Differential gene expression in granulosa cells from polycystic ovary syndrome patients with and without insulin resistance: identification of susceptibility gene sets through network analysis

Journal of Clinical Endocrinology and Metabolism

Volumn 97, Issue 10, 2012, Pages

  Kaur, Surleen ^a   Archer, Kellie J ^b   Devi, M Gouri ^c   Kriplani, Alka ^d   Strauss III, Jerome F ^e   Singh, Rita ^a  

^a UNIVERSITY OF DELHI   (India)

^b VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

^c Gouri Hospitals   (India)

^d ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^e VIRGINIA COMMONWEALTH UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRANSFORMING GROWTH FACTOR BETA;

ARTICLE; CARDIOVASCULAR DISEASE; CAV1 GENE; CLINICAL ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FEMALE; FEMALE INFERTILITY; FERTILIZATION IN VITRO; GENE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC LINKAGE; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; GRANULOSA CELL; HUMAN; HUMAN CELL; HYALURONAN SYNTHASE 2 GENE; INFLAMMATION; INSULIN GROWTH FACTOR II RECEPTOR GENE; INSULIN RESISTANCE; INTEGRIN ALPHA X GENE; MICROARRAY ANALYSIS; NEUTROPHIL CYTOSOLIC FACTOR 2 GENE; OVARY POLYCYSTIC DISEASE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SERPINA1 GENE; TAB2 GENE; TXNIP GENE;

CARDIOVASCULAR DISEASES; DIABETES MELLITUS; FEMALE; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENETIC PREDISPOSITION TO DISEASE; GRANULOSA CELLS; HUMANS; INFLAMMATION; INSULIN RESISTANCE; POLYCYSTIC OVARY SYNDROME; TRANSCRIPTOME;

EID: 84867251597     PISSN: 0021972X     EISSN: 19457197     Source Type: Journal    
DOI: 10.1210/jc.2011-3441     Document Type: Article

References (22)

1. Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group 2004 Revised 2003 consensus on diagnostic criteria and longterm health risks related to polycystic ovary syndrome (PCOS).Hum Reprod 19:41-47
2. Jabara S, Coutifaris C 2003 In vitro fertilization in the PCOS patient: clinical considerations. Semin Reprod Med 21:317-324 (Pubitemid 37296804)
3. Cano F, García-Velasco JA, Millet A, Remohí J, Simón C, Pellicer A 1997 Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women. J Assist Reprod Genet 14:254-261 (Pubitemid 27199986)
4. Dokras A, Bochner M, Hollinrake E, Markham S, Vanvoorhis B, Jagasia DH 2005 Screening women with polycystic ovary syndrome for metabolic syndrome. Obstet Gynecol 106:131-137 (Pubitemid 40898445)
5. Cussons AJ, Stuckey BG, Watts GF 2007 Metabolic syndrome and cardiometabolic risk in PCOS. Curr Diab Rep 7:66-73 (Pubitemid 46344191)
6. Perlmutter DH, May LT, Sehgal PB 1989 Interferon β 2/interleukin 6 modulates synthesis of α 1-antitrypsin in human mononuclear phagocytes and in human hepatoma cells. J Clin Invest 84:138-144 (Pubitemid 19170103)
7. Feng D, Yang C, Geurts AM, Kurth T, Liang M, Lazar J, Mattson DL, O'Connor PM, Cowley Jr AW 2012 Increased expression of NAD(P)H oxidase subunit p67(phox) in the renal medulla contributes to excess oxidative stress and salt-sensitive hypertension. Cell Metab 15:201-208
8. Ahlzén M, Johansson LE, Cervin C, Tornqvist H, Groop L, Ridderstråle M 2008 Expression of the transcription factor 7-like 2 gene (TCF7L2) in human adipocytes is down regulated by insulin. Biochem Biophys Res Commun 370:49-52
9. Lyssenko V, Lupi R, Marchetti P, Del Guerra S, Orho-Melander M, Almgren P, Sjögren M, Ling C, Eriksson KF, Lethagen AL, Mancarella R, Berglund G, Tuomi T, Nilsson P, Del Prato S, Groop L 2007 Mechanisms by which common variants in the TCF7L2 gene increase risk of type 2 diabetes. J Clin Invest 117:2155-2163 (Pubitemid 47219560)
10. Schellings MW, Vanhoutte D, Swinnen M, Cleutjens JP, Debets J, van Leeuwen RE, d'Hooge J, Van de Werf F, Carmeliet P, Pinto YM, Sage EH, Heymans S 2009 Absence of SPARC results in increased cardiac rupture and dysfunction after acute myocardial infarction. J Exp Med 206:113-123
11. Bagavandoss P, Sage EH, Vernon RB 1998 Secreted protein, acidic and rich in cysteine (SPARC) and thrombospondin in the developing follicle and corpus luteum of the rat. J Histochem Cytochem 46: 1043-1049 (Pubitemid 28402485)
12. Gower RM, Wu H, Foster GA, Devaraj S, Jialal I, Ballantyne CM, Knowlton AA, Simon SI 2011 CD11c/CD18 expression is upregulated on blood monocytes during hypertriglyceridemia and enhances adhesion to vascular cell adhesion molecule-1. Arterioscler Thromb Vasc Biol 31:160-166
13. Wu H, Gower RM, Wang H, Perrard XY, Ma R, Bullard DC, Burns AR, Paul A, Smith CW, Simon SI, Ballantyne CM 2009 Functional role of CD11c+ monocytes in atherogenesis associated with hypercholesterolemia. Circulation 119:2708-2717
14. Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K 2000 TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway. Mol Cell 5:649-658
15. Owerbach D, Piña L, Gabbay KH 2004 A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes. Diabetes 53:1890-1893 (Pubitemid 38857049)
16. Liu P, Rudick M, Anderson RG 2002 Multiple functions of caveo-lin-1. J Biol Chem 277:41295-41298
17. Diouf MN, Lefebvre R, Silversides DW, Sirois J, Lussier JG 2006 Induction of α-caveolin-1 (αCAV1) expression in bovine granulosa cells in response to an ovulatory dose of human chorionic gonadotropin. Mol Reprod Dev 73:1353-1360 (Pubitemid 44423724)
18. Brown J, Delaine C, Zaccheo OJ, Siebold C, Gilbert RJ, van Boxel G, Denley A, Wallace JC, Hassan AB, Forbes BE, Jones EY 2008 Structure and functional analysis of the IGF-II/IGF2R interaction. EMBO J 27:265-276
19. Wang Y, De Keulenaer GW, Lee RT 2002 Vitamin D(3)-up-regulated protein-1 is a stress-responsive gene that regulates cardiomyocyte viability through interaction with thioredoxin. J Biol Chem 277:26496-26500 (Pubitemid 34967145)
20. Elgort MG, O'Shea JM, Jiang Y, Ayer DE 2010 Transcriptional and translational downregulation of thioredoxin interacting protein is required for metabolic reprogramming during G(1). Genes Cancer 1:893-907
21. Fülöp C, Salustri A, Hascall VC 1997 Coding sequence of a hyaluronan synthase homologue expressed during expansion of the mouse cumulusoocyte complex. Arch Biochem Biophys 337:261-266 (Pubitemid 27198190)
22. Stock AE, Bouchard N, Brown K, Spicer AP, Underhill CB, Doré M, Sirois J 2002 Induction of hyaluronan synthase 2 by human chorionic gonadotropin in mural granulosa cells of equine preovulatory follicles. Endocrinology 143:4375-4384 (Pubitemid 35239571)