Finite-element model predicts current density distribution for clinical applications of tDCS and tACS

Frontiers in Psychiatry

Volumn 3, Issue SEP, 2012, Pages

  Neuling, Toralf ^a   Wagner, Sven ^b   Wolters, Carsten H ^b   Zaehle, Tino ^c   Herrmann, Christoph S ^a  

^a UNIVERSITY OF OLDENBURG   (Germany)

^b UNIVERSITY OF MÜNSTER   (Germany)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

Author keywords

Finite element modeling; tACS; tDCS

Indexed keywords

ARTICLE; BRAIN REGION; CEREBROSPINAL FLUID; ELECTRIC CURRENT; FINITE ELEMENT ANALYSIS; FRONTAL CORTEX; GRAY MATTER; NERVE STIMULATION; OCCIPITAL CORTEX; PARIETAL CORTEX; PREDICTION; SIMULATION; SKIN CONDUCTANCE; SKIN ELECTRODE; SKULL; TEMPORAL CORTEX; TRANSCRANIAL ALTERNATING CURRENT STIMULATION; TRANSCRANIAL DIRECT CURRENT STIMULATION; WHITE MATTER;

EID: 84867137726     PISSN: None     EISSN: 16640640     Source Type: Journal    
DOI: 10.3389/fpsyt.2012.00083     Document Type: Article

References (77)

