Effects of nuclear receptor transactivation on steroid hormone synthesis and gene expression in porcine Leydig cells

Journal of Steroid Biochemistry and Molecular Biology

Volumn 133, Issue 1, 2013, Pages 93-100

  Gray, Matthew A ^a   Squires, E James ^a  

^a UNIVERSITY OF GUELPH   (Canada)

Author keywords

16 Androstenes; Leydig cells; Nuclear receptors; Steroidogenesis; Transcription

Indexed keywords

6 (4 CHLOROPHENYL)IMIDAZO[2,1 B][1,3]THIAZOLE 5 CARBALDEHYDE O (3,4 DICHLOROBENZYL)OXIME; AGENTS INTERACTING WITH TRANSMITTER, HORMONE OR DRUG RECEPTORS; ANDROST 16 ENE; CELL NUCLEUS RECEPTOR; CHENODEOXYCHOLIC ACID; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME; CYTOCHROME B5 REDUCTASE 1; CYTOCHROME B5A; FARNESOID X RECEPTOR; PREGNANE X RECEPTOR; RIFAMPICIN; SEX HORMONE; TESTOSTERONE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BOAR (MALE PIG); CELL ISOLATION; CELL METABOLISM; CONTROLLED STUDY; GENE EXPRESSION; LEYDIG CELL; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; STEROID METABOLISM; STEROIDOGENESIS;

ANDROSTENEDIONE; ANIMALS; BASE SEQUENCE; GENE EXPRESSION; LEYDIG CELLS; MALE; ODORS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; STEROID 17-ALPHA-HYDROXYLASE; STEROIDS; SUS SCROFA; TRANSCRIPTIONAL ACTIVATION;

ANIMALIA; SUIDAE; SUS;

EID: 84867075045     PISSN: 09600760     EISSN: 18791220     Source Type: Journal    
DOI: 10.1016/j.jsbmb.2012.09.014     Document Type: Article

References (30)

