Inappropriate Drugs in Elderly Patients with Severe Cognitive Impairment: Results from the Shelter Study

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Colloca, Giuseppe ^a   Tosato, Matteo ^a   Vetrano, Davide L ^a   Topinkova, Eva ^b   Fialova, Daniela ^b   Gindin, Jacob ^c   van der Roest, Henriëtte G ^d   Landi, Francesco ^a   Liperoti, Rosa ^a   Bernabei, Roberto ^a   Onder, Graziano ^a  

^a CATHOLIC UNIVERSITY   (Italy)

^b CHARLES UNIVERSITY   (Czech Republic)

^c UNIVERSITY OF HAIFA   (Israel)

^d VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA ADRENERGIC RECEPTOR BLOCKING AGENT; ANTIARRHYTHMIC AGENT; ANTIESTROGEN; ANTILIPEMIC AGENT; ANTITHROMBOCYTIC AGENT; BISPHOSPHONIC ACID DERIVATIVE; CHOLINESTERASE INHIBITOR; CLONIDINE; CYTOTOXIC AGENT; DIGOXIN; HEPARIN; HORMONE ANTAGONIST; IMMUNOMODULATING AGENT; LEUKOTRIENE RECEPTOR BLOCKING AGENT; LOW MOLECULAR WEIGHT HEPARIN; MEMANTINE; MINERALOCORTICOID; SPASMOLYTIC AGENT; TAMSULOSIN; WARFARIN;

AGED; ARTICLE; CEREBROVASCULAR ACCIDENT; COGNITION; COGNITIVE DEFECT; COMORBIDITY; CROSS-SECTIONAL STUDY; DIABETES MELLITUS; DISEASE SEVERITY; DRUG USE; EUROPE; FEMALE; GERIATRIC PATIENT; HEALTH SERVICE; HEART FAILURE; HOSPITALIZATION; HUMAN; INAPPROPRIATE PRESCRIBING; INDEPENDENT VARIABLE; MAJOR CLINICAL STUDY; MALE; NURSING HOME; PREVALENCE;

AGED; AGED, 80 AND OVER; ASPIRIN; CHOLINESTERASE INHIBITORS; COGNITION DISORDERS; CROSS-SECTIONAL STUDIES; FEMALE; HEALTH SERVICES FOR THE AGED; HOMES FOR THE AGED; HUMANS; HYPOLIPIDEMIC AGENTS; LONG-TERM CARE; MALE; PARASYMPATHOLYTICS;

EID: 84867068548     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046669     Document Type: Article

References (28)

