Localization of the nephron site of gentamicin-induced hypercalciuria in the rat: A micropuncture study

British Journal of Pharmacology

Volumn 130, Issue 2, 2000, Pages 441-449

  Parsons, P P ^b   Garland, H O ^c   Harpur, E S ^a  

^a Alnwick Research Centre   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

^c NONE

Author keywords

Gentamicin induced hypercalciuria; Microinfusion; Microperfusion; Micropuncture; Nephron site

Indexed keywords

CALCIUM; GENTAMICIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CALCIUM ABSORPTION; CALCIUM URINE LEVEL; CONTROLLED STUDY; HENLE LOOP; HYPERCALCIURIA; KIDNEY DISTAL TUBULE; KIDNEY PERFUSION; KIDNEY PROXIMAL TUBULE; MALE; MICTURITION; NEPHRON; NEPHROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PUNCH BIOPSY; RAT; SODIUM EXCRETION; WATER ABSORPTION;

EID: 0034100580     PISSN: 00071188     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjp.0703329     Document Type: Article

References (55)

1. ADAMS, R.H. & DURRETT, L.R. (1978). Gentamicin blockade of slow calcium channels in atrial myocardium of guinea pigs. J. Clin. Invest., 78, 241-257.
2. ALI, B.H., BASHIR, A.A. & TANIRA, M.O.M. (1995). The effect of thyroxine or carbimazole treatment on gentamicin nephrotoxicity in rats. Human Exp. Toxicol., 14, 13-17.
3. BACSKAI. B.J. & FRIEDMAN, P.A. (1990). Activation of latent calcium channels in renal epithelial cells by parathyroid hormone. Nature, 347, 388-391.
4. BENNETT, W.M., PULLIAM, J.P., PORTER, G.A. & HOUGHTON. D.C. (1985). Modification of experimental gentamicin nephrotoxicity by selective parathyroidectomy. Am. J. Physiol., 249, F832-F835.
5. BISHOP, J.H.V., GREEN, R. & THOMAS, S. (1981). Glucose transport by short loops of Henle in the rat. J. Physiol. 320, 127-138.
6. BRIGITTE, K. (1982). Structural aspects of adaptive changes in renal electrolyte excretion. Am. J. Physiol., 243, F211-F226.
7. BRUNETTE, M.G., MAILLOUX, J. & LAJEUNESSE, D. (1992a). Calcium transport through the luminal membrane of the distal tubule. I. Inter-relationship with sodium. Kidney Int., 41, 281-288.
8. BRUNETTE, M.G., MAILLOUX. J. & LAJEUNESSE, D. (1992b). Calcium transport through the luminal membrane of the distal tubule. II. Effect of pH, electrical potential and calcium channel inhibitors. Kidney Int., 41, 289-296.
9. CARRADO, A.P., PRADO. W.A. & DEMORAIS. P. (1975). Competitive antagonism between calcium and aminoglycoside antibiotics in skeletal and smooth muscles. In Concepts of Membranes in Regulation and Excitation. ed. Rocha, M., Silva, E. & Suarez-Kurtz, G. pp. 201-215. New York: Raven Press.
10. CHAHWALA, S.B. & HARPUR, E.S. (1983). Gentamicin-induced hypercalciuria in the rat. Acta Pharmacol. Toxicol., 53, 358-362.
11. COSTANZO, L.S. (1984). Comparison of calcium and sodium transport in early and late rat distal tubules: effect of amiloride. Am. J. Physiol., 246, F937-F945.
12. COSTANZO, L.S. (1985). Localisation of diuretic action in micro-perfused rat distal tubules: sodium and calcium transport. Am. J. Physiol, 248, F527-F535.
13. CRONIN, R.E. & NEWMAN, J.A. (1985). Protective effect of thyroxine but not parathyroidectomy on gentamicin nephrotoxicity. Am. J. Physiol., 248, F332-F339.
14. CRONIN, R.E., NIX, K.L., FERGUSON, E. R., SOUTHERN, P.M. & HENRICH, W.L. (1982). Renal cortex ion composition and Na/K ATPase activity in gentamicin nephrotoxicity. Am. J. Physiol., 242, F477-F483.
15. DOMINGUEZ, J.H., JUHASHZOUI, M., KLEIBOEKER, S.B., HALE, C.C. & FEISTER, H.A. (1992). Sodium-calcium exchanger of rat proximal tubule: gene expression and subcellular localisation. Am. J. Physiol., 263, F945-F950.
