005) New insight into the pathophysiology of lipid abnormalities in type 2 diabetes. Diabetes and Metabolism, 31, 429-439.
25. Richelsen, B., Pedersen, S.B., Kristensen, K. et al. (2000) Regulation of lipoprotein lipase and hormone-sensitive lipase activity and gene expression in adipose and muscle tissue by growth hormone treatment during weight loss in obese patients. Metabolism, 49, 906-911.
26. Ameen, C. & Oscarsson, J. (2003) Sex difference in hepatic microsomal triglyceride transfer protein expression is determined by the growth hormone secretory pattern in the rat. Endocrinology, 144, 3914-3921.
27. Borggreve, S.E., De Vries, R. & Dullaart, R.P. (2003) Alterations in high-density lipoprotein metabolism and reverse cholesterol transport in insulin resistance and type 2 diabetes mellitus: role of lipolytic enzymes, lecithin:cholesterol acyltransferase and lipid transfer proteins. European Journal of Clinical Investigation, 33, 1051-1069.
28. Brites, F.D., Bonavita, C.D., De Geitere, C. et al. (2000) Alterations in the main steps of reverse cholesterol transport in male patients with primary hypertriglyceridemia and low HDL-cholesterol levels. Atherosclerosis, 152, 181-192.
29. Andreassen, M., Vestergaard, H. & Kristensen, L.O. (2007) Concentrations of the acute phase reactants high-sensitive C-reactive protein and YKL-40 and of interleukin-6 before and after treatment in patients with acromegaly and growth hormone deficiency. Clinical Endocrinology, 67, 909-916.
30. Searle, A., Gomez-Rosso, L., Merono, T. et al. (2011) High LDL levels are associated with increased lipoprotein-associated phospholipase A(2) activity on nitric oxide synthesis and reactive oxygen species formation in human endothelial cells. Clinical Biochemistry, 44, 171-177.
31. Yarman, S., Ozden, T.A. & Gokkusu, C. (2003) The evaluation of lipid peroxidation and acute effect of octreotide on lipid peroxidation in patients with active acromegaly. Clinica Chimica Acta, 336, 45-48.
32. Andersson, I.J., Johansson, M.E., Wickman, A. et al. (2006) Endothelial dysfunction in growth hormone transgenic mice. Clinical Science, 110, 217-225.
33. Sainani, G.S., Maru, V.G. & Mehra, A.P. (2005) Role of endothelin-1 in genesis of coronary artery disease. Indian Heart Journal, 57, 121-127.
34. Kirilov, G., Zacharieva, S., Alexandrov, A.S. et al. (2009) Increased plasma endothelin level as an endothelial marker of cardiovascular risk in patients with active acromegaly: a comparison with plasma homocysteine. Methods and Findings in Experimental and Clinical Pharmacology, 31, 457-461.