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Volumn 38, Issue 11, 2012, Pages 1958-1969

Bioeffects of Ultrasound-Stimulated Microbubbles on Endothelial Cells: Gene Expression Changes Associated with Radiation Enhancement In Vitro

Author keywords

Apoptosis; Bioeffect; Ceramide; Gene expression; Microbubbles; Radiation; Ultrasound

Indexed keywords

APOPTOTIC PATHWAYS; BIO-EFFECTS; BIOEFFECT; CANCER THERAPY; CASPASES; CERAMIDES; GENE EXPRESSION ANALYSIS; GENE LEVELS; GENE PRODUCTS; IMMUNOHISTOCHEMISTRY; IN-VITRO; MICRO-BUBBLE; MICROBUBBLES; MORPHOLOGIC CHANGES; RADIATION ENHANCEMENT; SIGNALING PATHWAYS; TUMOR CELLS; UP-REGULATION; VASCULATURE;

EID: 84867008667     PISSN: 03015629     EISSN: 1879291X     Source Type: Journal    
DOI: 10.1016/j.ultrasmedbio.2012.07.009     Document Type: Article
Times cited : (52)

References (61)
  • 1
    • 0036187036 scopus 로고    scopus 로고
    • Three dimensional structure of the apoptosome: Implications for assembly, procaspase9 binding, and activation
    • Acehan D., Jiang X., Morgan D.G., Heuser J.E., Wang X., Akey C.W. Three dimensional structure of the apoptosome: Implications for assembly, procaspase9 binding, and activation. Mol Cell 2002, 9:423-432.
    • (2002) Mol Cell , vol.9 , pp. 423-432
    • Acehan, D.1    Jiang, X.2    Morgan, D.G.3    Heuser, J.E.4    Wang, X.5    Akey, C.W.6
  • 3
    • 44449136965 scopus 로고    scopus 로고
    • HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response
    • Ayoub N., Jeyasekharan A.D., Bernal J.A., Venkitaraman A.R. HP1-beta mobilization promotes chromatin changes that initiate the DNA damage response. Nature 2008, 29:682-686.
    • (2008) Nature , vol.29 , pp. 682-686
    • Ayoub, N.1    Jeyasekharan, A.D.2    Bernal, J.A.3    Venkitaraman, A.R.4
  • 5
    • 1642633746 scopus 로고    scopus 로고
    • Ceramide lances the lungs
    • Barnes P.J. Ceramide lances the lungs. Nat Med 2004, 10:130-131.
    • (2004) Nat Med , vol.10 , pp. 130-131
    • Barnes, P.J.1
  • 6
    • 61349187645 scopus 로고    scopus 로고
    • Endothelial cells form a phalanx to block tumor metastasis
    • Bautch V.L. Endothelial cells form a phalanx to block tumor metastasis. Cell 2009, 136:810-812.
    • (2009) Cell , vol.136 , pp. 810-812
    • Bautch, V.L.1
  • 7
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G., Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008, 8:592-603.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592-603
    • Bergers, G.1    Hanahan, D.2
  • 8
    • 79751529767 scopus 로고    scopus 로고
    • Microbubbles improve sonothrombolysis in vitro and decrease hemorrhage in vivo in a rabbit stroke model
    • Brown A.T., Flores R., Hamilton E., Roberson P.K., Borrelli M.J., Culp W.C. Microbubbles improve sonothrombolysis in vitro and decrease hemorrhage in vivo in a rabbit stroke model. Invest Radiol 2011, 46:202-207.
    • (2011) Invest Radiol , vol.46 , pp. 202-207
    • Brown, A.T.1    Flores, R.2    Hamilton, E.3    Roberson, P.K.4    Borrelli, M.J.5    Culp, W.C.6
  • 10
    • 0037066727 scopus 로고    scopus 로고
    • De novo ceramide regulates the alternative splicing of caspase 9 and Bclx in A549 lung adenocarcinoma cells
    • Chalfant C.E., Rathman K., Pinkerman R.L., Wood R.E., Obeid L.M., Ogretmen B., Hannun Y.A. De novo ceramide regulates the alternative splicing of caspase 9 and Bclx in A549 lung adenocarcinoma cells. J Biol Chem 2002, 277:12587-12595.
    • (2002) J Biol Chem , vol.277 , pp. 12587-12595
    • Chalfant, C.E.1    Rathman, K.2    Pinkerman, R.L.3    Wood, R.E.4    Obeid, L.M.5    Ogretmen, B.6    Hannun, Y.A.7
  • 11
    • 77953303635 scopus 로고    scopus 로고
    • Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures
    • Chopra R., Vykhodtseva N., Hynynen K. Influence of exposure time and pressure amplitude on blood-brain-barrier opening using transcranial ultrasound exposures. ACS Chem Neurosci 2010, 1:391-398.
    • (2010) ACS Chem Neurosci , vol.1 , pp. 391-398
    • Chopra, R.1    Vykhodtseva, N.2    Hynynen, K.3
  • 12
    • 0034969250 scopus 로고    scopus 로고
    • Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor is mediated by ceramide
    • Corda S., Laplace C., Vicaut E., Duranteau J. Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor is mediated by ceramide. Am J Respir Cell Mol Biol 2001, 24:762-768.
    • (2001) Am J Respir Cell Mol Biol , vol.24 , pp. 762-768
    • Corda, S.1    Laplace, C.2    Vicaut, E.3    Duranteau, J.4
  • 15
