Transplantation: Is donor T-cell engraftment a biomarker for tolerance?

Nature Reviews Nephrology

Volumn 8, Issue 10, 2012, Pages 560-561

  Xu, Hong ^a   Ildstad, Suzanne T ^a  

^a UNIVERSITY OF LOUISVILLE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOLOGICAL MARKER;

CHIMERA; ENGRAFTMENT; HUMAN; IMMUNOLOGICAL TOLERANCE; KIDNEY ALLOGRAFT; LYMPHOCYTOPOIESIS; NONHUMAN; PRIORITY JOURNAL; RHESUS MONKEY; SHORT SURVEY; T LYMPHOCYTE;

ANIMALS; BONE MARROW TRANSPLANTATION; CHIMERISM; GRAFT REJECTION; KIDNEY TRANSPLANTATION;

EID: 84867024392     PISSN: 17595061     EISSN: 1759507X     Source Type: Journal    
DOI: 10.1038/nrneph.2012.187     Document Type: Short Survey

References (10)

1. Ildstad, S. T. & Sachs, D. H. Reconstitution with syngeneic plus allogeneic or xenogeneic bone marrow leads to specific acceptance of allografts or xenografts. Nature 307, 168-170 (1984).
2. Kawai, T., et al. HLA-mismatched renal transplantation without maintenance immunosuppression. N. Engl. J. Med. 358, 353-361 (2008).
3. Leventhal, J., et al. Chimerism and tolerance without GVHD or engraftment syndrome in HLA-mismatched combined kidney and hematopoietic stem cell transplantation. Sci. Transl. Med. 4, 124ra28 (2012).
4. Ramakrishnan, S. K., et al. Evidence for kidney rejection after combined bone marrow and renal transplantation despite ongoing whole-blood chimerism in rhesus macaques. Am. J. Transplant. 12, 1755-1764 (2012).
5. Xu, H., Chilton, P. M., Huang, Y., Schanie, C. L. & Ildstad, S. T. Production of donor T cells is critical for induction of donor-specific tolerance and maintenance of chimerism. J. Immunol. 172, 1463-1471 (2004).
6. Xu, H., et al. Addition of cyclophosphamide to T cell depletion-based nonmyeloablative conditioning allows donor T cell engraftment and clonal deletion of alloreactive host T cells after bone marrow transplantation. Transplantation 83, 954-963 (2007).
7. Umemura, A., et al. Dissociation of hemopoietic chimerism and allograft tolerance after allogeneic bone marrow transplantation. J. Immunol. 167, 3043-3048 (2001).
8. Niederwieser, D., et al. Low-dose total body irradiation (TBI) and fludarabine followed by hematopoietic cell transplantation (HCT) from HLA-matched or mismatched unrelated donors and postgrafting immunosuppression with cyclosporine and mycophenolate mofetil (MMF) can induce durable complete chimerism and sustained remissions in patients with hematological diseases. Blood 101, 1620-1629 (2003).
9. Jochum, C., Beste, M., Zellmer, E., Graves, S. S. & Storb, R. CD154 blockade and donor-specific transfusions in DLA-identical marrow transplantation in dogs conditioned with 1 Gy total body irradiation. Biol. Blood Marrow Transplant. 13, 164-171 (2007).
10. Ozyurek, E., et al. Increasing mixed chimerism and the risk of graft loss in children undergoing allogeneic hematopoietic stem cell transplantation for non-malignant disorders. Bone Marrow Transplant. 42, 83-91 (2008).