Dose issues in antiepileptic therapy

Journal of Clinical Neuroscience

Volumn 19, Issue 11, 2012, Pages 1475-1477

  Vajda, F ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

Author keywords

Adverse effects; Antiepileptic drug therapy; Dose

Indexed keywords

ANTICONVULSIVE AGENT; CARBAMAZEPINE; ETIRACETAM; GABAPENTIN; LAMOTRIGINE; METHYLPHENOBARBITAL; OXCARBAZEPINE; PHENOBARBITAL; PHENYTOIN; PRIMIDONE; TOPIRAMATE; VALPROIC ACID; VIGABATRIN; ZONISAMIDE;

ATAXIA; AUTISM; BLOOD PRESSURE; COGNITION; COLLAPSE; COORDINATION DISORDER; DRUG BLOOD LEVEL; DRUG DEPENDENCE; DRUG DOSE INCREASE; DRUG EFFICACY; DRUG ERUPTION; DRUG SAFETY; DRUG SUBSTITUTION; DRUG WITHDRAWAL; EMOTIONAL DISORDER; EPILEPSY; EYE DISEASE; FATIGUE; FETUS MALFORMATION; FOCAL EPILEPSY; GENERALIZED EPILEPSY; HEART RHYTHM; HUMAN; INTELLIGENCE QUOTIENT; LANGUAGE DISABILITY; LOW DRUG DOSE; MONOTHERAPY; MYOCLONUS EPILEPSY; NEURAL TUBE DEFECT; NEUROTOXICITY; NYSTAGMUS; PARESTHESIA; PERIPHERAL VISION; POLYPHARMACY; PREGNANT WOMAN; PRENATAL DRUG EXPOSURE; PRIORITY JOURNAL; RECOMMENDED DRUG DOSE; REVIEW; SIDE EFFECT; SOMNOLENCE; STEVENS JOHNSON SYNDROME; TERATOGENICITY; TOXIC EPIDERMAL NECROLYSIS; VISION; WEIGHT GAIN;

ABNORMALITIES, DRUG-INDUCED; ADULT; ANTICONVULSANTS; AUSTRALIA; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG THERAPY, COMBINATION; EPILEPSY; FEMALE; HUMANS; PREGNANCY;

EID: 84867103217     PISSN: 09675868     EISSN: 15322653     Source Type: Journal    
DOI: 10.1016/j.jocn.2012.05.003     Document Type: Review

References (19)

1. K.J. Meador, G.A. Baker, and N. Browning Cognitive function at 3 years of age after fetal exposure to antiepileptic drugs N Engl J Med 360 2009 1597 1605
2. T. Tomson, D. Battino, and E. Bonizzoni Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry Lancet Neurol 10 2011 609 617
3. J. Jentink, M. Loane, and H. Dolk For the EUROCAT antiepileptic study working group. Maternal use of antiepileptic drugs and the risk of major congenital malformations JAMA 395 2011 1996 2002
4. L.B. Holmes, E.A. Harvey, and B.A. Coull The teratogenicity of anticonvulsant drugs N Engl J Med 344 2001 1132 1138
5. H. Kutt, and F. McDowell Management of epilepsy with diphenylhydantoin sodium dosage regulation for problem patients JAMA 203 1968 969 972
6. F.J. Vajda Monitoring antiepileptic drug therapy with serum level measurements Med J Aust 187 2007 581
7. C.B. Man, P. Kwan, and L. Baum Association between HLA-B1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese Epilepsia 48 2007 1015 1018
8. Medsafe: New Zealand Medicines and Medical Devices Safety Authority. Lamotrigine-reduced doses required in patients taking sodium valproate. Web site: November 2009. Prescriber Update 2009;30:24.
9. The Department of Health and Ageing: Therapeutic Goods Administration. Medicines Safety Update No.6; 2010: Lamotrigine and serious skin reactions. Australian Capital Territory: Therapeutic Goods Administration 2011; Available from: http://www.tga.gov.au/hp/msu-2010-06.htm#lamotrigine.
10. M.J. Brodie, and A.W. Yuen Lamotrigine substitution study: evidence for synergism with sodium valproate? 105 study group Epilepsy Res 26 1997 423 432
11. A. Sabers, I. Öhman, and J. Christensen Oral contraceptives reduce lamotrigine plasma levels Neurology 61 2003 570 575
12. F. Vajda, A. Hitchcock, and J. Graham The teratogenic risk of antiepileptic drug polytherapy Epilepsia 51 2010 805 810
13. M. Privitera, R. Fincham, and J. Penry Topiramate placebo-controlled dose-ranging trial in refractory partial epilepsy using 600-800- and 1,000-mg daily dosages. Topiramate YE Study Group Neurology 46 1996 1678 1683
14. U.S. Food and Drug Administration. FDA warning and change of label topamax (topiramate): label change - risk for development of cleft lip and/or cleft palate in newborns available as generic topiramate posted 03/04/2011. Available from: http://www.fda.gov/Safety/MedWatch/SafetyInformation/ SafetyAlertsforHumanMedicalProducts/ucm245777.htm.
15. F.J. Vajda, J. Graham, and A. Roten Teratogenicity of the newer antiepileptic drugs - the Australian experience J Clin Neurosci 19 2012 57 59
16. W. Loscher Basic pharmacology of valproate: a review after 35 years of clinical use for the treatment of epilepsy CNS Drugs 16 2002 669 694
17. G. Chen, W.Z. Zeng, and P.X. Yuan The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS J Neurochem 72 1999 879 882
18. B.F. Bourgeois Chronic management of seizures in the syndromes of idiopathic generalized epilepsy Epilepsia 44 2003 27 32
19. F. Vajda, A. Hitchcock, and J. Graham Seizure control in antiepileptic drug-treated pregnancy Epilepsia 49 2008 172 175