Role of p38 mitogen-activated protein kinase in posttraumatic immunosuppression in mice

Journal of Trauma and Acute Care Surgery

Volumn 73, Issue 4, 2012, Pages 861-868

  Ding, Nadine ^a   Dahlke, Katja ^b   Janze, Ann Kathrin ^a   Mailer, Petra C ^a   Maus, Regina ^a   Bohling, Jennifer ^a   Welte, Tobias ^a   Bauer, Michael ^b   Riedemann, Niels C ^b   Maus, Ulrich A ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

^b JENA UNIVERSITY HOSPITAL   (Germany)

Author keywords

hemorrhage; lung; mitogen activated protein kinase; Streptococcus pneumoniae; Trauma

Indexed keywords

DORAMAPIMOD; MITOGEN ACTIVATED PROTEIN KINASE P38; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; APOPTOSIS; ARTERY CATHETERIZATION; ARTICLE; BACTERIAL GROWTH; BACTERIAL STRAIN; BACTERICIDAL ACTIVITY; BLEEDING; CANNULATION; CONTROLLED STUDY; DRUG EFFICACY; ENZYME ACTIVITY; ESCHERICHIA COLI; FEMALE; FEMORAL ARTERY; FEMORAL VEIN; IMMUNE DYSREGULATION; IMMUNITY; IN VITRO STUDY; IN VIVO STUDY; INJURY; LAPAROTOMY; LUNG; MACROPHAGE; MIDLINE LAPAROTOMY; MOUSE; NONHUMAN; PHAGOCYTOSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; STREPTOCOCCUS PNEUMONIA; STREPTOCOCCUS PNEUMONIAE; SURVIVAL RATE;

ANIMALS; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; FEMALE; IMMUNE TOLERANCE; IMMUNOCOMPROMISED HOST; MACROPHAGES, ALVEOLAR; MICE; MICE, INBRED C57BL; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PNEUMONIA, PNEUMOCOCCAL; SIGNAL TRANSDUCTION; STREPTOCOCCUS PNEUMONIAE; WOUNDS AND INJURIES;

EID: 84867055280     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31825ab11f     Document Type: Article

References (40)

