Endothelial dysfunction in growth hormone transgenic mice

Clinical Science

Volumn 110, Issue 2, 2006, Pages 217-225

  Andersson, Irene J ^a   Johansson, Maria E ^a   Wickman, Anna ^a   Bohlooly Y, Mohammad ^b   Klintland, Natalia ^a   Caidahl, Kenneth ^a   Gustafsson, Maria ^c   Borén, Jan ^c   Gan, Li Ming ^a   Bergström, Göran ^a  

^a UNIVERSITY OF GOTHENBURG   (Sweden)

^b ASTRAZENECA R AND D   (Sweden)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Acetylcholine; Endothelial function; Growth factor; Transgenic mouse; Vasodilation

Indexed keywords

ENDOTHELIAL NITRIC OXIDE SYNTHASE; GROWTH HORMONE; HYDROETHIDINE; MANGANESE TETRAKIS(4 BENZOIC ACID)PORPHYRIN CHLORIDE; MESSENGER RNA; PORPHYRIN DERIVATIVE; SCAVENGER; SUPEROXIDE; SUPEROXIDE DISMUTASE; UNCLASSIFIED DRUG;

ACROMEGALY; ADOLESCENT; AGED; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA; ARTICLE; CARDIOVASCULAR DISEASE; CAROTID ARTERY; CONTROLLED STUDY; ENDOTHELIAL DYSFUNCTION; GENE OVEREXPRESSION; HYPERCHOLESTEROLEMIA; HYPERTENSION; MOUSE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; TRANSGENIC MOUSE; VASODILATATION;

ACETYLCHOLINE; ACROMEGALY; AGING; ANIMALS; AORTA; CARDIOVASCULAR DISEASES; CAROTID ARTERIES; CHOLINERGIC AGENTS; ENDOTHELIUM, VASCULAR; FEMALE; GENE EXPRESSION; GROWTH HORMONE; MICE; MICE, TRANSGENIC; MODELS, ANIMAL; OXIDATIVE STRESS; VASODILATION;

EID: 32644432376     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20050281     Document Type: Article

References (25)

1. Baldwin, A., Cundy, T., Butler, J. and Timmis, A. D. (1985) Progression of cardiovascular disease in acromegalic patients treated by external pituitary irradiation. Acta Endocrinol. 108, 26-30
2. Wright, A. D., Hill, D. M., Lowy, C. and Fraser, T. R. (1970) Mortality in acromegaly. Q. J. Med. 39, 1-16
3. Bengtsson, B. A., Eden, S., Ernest, I., Oden, A. and Sjogren, B. (1988) Epidemiology and long-term survival in acromegaly. A study of 166 cases diagnosed between 1955 and 1984. Acta Med. Scand. 223, 327-335
4. Bohlooly, Y. M., Carlson, L., Olsson, B. et al. (2001) Vascular function and blood pressure in GH transgenic mice. Endocrinology 142, 3317-3323
5. Frick, F., Bohlooly-Y, M., Linden, D. et al. (2001) Long-term growth hormone excess induces marked alterations in lipoprotein metabolism in mice. Am. J. Physiol. Endocrinol. Metab. 281, E1230-E1239
6. Schiffrin, E. (2002) Beyond blood pressure: the endothelium and atherosclerosis progression. Am. J. Hypertens. 15, S115-S122
7. Sherman, D. L. and Loscalzo, J. (1997) Endothelial dysfunction and cardiovascular disease. Cardiologia 42, 177-187
8. Elliott, H. L. (1998) Endothelial dysfunction in cardiovascular disease: risk factor, risk marker, or surrogate end point? J. Cardiovasc. Pharmacol. 32, S74-S77
9. Wolin, M. S, Gupte, S. A. and Oeckler, R. A. (2002) Superoxide in the vascular system. J. Vasc. Res. 39, 191-207
10. d'Uscio, L. V., Smith, L. A. and Katusic, Z. S. (2001) Hypercholesterolemia impairs endothelium-dependent relaxations in common carotid arteries of apolipoprotein E-deficient mice. Stroke. 32, 2658-2664
11. Hsueh, W. A. and Quinones, M. J. (2003) Role of endothelial dysfunction in insulin resistance. Am. J. Cardiol. 92, 10-17
12. Sandstedt, J., Ohlsson, C., Norjavaara, E., Nilsson, J. and Tornell, J. (1994) Disproportional bone growth and reduced weight gain in gonadectomized male bovine growth hormone transgenic and normal mice. Endocrinology 135, 2574-2580
13. Chen, W. Y., Chen, N. Y., Yun, J. et al. (1995) Amino acid residues in the third α-helix of growth hormone involved in growth promoting activity. Mol. Endocrinol. 9, 292-302
14. Olsson, B., Bohlooly-Y, M., Brusehed, O. et al. (2003) Bovine growth hormone-transgenic mice have major alterations in hepatic expression of metabolic genes. Am. J. Physiol. Endocrinol. Metab. 285, E504-E511
15. Gan, L., Doroudi, R., Hagg, U., Johansson, A., Selin-Sjogren, L. and Jern, S. (2000) Differential immediate-early gene responses to shear stress and intraluminal pressure in intact human conduit vessels. FEBS Lett. 477, 89-94
16. Miller, F. J., Gutterman, D. D., Rios, C. D., Heistad, D. D. and Davidson, B. L. (1998) Superoxide production in vascular smooth muscle contributes to oxidative stress and impaired relaxation in atherosclerosis. Circ. Res. 82, 1298-1305
17. Wickman, A., Klintland, N., Gan, L.-m. et al. (2003) A technique to estimate the rate of whole body nitric oxide formation in conscious mice. Nitric Oxide 9, 77-85
18. Thorner, M. O., Vance, M. L., Laws, E. R., Horvath, E. and Kovacs, K. (1998) The anterior pituitary. In Williams Textbook of Endocrinology (Williams, R. H. and Wilson, J. D., eds.), pp. 295-307, Saunders, Philadelphia
19. Connell, J. M. C. and Davis, D. L. (1994) Endocrine hypertension: thyroid disease and acromegaly. In Textbook of Hypertension (Swales, J. D., ed.), pp. 959-968, Blackwell Science Publishing, Oxford
20. Gryglewski, R. J., Palmer, R. M. and Moncada, S. (1986) Superoxide anion is involved in the breakdown of endothelium-derived vascular relaxing factor. Nature (London) 320, 454-456
21. Shimokawa, H. (1999) Primary endothelial dysfunction: atherosclerosis. J. Mol. Cell. Cardiol. 31, 23-37
22. Colao, A., Spiezia, S., Cerbone, G. et al. (2001) Increased arterial intima-media thickness by B-M mode echodoppler ultrasonography in acromegaly. Clin. Endocrinol. 54, 515-524
23. Fukai, T., Galis, Z. S., Meng, X. P., Parthasarathy, S. and Harrison, D. G. (1998) Vascular expression of extracellular superoxide dismutase in atherosclerosis. J. Clin. Invest. 101, 2101-2111
24. Oury, T. D., Day, B. J. and Crapo, J. D. (1996) Extracellular superoxide dismutase: a regulator of nitric oxide bioavailability. Lab. Invest. 75, 617-636
25. Munzel, T., Afanas'ev, I. B., Kleschyov, A. L. and Harrison, D. G. (2002) Detection of superoxide in vascular tissue. Arterioscler., Thromb., Vasc. Biol. 22, 1761-1768