1. Magaziner J, German P, Zimmerman SI, Hebel JR, Burton L, et al. (2000) The prevalence of dementia in a statewide sample of new nursing home admissions aged 65 and older: diagnosis by expert panel. Epidemiology of Dementia in Nursing Homes Research Group. The Gerontologist (40) (): 663-72.
2. Doshi JA, Shaffer T, Briesacher BA, (2005) National estimates of medication use in nursing homes: findings from the 1997 medicare current beneficiary survey and the 1996 medical expenditure survey. Journal of the American Geriatrics Society. 53: 438-43.
3. Tjia J, Rothman MR, Kiely DK, Shaffer ML, Holmes HM, et al. (2010) Daily medication use in nursing home residents with advanced dementia. Journal of the American Geriatrics Society (58) (): 880-8.
4. Huey ED, Taylor JL, Luu P, Oehlert J, Tinklenberg JR, (2006) Factors associated with use of medications with potential to impair cognition or cholinesterase inhibitors among Alzheimer's disease patients. Alzheimers Dement (2) (): 314-21.
5. Brauner DJ, Muir JC, Sachs GA, (2000) Treating nondementia illnesses in patients with dementia. JAMA. 283: 3230-5.
6. Onder G, Gambassi G, Scales CJ, Cesari M, Vedova CD, et al. (2002) Adverse drug reactions and cognitive function among hospitalized older adults. Eur J Clin Pharmacol. 58: 371-7.
7. Fried TR, Tinetti ME, Iannone L, (2011) Primary care clinicians' experiences with treatment decision making for older persons with multiple conditions. Arch Intern Med. 171: 75-80.
8. Onder G, Liperoti R, Fialova D, Tosato M, Danese P, et al. (2012) Polypharmacy in Nursing Home in Europe: Results From the SHELTER Study. J Gerontol A Biol Sci Med Sci. 6: 698-704.
9. Holmes HM, Sachs GA, Shega JW, Hougham GW, Cox Hayley D, et al. (2008) Integrating palliative medicine into the care of persons with advanced dementia: identifying appropriate medication use. Journal of the American Geriatrics Society. 56: 1306-11.
10. Shega JW, Levin A, Hougham GW, Cox-Hayley D, Luchins D, et al. (2003) Palliative Excellence in Alzheimer Care Efforts (PEACE): a program description. Journal of palliative medicine (6) (): 315-20.
11. Onder G, Carpenter I, Finne-Soveri H, Gindin J, Frijters D, et al. (2012) Assessment of nursing home residents in Europe: the Services and Health for Elderly in Long TERm care (SHELTER) study. BMC health services research (12) (): 5.
12. Landi F, Sgadari A, Zuccala G, Pahor M, Carbonin P, et al. (1999) A brief training program on resident assessment instrument improves motivation of nursing home staff. The journal of nutrition, health & aging. 3: 24-8.
13. Anon. WHOCC- Home. Available at: http://www.whocc.no/.
14. Morris JN, Fries BE, Mehr DR, Hawes C, Phillips C, et al. (1994) The MDS Cognitive Performance Scale. Journal of Gerontology. 49: 174-182.
15. Teno JM, Mitchell SL, Gozalo PL, Dosa D, Hsu A, et al. (2010) Hospital characteristics associated with feeding tube placement in nursing home residents with advanced cognitive impairment. JAMA. 303: 544-50.
16. Morris JN, Fries BE, Morris SA, (1999) Scaling ADLs within the MDS. The journals of gerontology. Series A, Biological Sciences and Medical Sciences. 54(11): M546-53.
17. Hanley JA, Negassa A, Edwardes MD deB, Forrester JE, (2003) Statistical analysis of correlated data using generalized estimating equations: an orientation. American Journal of Epidemiology. 157: 364-75.
18. Mitchell SL, Teno JM, Roy J, Kabumoto G, Mor V, (2003) Clinical and organizational factors associated with feeding tube use among nursing home residents with advanced cognitive. impairment (JAMA.290) (): 73-80.
19. Howard R, McShane R, Lindesay J, Ritchie C, Phillips P, et al. (2012) Donepezil and memantine for moderate-to-severe Alzheimer's disease.N Engl J Med. 366: 893-903.
20. Colloca G, Santoro M, Gambassi G, (2010) Age-related physiologic changes and perioperative management of elderly patients. Surgical oncology. 19: 124-30.
21. Onder G, Petrovic M, Tangiisuran B, Meinardi MC, Markito-Notenboom WP, et al. (2010) Development and validation of a score to assess risk of adverse drug reactions among in-hospital patients 65 years or older: the GerontoNet ADR risk score. Arch Intern Med. 170: 1142-8.
22. Fusco D, Lattanzio F, Tosato M, Corsonello A, Cherubini A, et al. (2009) Development of CRIteria to assess appropriate Medication use among Elderly complex patients (CRIME) project: rationale and methodology. Drugs & Aging. 26Suppl 1: 3-13.
23. Lee M, Chodosh J, (2009) Dementia and life expectancy: what do we know? Journal of the American Medical Directors Association (10) (): 466-71.
24. Holmes HM, (2009) Rational prescribing for patients with a reduced life expectancy. Clinical Pharmacology and Therapeutics. 85: 103-7.
25. Sabbagh M, Cummings J, (2011) Progressive cholinergic decline in Alzheimer's Disease: consideration for treatment with donepezil 23 mg in patients with moderate to severe symptomatology. BMC neurology. 11: 21.
26. Tariot PN, Farlow MR, Grossberg GT, Graham SM, McDonald S, et al. (2004) Memantine treatment in patients with moderate to severe Alzheimer disease already receiving donepezil: a randomized controlled trial. JAMA. 291: 317-24.
27. Schneider LS, (2012) Discontinuing donepezil or starting memantine for Alzheimer's disease. N Engl J Med. 366: 957-9.
28. Onder G, Lattanzio F, Battaglia M, Cerullo F, Sportiello R, et al. (2011) The Risk of Adverse Drug Reactions in Older Patients: Beyond Drug Metabolism. Curr Drug Metab. 12: 647-51.