1. Akhtari, M., Bryant, H. C., Marnelak, A. N., Flynn, E. R., Heller, L., Shih, J. J., Mandelkern, M., Matlachov, A., Ranken, D. M., Best, E. D., DiMauro, M. A., Lee, R. R., and Sutherling, W. W. (2002). Conductivities of threelayer live human skull. Brain Topogr. 14, 151-167.
2. Antal, A., Boros, K., Poreisz, C., Chaieb, L., Terney, D., and Paulus, W. (2008). Comparatively weak aftereffects of transcranial alternating current stimulation (tACS) on cortical excitability in humans. Brain Stimul. 1, 97-105.
3. Antal, A., Kincses, T. Z., Nitsche, M. A., and Paulus, W. (2003). Manipulation of phosphene thresholds by transcranial direct current stimulation in man. Exp. Brain Res. 150, 375-378.
4. Antal, A., Kinsces, T. Z., Nitsche, M. A., Bartfai, O., and Paulus, W. (2004). Excitability changes induced in the human primary visual cortex by transcranial direct current stimulation: direct electrophysiological evidence. Invest. Ophthalmol. Vis. Sci. 45, 702-707.
5. Antal, A., and Paulus, W. (2008). Transcranial direct current stimulation and visual perception. Perception 37, 367-374.
6. Baker, J. M., Rorden, C., and Fridriksson, J. (2010). Using transcranial direct-current stimulation to treat stroke patients with aphasia. Stroke 41, 1229-1236.
7. Baumann, S. B., Wozny, D. R., Kelly, S. K.,and Meno,F. M. (1997). The electrical conductivity of human cerebrospinal fluid at body temperature. IEEE Trans. Biomed. Eng. 44, 220-223.
8. Benninger, D. H., Lomarev, M., Lopez, G., Wassermann, E. M., Li, X., Considine, E., and Hallett, M. (2010). Transcranial direct current stimulation for the treatment of Parkinson's disease. J. Neurol. Neurosurg. Psychiatr. 81, 1105-1111.
9. Bindman, L. J., Lippold, O. C. J., and Redfearn, J. W. T. (1964). The action of brief polarizing currents on the cerebral cortex of the rat (1) during current flow and (2) in the production of long-lasting after-effects. J. Physiol. (Lond.) 172, 369-382.
10. Boggio, P. S., Amancio, E. J., Correa, C. F., Cecilio, S., Valasek, C., Bajwa, Z., Freedman, S. D., Pascual-Leone, A., Edwards, D. J., and Fregni, F. (2009). Transcranial DC stimulation coupled with TENS for the treatment of chronic pain: a preliminary study. Clin. J. Pain 25, 691-695.
11. Boggio, P. S., Ferrucci, R., Rigonatti, S. P., Covre, P., Nitsche, M., Pascual-Leone, A., and Fregni, F. (2006). Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease. J. Neurol. Sci. 249, 31-38.
12. Boggio, P. S., Rigonatti, S. P., Ribeiro, R. B., Myczkowski, M. L., Nitsche, M. A., Pascual-Leone,A., and Fregni, F. (2008). A randomized, doubleblind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression. Int. J. Neuropsychopharmacol. 11, 249-254.
13. Boggio, P. S., Valasek, C. A., Campanhã, C., Giglio, A. C., Baptista, N. I. Lapenta,O. M.,and Fregni,F. (2011). Non-invasive brain stimulation to assess and modulate neuroplasticity inAlzheimer's disease. Neuropsychol. Rehabil. 21, 703-716.
14. Brunoni, A. R., Nitsche, M. A., Bolognini, N., Bikson, M., Wagner, T., Merabet, L., Edwards, D. J., Valero-Cabre, A., Rotenberg, A., Pascual-Leone, A., Ferrucci, R., Priori, A., Boggio, P. S., and Fregni, F. (2012). Clinical research with transcranial direct current stimulation (tDCS): challenges and future directions. Brain Stimul. 5, 175-195.
15. Chaieb, L., Antal, A., and Paulus, W. (2008). Gender-specific modulation of short-term neuroplasticity in the visual cortex induced by transcranial direct current stimulation. Vis. Neurosci. 25, 77-81.
16. Chapman, R. M., Ilmoniemi, R. J., Barbanera, S., and Romani, G. L. (1984). Selective localization of alpha brain activity with neuromagnetic measurements. Electroen-cephalogr. Clin. Neurophysiol. 58, 569-572.
17. Dannhauer, M., Lanfer, B., Wolters, C. H., and Knösche, T. R. (2011). Modeling of the human skull in EEG source analysis. Hum. Brain Mapp. 32, 1383-1399.
18. Datta, A., Bansal, V., Diaz, J., Patel, J., Reato, D., and Bikson, M. (2009). Gyri-precise head model of transcranial direct current stimulation: Improved spatial focality using a ring electrode versus conventional rectangular pad. Brain Stimul. 2, 201-207.
