Effect of maternal excessive iodine intake on neurodevelopment and cognitive function in rat offspring

BMC Neuroscience

Volumn 13, Issue 1, 2012, Pages

  Zhang, Le ^a   Teng, Weiping ^a   Liu, Yuhui ^a   Li, Jing ^a   Mao, Jinyuan ^a   Fan, Chenling ^a   Wang, Hong ^a   Zhang, Hongmei ^a   Shan, Zhongyan ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

Hippocampus; Iodine deficiency; Iodine excess; Neurodevelopment; Thyroid hormone

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; IODINE; THYROXINE;

AMNESIA; ANIMAL EXPERIMENT; ARTICLE; BRAIN DEVELOPMENT; BRAIN REGION; BREAST FEEDING; COGNITION; HIPPOCAMPUS; LEARNING; MATERNAL NUTRITION; MAZE TEST; NERVE CELL DIFFERENTIATION; NONHUMAN; ONCOGENE C FOS; PERINATAL PERIOD; PREGNANCY; PROGENY; PROTEIN EXPRESSION; RAT; THYROID GLAND; URINE;

AGE FACTORS; ANIMALS; ANIMALS, NEWBORN; ANTI-INFECTIVE AGENTS, LOCAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION DISORDERS; DEVELOPMENTAL DISABILITIES; FEMALE; IODINE; MALE; MAZE LEARNING; NERVOUS SYSTEM DISEASES; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RATS; RATS, WISTAR; THYROID GLAND; THYROTROPIN; THYROXINE;

EID: 84867034780     PISSN: None     EISSN: 14712202     Source Type: Journal    
DOI: 10.1186/1471-2202-13-121     Document Type: Article

References (44)

