Synergistic effects of exposure to concentrated ambient fine pollution particles and nitrogen dioxide in humans

Inhalation Toxicology

Volumn 24, Issue 12, 2012, Pages 790-797

  Huang, Yuh Chin T ^a   Rappold, Ana G ^b   Graff, Donald W ^c   Ghio, Andrew J ^b   Devlin, Robert B ^b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^c MDS Inc   (Canada)

Author keywords

Air pollution; Cardiovascular effects; Heart rate variability; Mulipollutants; Particulate matter

Indexed keywords

ALPHA 1 ANTITRYPSIN; CHOLESTEROL; HIGH DENSITY LIPOPROTEIN; NITROGEN DIOXIDE;

ADULT; AIR; AIR POLLUTANT; AIR POLLUTION CONTROL; AMBIENT AIR; ARTICLE; CARDIOVASCULAR EFFECT; CONTROLLED STUDY; EXERCISE; EXPOSURE; FEMALE; HEALTH HAZARD; HEART RATE VARIABILITY; HEART REPOLARIZATION; HUMAN; HUMAN EXPERIMENT; LUNG FUNCTION; LUNG LAVAGE; MALE; NORMAL HUMAN; PARTICULATE MATTER; PRIORITY JOURNAL; T WAVE;

ADULT; AIR POLLUTANTS; ALPHA 1-ANTITRYPSIN; ARRHYTHMIAS, CARDIAC; ATMOSPHERE EXPOSURE CHAMBERS; BRONCHOALVEOLAR LAVAGE FLUID; CARDIOVASCULAR AGENTS; CARDIOVASCULAR SYSTEM; CHOLESTEROL; DRUG SYNERGISM; FEMALE; HEART RATE; HUMANS; HYPERCHOLESTEROLEMIA; LACTATE DEHYDROGENASES; MALE; NITROGEN DIOXIDE; NORTH CAROLINA; PARTICULATE MATTER; YOUNG ADULT;

EID: 84867180167     PISSN: 08958378     EISSN: 10917691     Source Type: Journal    
DOI: 10.3109/08958378.2012.718809     Document Type: Article

References (28)

