Platelet receptors

Handbook of Experimental Pharmacology

Volumn 210, Issue , 2012, Pages 23-57

  Kauskot, Alexandre ^a   Hoylaerts, Marc F ^a  

^a UNIVERSITY OF LEUVEN   (Belgium)

Author keywords

Adhesion; Aggregation; Amplification; Bleeding; Platelet receptors; Stabilization; Thrombosis

Indexed keywords

C TYPE LECTIN LIKE RECEPTOR 2 PROTEIN; CD151 ANTIGEN; CELL PROTEIN; CELL RECEPTOR; COLLAGEN RECEPTOR; EPH KINASE RECEPTOR; G PROTEIN COUPLED RECEPTOR; GLYCOPROTEIN VI; GROWTH ARREST SPECIFIC PROTEIN 6; PROSTACYCLIN RECEPTOR; PROSTAGLANDIN E RECEPTOR 1; PROSTAGLANDIN E RECEPTOR 2; PROSTAGLANDIN E RECEPTOR 3; PROSTAGLANDIN E RECEPTOR 4; PROTEIN ALPHA2B BETA3; PROTEIN CD148; PROTEINASE ACTIVATED RECEPTOR 1; PROTEINASE ACTIVATED RECEPTOR 3; PROTEINASE ACTIVATED RECEPTOR 4; PURINERGIC P2X1 RECEPTOR; PURINERGIC P2Y1 RECEPTOR; PURINERGIC P2Y12 RECEPTOR; THROMBIN RECEPTOR; THROMBOCYTE RECEPTOR; THROMBOXANE A2 RECEPTOR; THROMBOXANE RECEPTOR; UNCLASSIFIED DRUG; UNINDEXED DRUG; VERY LATE ACTIVATION ANTIGEN 2; VERY LATE ACTIVATION ANTIGEN 6; VITRONECTIN RECEPTOR; CELL SURFACE RECEPTOR; GLYCOPROTEIN RECEPTOR GPIB IX; GLYCOPROTEIN RECEPTOR GPIB-IX; INTEGRIN; PROSTAGLANDIN E RECEPTOR;

ARTICLE; BERNARD SOULIER DISEASE; BIOCHEMICAL COMPOSITION; BLEEDING; CD148 GENE; DIMERIZATION; GENE; HUMAN; MUTATIONAL ANALYSIS; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; THROMBOCYTE ACTIVATION; THROMBOCYTE ADHESION; THROMBOCYTE AGGREGATION; ANIMAL; CHEMISTRY; PHYSIOLOGY; REVIEW; THROMBOCYTE;

ANIMALS; BLOOD PLATELETS; HUMANS; INTEGRINS; PLATELET ADHESIVENESS; PLATELET AGGREGATION; PLATELET GLYCOPROTEIN GPIB-IX COMPLEX; RECEPTORS, CELL SURFACE; RECEPTORS, COLLAGEN; RECEPTORS, PROSTAGLANDIN E;

EID: 84867177503     PISSN: 01712004     EISSN: 18650325     Source Type: Book Series    
DOI: 10.1007/978-3-642-29423-5_2     Document Type: Article

References (90)