19. Datta, A., Elwassif, M., Battaglia, F., and Bikson, M. (2008). Transcranial current stimulation focality using disc and ring electrode configurations. J. Neural Eng. 5, 163-174.
20. Datta, A., Scaturro, A. R. J., and Bikson, M. (2010). Electrode montages for tDCS and weak transcranial electrical stimulation role of 'return' electrode's position and size. Clin. Neurophysiol. 121, 1976-1978.
21. Dell'Osso, B., Zanoni, S., Ferrucci, R., Vergari, M., Castellano, F., D'Urso, N., Dobrea, C., Benatti, B., Arici, C., Priori, A., and Altamura, A. C. (2011). Transcranial direct current stimulation for the outpatient treatment of poor-responder depressed patients. Eur. Psychiatry. doi: 10.1016/j.eurpsy.2011.02.008
22. Edwards, D. J., Krebs, H. I., Rykman, A., Zipse, J., Thickbroom, G. W., Mastaglia, F. L., Pascual-Leone, A., and Volpe, B. T. (2009). Raised corticomotor excitability of M1 forearm area following anodal tDCS is sustained during robotic wrist therapy in chronic stroke. Restor. Neurol. Neurosci. 27, 199-207.
23. Feira, P., Leal, A., and Miranda, P. C. (2009). "Comparing different electrode configurations using the 10-10 international system in tDCS:a finite element method analysis," in 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society, Minneapolis, 1596- 1599.
24. Ferrucci, R., Mameli, F., Guidi, I., Mrakic-Sposta, S., Vergari, M., Marceglia, S., Cogiamanian, F., Barbieri, S., Scarpini, E., and Priori, A. (2008). Transcranial direct current stimulation improves recognition memory in Alzheimer disease. Neurology 71, 493-498.
25. Francis, J., Gluckman, B. J., and Schiff, S. J. (2003). Sensitivity of neurons to weak electric fields. J. Neurosci. 23, 7255-7261.
26. Fregni, F., Boggio, P. S., Nitsche, M. A., Rigonatti, S. P., and Pascual-Leone, A. (2006a). Cognitive effects of repeated sessions of transcranial direct current stimulation in patients with depression. Depress. Anxiety 23, 482-484.
27. Fregni, F., Thome-Souza, S., Nitsche, M. A., Freedman, S. D., Valente, K. D., and Pascual-Leone, A. (2006b). A controlled clinical trial of cathodal DC polarization in patients with refractory epilepsy. Epilepsia 47, 335-342.
28. Fridriksson, J., Richardson, J. D., Baker, J. M., and Rorden, C. (2011). Transcranial direct current stimulation improves naming reaction time in fluent aphasia: a double-blind, sham-controlled study. Stroke 42, 819-821.
29. George, M. S., and Aston-Jones, G. (2010). Noninvasive techniques for probing neurocircuitry and treating illness: vagus nerve stimulation (VNS),transcranial magnetic stimulation (TMS) and transcranial direct current stimulation (tDCS). Neuropsychopharmacology 35, 301-316.
30. Grimm, S., Beck, J., Schuepbach, D., Hell, D., Boesiger, P., Bermpohl, F., Niehaus, L., Boeker, H., and Northoff, G. (2008). Imbalance between left and right dorsolateral prefrontal cortex in major depression is linked to negative emotional judgment: an fMRI study in severe major depressive disorder. Biol. Psychiatry 63, 369-376.
31. Halko, M. A., Datta, A., Plow, E. B., Scaturro, J., Bikson, M., and Merabet, L. B. (2011). Neuroplastic changes following rehabilitative training correlate with regional electric field induced with tDCS. Neuroimage 57, 885-891.
32. Heimrath, K., Sandmann, P., Becke, A., Müller, N. G., and Zaehle, T. (2012). Behavioral and electrophysiological effects of transcranial direct current stimulation (tDCS) of the parietal cortex in a visuo-spatial working memory task. Front Psychiatry 3:56. doi:10.3389/fpsyt.2012.00056
33. Herrmann, C. S., and Demiralp, T. (2005). Human EEG gamma oscillations in neuropsychiatric disorders. Clin. Neurophysiol. 116, 2719-2733.
34. Herrmann, C. S., Grigutsch, M., and Busch, N. (2004). "EEG oscillations and wavelet analysis," in Event-Related Potentials: A Methods Hand-book, ed. T. C. Handy (Cambridge, MA: Bradford Book), 229-259.
35. Hillis, A. E., Work, M., Barker, P. B., Jacobs, P. B., Breese, E. L., and Maurer, K. (2004). Reexamining the brain regions crucial for orchestrating speech articulation. Brain 127, 1479-1487
36. Holdefer, R., Sadleir, R., and Russell, M. (2006). Predicted current densities in the brain during transcranial electrical stimulation. Clin. Neurophysiol. 117, 1388-1397.
