Statistical Evaluation of Toxicological Experimental Design for Bayesian Model Averaged Benchmark Dose Estimation with Dichotomous Data

Human and Ecological Risk Assessment

Volumn 18, Issue 5, 2012, Pages 1096-1119

  Shao, Kan ^a   Small, Mitchell J ^b  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

^b CARNEGIE MELLON UNIVERSITY   (United States)

Author keywords

Bayesian model averaged Benchmark dose (BMA BMD); dose response modeling; experimental design; pre posterior analysis; TCDD

Indexed keywords

ANIMALIA;

EID: 84867156852     PISSN: 10807039     EISSN: 15497860     Source Type: Journal    
DOI: 10.1080/10807039.2012.707938     Document Type: Article

References (23)

1. Bailer, A, Noble, R B and Wheeler, M W. 2005. Model uncertainty and risk estimation for experimental studies of quantal responses. Risk Anal, 25(2): 291-9.
2. Choi, T, Schervish, M JSchmitt, K A. 2010. Bayesian hierarchical analysis for multiple health endpoints in a toxicity study. J Agricul, Biol, Environ Stat, 15(3): 290-307.
3. Crump, KS. 1984. A new method for determining allowable daily intakes. Fund App Toxicol, 4(5): 854-71.
4. Crump, KS. 1995. Calculation of benchmark doses from continuous data. Risk Anal, 15(1): 79-89.
5. Gaylor, DW. 1983. The use of safety factors for controlling risk. J Toxicol Environ Health, 11: 329-36.
6. Gaylor, D W, Chen, J J and Kodell, R L. 1985. Experimental design of bioassays for screening and low dose extrapolation. Risk Anal, 5(1): 9-16.
7. Heol, P G and Jennrich, R I. 1979. Optimal designs for dose response experiments in cancer research. Biometrika, 66(2): 307-16.
8. Johnson, R, Tietge, J and Botts, S. 1992. Carcinogenicity of 2,3,7,8-TCDD to Medaca. Toxicologist, 12: 476
9. Kavlock, R J, Schmid, J E and Setzer, R W. 1996. A simulation study of the influence of study design on the estimation of benchmark doses for developmental toxicity. Risk Anal, 16(3): 399-410.
10. Kimmel, C A and Gaylor, D W. 1988. Issues in qualitative and quantitative risk analysis for developmental toxicity. Risk Anal, 8(1): 15-20.
11. Kociba, R J, Keyes, D GBeyer, J E. 1978. Results of a two-year chronic toxicity and oncogenicity study of 2,3,7,8-tetrachlorodibenzo-p-dioxin in rats. Toxicol App Pharmaco, 46(2): 279-303.
12. Leisenring, W and Ryan, L. 1992. Statistical properties at the NOAEL. Regulat Toxicol Pharmacol, 15(Part 2): 161-71.
13. NTP (National Toxicology Program). 1982. Carcinogenesis Bioassay of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (CAS No. 1746-01-6) in Osborne-Mendel Rats and B6C3F1 Mice (Gavage Study), Research Triangle Park, Bethesda, NC, MD, USA: Department of Health and Human Services, Public Health Service and National Institutes of Health.
14. Portier, C J and Hoel, D G. 1983. Low-dose-rate extrapolation using the multistage model. Biometrics, 39: 897-906.
15. Portier, C J and Hoel, D G. 1984. Design of animal carcinogenicity studies for goodness-of-fit of multistage models. Fund App Toxicol, 4: 949-59.
16. Rao, M S, Subbarao, VPrasas, J D. 1988. Carcinogenicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin in the Syrian golden hamster. Carcinogenesis, 9(9): 1677-9.
17. Shao, K and Small, M J. 2011. Potential uncertainty reduction in model average benchmark dose estimates informed by an additional dose study. Risk Anal, 31(10): 1561-75.
18. Slob, W, Moerbeek, MRauniomaa, E. 2005. A statistical evaluation of toxicity study designs for the estimation of the benchmark dose in continuous endpoints. Toxicol Sci, 84(1): 167-85.
19. USEPA (US Environmental Protection Agency). 2003. Exposure and Human Health Reassessment of 2,3,7,8-Tetrachlorodibenzo-p-Dioxin (TCDD) and Related Compounds National Academy Sciences (NAS) Review Draft, Part II Chapter 6. EPA/600/P-00/001Cb Available at U.S. Environmental Protection Agency: http://www.epa.gov/ncea/pdfs/dioxin/nas-review/pdfs/part2/dioxin_pt2_ch06_dec2003.pdf (accessed June 17, 2010)
20. Van Miller, J P, Lalich, J J and Allen, J R. 1977. Increased incidence of neoplasms in rats exposed to low levels of 2,3,7,8-tetrachlorodibenzo-p-dioxin. Chemosphere, 6: 537-44.
21. Wasserman, L. 2000. Bayesian model selection and model averaging. J Mathemat Psychol, 44(1): 92-107.
22. Weller, E A, Catalano, P J and Williams, P L. 1995. Implication of developmental toxicity study design for quantitative risk assessment. Risk Anal, 15(5): 567-74.
23. Whitney, M and Ryan, L. 2009. "Quantifying dose-response uncertainty using Bayesian model averaging". In Uncertainty Modeling in Dose Response: Bench Testing Environmental Toxicity, Edited by: Cooke, R M. Hoboken, NJ, USA: John Wiley and Sons, Inc. pp. 165-79