1. von Dossow V, Rotard K, Redlich U, Hein OV, Spies CD. Circulating immune parameters predicting the progression from hospital-acquired pneumonia to septic shock in surgical patients. Crit Care. 2005;9: R662-R669.
2. Baue AE, Durham R, Faist E. Systemic inflammatory response syndrome (SIRS), multiple organ dysfunction syndrome (MODS), multiple organ failure (MOF): are we winning the battle? Shock. 1998;10:79-89. (Pubitemid 128463838)
3. Angele MK, Faist E. Clinical review: immunodepression in the surgical patient and increased susceptibility to infection. Crit Care. 2002;6: 298-305. (Pubitemid 34863695)
4. Tejada Artigas A, Bello Dronda S, Chacon Valles E, Munoz Marco J, Villuendas Uson MC, Figueras P, Suarez FJ, Hernandez A. Risk factors for nosocomial pneumonia in critically ill trauma patients. Crit Care Med. 2001;29:304-309. (Pubitemid 32171774)
5. Maloney SA, Jarvis WR. Epidemic nosocomial pneumonia in the intensive care unit. Clin Chest Med. 1995;16:209-223.
6. Rodriguez JL, Gibbons KJ, Bitzer LG, Dechert RE, Steinberg SM, Flint LM. Pneumonia: incidence, risk factors, and outcome in injured patients. J Trauma. 1991;31:907-912; discussion 912-904.
7. Jarrar D, Kuebler JF, Rue LW, 3rd, Matalon S, Wang P, Bland KI, Chaudry IH. Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NF-kappaB and MAPK/ERK mechanisms. Am J Physiol Lung Cell Mol Physiol. 2002;283:L799-L805.
8. Khadaroo RG, Lu Z, Powers KA, Papia G, Kapus A, Rotstein OD. Impaired activation of mitogen-activated protein kinases after hemorrhagic shock. Surgery. 2002;132:360-364. (Pubitemid 35024785)
9. Jarrar D, Song GY, Kuebler JF, Rue LW, Bland KI, Chaudry IH. The effect of inhibition of a major cell signaling pathway following trauma hemorrhage on hepatic injury and interleukin 6 levels. Arch Surg. 2004;139:896-901. (Pubitemid 39038003)
10. Muehlstedt SG, Richardson CJ, West MA, Lyte M, Rodriguez JL. Cytokines and the pathogenesis of nosocomial pneumonia. Surgery. 2001;130:602-609; discussion 609-611.
11. Song GY, Chung CS, Chaudry IH, Ayala A. MAPK p38 antagonism as a novel method of inhibiting lymphoid immune suppression in polymicrobial sepsis. Am J Physiol Cell Physiol. 2001;281:C662-C669.
12. Thobe BM, Frink M, Choudhry MA, Schwacha MG, Bland KI, Chaudry IH. Src family kinases regulate p38 MAPK-mediated IL-6 production in Kupffer cells following hypoxia. Am J Physiol Cell Physiol. 2006; 291:C476-C482. (Pubitemid 44343630)
13. Winter C, Taut K, Langer F, Mack M, Briles DE, Paton JC, Maus R, Srivastava M, Welte T, Maus UA. FMS-like tyrosine kinase 3 ligand aggravates the lung inflammatory response to Streptococcus pneumoniae infection in mice: role of dendritic cells. J Immunol. 2007;179: 3099-3108.
14. Winter C, Herbold W, Maus R, Langer F, Briles DE, Paton JC, Welte T, Maus UA. Important role for CC chemokine ligand 2-dependent lung mononuclear phagocyte recruitment to inhibit sepsis in mice infected with Streptococcus pneumoniae. J Immunol. 2009;182:4931-4937.
15. Winter C, Taut K, Srivastava M, Langer F, Mack M, Briles DE, Paton JC, Maus R, Welte T, Gunn MD, et al. Lung-specific overexpression of CC chemokine ligand (CCL) 2 enhances the host defense to Streptococcus pneumoniae infection in mice: role of the CCL2-CCR2 axis. J Immunol. 2007;178:5828-5838. (Pubitemid 46674380)
16. Maus UA, Koay MA, Delbeck T, Mack M, Ermert M, Ermert L, Blackwell TS, Christman JW, Schlondorff D, Seeger W, et al. Role of resident alveolar macrophages in leukocyte traffic into the alveolar air space of intact mice. Am J Physiol Lung Cell Mol Physiol. 2002;282: L1245-L1252. (Pubitemid 34654580)
17. Taut K, Winter C, Briles DE, Paton JC, Christman JW, Maus R, Baumann R, Welte T, Maus UA.Macrophage turnover kinetics in the lungs ofmice infected with Streptococcus pneumoniae. Am J Respir Cell Mol Biol. 2008;38: 105-113.
18. Maus UA, Backi M, Winter C, Srivastava M, Schwarz MK, Ruckle T, Paton JC, Briles D, Mack M, Welte T, et al. Importance of phosphoinositide 3-kinase gamma in the host defense against pneumococcal infection. Am J Respir Crit Care Med. 2007;175:958-966. (Pubitemid 46684707)
19. Briles DE, Hollingshead SK, Paton JC, Ades EW, Novak L, van Ginkel FW, Benjamin WH, Jr. Immunizations with pneumococcal surface protein A and pneumolysin are protective against pneumonia in a murine model of pulmonary infection with Streptococcus pneumoniae. J Infect Dis. 2003;188: 339-348. (Pubitemid 36966099)