1. Abdullah NM, Kachman M, Walker A, Hawley AE, Wrobleski SK, Myers DD, Strahler JR, Andrews PC, Michailidis GC, Ramacciotti E, Henke PK, Wakefield TW (2009) Microparticle surface protein are associated with experimental venous thrombosis: a preliminary study. Clin Appl Thromb Hemost 15:201-208
2. Adam F, Bouton MC, Huisse MG, Jandrot-Perrus M (2003) Thrombin interaction with platelet membrane glycoprotein Ib alpha. Trends Mol Med 9:461-464
3. Angelillo-Scherrer A, Burnier L, Flores N, Savi P, DeMol M, Schaeffer P, Herbert JM, Lemke G, Goff SP, Matsushima GK, Earp HS, Vesin C, Hoylaerts MF, Plaisance S, Collen D, Conway EM, Wehrle-Haller B, Carmeliet P (2005) Role of Gas6 receptors in platelet signaling during thrombus stabilization and implications for antithrombotic therapy. J Clin Invest 115:237-246
4. Arthur JF, Dunkley S, Andrews RK (2007) Platelet glycoprotein VI-related clinical defects. Br J Haematol 139:363-372
5. Autschbach F, Palou E, Mechtersheimer G, Rohr C, Pirotto F, Gassler N, Otto HF, Schraven B, Gaya A (1999) Expression of the membrane protein tyrosine phosphatase CD148 in human tissues. Tissue Antigens 54:485-498
6. Baglia FA, Badellino KO, Li CQ, Lopez JA, Walsh PN (2002) Factor XI binding to the platelet glycoprotein Ib-IX-V complex promotes factor XI activation by thrombin. J Biol Chem 277:1662-1668
7. Bender M, Hofmann S, Stegner D, Chalaris A, Bosl M, Braun A, Scheller J, Rose-John S, Nieswandt B (2010) Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases. Blood 116:3347-3355
8. Bradford HN, Pixley RA, ColmanRW(2000) Human factor XII binding to the glycoprotein Ib-IX-V complex inhibits thrombin-induced platelet aggregation. J Biol Chem 275:22756-22763
9. Clemetson KJ, Clemetson JM (2001) Platelet collagen receptors. Thromb Haemost 86:189-197
10. Coller BS, Shattil SJ (2008) The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend. Blood 112:3011-3025
11. Cosemans JM, Munnix IC, Wetzker R, Heller R, Jackson SP, Heemskerk JW (2006) Continuous signaling via PI3K isoforms beta and gamma is required for platelet ADP receptor function in dynamic thrombus stabilization. Blood 108:3045-3052
12. Cosemans JM, Iserbyt BF, Deckmyn H, Heemskerk JW (2008) Multiple ways to switch platelet integrins on and off. J Thromb Haemost 6:1253-1261
13. Cosemans JM, Van Kruchten R, Olieslagers S, Schurgers LJ, Verheyen FK, Munnix IC, Waltenberger J, Angelillo-Scherrer A, Hoylaerts MF, Carmeliet P, Heemskerk JW (2010) Potentiating role of Gas6 and Tyro3, Axl and Mer (TAM) receptors in human and murine platelet activation and thrombus stabilization. J Thromb Haemost 8:1797-1808
14. De Marco L, Mazzucato M, Masotti A, Ruggeri ZM (1994) Localization and characterization of an alpha-thrombin-binding site on platelet glycoprotein Ib alpha. J Biol Chem 269:6478-6484
15. Devreese K, Peerlinck K, Hoylaerts MF (2010) Thrombotic risk assessment in the antiphospholipid syndrome requires more than the quantification of lupus anticoagulants. Blood 115:870-878
16. Dumont B, Lasne D, Rothschild C, Bouabdelli M, Ollivier V, Oudin C, Ajzenberg N, Grandchamp B, Jandrot-Perrus M (2009) Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations. Blood 114:1900-1903
17. Ellison S, Mori J, Barr AJ, Senis YA (2010) CD148 enhances platelet responsiveness to collagen by maintaining a pool of active Src family kinases. J Thromb Haemost 8:1575-1583
18. Fang J, Jensen ES, Boudreaux MK, Du LM, Hawkins TB, Koukouritaki SB, Cornetta K, Wilcox DA (2011) Platelet gene therapy improves hemostatic function for integrin {alpha}IIb{beta}3- deficient dogs. Proc Natl Acad Sci USA 108(23):9583-9588
19. Fiore M, Pillois X, Nurden P, Nurden AT, Austerlitz F (2011) Founder effect and estimation of the age of the French Gypsy mutation associated with Glanzmann thrombasthenia in Manouche families. Eur J Hum Genet 19(9):981-987
