A simulation study of the influence of study design on the estimation of benchmark doses for developmental toxicity

Risk Analysis

Volumn 16, Issue 3, 1996, Pages 399-410

  Kavlock, Robert J ^a   Schmid, Judith E ^a   Woodrow Setzer Jr , R ^a  

^a U S ENVIRONMENTAL PROTECTION AGENCY   (United States)

Author keywords

Benchmark dose; developmental toxicity; dose response; risk assessment; simulation; study design

Indexed keywords

CALCULATIONS; COMPUTER SIMULATION; DRUG DOSAGE; ESTIMATION; MATHEMATICAL MODELS; OPTIMIZATION; RISK ASSESSMENT; STANDARDS;

BENCHMARK DOSE; DEVELOPMENTAL TOXICITY; DOSE RESPONSE; LOG LOGISTIC MODEL; MAXIMUM LIKELIHOOD ESTIMATE; MEAN SQUARE ERROR; STUDY DESIGN;

TOXICITY;

ANIMAL MODEL; ARTICLE; BIOASSAY; CONTROLLED STUDY; DOSE RESPONSE; EMBRYO; EMBRYOTOXICITY; FETOTOXICITY; FETUS; FETUS WEIGHT; LITTER SIZE; MAXIMUM LIKELIHOOD METHOD; NONHUMAN; RAT; RISK ASSESSMENT; SIMULATION; STATISTICAL MODEL;

EID: 0030175717     PISSN: 02724332     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1539-6924.1996.tb01474.x     Document Type: Article

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