A rat model of early sepsis: Relationships between gentamicin pharmacokinetics and systemic and renal effects of bacterial lipopolysaccharide combined with interleukin-2

Biological and Pharmaceutical Bulletin

Volumn 35, Issue 10, 2012, Pages 1703-1710

  Studena, Sarka ^a   Martinkova, Jirina ^a   Slizova, Dasa ^a   Krs, Otakar ^a   Senkerik, Marian ^b   Springer, Drahomira ^c   Chládek, Jaroslav ^a  

^a CHARLES UNIVERSITY   (Czech Republic)

^b UNIVERSITY HOSPITAL HRADEC KRALOVE   (Czech Republic)

^c CHARLES UNIVERSITY   (Czech Republic)

Author keywords

Early endotoxemia; Gentamicin; LPSIL 2; Multi organ injury; Pharmacokinetics; Sepsis

Indexed keywords

BACTERIUM LIPOPOLYSACCHARIDE; CREATININE; GENTAMICIN; INTERLEUKIN 2; UREA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CAPILLARY LEAK SYNDROME; CONTROLLED STUDY; CREATININE CLEARANCE; DRUG DISTRIBUTION; DRUG HALF LIFE; GLOMERULUS FILTRATION RATE; KIDNEY CLEARANCE; KIDNEY FUNCTION; KIDNEY TUBULE FUNCTION; MALE; MICTURITION; NONHUMAN; PLASMA CLEARANCE; PSEUDOMONAS AERUGINOSA; RAT; SEPSIS; STEADY STATE;

ANIMALS; ANTI-BACTERIAL AGENTS; CAPILLARY PERMEABILITY; DISEASE MODELS, ANIMAL; GENTAMICINS; GLOMERULAR FILTRATION RATE; INTERLEUKIN-2; KIDNEY; LIPOPOLYSACCHARIDES; MALE; RATS; RATS, WISTAR; SEPSIS;

EID: 84867275944     PISSN: 09186158     EISSN: 13475215     Source Type: Journal    
DOI: 10.1248/bpb.b12-00205     Document Type: Article

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