Protease-activated receptor-4 deficiency does not protect against bleomycin-induced pulmonary fibrosis in mice

European Respiratory Journal

Volumn 40, Issue 4, 2012, Pages 1056-1057

  Borensztajn, Keren ^a,b   Duitman, Jan Willem ^a   Brüggemann, Lois W ^a   Spek, C Arnold ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

^b INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BLEOMYCIN SULFATE; COLLAGEN TYPE 1; COLLAGEN TYPE 3; FIBRONECTIN; PROTEINASE ACTIVATED RECEPTOR 4;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONTROLLED STUDY; DISEASE SEVERITY; GENE EXPRESSION; LETTER; LUNG FIBROSIS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTECTION; WILD TYPE;

ANIMALS; BLEOMYCIN; DISEASE MODELS, ANIMAL; EPITHELIAL-MESENCHYMAL TRANSITION; MICE; PULMONARY FIBROSIS; RECEPTORS, THROMBIN;

EID: 84867116307     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00045812     Document Type: Letter

References (5)

1. Macfarlane SR, Seatter MJ, Kanke T, et al. Protease-activated receptors. Phamacol Rev 2001; 53: 245-282.
2. Ando S, Otani H, Yagi Y, et al. Proteinase-activated receptor 4 stimulation-induced epithelial-mesenchymal transition in alveolar epithelial cells. Respir Res 2007; 8: 31.
3. Peters T, Henry PJ. Protease-activated receptors and prostaglandins in inflammatory lung disease. Br J Pharmacol 2009; 158: 1017-1033.
4. Ramachandran R, Noorbakhsh F, Defea K, et al. Targeting proteinase-activated receptors: therapeutic potential and challenges. Nat Rev Drug Discov 2012; 11: 69-86.
5. Borensztajn K, Bresser P, van der Loos C, et al. Protease-activated receptor-2 induces myofibroblast differentiation and tissue factor up-regulation during bleomycin-induced lung injury: potential role in pulmonary fibrosis. Am J Pathol 2010; 177: 2753-2764.