20. Franchini M, Montagnana M, Lippi G (2008) Clinical, laboratory and therapeutic aspects of platelet-type von Willebrand disease. Int J Lab Hematol 30:91-94
21. Freson K, Hashimoto H, Thys C, Wittevrongel C, Danloy S, Morita Y, Shintani N, Tomiyama Y, Vermylen J, Hoylaerts MF, Baba A, Van Geet C (2004) The pituitary adenylate cyclaseactivating polypeptide is a physiological inhibitor of platelet activation. J Clin Invest 113:905-912
22. Gachet C (2008) P2 receptors, platelet function and pharmacological implications. Thromb Haemost 99:466-472
23. Ghosh A, Murugesan G, Chen K, Zhang L, Wang Q, Febbraio M, Anselmo RM, Marchant K, Barnard J, Silverstein RL (2011) Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms. Blood 117:6355-6366
24. Giomarelli B, Washington VA, Chisholm MM, Quigley L, McMahon JB, Mori T, McVicar DW (2007) Inhibition of thrombin-induced platelet aggregation using human single-chain Fv antibodies specific for TREM-like transcript-1. Thromb Haemost 97:955-963
25. Goschnick MW, Lau LM, Wee JL, Liu YS, Hogarth PM, Robb LM, Hickey MJ, Wright MD, Jackson DE (2006) Impaired "outside-in" integrin alphaIIbbeta3 signaling and thrombus stability in TSSC6-deficient mice. Blood 108:1911-1918
26. Gross S, Tilly P, Hentsch D, Vonesch JL, Fabre JE (2007) Vascular wall-produced prostaglandin E2 exacerbates arterial thrombosis and atherothrombosis through platelet EP3 receptors. J Exp Med 204:311-320
27. Habib A, FitzGerald GA, Maclouf J (1999) Phosphorylation of the thromboxane receptor alpha, the predominant isoform expressed in human platelets. J Biol Chem 274:2645-2651
28. Hermans C, Wittevrongel C, Thys C, Smethurst PA, Van Geet C, Freson K (2009) A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder. J Thromb Haemost 7:1356-1363
29. Herrera-Galeano JE, Becker DM, Wilson AF, Yanek LR, Bray P, Vaidya D, Faraday N, Becker LC (2008) A novel variant in the platelet endothelial aggregation receptor-1 gene is associated with increased platelet aggregability. Arterioscler Thromb Vasc Biol 28:1484-1490
30. Hirata T, Ushikubi F, Kakizuka A, Okuma M, Narumiya S (1996) Two thromboxane A2 receptor isoforms in human platelets. Opposite coupling to adenylyl cyclase with different sensitivity to Arg60 to Leu mutation. J Clin Invest 97:949-956
31. Hoylaerts MF, Yamamoto H, Nuyts K, Vreys I, Deckmyn H, Vermylen J (1997) von Willebrand factor binds to native collagen VI primarily via its A1 domain. Biochem J 324(Pt 1):185-191
32. Hu H, Hoylaerts MF (2010) The P2X1 ion channel in platelet function. Platelets 21:153-166
33. Hughes CE, Navarro-Nunez L, Finney BA, Mourao-Sa D, Pollitt AY, Watson SP (2010) CLEC- 2 is not required for platelet aggregation at arteriolar shear. J Thromb Haemost 8:2328-2332
34. Ibrahim S, Tetruashvily M, Frey AJ, Wilson SJ, Stitham J, Hwa J, Smyth EM (2010) Dominant negative actions of human prostacyclin receptor variant through dimerization: implications for cardiovascular disease. Arterioscler Thromb Vasc Biol 30:1802-1809
35. Johnson AD, Yanek LR, Chen MH, Faraday N, Larson MG, Tofler G, Lin SJ, Kraja AT, Province MA, Yang Q, Becker DM, O'Donnell CJ, Becker LC (2010) Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists. Nat Genet 42:608-613
36. Jones CI, Bray S, Garner SF, Stephens J, de Bono B, Angenent WG, Bentley D, Burns P, Coffey A, Deloukas P, Earthrowl M, Farndale RW, Hoylaerts MF, Koch K, Rankin A, Rice CM, Rogers J, Samani NJ, Steward M, Walker A, Watkins NA, Akkerman JW, Dudbridge F, Goodall AH, Ouwehand WH (2009a) A functional genomics approach reveals novel quantitative trait loci associated with platelet signaling pathways. Blood 114:1405-1416
37. Jones CI, Garner SF, Moraes LA, Kaiser WJ, Rankin A, Ouwehand WH, Goodall AH, Gibbins JM (2009b) PECAM-1 expression and activity negatively regulate multiple platelet signaling pathways. FEBS Lett 583:3618-3624