37. Holland, R., Leff, A. P., Josephs, O., Galea, J. M., Desikan, M., Price, C. J., Rothwell, J. C., and Crinion, J. (2011). Speech facilitation by left inferior frontal cortex stimulation. Curr. Biol. 21, 1403-1407.
38. Hummel, F., Celnik, P., Giraux, P., Floel, A., Wu, W.-H., Gerloff, C., and Cohen, L. G. (2005). Effects of non-invasive cortical stimulation on skilled motor function in chronic stroke. Brain 128, 490-499.
39. Jenkinson, M., Pechaud, M., and Smith, S. (2005). "BET2: MR-based estimation of brain, skull and scalp surfaces," in Eleventh Annual Meeting of the Organization for Human Brain Mapping, Toronto.
40. Jenkinson, M., and Smith, S. (2001). A global optimisation method for robust affine registration of brain images. Med. Image Anal. 5, 143-156.
41. Kalu, U. G., Sexton, C. E., Loo, C. K., and Ebmeier, K. P. (2012). Transcranial direct current stimulation in the treatment of major depression: a meta-analysis. Psychol. Med. 12, 1-10.
42. Kanai,R.,Chaieb,L.,Antal,A.,Walsh,V., and Paulus, W. (2008). Frequencydependent electrical stimulation of the visual cortex. Curr. Biol. 18, 1839-1843.
43. Lew, S.,Wolters, C. H., Röer, C., Dierkes, T., and MacLeod, R. S. (2009). Accuracy and run-time comparison for different potential approaches and iterative solvers in finite element method based EEG source analysis. Appl. Numer. Math. 59, 1970-1988.
44. Marangolo, P., Marinelli, C. V., Bonifazi, S., Fiori, V., Ceravolo, M. G., and Tomaiuolo, L. P. F. (2011). Electrical stimulation over the left inferior frontal gyrus (IFG) determines longterm effects in the recovery of speech apraxia in three chronic aphasics. Behav. Brain Res. 225, 498-504.
45. Marshall, L., Helgadottir, H., Mölle, M., and Born, J. (2006). Boosting slow oscillations during sleep potentiates memory. Nature 444, 610-613.
46. Miranda, P. C., Lomarev, M., and Hallett, M. (2006). Modeling the current distribution during transcranial direct current stimulation. Clin. Neurophysiol. 117, 1623-1629.
47. Monti, A., Cogiamanian, F., Marceglia, S., Ferrucci, R., Mameli, F., Mrakic-Sposta, S., Vergari, M., Zago, S., and Priori, A. (2008). Improved naming after transcranial direct current stimulation in aphasia. J. Neurol. Neurosurg. Psychiatr. 79, 451-453.
48. Nikouline, V. V., Linkenkaer-Hansen, K., Huttunen, J., and Ilmoniemi, R. J. (2001). Interhemispheric phase synchrony and amplitude correlation of spontaneous beta oscillations in human subjects: a magnetoencephalographic study. Neuroreport 12, 2487-2491.
49. Nitsche, M. A., Doemkes, S., Karaköse, T., Antal, A., Liebetanz, D., Lang, N., Tergau, F., and Paulus, W. (2007). Shaping the effects of transcranial direct current stimulation of the human motor cortex. J. Neurophysiol. 97, 3109-3117.
50. Nitsche, M. A., and Paulus, W. (2000). Excitability changes induced in the human motor cortex by weak transcranial direct current stimulation. J. Physiol. 527, 633-639.
51. Nitsche, M. A., and Paulus, W. (2001). Sustained excitability elevations induced by transcranial dc motor cortex stimulation in humans. Neurology 57, 1899-1901.
52. Nitsche, M. A., and Paulus, W. (2009). Noninvasive brain stimulation protocols in the treatment of epilepsy: current state and perspectives. Neurotherapeutics 6, 244-250.
53. Nowak, L. G., and Bullier, J. (1998). Axons, but not cell bodies, are activated by electrical stimulation in cortical gray matter I. Evidence from chronaxie measurements. Exp. Brain Res. 118, 477-488.
54. Nunez,P. L.,Wingeier,B. M.,and Silberstein, R. B. (2001). Spatial-temporal structures of human alpha rhythms: theory, microcurrent sources, multiscale measurements, and global binding of local networks. Hum. Brain Mapp. 13, 125-164.
55. Olesch, J., Ruthotto, L., Kugel, H., Skare, S., Fischer, B., and Wolters, C. H. (2010). A variational approach for the correction of field-inhomogeneities in EPI sequences. SPIE Med. Imag. Image Process. 7623, 1-8.
56. Paulus, W. (2010). On the difficulties of separating retinal from cortical origins of phosphenes when using transcranial alternating current stimulation (tACS). Clin Neurophysiol 121, 987-991.
