Crystal packing modifies ligand binding affinity: The case of aldose reductase

Proteins: Structure, Function and Bioinformatics

Volumn 80, Issue 11, 2012, Pages 2552-2561

  Cousido Siah, Alexandra ^a   Petrova, Tatiana ^b   Hazemann, Isabelle ^a   Mitschler, André ^a   Ruiz, Francesc X ^a   Howard, Eduardo ^c   Ginell, Stephan ^d   Atmanene, Cédric ^a,e   Van Dorsselaer, Alain ^a,e   Sanglier Cianférani, Sarah ^a,e   Joachimiak, Andrzej ^d   Podjarny, Alberto ^a  

^a UNIVERSITÉ DE STRASBOURG   (France)

^b INSTITUTE OF MATHEMATICAL PROBLEMS OF BIOLOGY   (Russian Federation)

^c Instituto de Fisica de Liquidos y Sistemas Biologicos   (Argentina)

^d ARGONNE NATIONAL LABORATORY   (United States)

^e CNRS   (France)

Author keywords

Competitive binding; High resolution crystallography; Ligand soaking; Mass spectrometry; Protein crystallography

Indexed keywords

ALDEHYDE REDUCTASE; ALDOSE REDUCTASE INHIBITOR; FIDARESTAT; IDD 594; UNCLASSIFIED DRUG;

ARTICLE; CRYSTAL STRUCTURE; CRYSTALLIZATION; DRUG STRUCTURE; ELECTROSPRAY MASS SPECTROMETRY; LIGAND BINDING; PRIORITY JOURNAL; STRUCTURE ANALYSIS; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

ALDEHYDE REDUCTASE; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; ENZYME INHIBITORS; HUMANS; LIGANDS; MODELS, MOLECULAR; PROTEIN BINDING;

EID: 84867191624     PISSN: 08873585     EISSN: 10970134     Source Type: Journal    
DOI: 10.1002/prot.24136     Document Type: Article

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