1. A.J. Francis, E. Fayard, F. Picard, and J. Auwerx Nuclear receptors and the control of metabolism Annual Review of Physiology 65 2003 261 311
2. A.L. Bookout, Y. Jeong, M. Downes, R.T. Yu, R.M. Evans, and D.J. Mangelsdorf Anatomical profiling of nuclear receptor expression reveals a hierarchical transcriptional network Cell 126 2006 789 799
3. D.J. Mangelsdorf, C. Thummel, M. Beato, P. Herrlich, G. Schütz, K. Umesono, B. Blumberg, P. Kastner, M. Mark, P. Chambon, and R.M. Evans The nuclear receptor superfamily: the second decade Cell 85 1995 835 839
4. M. Baes, T. Gulick, H-S. Choi, M.G. Martinoli, D. Simha, and D.D. Morre A new orphan member of the nuclear hormone receptor superfamily that interacts with a subset of retinoic acid response elements Molecular and Cellular Biology 14 1994 1544 1552
5. W.S. Baldwin, and J.A. Roling A concentration addition model for the activation of the constitutive androstane receptor by xenobiotic mixtures Toxicological Sciences 107 2009 93 105
6. S.A. Kliewer, J.T. Moore, L. Wade, L. Staudinger, M.A. Watson, S.A. Jones, D.D. McKee, B.B. Oliver, T.M. Willson, R.H. Zetterstrom, T. Perlmann, and J.M. Lehmann An orphan nuclear receptor activated by pregnanes defines a novel steroid signaling pathway Cell 92 1998 73 82
7. C. Handschin, and U.A. Meyer Induction of drug metabolism: the role of nuclear receptors Pharmacological Research 55 2003 649 673
8. E.S. Tien, and M. Negishi Nuclear receptors CAR and PXR in the regulation of hepatic metabolism Xenobiotica 36 2006 1152 1163
9. M. Makishima, A.Y. Okamoto, J.J. Repa, H. Tu, R.M. Learned, A. Luk, M.V. Hull, K.D. Lustig, D.J. Mangelsdorf, and B. Shan Identification of a nuclear receptor for bile acids Science 284 1999 1362 1365
10. M.A. Gray, J.N. Peacock, and E.J. Squires Characterization of the porcine constitutive androstane receptor (CAR) and its splice variants Xenobiotica 39 2009 915 930
11. M.A. Gray, C.B. Pollock, L.B. Schook, and E.J. Squires Characterization of porcine pregnane X receptor, farnesoid X receptor and their splice variants Experimental Biology and Medicine 235 2010 718 736
12. R.L.S. Patterson 5a-Androst-16-en-3-one: compound responsible for taint in boar fat Journal of the Science of Food and Agriculture 19 1968 31 38
13. C. Baek, J. HansenMoller, C. Friis, C. Cornett, and S.H. Hansen Identification of selected metabolites of skatole in plasma and urine from pigs Journal of Agricultural and Food Chemistry 45 1997 2332 2340
14. M.J. Billen, and E.J. Squires The role of porcine cytochrome b5A and cytochrome b5B in the regulation of cytochrome P45017A1 activity Journal of Steroid Biochemistry and Molecular Biology 113 2009 98 114
15. M. Moe, T. Meuwissen, S. Lien, C. Bendixen, X. Wang, L.N. Conley, I. Berget, H. Tajet, and E. Grindflek Gene expression profiles in testis of pigs with extreme high and low levels of androstenone BMC Genomics 8 2007 405
16. M.C. Leung, K.L. Bowley, and E.J. Squires Examination of testicular gene expression patterns in Yorkshire pigs with high and low levels of boar taint Animal Biotechnology 2 2010 77 87
17. P.A. Sinclair, E.J. Squires, J.I. Raeside, and R. Renaud Synthesis of free and sulphoconjugated 16-androstene steroids by the Leydig cells of the mature domestic boar Journal of Steroid Biochemistry and Molecular Biology 96 2005 217 228
18. G. Zamaratskaia, and E.J. Squires Biochemical, nutritional and genetic effects on boar taint in entire male pigs Animal 3 2009 1508 1521
19. M. Moe, S. Lien, C. Bendixen, J. Hedegaard, H. Hornshoj, I. Berget, T.H. Meuwissen, and E. Grindflek Gene expression profiles in liver of pigs with extreme high and low levels of androstenone BMC Veterinary Research 4 2008 29
20. B. Goodwin, L.B. Moore, C.M. Stoltz, D.D. McKee, and S.A. Kliewer Regulation of human CYP2B6 gene by nuclear pregnane X receptor Molecular Pharmacology 60 2001 427 431
21. P.A. Sinclair, W.J. Gilmore, Z. Lin, Y. Lou, and E.J. Squires Molecular cloning and regulation of porcine SULT2A1: relationship between SULT2A1 expression and sulfoconjugation of androstenone Journal of Molecular Endocrinology 36 2006 301 311
22. K.J. Livak, and T.D. Schmittgen Analysis of relative gene expression data using real-time quantitative PCR and the 2-ΔΔCT method Methods 25 2001 402 408
23. E. Willems, L. Leyns, and J. Vandesompele Standardization of real-time PCR gene expression data from independent biological replicates Analytical Biochemistry 379 2008 127 129
24. P.A. Sinclair, and E.J. Squires Testicular sulfoconjugation of the 16-androstene steroids by hydroxysteroid sulfotransferase: its effects on the concentrations of 5 alpha-androstenone in plasma and fat of the mature domestic boar Journal of Animal Science 83 2005 358 365
25. W.J. Meadus, J.I. Mason, and E.J. Squires Cytochrome p450c17 from porcine and bovine adrenal catalyses the formation of 5,16-androstadien-3b-ol from pregnenolone in the presence of cytochrome b5 Journal of Steroid Biochemistry and Molecular Biology 46 1993 565 572
26. E. Grindflek, I. Berget, M. Moe, P. Oeth, and S. Lien Transcript profiling of candidate genes in testis of pigs exhibiting large differences in androstenone levels Chemico-Biological Interactions 11 2010 4
27. J. Babol, E.J. Squires, and K. Lundström Relationship between metabolism of androstenone and skatole in intact male pigs Journal of Animal Science 77 1999 84 92
28. E. Doran, F.W. Whittington, J.D. Wood, J.D. McGivan, and P450I.I.E1 Cytochrome (CYP2E1) is induced by skatole and this induction is blocked by androstenone in isolated pig hepatocytes Chemico-Biological Interactions 140 2002 81 92
29. W.S. Tambyrajah, E. Doran, J.D. Wood, and J.D. McGivan The pig CYP2E1 promoter is activated by COUP-TF1 and HNF-1 and is inhibited by androstenone Archives of Biochemistry and Biophysics 431 2004 252 260
30. G. Zamaratskaia, W.J. Gilmore, K. Lundström, and E.J. Squires Effect of testicular steroids on catalytic activity of cytochrome P450 enzymes in porcine liver microsomes Food and Chemical Toxicology 45 2007 676 681