Synaptic localisation of agmatinase in rat cerebral cortex revealed by virtual pre-embedding

Amino Acids

Volumn 43, Issue 3, 2012, Pages 1399-1403

  Madai, V I ^a   Poller, W C ^a   Peters, D ^a   Berger, J ^a   Paliege, K ^a,b   Bernard, R ^a   Veh, R W ^a   Laube, G ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b Head and Neck Surgery at UKB   (Germany)

Author keywords

Agmatinase; Agmatine; Mood disorders; Neurotransmission; Pre embedding

Indexed keywords

AGMATINASE; AGMATINE; ARGINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DENDRITIC SPINE; ELECTRON MICROSCOPY; EMBEDDING; ENZYME LOCALIZATION; MICROSCOPY; NONHUMAN; POSTSYNAPTIC DENSITY; POSTSYNAPTIC MEMBRANE; PRESYNAPTIC NERVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; SYNAPSE; VIRTUAL PRE EMBEDDING;

ANIMALS; DENDRITIC SPINES; FLUORESCENT DYES; PARIETAL LOBE; PLASTIC EMBEDDING; RATS; RHODAMINES; STAINING AND LABELING; SYNAPSES; UREOHYDROLASES;

RATTUS;

EID: 84867070694     PISSN: 09394451     EISSN: 14382199     Source Type: Journal    
DOI: 10.1007/s00726-011-1195-5     Document Type: Article

References (20)

1. Agostinelli E, Marques MP, Calheiros R, Gil FP, Tempera G, Viceconte N, Battaglia V, Grancara S, Toninello A (2010) Polyamines: fundamental characters in chemistry and biology. Amino Acids 38(2):393-403
2. Bernstein HG, Derst C, Stich C, Pruss H, Peters D, Krauss M, Bogerts B, Veh RW, Laube G (2011) The agmatine-degrading enzyme agmatinase: a key to agmatine signaling in rat and human brain? Amino Acids 40(2):453-465
3. Bernstein HG, Stich C, Jager K, Dobrowolny H, Wick M, Steiner J, Veh R, Bogerts B, Laube G (2012) Agmatinase, an inactivator of the putative endogenous antidepressant agmatine, is strongly upregulated in hippocampal interneurons of subjects with mood disorders. Neuropharmacology 62(1):237-246
4. Bobrow MN, Harris TD, Shaughnessy KJ, Litt GJ (1989) Catalyzed reporter deposition, a novel method of signal amplification. Application to immunoassays. J Immunol Methods 125(1-2):279-285 (Pubitemid 20018033)
5. Gilad GM, Wollam Y, Iaina A, Rabey JM, Chernihovsky T, Gilad VH (1996) Metabolism of agmatine into urea but not into nitric oxide in rat brain. Neuroreport 7(11):1730-1732 (Pubitemid 26348245)
6. Goracke-Postle CJ, Overland AC, Stone LS, Fairbanks CA (2007) Agmatine transport into spinal nerve terminals is modulated by polyamine analogs. J Neurochem 100(1):132-141 (Pubitemid 46085844)
7. Gorbatyuk OS, Milner TA, Wang G, Regunathan S, Reis DJ (2001) Localization of agmatine in vasopressin and oxytocin neurons of the rat hypothalamic paraventricular and supraoptic nuclei. Exp Neurol 171(2):235-245 (Pubitemid 32955285)
8. Hopman AH, Ramaekers FC, Speel EJ (1998) Rapid synthesis of biotin-, digoxigenin-, trinitrophenyl-, and fluorochrome-labeled tyramides and their application for in situ hybridization using CARD amplification. J Histochem Cytochem 46(6):771-777 (Pubitemid 28272213)
9. Humbel BM, de Jong MD, Muller WH, Verkleij AJ (1998) Preembedding immunolabeling for electron microscopy: an evaluation of permeabilization methods and markers. Microsc Res Tech 42(1):43-58 (Pubitemid 28363794)
10. Kim JH, Yenari MA, Giffard RG, Cho SW, Park KA, Lee JE (2004) Agmatine reduces infarct area in a mouse model of transient focal cerebral ischemia and protects cultured neurons from ischemia-like injury. Exp Neurol 189(1):122-130 (Pubitemid 39024461)
11. Krauss M, Langnaese K, Richter K, Brunk I, Wieske M, Ahnert-Hilger G, Veh RW, Laube G (2006) Spermidine synthase is prominently expressed in the striatal patch compartment and in putative interneurones of the matrix compartment. J Neurochem 97(1):174-189
12. Krauss M, Weiss T, Langnaese K, Richter K, Kowski A, Veh RW, Laube G (2007) Cellular and subcellular rat brain spermidine synthase expression patterns suggest region-specific roles for polyamines, including cerebellar pre-synaptic function. J Neurochem 103(2):679-693 (Pubitemid 47498020)
13. Lewandowski NM, Ju S, Verbitsky M, Ross B, Geddie ML, Rockenstein E, Adame A, Muhammad A, Vonsattel JP, Ringe D, Cote L, Lindquist S, Masliah E, Petsko GA, Marder K, Clark LN, Small SA (2010) Polyamine pathway contributes to the pathogenesis of Parkinson disease. Proc Natl Acad Sci USA 107(39):16970-16975
14. Li G, Regunathan S, Barrow CJ, Eshraghi J, Cooper R, Reis DJ (1994) Agmatine: an endogenous clonidine-displacing substance in the brain. Science 263(5149):966-969 (Pubitemid 24094560)
15. Ottersen OP (1987) Postembedding light- and electron microscopic immunocytochemistry of amino acids: description of a new model system allowing identical conditions for specificity testing and tissue processing. Exp Brain Res 69(1):167-174 (Pubitemid 18012826)
16. Reis DJ, Regunathan S (2000) Is agmatine a novel neurotransmitter in brain? Trends Pharmacol Sci 21(5):187-193 (Pubitemid 30243201)
17. Roberts JC, Grocholski BM, Kitto KF, Fairbanks CA (2005) Pharmacodynamic and pharmacokinetic studies of agmatine after spinal administration in the mouse. J Pharmacol Exp Ther 314(3):1226-1233 (Pubitemid 41205988)
18. Seidl R, Beninati S, Cairns N, Singewald N, Risser D, Bavan H, Nemethova M, Lubec G (1996) Polyamines in frontal cortex of patients with Down syndrome and Alzheimer disease. Neurosci Lett 206(2-3):193-195 (Pubitemid 26094691)
19. Wang CC, Chio CC, Chang CH, Kuo JR, Chang CP (2010) Beneficial effect of agmatine on brain apoptosis, astrogliosis, and edema after rat transient cerebral ischemia. BMC Pharmacol 10:11
20. Yang XC, Reis DJ (1999) Agmatine selectively blocks the N-methyl-D-aspartate subclass of glutamate receptor channels in rat hippocampal neurons. J Pharmacol Exp Ther 288(2):544-549 (Pubitemid 29119663)