1. de Escobar GM, Obregón MJ, del Rey FE. Role of thyroid hormone during early brain development. Eur J Endocrinol 2004, 151(Suppl 3):U25-U37.
2. Zoeller RT, Rovet J. Timing of thyroid hormone action in the developing brain: Clinical observations and experimental findings. J Neuroendocrinol 2004, 16(10):809-818. 10.1111/j.1365-2826.2004.01243.x, 15500540.
3. Chen ZP, Hetzel BS. Cretinism revisited. Best Pract Res Clin Endocrinol Metab 2010, 24(1):39-50. 10.1016/j.beem.2009.08.014, 20172469.
4. Skeaff SA. Iodine deficiency in pregnancy: the effect on neurodevelopment in the child. Nutrients 2011, 3(2):265-273. 10.3390/nu3020265, 3257674, 22254096.
5. Zimmermann MB. The role of iodine in human growth and development. Semin Cell Dev Biol 2011, 22(6):645-652. 10.1016/j.semcdb.2011.07.009, 21802524.
6. Teng W, Shan Z, Teng X, Guan H, Li Y, Teng D, Jin Y, Yu X, Fan C, Chong W, Yang F, Dai H, Yu Y, Li J, Chen Y, Zhao D, Shi X, Hu F, Mao J, Gu X, Yang R, Tong Y, Wang W, Gao T, Li C. Effects of iodine intake on thyroid diseases in China. N Engl J Med 2006, 354(26):2783-2793. 10.1056/NEJMoa054022, 16807415.
7. Dong J, Yin H, Liu W, Wang P, Jiang Y, Chen J. Congenital iodine deficiency and hypothyroidism impair LTP and decrease c-Fos and c-Jun expression in rat hippocampus. Neurotoxicology 2005, 26(3):417-426. 10.1016/j.neuro.2005.03.003, 15935212.
8. Guzowski JF. Insights into immediate-early gene function in hippocampal memory consolidation using antisense oligonucleotide and fluorescent imaging approaches. Hippocampus 2002, 12(1):86-104. 10.1002/hipo.10010, 11918292.
9. Opazo MC, Gianini A, Pancetti F, Azkcona G, Alarcón L, Lizana R, Noches V, Gonzalez PA, Marassi MP, Mora S, Rosenthal D, Eugenin E, Naranjo D, Bueno SM, Kalergis AM, Riedel CA. Maternal hypothyroxinemia impairs spatial learning and synaptic nature and function in the offspring. Endocrinology 2008, 149(10):5097-5106. 10.1210/en.2008-0560, 18566112.
10. Liu D, Teng W, Shan Z, Yu X, Gao Y, Wang S, Fan C, Wang H, Zhang H. The effect of maternal subclinical hypothyroidism during pregnancy on brain development in rat offspring. Thyroid 2010, 20(8):909-915. 10.1089/thy.2009.0036, 20615128.
11. Lasley SM, Gilbert ME. Developmental thyroid hormone insufficiency reduces expression of brain-derived neurotrophic factor (BDNF) in adults but not in neonates. Neurotoxicol Teratol 2011, 33(4):464-472. 10.1016/j.ntt.2011.04.001, 21530650.
12. Dowling ALS, Iannacone EA, Zoeller RT. Maternal hypothyroidism selectively affects the expression of neuroendocrine-specific protein a messenger ribonucleic acid in the proliferative zone of the fetal rat brain cortex. Endocrinology 2001, 142(1):390-399. 10.1210/en.142.1.390, 11145602.
13. Dong J, Liu W, Wang Y, Hou Y, Xi Q, Chen J. Developmental iodine deficiency resulting in hypothyroidism reduces hippocampal ERK1/2 and CREB in lactational and adolescent rats. BMC Neurosci 2009, 10:149. 10.1186/1471-2202-10-149, 2804698, 20021662.
14. Gong J, Liu W, Dong J, Wang Y, Xu H, Wei W, Zhong J, Xi Q, Chen J. Developmental iodine deficiency and hypothyroidism impair neural development in rat hippocampus: involvement of doublecortin and NCAM-180. BMC Neurosci 2010, 11:50. 10.1186/1471-2202-11-50, 2876162, 20412599.
15. Anderson GW, Schoonover CM, Jones SA. Control of Thyroid Hormone Action in the Developing Rat Brain. Thyroid 2003, 13(11):1039-1056. 10.1089/105072503770867219, 14651788.
16. Babikian T, Prins ML, Cai Y, Barkhoudarian G, Hartonian I, Hovda DA, Giza CC. Molecular and physiological responses to juvenile traumatic brain injury:focus on growth and metabolism. Dev Neurosci 2010, 32(5-6):431-441. 3215243, 21071915.
17. Evans IM, Pickard MR, Sinha AK, Leonard AJ, Sampson DC, Ekins RP. Influence of maternal hyperthyroidism in the rat on the expression of neuronal and astrocytic cytoskeletal proteins in fetal brain. J Endocrinol 2002, 175(3):597-604. 10.1677/joe.0.1750597, 12475371.
18. Gilbert ME, Sui L, Walker MJ, Anderson W, Thomas S, Smoller SN, Schon JP, Phani S, Goodman JH. Thyroid hormone insufficiency during brain development reduces parvalbumin immunoreactivity and inhibitory function in the hippocampus. Endocrinology 2007, 148(1):92-102.
19. Hwang S, Lee EY, Lee WK, Shin DY, Lee EJ. Correlation between iodine intake and thyroid function in subjects with normal thyroid function. Biol Trace Elem Res 2011, 143(3):1393-1397. 10.1007/s12011-011-8997-x, 21340678.
20. Orito Y, Oku H, Kubota S, Amino N, Shimogaki K, Hata M, Manki K, Tanaka Y, Sugino S, Ueta M, Kawakita K, Nunotani T, Tatsumi N, Ichihara K, Miyauchi A, Miyake M. Thyroid Function in Early Pregnancy in Japanese Healthy Women: Relation to Urinary Iodine Excretion, Emesis, and Fetal and Child Development. J Clin Endocrinol Metab 2009, 94(5):1683-1688. 10.1210/jc.2008-2111, 19258403.
21. Thomopoulos P. Iodine excess and thyroid dysfunction. La Revue du Praticien 2005, 55(2):180-182.
22. Bourdoux PP, Ermans AM, Mukalay wa Mukalay A, Filetti S, Vigneri R. Iodine induced thyrotoxicosis in Kiwu Zaire. Lancet 1996, 347(9000):552-553.