16. ELLIOTT, W.C. & PATCHIN, D.S. (1992). Aminoglycoside-mediated calciuresis. J. Pharmacol. Expt. Ther., 262, 151-156.
17. ELLIOTT, W.C., PATCHIN, D.S. & JONES, D.B. (1987). Effect of parathyroid hormone activity on gentamicin nephrotoxicity. J. Lab. Clin. Med., 109, 48-54.
18. ELLISON, D.H., VELAZQUEZ, H. & WRIGHT, F.S. (1987). Thiazide-sensitive sodium transport in early distal tubule. Am. J. Physiol., 253, F546-F554.
19. FOSTER, J.E., HARPUR, E.S. & GARLAND, H.O. (1992). An investigation of the acute effect of gentamicin on the renal handling of electrolytes in the rat. J. Pharmacol. Exp. Ther., 261, 38-43.
20. FOSTER, J.E., HARPUR, E.S. & PERRIS, A.D. (1988). Evidence that the hypercalciuric and hypermagnesiuric responses to gentamicin in the rat are not mediated by inhibition of parathyroid hormone. J. Physiol., 403, 19 p.
21. FRIEDMAN, P.A. & GESEK, F.A. (1994). Hormone-responsive calcium entry in distal convoluted tubules. J. Am. Soc. Nephrol., 4, 1396-1404.
22. FUKUDA, Y., EKLOF, A.C., MALMBORG, A.S. & APERIA, A. (1992). Calcium supplementation and thyroid hormone protect against gentamicin-induced inhibition of proximal tubular Na, K ATPase activity and other renal functional changes. Acta Physiol. Scand., 145, 93-98.
23. GARLAND, H.O., BIRDSEY, T.J., DAVIDGE, C.G., McLAUGHLIN, L.M., OAKES, A.J., SMITH, A.J. & HARPUR, E.S. (1994). Effects of gentamicin, neomycin and tobramycin on renal calcium and magnesium handling in two rat strains. Clin. Expt. Pharmacol. Physiol., 21, 109-115.
24. GARLAND, H.O., HARRIS, P.J. & MORGAN, T.O. (1991). Calcium transport in the proximal convoluted tubule and loop of Henle of rats made diabetic with streptozotocin. J. Endocriniol., 131, 373-380.
25. GARLAND, H.O., PHIPPS, D.J. & HARPUR, E.S. (1992). Gentamicin-induced hypercalciuria in the rat: assessment of nephron site involved. J. Pharmacol. Expt. Ther., 263, 293-297.
26. GREGER, R., LANG, F. & OBERLEITHNER, H. (1978). Distal site of calcium reabsorption in the rat nephron. Pflügers Arch., 374, 153-157.
27. HARPUR, E.S., FATHALLA, S.A.K. & PHIPPS, D.J. (1985). Increased urinary excretion of calcium and magnesium is an early manifestation of gentamicin-induced nephrotoxicity in the rat. In Renal Heterogeneity and Target Cell Toxicity. ed. Bach, P.H. pp. 349-352. Chichester: John Wiley & Sons.
28. JOHNSTON, P.A. & KAU, S.T. (1992). Evaluation of the renal site of action of a novel, eukalaemic diuretic, ICI 207828. J. Pharmacol. Expt. Ther., 260, 458-462.
29. KACEW, S. (1990). Pathogenic factors in aminoglycoside-induced nephrotoxicity. Toxicol. Lett.. 51, 241-259.
30. KOEPPEN, B.M. & STANTON, B.A. (1992). Renal fluid and electrolyte reabsorption. In Renal Physiology. ed. Koeppen, B.M. & Stanton, B.A. pp. 49-69. Missouri, USA: Mosby Year Book.
31. KOHLEPP, S.J., PLANT, S.B., McCARRON, D.A & GILBERT, D.N. (1982). Gentamicin does not chelate calcium. Antimicrob. Agents Chemother., 21, 668-669.
32. KRIZ, W. & BANKIR, L. (1988). A standard nomenclature for structures of the kidney. Am. J. Physiol., 254, F1-F8.
33. KUMAR, R., BORKE, J.L., CARIDE, A., VERMA, A.K. & PENNISTON, J.T. (1988). Localisation of erythrocyte Ca/Mg ATPase and 28-KDa-calcium binding protein in the rat kidney distal tubules. Clin. Res., 36, 595A.
34. LANADAU, D. & KHER, K.K. (1997). Gentamicin-induced Bartter-like syndrome. Paed. Nephrol., 11, 737-740.
