In Vitro Fertilization in the PCOS Patient: Clinical Considerations

Seminars in Reproductive Medicine

Volumn 21, Issue 3, 2003, Pages 317-324

  Jabara, Sami ^a   Coutifaris, Christos ^a  

^a HOSPITAL OF THE UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

High responders; Implantation; In vitro fertilization; Oocyte; Ovarian hyperstimulation syndrome; Polycystic ovaries

Indexed keywords

ANDROGEN; BUSERELIN; CHORIONIC GONADOTROPIN; ESTRADIOL; FOLLITROPIN; GONADORELIN AGONIST; GONADOTROPIN; LEUPRORELIN; LUTEINIZING HORMONE; ORAL CONTRACEPTIVE AGENT; PROGESTERONE;

CELL MATURATION; CLINICAL FEATURE; EMBRYO TRANSFER; FEMALE; FEMALE INFERTILITY; FERTILIZATION; FERTILIZATION IN VITRO; HUMAN; OOCYTE; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; PREGNANCY; REVIEW; RISK FACTOR; SIDE EFFECT; TREATMENT OUTCOME;

EMBRYO; FEMALE; FERTILIZATION IN VITRO; HUMANS; INFERTILITY, FEMALE; LUTEINIZING HORMONE; OOCYTES; OVARIAN HYPERSTIMULATION SYNDROME; POLYCYSTIC OVARY SYNDROME; PREGNANCY;

EID: 0142062614     PISSN: 15268004     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2003-43310     Document Type: Review

References (41)

