HTLV-2 tax immortalizes human CD4+ memory T lymphocytes by oncogenic activation and dysregulation of autophagy

Journal of Biological Chemistry

Volumn 287, Issue 41, 2012, Pages 34683-34693

  Ren, Tong ^a,b   Dong, Wen ^a   Takahashi, Yoshinori ^a   Xiang, Di ^a   Yuan, Yunsheng ^a,c   Liu, Xin ^a   Loughran, Thomas P ^a   Sun, Shao Cong ^d   Wang, Hong Gang ^a,b   Cheng, Hua ^a,b  

^a PENN STATE CANCER INSTITUTE   (United States)

^b PENN STATE COLLEGE OF MEDICINE   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; CELL DEATH; CHEMICAL ACTIVATION; DISEASES; ENZYMES; TAXATION; VIRUSES;

AUTOPHAGY; CD4 T-LYMPHOCYTES; GENOME ENCODES; HUMAN T CELLS; IMMUNOPHENOTYPES; ONCOGENIC ACTIVATION; T LYMPHOCYTES; T-CELL LEUKEMIA; TRANSACTIVATORS; VIRAL GENOME;

T-CELLS;

BECLIN 1; CD3 ANTIGEN; CD4 ANTIGEN; CD45RO ANTIGEN; CD69 ANTIGEN; I KAPPA B KINASE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 2 RECEPTOR ALPHA; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN MCL 1; STAT3 PROTEIN; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TAX PROTEIN;

APOPTOSIS; ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; CD4+ T LYMPHOCYTE; CELL IMMORTALIZATION; CELL SURVIVAL; CONTROLLED STUDY; ENZYME ACTIVATION; GROWTH RETARDATION; HUMAN; HUMAN CELL; HUMAN T CELL LEUKEMIA VIRUS 2; IMMUNOPHENOTYPING; LYMPHOCYTE ACTIVATION; LYMPHOCYTE CULTURE; LYMPHOCYTE PROLIFERATION; MEMORY T LYMPHOCYTE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

EID: 84867247582     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.377143     Document Type: Article

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