CUG binding protein 1 binds to a specific region within the human albumin 3' untranslated region

Biochemical and Biophysical Research Communications

Volumn 426, Issue 4, 2012, Pages 539-543

  Khaziapoul, Siavash ^a   Pearson, Mark J ^a   Pryme, Ian F ^b,c   Stern, Beate ^b,c   Hesketh, John E ^a  

^a NEWCASTLE UNIVERSITY   (United Kingdom)

^b UniTargetingResearch AS   (Norway)

^c UNIVERSITY OF BERGEN   (Norway)

Author keywords

CELF1; Proteomics; RNA affinity; RNA protein binding; UV cross linking

Indexed keywords

BINDING PROTEIN; CUG BINDING PROTEIN 1; HUMAN ALBUMIN; NUCLEOTIDE DERIVATIVE; UNCLASSIFIED DRUG;

3' UNTRANSLATED REGION; ANIMAL CELL; ARTICLE; BINDING AFFINITY; CHO CELL; CONTROLLED STUDY; FUNCTIONAL PROTEOMICS; GEL MOBILITY SHIFT ASSAY; HUMAN; HUMAN CELL; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CROSS LINKING; PROTEIN EXPRESSION;

3' UNTRANSLATED REGIONS; ALBUMINS; ANIMALS; CHO CELLS; CRICETINAE; ELECTROPHORETIC MOBILITY SHIFT ASSAY; GENE EXPRESSION REGULATION; HUMANS; RNA-BINDING PROTEINS;

CRICETULUS GRISEUS;

EID: 84867203048     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.123     Document Type: Article

References (16)

1. Pesole G., Liuni S., Grillo G., Saccone C. Structural and compositional features of untranslated regions of eukaryotic mRNAs. Gene 1997, 205:95-102.
2. Grillo G., Turi A., Licciulli F., et al. UTRdb and UTRsite (RELEASE 2010): a collection of sequences and regulatory motifs of the untranslated regions of eukaryotic mRNAs. Nucleic Acids Res. 2010, 38:75-80.
3. Chabanon H., Mickleburgh I., Hesketh J. Zipcodes and postage stamps: mRNA localisation signals and their trans-acting binding proteins. Brief Funct. Genomic Proteomic 2004, 3:240-256.
4. Espel E. The role of the AU-rich elements of mRNAs in controlling translation. Semin. Cell Dev. Biol. 2005, 16:59-67.
5. Eberhardt E., Doller A., Akool el-S., Pfeilschifter J. Modulation of mRNA stability as a novel therapeutic approach. Pharmacol. Ther. 2007, 114:56-73.
6. Keene J.D. RNA regulons: coordination of post-transcriptional events. Nat. Rev. Genet. 2007, 8:533-543.
7. Pearson M., Khazaipoul S., Optun A., et al. Albumin 3'untranslated region facilitates increased recombinant protein production from Chinese hamster ovary cells. J. Biotechnol. 2012, Epub ahead of print. 10.1002/biot.201200044.
8. Marquis J., Paillard L., Audic Y., et al. CUG-BP1/CELF1 requires UGU-rich sequences for high-affinity binding. Biochem. J. 2006, 400:291-301.
9. Mickleburgh I., Chabanon H., Nury D., et al. Elongation factor 1α binds to the region of the metallothionein-1 mRNA implicated in perinuclear localization - importance of an internal stem-loop. RNA 2006, 12:1397-1407.
10. Vlasova I.A., Tahoe N.M., Fan D., et al. Conserved GU-rich elements mediate mRNA decay by binding to CUG-binding protein 1. Mol. Cell 2008, 29:263-270.
11. Ladd A.N., Charlet N., Cooper T.A. The CELF family of RNA binding proteins is implicated in cell-specific and developmentally regulated alternative splicing. Cell Biol. 2001, 21:1285-1296.
12. Charlet-B N., Savkur R.S., Singh G., et al. Loss of the muscle-specific chloride channel in type 1 myotonic dystrophy due to misregulated alternative splicing. Mol. Cell 2002, 10:45-53.
13. Timchenko N.A., Wang G.L., Timchenko L.T. RNA CUG-binding protein 1 increases translation of 20kDa isoform of CCAAT/enhancer-binding protein beta by interacting with the alpha and beta subunits of eukaryotic initiation translation factor 2. J. Biol. Chem. 2005, 280:20549-20557.
14. Paillard L., Legagneux V., Osborne H.B. A functional deadenylation assay identifies human CUG-BP as a deadenylation factor. Biol. Cell 2003, 95:107-113.
15. Moraes K.C., Wilusz C.J., Wilusz J. CUG-BP binds to RNA substrates and recruits PARN deadenylase. RNA 2006, 12:1084-1091.
16. Beisang D., Rattenbacher B., Vlasova-St. Louis I.A., Bohjanen P.R. Regulation of CUG-binding protein 1 (CUGBP1) binding to target transcripts upon T cell activation. J. Biol. Chem. 2012, 287:951-960.