Increased expression of the glucocorticoid receptor β in infants with RSV bronchiolitis

Pediatrics

Volumn 130, Issue 4, 2012, Pages

  Diaz, Patricia V ^a   Pinto, Ricardo A ^a   Mamani, Rossana ^a   Uasapud, Paola A ^c   Bono, Maria R ^b   Gaggero, Aldo A ^a   Guerrero, Julia ^a   Goecke, Annelise ^a  

^a UNIVERSITY OF CHILE   (Chile)

^b UNIVERSITY OF CHILE   (Chile)

^c Centro de Salud Familiar Agustin Cruz Melo   (Chile)

Author keywords

Glucocorticoid receptor; Infants; Interleukin 6; Interleukin 8; RSV bronchiolitis

Indexed keywords

CORTICOSTEROID; GAMMA INTERFERON; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR ALPHA; GLUCOCORTICOID RECEPTOR BETA; HYDROCORTISONE; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 17; INTERLEUKIN 1BETA; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5; INTERLEUKIN 6; INTERLEUKIN 8; ISOPROTEIN; TUMOR NECROSIS FACTOR ALPHA;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DRUG BINDING; FEMALE; HUMAN; HUMAN CELL; HYDROCORTISONE BLOOD LEVEL; INFANT; MALE; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; RESPIRATORY SYNCYTIAL PNEUMOVIRUS; SCORING SYSTEM; VIRAL BRONCHIOLITIS;

ANALYSIS OF VARIANCE; BIOLOGICAL MARKERS; BRONCHIOLITIS, VIRAL; CASE-CONTROL STUDIES; CYTOKINES; DRUG RESISTANCE; FEMALE; FLOW CYTOMETRY; GLUCOCORTICOIDS; HUMANS; HYDROCORTISONE; INFANT; LEUKOCYTE COUNT; MALE; RADIOIMMUNOASSAY; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, GLUCOCORTICOID; RESPIRATORY SYNCYTIAL VIRUS INFECTIONS; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; UP-REGULATION;

EID: 84867166641     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2012-0160     Document Type: Article

References (28)