38. Kasirer-Friede A, Kahn ML, Shattil SJ (2007) Platelet integrins and immunoreceptors. Immunol Rev 218:247-264
39. Konstantinides S, Ware J, Marchese P, Almus-Jacobs F, Loskutoff DJ, Ruggeri ZM (2006) Distinct antithrombotic consequences of platelet glycoprotein Ibalpha and VI deficiency in a mouse model of arterial thrombosis. J Thromb Haemost 4:2014-2021
40. Lanza F (2006) Bernard-Soulier syndrome (hemorrhagiparous thrombocytic dystrophy). Orphanet J Rare Dis 1:46
41. Ma H, Hara A, Xiao CY, Okada Y, Takahata O, Nakaya K, Sugimoto Y, Ichikawa A, Narumiya S, Ushikubi F (2001) Increased bleeding tendency and decreased susceptibility to thromboembolism in mice lacking the prostaglandin E receptor subtype EP(3). Circulation 104:1176-1180
42. Mangin P, Yap CL, Nonne C, Sturgeon SA, Goncalves I, Yuan Y, Schoenwaelder SM, Wright CE, Lanza F, Jackson SP (2006) Thrombin overcomes the thrombosis defect associated with platelet GPVI/FcRgamma deficiency. Blood 107:4346-4353
43. Massberg S, Gawaz M, Gruner S, Schulte V, Konrad I, Zohlnhofer D, Heinzmann U, Nieswandt B (2003) A crucial role of glycoprotein VI for platelet recruitment to the injured arterial wall in vivo. J Exp Med 197:41-49
44. May F, Hagedorn I, Pleines I, Bender M, Vogtle T, Eble J, Elvers M, Nieswandt B (2009) CLEC-2 is an essential platelet-activating receptor in hemostasis and thrombosis. Blood 114:3464-3472
45. Miura Y, Takahashi T, Jung SM, Moroi M (2002) Analysis of the interaction of platelet collagen receptor glycoprotein VI (GPVI) with collagen. A dimeric form of GPVI, but not the monomeric form, shows affinity to fibrous collagen. J Biol Chem 277:46197-46204
46. Morel O, Morel N, Freyssinet JM, Toti F (2008) Platelet microparticles and vascular cells interactions: a checkpoint between the haemostatic and thrombotic responses. Platelets 19:9-23
47. Mori J, Pearce AC, Spalton JC, Grygielska B, Eble JA, Tomlinson MG, Senis YA, Watson SP (2008) G6b-B inhibits constitutive and agonist-induced signaling by glycoprotein VI and CLEC-2. J Biol Chem 283:35419-35427
48. Moshfegh K, Wuillemin WA, Redondo M, Lammle B, Beer JH, Liechti-Gallati S, Meyer BJ (1999) Association of two silent polymorphisms of platelet glycoprotein Ia/IIa receptor with risk of myocardial infarction: a case-control study. Lancet 353:351-354
49. Nanda N, Bao M, Lin H, Clauser K, Komuves L, Quertermous T, Conley PB, Phillips DR, Hart MJ (2005) Platelet endothelial aggregation receptor 1 (PEAR1), a novel epidermal growth factor repeat-containing transmembrane receptor, participates in platelet contact-induced activation. J Biol Chem 280:24680-24689
50. Nergiz-Unal R, Rademakers T, Cosemans JM, Heemskerk JW (2011) CD36 as a multiple-ligand signaling receptor in atherothrombosis. Cardiovasc Hematol Agents Med Chem 9:42-55
51. Nurden AT (2006) Glanzmann thrombasthenia. Orphanet J Rare Dis 1:10
52. Nurden P, Nurden AT (2008) Congenital disorders associated with platelet dysfunctions. Thromb Haemost 99:253-263
53. Nuyttens BP, Thijs T, Deckmyn H, Broos K (2011) Platelet adhesion to collagen. Thromb Res 127 (Suppl 2):S26-S29
54. Oestreich J (2009) SCH-530348, a thrombin receptor (PAR-1) antagonist for the prevention and treatment of atherothrombosis. Curr Opin Investig Drugs 10:988-996
55. Orlowski E, Chand R, Yip J, Wong C, Goschnick MW, Wright MD, Ashman LK, Jackson DE (2009) A platelet tetraspanin superfamily member, CD151, is required for regulation of thrombus growth and stability in vivo. J Thromb Haemost 7:2074-2084
56. Oury C, Sticker E, Cornelissen H, De Vos R, Vermylen J, Hoylaerts MF (2004) ATP augments von Willebrand factor-dependent shear-induced platelet aggregation through Ca2+-calmodulin and myosin light chain kinase activation. J Biol Chem 279:26266-26273
