Vitamin D and the scientific calcium dogma: Understanding the Panacea of the sun

European Journal of Clinical Nutrition

Volumn 66, Issue 10, 2012, Pages 1080-1081

  Stumpf, W E ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CALCIUM; CALCIUM BINDING PROTEIN; CALCIUM SENSING RECEPTOR; VITAMIN D;

CALCIUM HOMEOSTASIS; CALCIUM METABOLISM; DIAGNOSTIC TEST; EDITORIAL; HISTOCHEMISTRY; IN VITRO STUDY; PHILOSOPHY; PHOTOTHERAPY; VITAMIN BLOOD LEVEL;

CALCIUM; CALCIUM, DIETARY; HUMANS; RELIGION AND MEDICINE; SKIN; SUNLIGHT; VITAMIN D;

EID: 84867091956     PISSN: 09543007     EISSN: 14765640     Source Type: Journal    
DOI: 10.1038/ejcn.2012.78     Document Type: Editorial

References (24)

1. Dupuis. The origin of all religious worship. New Orleans, 1872.
2. Stumpf WE. Vitamin D sites and mechanisms of action: a histochemical perspective. Reflections on the utility of autoradiography and cytopharmacology for drug targeting. Histochem Cell Biol 1995; 104: 417-427.
3. Stumpf WE, Sar M, Reid FA, Tanaka Y, DeLuca HF. Target cells for 1,25-dihydroxyvitamin D3 intestinal tract, stomach, kidney, skin, pituitary, and parathyroid. Science 1979; 7206: 1188-1190.
4. Stumpf WE. Drug Localization in Tissues and Cells. IDDC Press University Bookstore): Chapel Hill, NC, 2003.
5. Colston K, Hirt M, Feldman D. Organ distribution of the cytoplasmic 1,25-dihydroxycholecalciferol receptor in various mouse tissues. Endocrinol 1980; 107: 1916-1922.
6. Gelbard HA, Stern PH, U'Prichard DC. 1 alpha, 25-Dihydroxyvitamin D3 nuclear receptors in pituitary. Science 1980; 209: 1247-1249.
7. Sandgren ME, Brönnegärd M, DeLuca HF. Tissue distribution of the 1,25- dihydroxyvitamin D3 receptor in the male rat. Biochem Biophys Res Commun 1991; 181: 611-616.
8. Kuhn TS. The Structure of Scientific Revolution. University of Chicago Press: Chicago, 1962.
9. Peterlik M, Cross HS. Vitamin D and calcium insufficiency-related chronic diseases: molecular and cellular pathophysiology. Eur J Clin Nutr 2009; 63: 1377-1386.
10. Stumpf WE. The endocrinology of sunlight and darkness. Complementary roles of vitamin D and pineal hormones. Naturwissenschaften 1988; 75: 247-251.
11. Stumpf WE. The main role of vitamin D: seasonal regulation of vital functions. High-resolution target recognition leads to a new paradigm and advanced drug development. Eur J Drug Metab Pharmacokinet 2007; 32: 1-6.
12. Vieth R. Vitamin D supplementation, 25-hydroxyvitamin D concentrations, and safety. Am J Clin Nutr 1999; 69: 842-856.
13. Stumpf WE. The dose makes the medicine. Drug Discov Today 2006; 11: 550-555.
14. Stumpf WE, Denny ME. Vitamin D (soltriol), light, and reproduction. Am J Obstet Gynecol 1989; 161: 1375-1384.
15. Narbaitz R, Stumpf WE, Sar M, Huang S, DeLuca HF. Autoradiographic localization of target cells for 1 alpha, 25-dihydroxyvitamin D3 in bones from fetal rats. Calcif Tissue Int 1983; 35: 177-182.
16. Stumpf WE, Sar M, Narbaitz R, Huang S, DeLuca HF. Autoradiographic localization of 1,25-dihydroxyvitamin D3 in rat placenta and yolk sac. Horm Res 1983; 18: 215-220.
17. Stumpf WE, Koike N, Hayakawa N, Tokuda K, Nishimiya K, Tsuchiya Y et al. 1,25-Dihydroxyvitamin D3 and 22-oxa-1,25-dihydroxyvitamin D3 in vivo nuclear receptor binding in developing bone during endochondral and intramembranous ossification. Histochemistry 1994; 102: 183-194.
18. Stumpf WE, Downs TW. Nuclear receptors for 1,25 (OH)2 vitamin D3 in thymus reticular cells studied by autoradiography. Histochemistry 1987; 87: 367-369.
19. Puchacz E, Stumpf WE, Stachowiak EK, Stachowiak MK. Vitamin D increases expression of the tyrosine hydroxylase gene in adrenal medullary cells. Brain Res Mol Brain Res 1996; 36: 193-196.
20. Stumpf WE. Vitamin D and the digestive system. Europ J Drug Metabol Pharmacokinet 2008; 33: 85-100.
21. Stumpf WE, O'Brien LP. 1,25 (OH)2 vitamin D3 sites of action in the brain. An autoradiographic study. Histochemistry 1987; 87: 393-406.
22. Stumpf WE. Drugs in the brain-cellular imaging with receptor microscopic autoradiography. Prog Histochem Cytochem 2012; 47: 1-26.
23. Gominak SC, Stumpf WE. The world epidemic of sleep disorders is linked to vitamin D deficiency. Med Hypotheses 2012; e-pub ahead of print 12 May 2012.
24. Stumpf WE. Vitamin D-soltriol the heliogenic steroid hormone: somatotrophic activator and modulator. Discoveries from histochemical studies lead to new concepts. Histochemistry 1988; 89: 209-219.