Mechanistic correlations between two itch biomarkers, cytokine interleukin-31 and neuropeptide β-endorphin, via STAT3/calcium axis in atopic dermatitis

British Journal of Dermatology

Volumn 167, Issue 4, 2012, Pages 794-803

  Lee, C H ^a,b,c   Hong, C H ^c,d,e   Yu, W T ^b   Chuang, H Y ^c   Huang, S K ^f   Chen, G S ^b,c   Yoshioka, T ^c   Sakata, M ^c   Liao, W T ^b,c   Ko, Y C ^c   Yu, H S ^b,c  

^a KAOHSIUNG MUNICIPAL HSIAO KANG HOSPITAL   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^d KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^e NATIONAL YANG MING UNIVERSITY   (Taiwan)

^f JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ENDORPHIN; BIOLOGICAL MARKER; INTERLEUKIN 31; INTERLEUKIN 31 RECEPTOR A; NEUROPEPTIDE; STAT3 PROTEIN; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; AGED; ANIMAL TISSUE; ARTICLE; ATOPIC DERMATITIS; BLOOD ANALYSIS; CALCIUM TRANSPORT; CHILD; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; CYTOKINE PRODUCTION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INFANT; KERATINOCYTE; MAJOR CLINICAL STUDY; MALE; MOUSE; NONHUMAN; PRESCHOOL CHILD; PRIORITY JOURNAL; PROSPECTIVE STUDY; PROTEIN EXPRESSION; PRURITUS; SCHOOL CHILD; SKIN EXAMINATION;

ADULT; ANIMALS; BETA-ENDORPHIN; BIOLOGICAL MARKERS; BLOTTING, WESTERN; CALCIUM; CASE-CONTROL STUDIES; CROSS-SECTIONAL STUDIES; DERMATITIS, ATOPIC; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPIDERMIS; HUMANS; INTERLEUKINS; KERATINOCYTES; MICE; PROSPECTIVE STUDIES; REAL-TIME POLYMERASE CHAIN REACTION; STAT3 TRANSCRIPTION FACTOR;

EID: 84867032689     PISSN: 00070963     EISSN: 13652133     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2012.11047.x     Document Type: Article

References (38)