57. Ozaki Y, Suzuki-Inoue K, Inoue O (2009) Novel interactions in platelet biology: CLEC- 2/podoplanin and laminin/GPVI. J Thromb Haemost 7(Suppl 1):191-194
58. Patrono C, Garcia Rodriguez LA, Landolfi R, Baigent C (2005) Low-dose aspirin for the prevention of atherothrombosis. N Engl J Med 353:2373-2383
59. Paul BZ, Ashby B, Sheth SB (1998) Distribution of prostaglandin IP and EP receptor subtypes and isoforms in platelets and human umbilical artery smooth muscle cells. Br J Haematol 102:1204-1211
60. Philipose S, Konya V, Sreckovic I, Marsche G, Lippe IT, Peskar BA, Heinemann A, Schuligoi R (2010) The prostaglandin E2 receptor EP4 is expressed by human platelets and potently inhibits platelet aggregation and thrombus formation. Arterioscler Thromb Vasc Biol 30:2416-2423
61. Pincus MR, Dykes DC, Carty RP, Miller JL (1991) Conformational energy analysis of the substitution of Val for Gly 233 in a functional region of platelet GPIb alpha in platelet-type von Willebrand disease. Biochim Biophys Acta 1097:133-139
62. Pitchford SC, Yano H, Lever R, Riffo-Vasquez Y, Ciferri S, RoseMJ, Giannini S, Momi S, Spina D, O'Connor B, Gresele P, Page CP (2003) Platelets are essential for leukocyte recruitment in allergic inflammation. J Allergy Clin Immunol 112:109-118
63. Poujol C, Ware J, Nieswandt B, Nurden AT, Nurden P (2002) Absence of GPIbalpha is responsible for aberrant membrane development during megakaryocyte maturation: ultrastructural study using a transgenic model. Exp Hematol 30:352-360
64. Prevost N, Woulfe D, Tognolini M, Brass LF (2003) Contact-dependent signaling during the late events of platelet activation. J Thromb Haemost 1:1613-1627
65. Prevost N, Woulfe DS, Jiang H, Stalker TJ, Marchese P, Ruggeri ZM, Brass LF (2005) Eph kinases and ephrins support thrombus growth and stability by regulating integrin outside-in signaling in platelets. Proc Natl Acad Sci USA 102:9820-9825
66. Ramacciotti E, Hawley AE, Farris DM, Ballard NE, Wrobleski SK, Myers DD Jr, Henke PK, Wakefield TW (2009) Leukocyte- and platelet-derived microparticles correlate with thrombus weight and tissue factor activity in an experimental mouse model of venous thrombosis. Thromb Haemost 101:748-754
67. Ramacciotti E, Blackburn S, Hawley AE, Vandy F, Ballard-Lipka N, Stabler C, Baker N, Guire KE, Rectenwald JE, Henke PK, Myers DD Jr, Wakefield TW (2011) Evaluation of soluble P-Selectin as a marker for the diagnosis of deep venous thrombosis. Clin Appl Thromb Hemost 17(4):425-431
68. Ramakrishnan V, DeGuzman F, Bao M, Hall SW, Leung LL, Phillips DR (2001) A thrombin receptor function for platelet glycoprotein Ib-IX unmasked by cleavage of glycoprotein V. Proc Natl Acad Sci USA 98:1823-1828
69. Rivera J, Lozano ML, Navarro-Nunez L, Vicente V (2009) Platelet receptors and signaling in the dynamics of thrombus formation. Haematologica 94:700-711
70. Roberts W, Magwenzi S, Aburima A, Naseem KM (2010) Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood 116:4297-4306
71. Romo GM, Dong JF, Schade AJ, Gardiner EE, Kansas GS, Li CQ, McIntire LV, Berndt MC, Lopez JA (1999) The glycoprotein Ib-IX-V complex is a platelet counterreceptor for P-selectin. J Exp Med 190:803-814
72. Salsmann A, Schaffner-Reckinger E, Kieffer N (2006) RGD, the Rho'd to cell spreading. Eur J Cell Biol 85:249-254
73. Santoro SA (1999) Platelet surface collagen receptor polymorphisms: variable receptor expression and thrombotic/hemorrhagic risk. Blood 93:3575-3577
74. Savage B, Almus-Jacobs F, Ruggeri ZM (1998) Specific synergy of multiple substrate-receptor interactions in platelet thrombus formation under flow. Cell 94:657-666
75. Senis YA, Tomlinson MG, Ellison S, Mazharian A, Lim J, Zhao Y, Kornerup KN, Auger JM, Thomas SG, Dhanjal T, Kalia N, Zhu JW, Weiss A, Watson SP (2009) The tyrosine phosphatase CD148 is an essential positive regulator of platelet activation and thrombosis. Blood 113:4942-4954
