CXCL1-deficient mice are highly sensitive to Pseudomonas aeruginosa but not herpes simplex virus type 1 corneal infection

Investigative Ophthalmology and Visual Science

Volumn 53, Issue 11, 2012, Pages 6785-6792

  Bryant Hudson, Katie M ^a   Carr, Daniel J J ^a  

^a UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CXCL1 CHEMOKINE; CXCL2 CHEMOKINE; GAMMA INTERFERON; MONOCYTE CHEMOTACTIC PROTEIN 1; RANTES;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL KERATITIS; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORNEA THICKNESS; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLOW CYTOMETRY; HERPES SIMPLEX; HERPES SIMPLEX VIRUS; HISTOPATHOLOGY; HOST RESISTANCE; IMMUNOFLUORESCENCE TEST; LEUKOCYTE ACTIVATION; LEUKOCYTE COUNT; MALE; MOUSE; NEUTROPHIL; NONHUMAN; OPTICAL COHERENCE TOMOGRAPHY; PATHOGEN CLEARANCE; PATHOGEN LOAD; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTION; VIRUS KERATITIS;

ANIMALS; BACTERIAL LOAD; CHEMOKINE CXCL1; CORNEA; CORNEAL ULCER; CYTOKINES; ENZYME-LINKED IMMUNOSORBENT ASSAY; EYE INFECTIONS, BACTERIAL; FEMALE; FLOW CYTOMETRY; HERPESVIRUS 1, HUMAN; KERATITIS, HERPETIC; LEUKOCYTES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSCOPY, CONFOCAL; PSEUDOMONAS AERUGINOSA; PSEUDOMONAS INFECTIONS; TOMOGRAPHY, OPTICAL COHERENCE; VIRAL LOAD;

EID: 84867134575     PISSN: 01460404     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.12-10400     Document Type: Article

References (30)