57. Paulus, W. (2011). Transcranial electrical stimulation (tES -tDCS; tRNS,tACS) methods. Neuropsychol. Rehab. 21, 602-617.
58. Plonsey, R., and Heppner, D. (1967). Considerations on quasistationarity in electro-physiological systems. Bull. Math. Biophys. 29, 657-664.
59. Rigonatti, S. P., Boggio, P. S., Myczkowski, M. L., Otta, E., Fiquer, J. T., Ribeiro, R. B., Nitsche, M. A., Pascual-Leone, A., and Fregni, F. (2008). Transcranial direct stimulation and fluoxetine for the treatment of depression. Eur. Psychiatry 23, 74-76.
60. Rodin, E. A., and Rodin, M. J. (1995). Dipole sources of the human alpha rhythm. Brain Topogr. 7, 201-208.
61. Rullmann, M., Anwander, A., Dannhauer, M., Warfield, S., Duffy, F., and Wolters, C. (2009). EEG source analysis of epileptiform activity using a 1 mm anisotropic hexahedra finite element head model. Neuroimage 44, 399-410.
62. Sabel, B. A., Fedorov, A. B., Naue, N., Borrmanna, A., Herrmann, C., and Gall, C. (2011). Non-invasive alternating current stimulation improves vision in optic neuropathy. Restor. Neurol. Neurosci. 29, 493-505.
63. Sadleir, R. J., Vannorsdall, T. D., Schretlen, D. J., and Gordon, B. (2010). Transcranial direct current stimulation (tDCS) in a realistic head model. Neuroimage 51, 1310-1318.
64. Salvador, R., Mekonnen, A., Ruffini, G., and Miranda, P. C. (2010). Modeling the electric field induced in a high resolution realistic head model during transcranial current stimulation. Conf. Proc. IEEE Eng. Med. Biol. Soc. 2010, 2073-2076.
65. Smith, S. M. (2002). Fast robust automated brain extraction. Hum. Brain Mapp. 17, 143-155.
66. Tuch, D. S., Wedeen, V. J., Dale, A. M., George, J. S., and Belliveau, J. W. (2001). Conductivity tensor mapping of the human brain using diffusion tensor MRI. Proc. Natl. Acad. Sci. U.S.A. 98, 11697-11701.
67. Uhlhaas, P. J., Haenschel, C., Nikolic, D., and Singer, W. (2008). The role of oscillations and synchrony in cortical networks and their putative relevance for the pathophysiology of schizophrenia. Schizophr. Bull. 34, 927-943.
68. Varela, F., Lachaux, J. P., Rodriguez, E., and Martinerie, J. (2001). The brainweb: phase synchronization and large-scale integration. Nat. Rev. Neurosci. 2, 229-239.
69. Wagner, T., Fregni, F., Fectau, S., Grodzinsky, A., Zahn, M., and Pascual-Leone, A. (2007). Transcranial direct current stimulation: a computer-based human model study. Neuroimage 35, 1113-1124.
70. Windhoff, M., Opitz,A., and Thielscher, A. (2011). Electric field calculations in brain stimulation based on finite elements: an optimized processing pipeline for the generation and usage of accurate individual head models. Hum. Brain Mapp. doi: 10.1002/hbm.21479
71. Wolters, C. H., Anwander, A., Berti, G., and Hartmann, U. (2007a). Geometry-adapted hexahedral meshes improve accuracy of finite element method based EEG source analysis. IEEE Trans. Biomed. Eng. 54, 1446-1453.
72. Wolters, C. H., Köstler, H., Möller, C., Härdtlein, J., Grasedyck, L., and Hackbusch, W. (2007b). Numerical mathematics of the subtraction method for the modeling of a current dipole in EEG source reconstruction using finite element head models. SIAM J. Sci. Comput. 30, 24-45.
73. Wolters, C. H., Kuhn, M., Anwander, A., and Reitzinger, S. (2002). A parallel algebraic multigrid solver for finite element method based source localization in the human brain. Comput. Vis. Sci. 5, 165-177.
74. Zaehle, T., Rach, S., and Herrmann, C. S. (2010). Transcranial alternating current stimulation enhances individual alpha activity in human EEG. PLoS ONE 5, e13766. doi:10.1371/journal.pone. 0013766
75. Zaehle, T., Sandmann, P., Thorne, J. D., Jäncke, L., and Herrmann, C. S. (2011). Transcranial direct current stimulation of the prefrontal cortex modulates working memory performance: combined behavioural and electrophysiological evidence. BMC Neurosci. 12, 1-11. doi:10.1186/1471-2202-12-2
76. Zhang, Y., Brady, M., and Smith, S. (2001). Segmentation of brain MR images through a hidden markov random field model and the expectation maximization algorithm. IEEE Trans. Med. Imaging 20, 45-57.
77. Ziemann, U. (2003). Pharmacology of TMS. Suppl. Clin. Neurophysiol. 56, 226-231