35. MACK, M.M., ZIMANYI, I. & PESSAH, I.N. (1992). Discrimination of multiple binding sites for antagonists of the calcium release channel complex of skeletal and cardiac sarcoplasmic reticulum. J. Pharmacol. Exp. Ther., 262, 1028-1037.
36. McGLYNN, H. & RYAN, M.P. (1993). In vitro mechanisms and models of gentamicin nephrotoxicity. Toxicol. Lett., 53, 197-200.
37. MURAYAMA, Y., MOREL, F. & LEGRIMELLEC, C. (1972). Phosphate, calcium and magnesium transfer in proximal tubules and loops of Henle as measured by single nephron microperfusion experiments in the rat. Pflügers Arch., 333, 1-16.
38. PARSONS, P.P., GARLAND, H.O. & HARPUR, E.S. (1994). Assessment of the dose-response relationship and nephron site of gentamicin-induced hypercalciuria in the anaesthetised rat. Human Exp. Toxicol., 13, 284.
39. PARSONS, P.P., GARLAND, H.O. & HARPUR, E.S. (1995). Effect of gentamicin on urinary recoveries of 45Ca from distal tubular microperfusions in the anaesthetised rat. J. Physiol., 483, 168P.
40. PARSONS, P.P., GARLAND, H.O., HARPUR, E.S. & OLD, S. (1997). Acute gentamicin-induced hypercalciuria and hypermagnesiuria in the rat: dose-response relationship and role of renal tubular injury. Br. J. Pharmacol., 122, 570-576.
41. PHIPPS, D.J., SPENCER, A.J. & HARPUR, E.S. (1990). Comparison of the renal response of male Fischer 344, Sprague Dawley and Wistar rats to administration of gentamicin. Toxicol. Lett., 53, 203-205.
42. PURNELL, J., HOUGHTON, D.C., PORTER, G.A. & BENNETT, W.M. (1985). Effect of amiloride on experimental gentamicin nephrotoxicity. Nephron, 40, 166-170.
43. RAMACHANDRAN, C. & BRUNETTE, M.G. (1989). The renal Na/Ca exchange system is located exclusively in the distal tubule. Biochem. J., 257, 259-264.
44. RICCARDI, D., LEE, W.-S., LEE, K., SEGRE, G.V., BROWN, E.M. & HERBERT, S. (1996). Localization of the extracellular calcium-sensing receptor and PTH/PTHrP receptor in rat kidney. Am. J. Physiol., 271, F951-956.
45. RICCARDI, D., PARK, J., LEE, W.-S., GAMBA, G., BROWN, E.M & HERBERT, S. (1995). Cloning and functional expression of a rat kidney extracellular calcium/polyvalent cation-sensing receptor. Proc. Natl. Acd. Sci., USA, 92, 131-135.
46. ROUSE, D. & SUKI, W.N. (1990). Renal control of extracellular calcium. Kidney Int., 38, 700-708.
47. 1) cells in culture. J. Pharmacol. Exp. Ther., 236, 254-262.
48. SENEKJIAN, H.O., KNIGHT, T.F. & WEINMAN, E.J. (1981). Micropuncture study of the handling of gentamicin by the rat kidney. Kidney Int., 19, 416-423.
49. SHIRLEY, D.G., POUJEOL, P. & LEGRIMELLEC, C. (1976). Phosphate, calcium and magnesium fluxes into the lumen of the rat proximal convoluted tubule. Pflügers Arch., 362, 247-254.
50. STEINHAUSEN, M. (1963). Eine methode zur differenzierung proximaler und distaler tubuli der nierenrinde von ratten in vivo und ihre anwendung zur bestimmung tubularer stromungsgeschwindigkeiten. Pflügers Arch., 277, 23-35.
51. SWAN, S.K. (1997). Aminoglycoside nephrotoxicity. Sem. in Nephrol., 17, 27-33.
52. ULLRICH, K.J., RUMRICH, G. & KLOSS, C.R. (1976). Active Ca reabsorption in the proximal tubule of the rat kidney. Pflügers Arch., 364, 223-228.
53. VELAZQUEZ, H., ELLISON, D.H. & WRIGHT, F.S. (1987). Chloride-dependent potassium secretion in early and late renal distal tubules. Am. J. Physiol., 253, F555-F562.
54. WATSON, A., HOLOHAN, P.D. & ROSS, C.R. (1983). Severe hypomagnesaemia and hypocalcaemia following gentamicin therapy. Ir. Med. J., 76, 381-383.
55. ZALOGA, G.P., CHERNOW, B., POCK, A., WOOD, B. & ZARITSKY, A. (1984). Hypomagnesaemia is a common complication of aminoglycoside therapy. Surg. Gynaecol. Obstet., 158, 561-565.