Extracellular 2′,3′-cAMP and 3′,5′-cAMP stimulate proliferation of preglomerular vascular endothelial cells and renal epithelial cells

American Journal of Physiology - Renal Physiology

Volumn 303, Issue 7, 2012, Pages

  Jackson, Edwin K ^a   Gillespie, Delbert G ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

2 ,3 cAMP; 3 ,5 cAMP; Adenosine; Adenosine receptors; Proximal tubular epithelial cells; Vascular endothelial cells

Indexed keywords

5' NUCLEOTIDASE; ADENOSINE; ADENOSINE 2' PHOSPHATE; ADENOSINE 2',3' PHOSPHATE; ADENOSINE 3' PHOSPHATE; ADENOSINE A2B RECEPTOR; ADENOSINE PHOSPHATE; CYCLIC AMP;

ANIMAL CELL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTHELIUM CELL; EPITHELIUM CELL; HUMAN; HUMAN CELL; KIDNEY EPITHELIUM; KIDNEY PROXIMAL TUBULE; NONHUMAN; PRIORITY JOURNAL; PURINE METABOLISM; RAT; VASCULAR ENDOTHELIUM; ANIMAL; CELL LINE; CYTOLOGY; DRUG EFFECT; KIDNEY; MALE; METABOLISM; WISTAR KYOTO RAT;

ADENOSINE; ANIMALS; CELL LINE; CELL PROLIFERATION; CYCLIC AMP; ENDOTHELIAL CELLS; ENDOTHELIUM, VASCULAR; EPITHELIAL CELLS; HUMANS; KIDNEY; MALE; RATS; RATS, INBRED WKY;

EID: 84867132146     PISSN: 1931857X     EISSN: 15221466     Source Type: Journal    
DOI: 10.1152/ajprenal.00335.2012     Document Type: Article

References (20)

1. 2B adenosine receptors stimulate growth of porcine and rat arterial endothelial cells. Hypertension 39: 530-535, 2002.
2. Dubey RK, Gillespie DG, Mi Z, Jackson EK. Extracellular 3,5-cyclic AMP-adenosine pathway inhibits glomerular mesangial cell growth. J Pharmacol Exp Ther 333: 808-815, 2010.
3. Dubey RK, Mi Z, Gillespie DG, Jackson EK. Cyclic AMP-adenosine pathway inhibits vascular smooth muscle cell growth. Hypertension 28: 765-771, 1996.
4. 2B-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med 18: 774-782, 2012.
5. Eltzschig HK, Carmeliet P. Hypoxia and inflammation. N Engl J Med 364: 656-665, 2011.
6. Frye CA, Patrick CW Jr. Isolation and culture of rat microvascular endothelial cells. In Vitro Cell Dev Biol Anim 38: 208-212, 2002.
7. Grenz A, Bauerle JD, Dalton JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R, Reyes G, Klawitter J, Ambler K, Magee K, Christians U, Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackburn MR, Osswald H, Coe IR, Nürnberg B, Haase VH, Xia Y, Sitkovsky M, Eltzschig HK. Equilibrative nucleoside transporter 1 (ENT1) regulates postischemic blood flow during acute kidney injury in mice. J Clin Invest 122: 693-710, 2012.
8. 2B receptors. J Pharmacol Exp Ther 337: 444-450, 2011.
9. Jackson EK, Mi Z, Zhu C, Dubey RK. Adenosine biosynthesis in the collecting duct. J Pharmacol Exp Ther 307: 888-896, 2003.
10. Jackson EK, Raghvendra DK. The extracellular cyclic AMP-adenosine pathway in renal physiology. Annu Rev Physiol 66: 571-599, 2004.
11. Jackson EK, Ren J, Cheng D, Mi Z. Extracellular cAMP-adenosine pathways in the mouse kidney. Am J Physiol Renal Physiol 301: F565-F573, 2011.
12. 2B receptors. Am J Physiol Heart Circ Physiol 301: H391-H401, 2011.
13. Jackson EK, Ren J, Gillespie DG, Dubey RK. Extracellular 2,3-cyclic adenosine 5-monophosphate is a potent inhibitor of preglomerular vascular smooth muscle cell and mesangial cell growth. Hypertension 56: 151-158, 2010.
14. Jackson EK, Ren J, Mi Z. Extracellular 2,3-cAMP is a source of adenosine. J Biol Chem 284: 33097-33106, 2009.
15. Jackson EK, Zacharia LC, Zhang M, Gillespie DG, Zhu C, Dubey RK. cAMP-adenosine pathway in the proximal tubule. J Pharmacol Exp Ther 317: 1219-1229, 2006.
16. Jacobson KA, Knutsen LJS. P1 and P2 purine and pyrimidine receptor ligands. In: Purinergic and Pyrmidinergic Signalling I, edited by Abbracchio MP and Williams M. Berlin, Germany: Springer-Verlag, 2001, p. 129-175.
17. Mokkapatti R, Vyas SJ, Romero GG, Mi Z, Inoue T, Dubey RK, Gillespie DG, Stout AK, Jackson EK. Modulation by angiotensin II of isoproterenol-induced cAMP production in preglomerular microvascular smooth muscle cells from normotensive and genetically hypertensive rats. J Pharmacol Exp Ther 287: 223-231, 1998.
18. Ren J, Mi Z, Stewart NA, Jackson EK. Identification and quantification of 2,3-cAMP release by the kidney. J Pharmacol Exp Ther 328: 855-865, 2009.
19. Zhang WR, Dai YB, Wang W, Ning C, Blackburn M, Kellems R, Xia Y. Elevated renal adenosine is a detrimental mediator for chronic hypertension and its progression. Hypertension 58: E142, 2011.
20. Zimmermann H. 5-Nucleotidase: molecular structure and functional aspects. Biochem J 285: 345-365, 1992.