23. Fradkin JE, Wolff J. Iodide-induced thyrotoxicosis. Medicine (Baltimore) 1983, 62(1):1-20.
24. Connolly RJ, Vidor GI, Stewart JC. Increase in thyrotoxicosis in endemic goitre area after iodation of bread. Lancet 1970, 1(7645):500-502.
25. Leung AM, Braverman LE. Iodine-induced thyroid dysfunction. Curr Opin Endocrinol Diabetes Obes 2012, 19(5):414-419.
26. Sebotsa ML, Dannhauser A, Jooste PL, Joubert G. Iodine status as determined by urinary iodine excretion in Lesotho two years after introducing legislation on universal salt iodization. Nutrition 2005, 21(1):20-24. 10.1016/j.nut.2004.09.005, 15661474.
27. Lewiński A, Szybiński Z, Bandurska-Stankiewicz E, Grzywa M, Karwowska A, Kinalska I, Kowalska A, Makarewicz J, Nauman J, Słowińska-Klencka D, Sowiński J, Syrenicz A, Zonenberg A, Huszno B, Klencki M. Iodine-induced hyperthyroidism-an epidemiological survey several years after institution of iodine prophylaxis in Poland. J Endocrinol Invest 2003, 26(2 Suppl):57-62.
28. Morreale de Escobar G, Pastor R, Obregon MJ, Escobar del Rey F. Effects of maternal hypothyroidism on the weight and thyroid hormone content of rat embryonic tissues, before and after onset of fetal thyroid function. Endocrinology 1985, 117(5):1890-1900. 10.1210/endo-117-5-1890, 4042969.
29. Ahmed OM, El-Gareib AW, El-Bakry AM, Abd El-Tawab SM, Ahmed RG. Thyroid hormones states and brain development interactions. Int J Dev Neurosci 2008, 26(2):147-209. 10.1016/j.ijdevneu.2007.09.011, 18031969.
30. Chen C, Zhou Z, Zhong M, Li M, Yang X, Zhang Y, Wang Y, Wei A, Qu M, Zhang L, Xu S, Chen S, Yu Z. Excess thyroid hormone inhibits embryonic neural stem/progenitor cells proliferation andmaintenance through STAT3 signalling pathway. Neurotox Res 2011, 20(1):15-25. 10.1007/s12640-010-9214-y, 20711698.
31. Ahmed OM, Abd El-Tawab SM, Ahmed RG. Effects of experimentally induced maternal hypothyroidism and hyperthyroidism on the development of rat offspring: I. The development of the thyroid hormones-neurotransmitters and adenosinergic system interactions. Int J Dev Neurosci 2010, 28(6):437-454. 10.1016/j.ijdevneu.2010.06.007, 20599606.
32. Emder PJ, Jack MM. Iodine-induced neonatal hypothyroidism secondary to maternal seaweed consumption: A common practice in some Asian cultures to promote breast milk supply. J Paediatr Child Health 2011, 47(10):750-752. 10.1111/j.1440-1754.2010.01972.x, 21276114.
33. Gao TS, Teng WP, Shan ZY, Jin Y, Guan HX, Teng XC, Yang F, Wang WB, Shi XG, Tong YJ, Li D, Chen W. Effect of different iodine intake on schoolchildren thyroid diseases and intelligence in rural areas. Chin Med J (Engl) 2004, 117(10):1518-1522.
34. Chung HR, Shin CH, Yang SW, Choi CW, Kim BI. Subclinical hypothyroidism in Korean preterm infants associated with high levels of iodine in breast milk. J Clin Endocrinol Metab 2009, 94(11):4444-4447. 10.1210/jc.2009-0632, 19808851.
35. Herdegen T, Skene P, Bähr M. The c-Jun transcription factor-bipotential mediator of neuronal death, survival and regeneration. Trends Neurosci 1997, 20(5):227-231. 10.1016/S0166-2236(96)01000-4, 9141200.
36. Wang Y, Su B, Xia Z. Brain-derived neurotrophic factor activates ERK5 in cortical neurons via a Rap1-MEKK2 signaling cascade. J Biol Chem 2006, 281(47):35965-35974. 10.1074/jbc.M605503200, 17003042.
37. Lewin GR, Barde YA. Physiology of the neurotrophins. Annu Rev Neurosci 1996, 19:289-317. 10.1146/annurev.ne.19.030196.001445, 8833445.
38. Lu B, Figurov A. Role of neurotrophins in synapse development and plasticity. Rev Neurosci 1997, 8(1):1-12.
39. Heldt SA, Stanek L, Chhatwal JP, Ressler KJ. Hippocampus-specific deletion of BDNF in adult mice impairs spatial memory and extinction of aversive memories. Mol Psychiatry 2007, 12(7):656-670. 10.1038/sj.mp.4001957, 2442923, 17264839.
40. Chakraborty G, Magagna-Poveda A, Parratt C, Umans JG, MacLusky NJ, Scharfman HE. Reduced hippocampal brain-derived neurotrophic factor (BDNF) in neonatal rats after prenatal exposure to propylthiouracil (PTU). Endocrinology 2012, 153(3):1311-1316. 10.1210/en.2011-1437, 22253429.
41. Wang S, Teng W, Gao Y, Fan C, Zhang H, Shan Z. Early levothyroxine treatment on maternal subclinical hypothyroidism improves spatial learning of offspring in rats. J Neuroendocrinol 2012, 24(5):841-848. 10.1111/j.1365-2826.2011.02275.x, 22192600.
42. Senden NH, Timmer ED, Boers JE, van de Velde HJ, Roebroek AJ, Van de Ven WJ, Broers JL, Ramaekers FC. Neuroendocrine-specific protein C (NSP-C): subcellular localization and differential expression in relation to NSP-A. Eur J Cell Biol 1996, 69(3):197-213.
43. Dowling ALS, Martz GU, Leonard JL, Zoeller RT. Acute changes in maternal thyroid hormone induce rapid and transient changes in gene expression in fetal rat brain. J Neurosci 2000, 20(6):2255-2265.
44. Brown RW, Flanigan TJ, Thompson KN, Thacker SK, Schaefer TL, Williams MT. Neonatal quinpirole treatment impairs Morris water task performance in early postweanling rats: relationship to increases in corticosterone and decreases in neurotrophic factors. Biol Psychiatry 2004, 56(3):161-168. 10.1016/j.biopsych.2004.05.003, 15271584.