1. Adams J, Polson DW, Franks S. Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J 1986;293:355-359
2. Hull MG. Epidemiology of infertility and polycystic ovarian disease: endocrinological and demographic studies. Gynecol Endocrinol 1997;1:235-245
3. Polson DW, Adams J, Wadsworth J, Franks S. Polycystic ovaries: a common finding in normal women. Lancet 1988;1: 870-872
4. Carmina E, Koyama T, Chang L, Stanczyk FZ, Lobo RA. Does ethnicity influence the prevalence of adrenal hyperandrogenism and insulin resistance in polycystic ovary syndrome? Am J Obstet Gynecol 1992;167:1907-1912
5. Dor J, Shulman A, Levran D, Ben-Rafael Z. The treatment of patients with polycystic ovarian syndrome by in-vitro fertilisation and embryo transfer: a comparison of results with patients with tubal infertility. Hum Reprod 1990;5:816-818
6. Salat-Baroux J, Alvarez S, Antoine JM, et al. Results of IVF in the treatment of polycystic ovary disease. Hum Reprod 1988;3:331-335
7. MacDougall MJ, Tan SL, Balen A, Jacobs HS. A controlled study comparing patients with or without polycystic ovaries undergoing in-vitro fertilisation. Hum Reprod 1993;8:233-237
8. Aboulghar M, Mansour RT, Serour G, Ramzy AM, Amin Y. Oocyte quality in patients with severe ovarian hyperstimulation syndrome. Fertil Steril 1997;69:1017-1021
9. Engmann L, Macanochie N, Sladkevicius P, Bekir J, Cambell S, Tan SL. The outcome of in-vitro fertilization treatment in women with sonographic evidence of polycystic ovarian morphology. Hum Reprod 1999;14:167-171
10. Cano F, Garcia-Velasco JA, Millet A, Remohi J, Simon C, Pellicer A. Oocyte quality in polycystic ovaries revisited: identification of a particular subgroup of women. J Assist Reprod Genet 1997;14:254-261
11. Remohi J, Vidal A, Pellicer A. Oocyte donation in low responders to conventional ovarian stimulation for in vitro fertilization. Fertil Steril 1993;59:1208-1215
12. Wong IL, Morris RS, Lobo RA, Paulson RJ, Sauer MV. Isolated polycystic morphology in ovum donors predicts response to ovarian stimulation. Hum Reprod 1995;10:524-528
13. Simon C, Cano F, Valbuena D, Remohi J, Pellicer A. Clinical evidence for a detrimental effect on uterine receptivity of high serum oestradiol concentrations in high and normal responder patients. Hum Reprod 1995;10:2432-2437
14. Simon C, Garcia Velasco JJ, Valbuena D, et al. Increasing uterine receptivity by decreasing estradiol levels during the preimplantation period in high responders with the use of a follide-stimulating hormone step-down regimen. Fertil Steril 1998;70:234-239
15. Hardy K, Robinson F, Paraschos T, Wicks R, Franks S, Winston R. Normal development and metabolic activity of preimplantation embryos in vitro from patients with polycystic ovaries. Hum Reprod 1995;10:2125-2135
16. Testart J, Forman R, Belaisch-Allart J, et al. Embryo quality and uterine receptivity in in-vitro fertilization cycles with or without agonists of gonadotrophin-releasing hormone. Hum Reprod 1989;4:198-201
17. Owen EJ, Shoham Z, Mason BA, Ostergaard H, Jacobs HS. Cotreatment with growth hormone after pituitary suppression for ovarian simulation in in-vitro fertilization: a randomized, double-blind, placebo-control trial. Fertil Steril 1991; 56:1104-1110
18. Tan SL, Kingsland C, Campbell S, et al. The long protocol of administration of gonadotropin-releasing hormone agonist is superior to the short protocol for ovarian stimulation for in vitro fertilization. Fertil Steril 1992;57:810-814
19. Homburg R, Levy T, Berkowitz D, et al. Gonadotropin-releasing hormone agonist reduces the miscarriage rate for pregnancies achieved in women with polycystic ovarian syndrome. Fertil Steril 1993;59:527-531
20. Balen A, Tan SL, MacDougall J, Jacobs H. Miscarriage rates following in-vitro fertilization are increased in women with polycystic ovaries and reduced by pituitary desensitization with buserelin. Hum Reprod 1993;8:959-964
21. Tesarik J, Mendoza C. Direct non-genomic effects of follicular steroids on maturing human oocytes: oestrogen versus androgen antagonism. Hum Reprod Update 1997;3:95-100
22. Tesarik J, Mendoza C. Nongenomic effects of 17 beta-estradiol on maturing human oocytes: relationship to oocyte developmental potential. J Clin Endocrinol Metab 1995;80:1438-1443
23. Yen SS. The polycystic ovary syndrome. Clin Endocrinol (Oxf) 1980;12:177-207
24. Franks S. Polycystic ovary syndrome. N Engl J Med 1995; 333:853-861
25. Regan L, Owen EJ, Jacobs HS. Hypersecretion of the luteinizing hormone, infertility and miscarriage. Lancet 1990; 336:1141-1144
26. Homburg R, Armrar NA, Eshel A, Adams J, Jacos HS. Influence of serum luteinizing hormone concentrations on ovulation conception and early pregnancy loss in polycystic ovary syndrome. Br Med J 1988,297:1024-1026
27. Stanger JD, Yovich JL. Reduced in-vitro fertilization of human oocyte from patients with based basal luteinizing hormone levels during the follicular phase. Br J Obstet Gynaecol 1985;92:385-393
28. Craft I, Gorgy A, Hill J, Menon D, Podsiadly B. Will GnRH antagonists provide new hope for patients considered "difficult responders" to GnRH agonist protocols? Hum Reprod 1999;14:2959-2962
29. Olivennes F, Fanchin R, Bouchard P, et al. The single or dual administration of the gonadotropin-releasing hormone antagonist Cetrorelix in an in vitro fertilization-embryo transfer program. Fertil Steril 1994;62:469-476
30. Damario MA, Barmat L, Liu HC, Davis OK, Rosenwaks Z. Dual suppression with oral contraceptives and gonadotrophin-releasing hormone agonists improves in-vitro fertilization outcome in high responder patients. Hum Reprod 1997;12: 2359-2365
31. Smitz J, Camus M, Devroey P, Wistano A, Van Steirteghem AC. Incidence of severe hyperstimulation syndrome after GnRH agonist/HMG superovulation for in-vitro fertilization. Hum Reprod 1991;6:933-937
32. Hamilton-Failrey D, Franks S. Common problems in induction ovulation. Baillieres Clin Obstet Gynaecol 1990;4:609-625
33. Seang-Lin T, Balen A, El Hussein E, Cambell S, Jacobs H. The administration of glucocorticoids for the prevention of ovarian hyperstimulation syndrome in in vitro fertilization: a prospective randomized study. Fertil Steril 1992;58:378-383
34. Rimington MR, Walker SM, Shaw RW. The use of laparoscopic ovarian electrocautery in preventing cancellation of in-vitro fertilization treatment cycles due to risk of ovarian hyperstimulation syndrome in women with polycystic ovaries. Hum Reprod 1997;12:1443-1447
35. Marci R, Senn A, Dessole S, et al. A low-dose stimulation protocol using highly purified follicle-stimulating hormone can lead to high pregnancy rates in in vitro fertilization patients with polycystic ovaries who are at risk of a high ovarian response to gonadotropins. Fertil Steril 2001;75:1131-1135
36. Benadiva CA, Davis O, Kligman I, Moomjy M, Liu H-C, Rosenwaks Z. Withholding gonadotropin administration is an effective alternative for the prevention of ovarian hyperstimulation syndrome. Fertil Steril 1997;67:724-727
37. Cha KY, Koo JJ, Ko JJ, Choi DH, Han SY, Yoon TK. Pregnancy after in vitro fertilization of human follicular oocytes collected from nonstimulated cycles, their culture in vitro and their transfer in a donor oocyte program. Fertil Steril 1991; 55:109-113
38. Trounson A, Wood C, Kausche A. In vitro maturation and the fertilization and developmental competence of oocytes recovered from untreated polycystic ovarian patients. Fertil Steril 1994;62:353-362
39. Russell JB, Knezevich KM, Fabian KF, Dickson JA. Unstimulated immature oocyte retrieval: early versus midfollicular endometrial priming. Fertil Steril 1997;67:616-620
40. Thornton MH, Francis MM, Paulson RJ. Immature oocyte retrieval: lessons from unstimulated IVF cycles. Fertil Steril 1998;70:647-650
41. Chian RC, Buckett WM, Tulandi T, Tan SL. Prospective randomized study of human chorionic gonadotrophin priming before immature oocyte retrieval from unstimulated women with polycystic ovarian syndrome. Hum Reprod 2000;15:165-170