1. Heart rate variability: standards of measurement, physiological interpretation and clinical use. Task Force of the European Society of Cardiology and the North American Society of Pacing and Electrophysiology. 1996. Circulation 93:1043-1065.
2. Adams WC, Brookes KA, Schelegle ES. 1987. Effects of NO2 alone and n combination with O3 on young men and women. J Appl Physiol 62:1698-1704. (Pubitemid 17070459)
3. Avol EL, Linn WS, Peng RC, Valencia G, Little D, Hackney JD. 1988. Laboratory study of asthmatic volunteers exposed to nitrogen dioxide and to ambient air pollution. Am Ind Hyg Assoc J 49:143-149.
4. Baccarelli A, Zanobetti A, Martinelli I, Grillo P, Hou L, Giacomini S, Bonzini M, Lanzani G, Mannucci PM, Bertazzi PA, Schwartz J. 2007. Effects of exposure to air pollution on blood coagulation. J Thromb Haemost 5:252-260. (Pubitemid 46139447)
5. Berger RD, Kasper EK, Baughman KL, Marban E, Calkins H, Tomaselli GF. 1997. Beat-to-beat QT interval variability: novel evidence for repolarization lability in ischemic and nonischemic dilated cardiomyopathy. Circulation 96:1557-1565. (Pubitemid 27375352)
6. Brook RD, Brook JR, Urch B, Vincent R, Rajagopalan S, Silverman F. 2002. Inhalation of fine particulate air pollution and ozone causes acute arterial vasoconstriction in healthy adults. Circulation 105:1534-1536. (Pubitemid 34297626)
7. Chan CC, Chuang KJ, Su TC, Lin LY. 2005. Association between nitrogen dioxide and heart rate variability in a susceptible population. Eur J Cardiovasc Prev Rehabil 12:580-586.
8. Chen TM, Gokhale J, Shofer S, Kuschner WG. 2007. Outdoor air pollution: nitrogen dioxide, sulfur dioxide, and carbon monoxide health effects. Am J Med Sci 333:249-256. (Pubitemid 46624817)
9. Devlin RB, Horstman DP, Gerrity TR, Becker S, Madden MC, Biscardi F, Hatch GE, Koren HS. 1999. Inflammatory response in humans exposed to 2.0 ppm nitrogen dioxide. Inhal Toxicol 11:89-109. (Pubitemid 29068716)
10. Felber Dietrich D, Gemperli A, Gaspoz JM, Schindler C, Liu LJ, Gold DR, Schwartz J, Rochat T, Barthélémy JC, Pons M, Roche F, Probst Hensch NM, Bridevaux PO, Gerbase MW, Neu U, Ackermann- Liebrich U; SAPALDIA Team. 2008. Differences in heart rate variability associated with long-term exposure to NO2. Environ Health Perspect 116:1357-1361.
11. Ghio AJ, Kim C, Devlin RB. 2000. Concentrated ambient air particles induce mild pulmonary inflammation in healthy human volunteers. Am J Respir Crit Care Med 162:981-988.
12. Gong H Jr, Linn WS, Clark KW, Anderson KR, Geller MD, Sioutas C. 2005. Respiratory responses to exposures with fine particulates and nitrogen dioxide in the elderly with and without COPD. Inhal Toxicol 17:123-132. (Pubitemid 40283864)
13. Graff DW, Cascio WE, Rappold A, Zhou H, Huang YC, Devlin RB. 2009. Exposure to concentrated coarse air pollution particles causes mild cardiopulmonary effects in healthy young adults. Environ Health Perspect 117:1089-1094.
14. Hesterberg TW, Bunn WB, McClellan RO, Hamade AK, Long CM, Valberg PA. 2009. Critical review of the human data on short-term nitrogen dioxide (NO2) exposures: evidence for NO2 no-effect levels. Crit Rev Toxicol 39:743-781.
15. Jerrett M, Finkelstein MM, Brook JR, Arain MA, Kanaroglou P, Stieb DM, Gilbert NL, Verma D, Finkelstein N, Chapman KR, Sears MR. 2009. A cohort study of traffic-related air pollution and mortality in Toronto, Ontario, Canada. Environ Health Perspect 117:772-777.
16. Kleinman MT, Bailey RM, Whynot JD, Anderson KR, Linn WS, Hackney JD. 1985. Controlled exposure to a mixture of SO2, NO2, and particulate air pollutants: effects on human pulmonary function and respiratory symptoms. Arch Environ Health 40:197-201. (Pubitemid 16223568)
17. Latza U, Gerdes S, Baur X. 2009. Effects of nitrogen dioxide on human health: systematic review of experimental and epidemiological studies conducted between 2002 and 2006. Int J Hyg Environ Health 212:271-287.
18. Liao D, Duan Y, Whitsel EA, Zheng ZJ, Heiss G, Chinchilli VM, Lin HM. 2004. Association of higher levels of ambient criteria pollutants with impaired cardiac autonomic control: a population-based study. Am J Epidemiol 159:768-777. (Pubitemid 38656134)
19. Mauderly JL, Samet JM. 2009. Is there evidence for synergy among air pollutants in causing health effects? Environ Health Perspect 117:1-6.
20. Pekkanen J, Brunner EJ, Anderson HR, Tiittanen P, Atkinson RW. 2000. Daily concentrations of air pollution and plasma fibrinogen in London. Occup Environ Med 57:818-822.
21. Rückerl R, Ibald-Mulli A, Koenig W, Schneider A, Woelke G, Cyrys J, Heinrich J, Marder V, Frampton M, Wichmann HE, Peters A. 2006. Air pollution and markers of inflammation and coagulation in patients with coronary heart disease. Am J Respir Crit Care Med 173:432-441. (Pubitemid 43228332)
22. Samet JM, Rappold A, Graff D, Cascio WE, Berntsen JH, Huang YC, Herbst M, Bassett M, Montilla T, Hazucha MJ, Bromberg PA, Devlin RB. 2009. Concentrated ambient ultrafine particle exposure induces cardiac changes in young healthy volunteers. Am J Respir Crit Care Med 179:1034-1042.
23. Schwartz J. 2001. Air pollution and blood markers of cardiovascular risk. Environ Health Perspect 109 Suppl 3:405-409.
24. Sioutas C, Koutrakis P, Burton RM. 1995. A technique to expose animals to concentrated fine ambient aerosols. Environ Health Perspect 103:172-177.
25. Sørensen M, Loft S, Andersen HV, Raaschou-Nielsen O, Skovgaard LT, Knudsen LE, Nielsen IV, Hertel O. 2005. Personal exposure to PM2.5, black smoke and NO2 in Copenhagen: relationship to bedroom and outdoor concentrations covering seasonal variation. J Expo Anal Environ Epidemiol 15:413-422. (Pubitemid 43109911)
26. US EPA 2009 Integrated Science Assessment for Particulate Matter (Final Report). U.S. Environmental Protection Agency.
27. Vagaggini B, Paggiaro PL, Giannini D, Franco AD, Cianchetti S, Carnevali S, Taccola M, Bacci E, Bancalari L, Dente FL, Giuntini C. 1996. Effect of short-term NO2 exposure on induced sputum in normal, asthmatic and COPD subjects. Eur Respir J 9:1852-1857. (Pubitemid 26294755)
28. Wheeler A, Zanobetti A, Gold DR, Schwartz J, Stone P, Suh HH. 2006. The relationship between ambient air pollution and heart rate variability differs for individuals with heart and pulmonary disease. Environ Health Perspect 114:560-566.