1. Howard M, Sellors JW, Jang D, et al. Regional distribution of antibodies to herpes simplex virus type 1 (HSV-1) and HSV-2 in men and women in Ontario, Canada. J Clin Microbiol. 2003; 41:84-89.
2. Taylor T, Brockman M, McNamee E, Knipe D. Herpes simplex virus. Front Biosci. 2002;7:d752-d764.
3. Wuest T, Carr DJJ. The role of chemokines during herpes simplex virus type-1 infection. Front Biosci. 2008;13:4862-4872.
4. Su Y, Yan X, Oakes J, Lausch R. Protective antibody therapy is associated with reduced chemokine transcripts in herpes simplex virus type 1 corneal infection. J Virol. 1996;70:1277-1281.
5. Tang Q, Hendricks RL. Interferon gamma regulates platelet endothelial cell adhesion molecule 1 expression and neutrophil infiltration into herpes simplex virus-infected mouse corneas. J Exp Med. 1996;184:1435-1447.
6. Kumaraguru U, Davis I, Rouse BT. Chemokines and ocular pathology caused by corneal infection with herpes simplex virus. J Neurovirol. 1999;5:42-47.
7. Oquendo P, Alberta J, Wen DZ, Graycar JL, Derynck R, Stiles CD. The platelet-derived growth factor-inducible KC gene encodes a secretory protein related to platelet alpha-granule proteins. J Biol Chem. 1989;264:4133-4137.
8. Wolpe SD, Sherry B, Juers D, Davatelis G, Yurt RW, Cerami A. Identification and characterization of macrophage inflammatory protein 2. Proc Natl Acad Sci U S A. 1989;86:612-616.
9. Wolpe SD, Davatelis G, Sherry B, et al. Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemokinetic properties. J Exp Med. 1988;167:570-581.
10. Yan XT, Tumpey TM, Kunkel SL, Oakes JE, Lausch RN. Role of MIP-2 in neutrophil migration and tissue injury in the herpes simplex virus-1-infected cornea. Invest Ophthalmol Vis Sci. 1998;39:1854-1862.
11. Banerjee K, Biswas PS, Kim B, Lee S, Rouse BT. CXCR2-/mice show enhanced susceptibility to herpetic stromal keratitis: a role for IL-6-induced neovascularization. J Immunol. 2004; 172:1237-1245.
12. Chintakuntlawar A, Chodosh J. Chemokine CXCL1/KC and its receptor CXCR2 are responsible for neutrophil chemotaxis in adenoviral keratitis. J Interferon Cytokine Res. 2009;29:657-666.
13. Daley JM, Thomay AA, Connolly MD, Reichner JS, Albina JE. Use of Ly6G-specific monoclonal antibody to deplete neutrophils in mice. J Leukoc Biol. 2008;83:64-70.
14. Wojtasiak M, Pickett DL, Tate MD, et al. Depletion of Gr-1{thorn}, but not Ly6G{thorn}, immune cells exacerbates virus replication and disease in an intranasal model of herpes simplex virus type 1 infection. J Gen Virol. 2010;91:2158-2166.
15. Wojtasiak M, Pickett DL, Tate MD, et al. Gr-1{thorn} cells, but not neutrophils, limit virus replication and lesion development following flank infection of mice with herpes simplex virus type-1. Virology. 2010;407:143-151.
16. Kernacki KA, Barrett RP, Hobden JA, Hazlett LD. Macrophage Inflammatory Protein-2 Is a Mediator of Polymorphonuclear Neutrophil Influx in Ocular Bacterial Infection. J Immunol. 2000;164:1037-1045.
17. Halford W, Gebhardt B, Carr D. Mechanisms of herpes simplex virus type 1 reactivation. J Virol. 1996;70:5051-5060.
18. Austin BA, Halford WP, Williams BRG, Carr DJJ. Oligoadenylate synthetase/protein kinase R pathways and alphabeta TCR{thorn} T cells are required for adenovirus vector: IFN-gamma inhibition of herpes simplex virus-1 in cornea. J Immunol. 2007;178: 5166-5172.
19. Wuest TR, Carr DJJ. Dysregulation of CXCR3 signaling due to CXCL10 deficiency impairs the antiviral response to herpes simplex virus 1 infection. J Immunol. 2008;181:7985-7993.
20. Wuest T, Austin BA, Uematsu S, et al. 9 and type I interferon signaling pathways are required to augment HSV-1 induced corneal CXCL9 and CXCL10. J Neuroimmunol. 2006;179:46-52.
21. Chusid M, Davis S. Experimental bacterial keratitis in neutropenic guinea pigs: polymorphonuclear leukocytes in corneal host defense. Infect Immun. 1979;24:948-952.
22. Carr DJJ, Tomanek L. Herpes simplex virus and the chemokines that mediate the inflammation. Curr Top Microbiol Immunol. 2006;303:47-65.
23. Tumpey T, Chen S, Oakes J, Lausch R. Neutrophil-mediated suppression of virus replication after herpes simplex virus type 1 infection of the murine cornea. J Virol. 1996;70:898-904.
24. Tumpey T.M., Fenton R., Molesworth-Kenyon S., Oakes J.E., Lausch R.N., Role for macrophage inflammatory protein 2 (MIP-2 (MIP-2), MIP-1{alpha}, and interleukin-1{alpha} in the delayed-type hypersensitivity response to viral antigen. J Virol. 2002;76: 8050-8057.
25. Höpken UE, Lu B, Gerard NP, Gerard C. The C5a chemo-attractant receptor mediates mucosal defence to infection. Nature. 1996;383:86-89.
26. Frank GM, Buela K-AG, Maker DM, Harvey SAK, Hendricks RL. Early responding dendritic cells direct the local NK response to control herpes simplex virus 1 infection within the cornea. J Immunol. 2012;188:1350-1359.
27. Conrady C, Zheng M, Mandal N, van Rooijen N, Carr D. IFN-alpha-drivin CCL2 production recruits inflammatory monocytes to infection site in mice [published online ahead of print June 13, 2012]. Mucosal Immunol. doi:10.1038/mi.2012.46.
28. Khan S, Cole N, Hume EB, et al. The role of CXC chemokine receptor 2 in Pseudomonas aeruginosa corneal infection. J Leukoc Biol. 2007;81:315-318.
29. Hazlett LD, Hendricks RL. Reviews for immune privilege in the year 2010: immune privilege and infection. Ocul Immunol Inflamm. 2010;18:237-243.
30. Sun Y, Karmakar M, Roy S, et al. TLR4 and TLR5 on corneal macrophages regulate Pseudomonas aeruginosa keratitis by signaling through MyD88-dependent and-independent pathways. J Immunol. 2010;185:4272-4283