1. Avendaño LF, Palomino MA, Larrañaga C. Surveillance for respiratory syncytial virus in infants hospitalized for acute lower respiratory infection in Chile (1989 to 2000). J Clin Microbiol. 2003;41(10):4879-4882 (Pubitemid 37259823)
2. Román M, Calhoun WJ, Hinton KL, et al. Respiratory Syncytial virus infection in infants is associated with predominant Th-2 like response. Am J Respir Crit Care Med. 1997;156:190-195 (Pubitemid 27293187)
3. Aberle JH, Aberle SW, Rebhandl W, Pracher E, Kundi M, Popow-Kraupp T. Decreased interferon-gamma response in respiratory syncytial virus compared to other respiratory viral infections in infants. Clin Exp Immunol. 2004;137(1):146-150 (Pubitemid 38869789)
4. Bont L, Heijnen CJ, Kavelaars A, et al. Peripheral blood cytokine responses and disease severity in respiratory syncytial virus bronchiolitis. Eur Respir J. 1999;14(1):144-149 (Pubitemid 29411248)
5. Legg JP, Hussain IR, Warner JA, Johnston SL, Warner JO. Type 1 and type 2 cytokine imbalance in acute respiratory syncytial virus bronchiolitis. Am J Respir Crit Care Med. 2003;168(6):633-639 (Pubitemid 37175965)
6. Pinto RA, Arredondo SM, Bono MR, Gaggero AA, Díaz PV. T helper 1/T helper 2 cytokine imbalance in respiratory syncytial virus infection is associated with increased endogenous plasma cortisol. Pediatrics. 2006;117(5). Available at: www.pediatrics.org/cgi/content/full/117/5/e878
7. Necela BM, Cidlowski JA. Mechanisms of glucocorticoid receptor action in nonin- flammatory and inflammatory cells. Proc Am Thorac Soc. 2004;1(3):239-246
8. Lu NZ, Cidlowski JA. The origin and functions of multiple human glucocorticoid receptor isoforms. Ann N Y Acad Sci. 2004;1024:102-123 (Pubitemid 38879596)
9. Oakley RH, Sar M, Cidlowski JA. The human glucocorticoid receptor beta isoform. Expression, biochemical properties, and putative function. J Biol Chem. 1996;271(16):9550-9559
10. Goecke A, Guerrero J. Glucocorticoid receptor beta in acute and chronic inflammatory conditions: clinical implications. Immunobiology. 2006;211(1-2):85-96 (Pubitemid 43150110)
11. Turnbull AV, Rivier CL. Regulation of the hypothalamic-pituitary-adrenal axis by cytokines: actions and mechanisms of action. Physiol Rev. 1999;79(1):1-71 (Pubitemid 29056948)
12. Panickar J, Lakhanpaul M, Lambert PC, et al. Oral prednisolone for preschool children with acute virus-induced wheezing. N Engl J Med. 2009;360(4):329-338
13. Fernandes RM, Bialy LM, Vandermeer B, et al. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev. 2010; (10):CD004878
14. Patel H, Platt R, Lozano JM, Wang EE. Glucocorticoids for acute viral bronchiolitis in infants and young children. Cochrane Database Syst Rev. 2004;3(3):CD004878
15. Bonville CA, Mehta PA, Krilov LR, Rosenberg HF, Domachowske JB. Epithelial cells infected with respiratory syncytial virus are resistant to the anti-inflammatory effect of hydrocortisone. Cell Immunol. 2001;213(2):134-140 (Pubitemid 34194834)
16. Hinzey A, Alexander J, Corry J, et al. Respiratory syncytial virus represses glucocorticoid receptor-mediated gene activation. Endocrinology. 2011;152(2):483-494
17. Leung DY, Hamid Q, Vottero A, et al. Association of glucocorticoid insensitivity with increased expression of glucocorticoid receptor b. J Exp Med. 1997;186(9):1567-1574 (Pubitemid 27479816)
18. Hamid QA, Wenzel SE, Hauk PJ, et al. Increased glucocorticoid receptor β in airway cells of glucocorticoid-insensitive asthma. Am J Respir Crit Care Med. 1999;159(5 pt 1):1600-1604 (Pubitemid 29227876)
19. Webster JC, Oakley RH, Jewell CM, Cidlowski JA. Proinflammatory cytokines regulate human glucocorticoid receptor gene expression and lead to the accumulation of the dominant negative β isoform: a mechanism for the generation of glucocorticoid resistance. Proc Natl Acad Sci USA. 2001;98(12):6865-6870 (Pubitemid 32538308)
20. Larrañaga CL, Ampuero SL, Luchsinger VF, et al. Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus. Pediatr Infect Dis J. 2009;28(10):867-873.
21. Goecke IA, Alvarez C, Henríquez J, et al. Methotrexate regulates the expression of glucocorticoid receptor alpha and beta isoforms in normal human peripheral mononuclear cells and human lymphocyte cell lines in vitro. Mol Immunol. 2007;44(8):2115-2123
22. Li LB, Leung DY, Hall CF, Goleva E. Divergent expression and function of glucocorticoid receptor beta in human monocytes and T cells. J Leukoc Biol. 2006;79(4):818-827 (Pubitemid 44835614)
23. Hew M, Chung KF. Corticosteroid insensitivity in severe asthma: significance, mechanisms and aetiology. Intern Med J. 2010;40(5):323-334
24. Goleva E, Li LB, Eves PT, Strand MJ, Martin RJ, Leung DY. Increased glucocorticoid receptor beta alters steroid response in glucocorticoid- insensitive asthma. Am J Respir Crit Care Med. 2006;173(6):607-616 (Pubitemid 43363801)
25. Haeberle HA, Takizawa R, Casola A, et al. Respiratory syncytial virus-induced activation of nuclear factor-kappa B in the lung involves alveolar macrophages and toll-like receptor 4-dependent pathways. J Infect Dis. 2002;186(9):1199-1206 (Pubitemid 35192997)
26. Fiedler MA, Wernke-Dollries K, Stark JM. Inhibition of viral replication reverses respiratory syncytial virus-induced NF-kappa B activation and interleukin-8 gene expression in A549 cells. J Virol. 1996;70(12):9079-9082 (Pubitemid 26378503)
27. Díaz PV, Pinto RA, Goecke A, Gaggero AA. Some inflammatory cytokines in nasopharyngeal aspirates from respiratory syncytial virus infected infants remain increased independently from the presence of the virus. J Allergy Clin Immunol. 2011;127(suppl 2):AB130
28. Tantisira KG, Lasky-Su J, Harada M, et al. Genomewide association between GLCCI1 and response to glucocorticoid therapy in asthma. N Engl J Med. 2011;365(13):1173-1183