20. Maus UA, Janzen S, Wall G, Srivastava M, Blackwell TS, Christman JW, Seeger W, Welte T, Lohmeyer J. Resident alveolar macrophages are replaced by recruited monocytes in response to endotoxin-induced lung inflammation. Am J Respir Cell Mol Biol. 2006;35:227-235. (Pubitemid 44175323)
21. Gruenbaum LM, SchwartzR, Woska JR, Jr., DeLeonRP, PeetGW, Warren TC, Capolino A, Mara L, Morelock MM, Shrutkowski A, et al. Inhibition of proinflammatory cytokine production by the dual p38/JNK2 inhibitor BIRB796 correlates with the inhibition of p38 signaling. Biochem Pharmacol. 2009;77:422-432.
22. Branger J, van den Blink B, Weijer S, Madwed J, Bos CL, Gupta A, Yong CL, Polmar SH, Olszyna DP, Hack CE, et al. Anti-inflammatory effects of a p38 mitogen-activated protein kinase inhibitor during human endotoxemia. J Immunol. 2002;168:4070-4077. (Pubitemid 34298414)
23. Regan J, Breitfelder S, Cirillo P, Gilmore T, Graham AG, Hickey E, Klaus B, Madwed J, Moriak M, Moss N, et al. Pyrazole urea-based inhibitors of p38 MAP kinase: from lead compound to clinical candidate. J Med Chem. 2002;45:2994-3008. (Pubitemid 34721521)
24. Faist E, Mewes A, Strasser T, Walz A, Alkan S, Baker C, ErtelW, Heberer G. Alteration of monocyte function following major injury. Arch Surg. 1988;123:287-292. (Pubitemid 18093295)
25. Faist E, Kupper TS, Baker CC, Chaudry IH, Dwyer J, Baue AE. Depression of cellular immunity after major injury. Its association with posttraumatic complications and its reversal with immunomodulation. Arch Surg. 1986;121:1000-1005.
26. Hensler T, Hecker H, Heeg K, HeideckeCD, BartelsH, BarthlenW, WagnerH, Siewert JR, Holzmann B. Distinct mechanisms of immunosuppres-sion as a consequence of major surgery. Infect Immun. 1997;65:2283-2291. (Pubitemid 27237311)
27. Meakins JL, Pietsch JB, Bubenick O, Kelly R, Rode H, Gordon J, MacLean LD. Delayed hypersensitivity: indicator of acquired failure of host defenses in sepsis and trauma. Ann Surg. 1977;186:241-250. (Pubitemid 8170965)
28. Miller-Graziano CL, Fink M, Wu JY, Szabo G, Kodys K. Mechanisms of altered monocyte prostaglandin E2 production in severely injured patients. Arch Surg. 1988;123:293-299. (Pubitemid 18093296)
29. Manderscheid PA, Bodkin RP, Davidson BA, Jensen E, Russo TA, Knight PR. Bacterial clearance and cytokine profiles in a murine model of postsurgical nosocomial pneumonia. Clin Diagn Lab Immunol. 2004;11:742-751. (Pubitemid 38943998)
30. Olszewski MA, Falkowski NR, Surana R, Sonstein J, Hartman A, Moore BB, Huffnagle GB, Toews GB. Effect of laparotomy on clearance and cytokine induction in Staphylococcus aureus infected lungs. Am J Respir Crit Care Med. 2007;176:921-929. (Pubitemid 350097082)
31. Namas R, Ghuma A, Torres A, Polanco P, Gomez H, Barclay D, Gordon L, Zenker S, Kim HK, Hermus L, et al. An adequately robust early TNF-alpha response is a hallmark of survival following trauma/hemorrhage. PLoS One. 2009;4:e8406.
32. Ayala A, Wang P, Ba ZF, Perrin MM, Ertel W, Chaudry IH. Differential alterations in plasma IL-6 and TNF levels after trauma and hemorrhage. Am J Physiol. 1991;260:R167-R171.
33. Bahrami S, Yao YM, Leichtfried G, Redl H, Marzi I, Schlag G. Significance of TNF in hemorrhage-related hemodynamic alterations, organ injury, and mortality in rats. Am J Physiol. 1997;272:H2219-H2226.
34. Yao YM, Redl H, Bahrami S, Schlag G. The inflammatory basis of trauma/shock-associated multiple organ failure. Inflamm Res. 1998;47:201-210. (Pubitemid 28256968)
35. Biffl WL, Moore EE, Moore FA, Peterson VM. Interleukin-6 in the injured patient. Marker of injury or mediator of inflammation? Ann Surg. 1996;224:647-664. (Pubitemid 26384888)
36. Bain J, Plater L, Elliott M, Shpiro N, Hastie CJ, McLauchlan H, Klevernic I, Arthur JS, Alessi DR, Cohen P. The selectivity of protein kinase inhibitors: a further update. Biochem J. 2007;408:297-315.
37. Kuma Y, Sabio G, Bain J, Shpiro N, Marquez R, Cuenda A. BIRB796 inhibits all p38 MAPK isoforms in vitro and in vivo. J Biol Chem. 2005;280:19472-19479. (Pubitemid 41379467)
38. Ipaktchi K, Mattar A, Niederbichler AD, Kim J, Hoesel LM, Hemmila MR, Su GL, Remick DG, Wang SC, Arbabi S. Attenuating burn wound inflammation improves pulmonary function and survival in a burnpneumonia model. Crit Care Med. 2007;35:2139-2144. (Pubitemid 47326451)
39. Su J, Cui X, Li Y, Mani H, Ferreyra GA, Danner RL, Hsu LL, Fitz Y, Eichacker PQ. SB203580, a p38 inhibitor, improved cardiac function but worsened lung injury and survival during Escherichia coli pneumonia in mice. J Trauma. 2010;68:1317-1327.
40. Abraham E. Alterations in cell signaling in sepsis. Clin Infect Dis. 2005;41(Suppl 7):S459-S464. (Pubitemid 41598306)