1. Leung DY, Bieber T,. Atopic dermatitis. Lancet 2003; 361: 151-60.
2. Lee CH, Chuang HY, Shih CC, et al. Transepidermal water loss, serum IgE and beta-endorphin as important and independent biological markers for development of itch intensity in atopic dermatitis. Br J Dermatol 2006; 154: 1100-7.
3. Greaves MW, Khalifa N,. Itch: more than skin deep. Int Arch Allergy Immunol 2004; 135: 166-72.
4. Yosipovitch G, Greaves MW, Schmelz M,. Itch. Lancet 2003; 361: 690-4.
5. Stander S, Steinhoff M,. Pathophysiology of pruritus in atopic dermatitis: an overview. Exp Dermatol 2002; 11: 12-24.
6. Ballantyne JC, Loach AB, Carr DB,. Itching after epidural and spinal opiates. Pain 1988; 33: 149-60.
7. Gan TJ, Ginsberg B, Glass PS, et al. Opioid-sparing effects of a low-dose infusion of naloxone in patient-administered morphine sulfate. Anesthesiology 1997; 87: 1075-81.
8. Woodhouse A, Hobbes AF, Mather LE, et al. A comparison of morphine, pethidine and fentanyl in the postsurgical patient-controlled analgesia environment. Pain 1996; 64: 115-21.
9. Cousins MJ, Mather LE,. Intrathecal and epidural administration of opioids. Anesthesiology 1984; 61: 276-310.
10. Tominaga M, Ogawa H, Takamori K,. Possible roles of epidermal opioid systems in pruritus of atopic dermatitis. J Invest Dermatol 2007; 127: 2228-35.
11. Zanello SB, Jackson DM, Holick MF,. An immunocytochemical approach to the study of beta-endorphin production in human keratinocytes using confocal microscopy. Ann N Y Acad Sci 1999; 885: 85-99.
12. Wintzen M, Yaar M, Burbach JP, et al. Proopiomelanocortin gene product regulation in keratinocytes. J Invest Dermatol 1996; 106: 673-8.
13. Dillon SR, Sprecher C, Hammond A, et al. Interleukin 31, a cytokine produced by activated T cells, induces dermatitis in mice. Nat Immunol 2004; 5: 752-60.
14. Diveu C, Lak-Hal AH, Froger J, et al. Predominant expression of the long isoform of GP130-like (GPL) receptor is required for interleukin-31 signaling. Eur Cytokine Netw 2004; 15: 291-302.
15. Bilsborough J, Leung DY, Maurer M, et al. IL-31 is associated with cutaneous lymphocyte antigen-positive skin homing T cells in patients with atopic dermatitis. J Allergy Clin Immunol 2006; 117: 418-25.
16. Neis MM, Peters B, Dreuw A, et al. Enhanced expression levels of IL-31 correlate with IL-4 and IL-13 in atopic and allergic contact dermatitis. J Allergy Clin Immunol 2006; 118: 930-7.
17. Ip WK, Wong CK, Li ML, et al. Interleukin-31 induces cytokine and chemokine production from human bronchial epithelial cells through activation of mitogen-activated protein kinase signalling pathways: implications for the allergic response. Immunology 2007; 122: 532-41.
18. Raap U, Wichmann K, Bruder M, et al. Correlation of IL-31 serum levels with severity of atopic dermatitis. J Allergy Clin Immunol 2008; 122: 421-3.
19. Lee CH, Chen JS, Sun YL, et al. Defective beta1-integrins expression in arsenical keratosis and arsenic-treated cultured human keratinocytes. J Cutan Pathol 2006; 33: 129-38.
20. Pan J, Nakade K, Huang YC, et al. Suppression of cell-cycle progression by Jun dimerization protein-2 (JDP2) involves downregulation of cyclin-A2. Oncogene 2010; 29: 6245-56.
21. Hanifin J, Rajka G,. Diagnostic features of atopic dermatitis. Acta Dermatol Venereol (Stockh) 1980; 92: 44-7.
22. Bootman MD, Collins TJ, Mackenzie L, et al. 2-aminoethoxydiphenyl borate (2-APB) is a reliable blocker of store-operated Ca2+ entry but an inconsistent inhibitor of InsP3-induced Ca2+ release. FASEB J 2002; 16: 1145-50.
23. Elsner J, Petering H, Kimmig D, et al. The CC chemokine receptor antagonist met-RANTES inhibits eosinophil effector functions. Int Arch Allergy Immunol 1999; 118: 462-5.
24. Prakriya M, Feske S, Gwack Y, et al. Orai1 is an essential pore subunit of the CRAC channel. Nature 2006; 443: 230-3.
25. Oh-Hora M, Yamashita M, Hogan PG, et al. Dual functions for the endoplasmic reticulum calcium sensors STIM1 and STIM2 in T cell activation and tolerance. Nat Immunol 2008; 9: 432-43.
26. Bikle DD, Ratnam A, Mauro T, et al. Changes in calcium responsiveness and handling during keratinocyte differentiation. Potential role of the calcium receptor. J Clin Invest 1996; 97: 1085-93.
27. Fatherazi S, Belton CM, Izutsu KT,. Sequential activation of store-operated currents in human gingival keratinocytes. J Invest Dermatol 2003; 121: 120-31.
28. Karvonen SL, Korkiamaki T, Yla-Outinen H, et al. Psoriasis and altered calcium metabolism: downregulated capacitative calcium influx and defective calcium-mediated cell signaling in cultured psoriatic keratinocytes. J Invest Dermatol 2000; 114: 693-700.
29. Dambacher J, Beigel F, Seiderer J, et al. Interleukin 31 mediates MAP kinase and STAT1/3 activation in intestinal epithelial cells and its expression is upregulated in inflammatory bowel disease. Gut 2007; 56: 1257-65.
30. Perrigoue JG, Li J, Zaph C, et al. IL-31-IL-31R interactions negatively regulate type 2 inflammation in the lung. J Exp Med 2007; 204: 481-7.
31. Jawa RS, Chattopadhyay S, Tracy E, et al. Regulated expression of the IL-31 receptor in bronchial and alveolar epithelial cells, pulmonary fibroblasts, and pulmonary macrophages. J Interferon Cytokine Res 2008; 28: 207-19.
32. Sonkoly E, Muller A, Lauerma AI, et al. IL-31: a new link between T cells and pruritus in atopic skin inflammation. J Allergy Clin Immunol 2006; 117: 411-17.
33. Teofoli P, Frezzolini A, Puddu P, et al. The role of proopiomelanocortin- derived peptides in skin fibroblast and mast cell functions. Ann N Y Acad Sci 1999; 885: 268-76.
34. Casale TB, Bowman S, Kaliner M,. Induction of human cutaneous mast cell degranulation by opiates and endogenous opioid peptides: evidence for opiate and nonopiate receptor participation. J Allergy Clin Immunol 1984; 73: 775-81.
35. Bigliardi-Qi M, Sumanovski LT, Buchner S, et al. Mu-opiate receptor and Beta-endorphin expression in nerve endings and keratinocytes in human skin. Dermatology 2004; 209: 183-9.
36. Bigliardi-Qi M, Lipp B, Sumanovski LT, et al. Changes of epidermal mu-opiate receptor expression and nerve endings in chronic atopic dermatitis. Dermatology 2005; 210: 91-9.
37. Toth C, Martinez JA, Liu WQ, et al. Local erythropoietin signaling enhances regeneration in peripheral axons. Neuroscience 2008; 154: 767-83.
38. Xu AW, Ste-Marie L, Kaelin CB, et al. Inactivation of signal transducer and activator of transcription 3 in proopiomelanocortin (POMC) neurons causes decreased POMC expression, mild obesity, and defects in compensatory refeeding. Endocrinology 2007; 148: 72-80.