Circulating cell-free mitochondrial DNA as a novel cancer biomarker: Opportunities and challenges

Mitochondrial DNA

Volumn 23, Issue 5, 2012, Pages 329-332

  Yu, Man ^a  

^a UNIVERSITY OF TORONTO   (Canada)

Author keywords

Biomarker; Cancer; Circulating cell free mitochondrial DNA

Indexed keywords

BIOLOGICAL MARKER; GENOMIC DNA; MITOCHONDRIAL DNA;

BLADDER CANCER; BLOOD LEVEL; BREAST CANCER; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CANCER RESEARCH; CELL FREE SYSTEM; DNA EXTRACTION; HUMAN; KIDNEY CANCER; NEOPLASM; OVARY CANCER; PRIORITY JOURNAL; PROSTATE CANCER; QUANTITATIVE ANALYSIS; REVIEW; TESTIS CANCER;

ANIMALS; DNA, MITOCHONDRIAL; GENOME, MITOCHONDRIAL; HUMANS; NEOPLASMS; NEOPLASTIC CELLS, CIRCULATING; TUMOR MARKERS, BIOLOGICAL;

EID: 84867242975     PISSN: 19401736     EISSN: 19401744     Source Type: Journal    
DOI: 10.3109/19401736.2012.696625     Document Type: Review

References (24)

1. Butt AN, Swaminathan R. 2008. Overview of circulating nucleic acids in plasma/serum. Ann NY Acad Sci 1137:236-242.
2. Chandra D, Singh KK. 2011. Genetic insights into OXPHOS defect and its role in cancer. Biochim Biophys Acta 1807: 620-625.
3. Chang CC, Lui CC, Lee CC, Chen SD, Chang WN, Lu CH. 2012. Clinical significance of serological biomarkers and neuropsychological performances in patients with temporal lobe epilepsy. BMC Neurol 12:15.
4. Chatterjee A, Dasgupta S, Sidransky D. 2011. Mitochondrial subversion in cancer. Cancer Prev Res (Phila) 4:638-654.
5. ChenW, Cai F, Zhang B, Yan Zhong X. 2012. Strategies of reducing input sample volume for extracting circulating cell-free nuclear DNA and mitochondrial DNA in plasma. Clin Chem Lab Med 50:261-265.
6. Chiu RW, Chan LY, LamNY, Tsui NB, Ng EK, Rainer TH, Lo YM. 2003. Quantitative analysis of circulating mitochondrial DNA in plasma. Clin Chem 49:719-726.
7. ClayMontier LL, Deng JJ, Bai Y. 2009. Number matters: Control of mammalian mitochondrial DNA copy number. J Genet Genomics 36:125-131.
8. Ellinger J, Muller SC,Wernert N, von Ruecker A, Bastian PJ. 2008. Mitochondrial DNA in serum of patients with prostate cancer: A predictor of biochemical recurrence after prostatectomy. Br J Urol Int 102:628-632.
9. Ellinger J, Albers P, Muller SC, von Ruecker A, Bastian PJ. 2009. Circulating mitochondrial DNA in the serum of patients with testicular germ cell cancer as a novel noninvasive diagnostic biomarker. Br J Urol Int 104:48-52.
10. Ellinger J, Muller DC, Muller SC, Hauser S, Heukamp LC, von Ruecker A, Bastian PJ, Walgenbach-Brunagel G. 2012. Circulating mitochondrialDNAin serum: A universal diagnostic biomarker for patients with urological malignancies. Urol Oncol, doi: 10.1016/j.urolonc.2010.03.004.
11. Fleischhacker M, Schmidt B. 2007. Circulating nucleic acids (CNAs) and cancer - A survey. Biochim Biophys Acta 1775: 181-232.
12. Greaves LC, Reeve AK, Taylor RW, Turnbull DM. 2012. Mitochondrial DNA and disease. J Pathol 226:274-286.
13. Jiang WW, Masayesva B, Zahurak M, Carvalho AL, Rosenbaum E, Mambo E, Zhou S, Minhas K, Benoit N,Westra WH, Alberg A, SidranskyD, KochW, Califano J. 2005. Increased mitochondrial DNA content in saliva associated with head and neck cancer. Clin Cancer Res 11:2486-2491.
14. Kohler C, Radpour R, Barekati Z, Asadollahi R, Bitzer J, Wight E, Burki N, Diesch C, Holzgreve W, Zhong XY. 2009. Levels of plasma circulating cell free nuclear and mitochondrial DNA as potential biomarkers for breast tumors. Mol Cancer 8:105.
15. Malik AN, Shahni R, Iqbal MM. 2009. Increased peripheral blood mitochondrial DNA in type 2 diabetic patients with nephropathy. Diabetes Res Clin Pract 86:e22-e24.
16. Malik AN, Shahni R, Rodriguez-de-Ledesma A, Laftah A, Cunningham P. 2011. Mitochondrial DNA as a non-invasive biomarker: accurate quantification using real time quantitative PCR without co-amplification of pseudogenes and dilution bias. Biochem Biophys Res Commun. 412:1-7.
17. Mehra N, Penning M, Maas J, van Daal N, Giles RH, Voest EE. 2007. Circulating mitochondrial nucleic acids have prognostic value for survival in patients with advanced prostate cancer. Clin Cancer Res 13:421-426.
18. Tourmen Y, Baris O, Dessen P, Jacques C, Malthiery Y, Reynier P. 2002. Structure and chromosomal distribution of human mitochondrial pseudogenes. Genomics 80:71-77.
19. Wallace DC. 2010. Mitochondrial DNA mutations in disease and aging. Environ Mol Mutagen 51:440-450.
20. Xing J, Chen M, Wood CG, Lin J, Spitz MR, Ma J, Amos CI, Shields PG, Benowitz NL, Gu J, de Andrade M, Swan GE, Wu X. 2008.
21. Mitochondrial DNA content: Its genetic heritability and association with renal cell carcinoma. J Natl Cancer Inst 100:1104-1112.
22. Yu M. 2011. Generation function and diagnostic value of mitochondrial DNA copy number alterations in human cancers. Life Sci 89:65-71.
23. Yu M. 2012. Somatic mitochondrial DNA mutations in human cancers. Adv Clin Chem 57:99-138.
24. Zachariah RR, Schmid S, Buerki N, Radpour R, Holzgreve W, Zhong X. 2008. Levels of circulating cell-free nuclear and mitochondrial DNA in benign and malignant ovarian tumors. Obstet Gynecol 112:843-850.