Phosphatidylinositol 4,5-biphosphate (PIP2) lipids regulate the phosphorylation of syntaxin N-terminus by modulating both its position and local structure

Biochemistry

Volumn 51, Issue 39, 2012, Pages 7685-7698

  Khelashvili, George ^a   Galli, Aurelio ^b   Weinstein, Harel ^a  

^a WEILL CORNELL MEDICAL COLLEGE   (United States)

^b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPUTATIONAL STRATEGY; CONFORMATIONAL DIFFERENCES; CONTINUUM MODELING; DE-MIXING; ION CHANNEL; LOCAL STRUCTURE; MESOSCALE; MOLECULAR DYNAMICS SIMULATIONS; N-TERMINALS; PHOSPHATIDYLINOSITOL 4; PROTEIN RECEPTORS; PROTEIN-MEMBRANE INTERACTIONS; PROTEIN-PROTEIN INTERACTIONS; QUANTITATIVE EVALUATION; SPECIFIC SITES; STRUCTURAL MODIFICATIONS; SYNTAXIN;

AMINO ACIDS; CELL MEMBRANES; COMPUTATIONAL CHEMISTRY; CONTINUUM MECHANICS; ENZYMES; ION EXCHANGE; LIPIDS; MOLECULAR DYNAMICS; PHOSPHORYLATION;

PROTEINS;

PHOSPHATIDYLINOSITOL 4,5 BISPHOSPHATE; SNARE PROTEIN; SYNTAXIN; SYNTAXIN 1A; SYNTAXIN 1B; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; LIPID ANALYSIS; LIPID MEMBRANE; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN LIPID INTERACTION; PROTEIN PHOSPHORYLATION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS REGULATION; STATIC ELECTRICITY;

AMINO ACID SEQUENCE; HUMANS; MOLECULAR DYNAMICS SIMULATION; MOLECULAR SEQUENCE DATA; PHOSPHATIDYLCHOLINES; PHOSPHATIDYLINOSITOL 4,5-DIPHOSPHATE; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN ISOFORMS; QA-SNARE PROTEINS; SEQUENCE ALIGNMENT; SNARE PROTEINS;

EID: 84867057655     PISSN: 00062960     EISSN: 15204995     Source Type: Journal    
DOI: 10.1021/bi300833z     Document Type: Article

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