76. Siljander PR, Hamaia S, Peachey AR, Slatter DA, Smethurst PA, Ouwehand WH, Knight CG, Farndale RW (2004) Integrin activation state determines selectivity for novel recognition sites in fibrillar collagens. J Biol Chem 279:47763-47772
77. Soeki T, Tamura Y, Shinohara H, Sakabe K, Onose Y, Fukuda N (2003) Increased soluble platelet/ endothelial cell adhesion molecule-1 in the early stages of acute coronary syndromes. Int J Cardiol 90:261-268
78. Staron M, Wu S, Hong F, Stojanovic A, Du X, Bona R, Liu B, Li Z (2011) Heat-shock protein gp96/grp94 is an essential chaperone for the platelet glycoprotein Ib-IX-V complex. Blood 117:7136-7144
79. Stitham J, Stojanovic A, Hwa J (2002) Impaired receptor binding and activation associated with a human prostacyclin receptor polymorphism. J Biol Chem 277:15439-15444
80. Stitham J, Arehart EJ, Gleim SR, Douville KL, Hwa J (2007) Human prostacyclin receptor structure and function from naturally-occurring and synthetic mutations. Prostaglandins Other Lipid Mediat 82:95-108
81. StithamJ, Arehart E, Elderon L, GleimSR, Douville K, Kasza Z, FetalveroK,MacKenzie T, Robb J, Martin KA, Hwa J (2011) Comprehensive biochemical analysis of rare prostacyclin receptor variants: study of association of signaling with coronary artery obstruction. J Biol Chem 286:7060-7069
82. Suzuki-Inoue K, Fuller GL, Garcia A, Eble JA, Pohlmann S, Inoue O, Gartner TK, Hughan SC, Pearce AC, Laing GD, Theakston RD, Schweighoffer E, Zitzmann N, Morita T, Tybulewicz VL, Ozaki Y, Watson SP (2006) A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2. Blood 107:542-549
83. Suzuki-Inoue K, Inoue O, Ding G, Nishimura S, Hokamura K, Eto K, Kashiwagi H, Tomiyama Y, Yatomi Y, Umemura K, Shin Y, Hirashima M, Ozaki Y (2010) Essential in vivo roles of the C-type lectin receptor CLEC-2: embryonic/neonatal lethality of CLEC-2-deficient mice by blood/lymphatic misconnections and impaired thrombus formation of CLEC-2-deficient platelets. J Biol Chem 285:24494-24507
84. Tamburrelli C, Crescente M, Izzi B, Barisciano M, Donati MB, de Gaetano G, Cerletti C (2011) Epoprostenol inhibits human platelet-leukocyte mixed conjugate and platelet microparticle formation in whole blood. Thromb Res 128(5):446-451
85. Varga-Szabo D, Pleines I, Nieswandt B (2008) Cell adhesion mechanisms in platelets. Arterioscler Thromb Vasc Biol 28:403-412
86. Washington AV, Gibot S, Acevedo I, Gattis J, Quigley L, Feltz R, De La Mota A, Schubert RL, Gomez-Rodriguez J, Cheng J, Dutra A, Pak E, Chertov O, Rivera L, Morales J, Lubkowski J, Hunter R, Schwartzberg PL, McVicar DW (2009) TREM-like transcript-1 protects against inflammation-associated hemorrhage by facilitating platelet aggregation in mice and humans. J Clin Invest 119:1489-1501
87. Wilson SJ, Roche AM, Kostetskaia E, Smyth EM (2004) Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation. J Biol Chem 279:53036-53047
88. Wilson SJ, Dowling JK, Zhao L, Carnish E, Smyth EM (2007) Regulation of thromboxane receptor trafficking through the prostacyclin receptor in vascular smooth muscle cells: role of receptor heterodimerization. Arterioscler Thromb Vasc Biol 27:290-296
89. Wu G, Essex DW, Meloni FJ, Takafuta T, Fujimura K, Konkle BA, Shapiro SS (1997) Human endothelial cells in culture and in vivo express on their surface all four components of the glycoprotein Ib/IX/V complex. Blood 90:2660-2669
90. Wu YP, Vink T, Schiphorst M, van Zanten GH, IJsseldijk MJ, de Groot PG, Sixma JJ (2000) Platelet thrombus formation on collagen at high shear rates is mediated by von Willebrand factor-glycoprotein Ib interaction and inhibited by von Willebrand factor-glycoprotein IIb/IIIa interaction. Arterioscler Thromb Vasc Biol 20:1661-1667