    • 47949089077 scopus 로고    scopus 로고
    • VEGF targeted therapy: Mechanisms of antitumour activity
    • Ellis L.M., Hicklin D.J. VEGF targeted therapy: Mechanisms of antitumour activity. Nat Rev Cancer 2008, 8:579-591.
    • (2008) Nat Rev Cancer , vol.8 , pp. 579-591
    • Ellis, L.M.1    Hicklin, D.J.2
  • 16
    • 58149190795 scopus 로고    scopus 로고
    • Pathways mediating resistance to vascular endothelial growth factor targeted therapy
    • Ellis L.M., Hicklin D.J. Pathways mediating resistance to vascular endothelial growth factor targeted therapy. Clin Cancer Res 2008, 14:6371-6375.
    • (2008) Clin Cancer Res , vol.14 , pp. 6371-6375
    • Ellis, L.M.1    Hicklin, D.J.2
  • 17
    • 33645017870 scopus 로고    scopus 로고
    • Numerical approximation of solutions of a nonlinear inverse problem arising in olfaction experimentation
    • French D., Flannery R., Groetsch C., Krantz W., Kleene S. Numerical approximation of solutions of a nonlinear inverse problem arising in olfaction experimentation. Math Comput Model 2006, 43:945-956.
    • (2006) Math Comput Model , vol.43 , pp. 945-956
    • French, D.1    Flannery, R.2    Groetsch, C.3    Krantz, W.4    Kleene, S.5
  • 20
    • 0034631968 scopus 로고    scopus 로고
    • Apoptosis and sphingomyelin hydrolysis: The flip side
    • Green D.R. Apoptosis and sphingomyelin hydrolysis: The flip side. J Cell Biol 2000, 150:F5-F7.
    • (2000) J Cell Biol , vol.150
    • Green, D.R.1
  • 21
    • 0030576517 scopus 로고    scopus 로고
    • Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis
    • Hanahan D., Folkman J. Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1996, 86:353-364.
    • (1996) Cell , vol.86 , pp. 353-364
    • Hanahan, D.1    Folkman, J.2
  • 22
    • 0034046077 scopus 로고    scopus 로고
    • Sound scattering and localized heat deposition of pulse-driven microbubbles
    • Hilgenfeldt S., Lohse D., Zomack M. Sound scattering and localized heat deposition of pulse-driven microbubbles. J Acoust Soc Am 2000, 107:3530-3539.
    • (2000) J Acoust Soc Am , vol.107 , pp. 3530-3539
    • Hilgenfeldt, S.1    Lohse, D.2    Zomack, M.3
  • 23
    • 0344908231 scopus 로고    scopus 로고
    • Portrait of a killer: The mitochondrial apoptosome emerges from the shadows
    • Hill M.M., Adrain C., Martin S.J. Portrait of a killer: The mitochondrial apoptosome emerges from the shadows. Mol Interv 2003, 3:1926.
    • (2003) Mol Interv , vol.3 , pp. 1926
    • Hill, M.M.1    Adrain, C.2    Martin, S.J.3
  • 24
    • 85027914131 scopus 로고    scopus 로고
    • Quantitative mapping of tumor vascularity using volumetric contrast-enhanced ultrasound
    • [Epub ahead of print]
    • Hoyt K., Sorace A., Saini R. Quantitative mapping of tumor vascularity using volumetric contrast-enhanced ultrasound. Invest Radiol 2011, [Epub ahead of print].
    • (2011) Invest Radiol
    • Hoyt, K.1    Sorace, A.2    Saini, R.3
  • 25
    • 84861464496 scopus 로고    scopus 로고
    • Ultrasound molecular imaging of arterial thrombi with novel microbubbles modified by cyclic RGD in vitro and in vivo
    • [Epub ahead of print]
    • Hu G., Liu C., Liao Y., Yang L., Huang R., Wu J., Xie J., Bundhoo K., Liu Y., Bin J. Ultrasound molecular imaging of arterial thrombi with novel microbubbles modified by cyclic RGD in vitro and in vivo. Thromb Haemost 2011, [Epub ahead of print].
    • (2011) Thromb Haemost
    • Hu, G.1    Liu, C.2    Liao, Y.3    Yang, L.4    Huang, R.5    Wu, J.6    Xie, J.7    Bundhoo, K.8    Liu, Y.9    Bin, J.10
  • 26
    • 78149461802 scopus 로고    scopus 로고
    • Focused ultrasound-mediated BB disruption is associated with an increase in activation of AKT: Experimental study in rats
    • Jalali S., Huang Y., Dumont D.J., Hynynen K. Focused ultrasound-mediated BB disruption is associated with an increase in activation of AKT: Experimental study in rats. BMC Neurol 2010, 10:114.
    • (2010) BMC Neurol , vol.10 , pp. 114
    • Jalali, S.1    Huang, Y.2    Dumont, D.J.3    Hynynen, K.4
  • 27
    • 43049150134 scopus 로고    scopus 로고
    • Low-intensity ultrasound-exposed microbubbles provoke local hyper polarization of the cell membrane via activation of BK(Ca) channels
    • Juffermans L.J., Kamp O., Dijkmans P.A., Visser C.A., Musters R.J. Low-intensity ultrasound-exposed microbubbles provoke local hyper polarization of the cell membrane via activation of BK(Ca) channels. Ultrasound Med Biol 2008, 34:502-508.
    • (2008) Ultrasound Med Biol , vol.34 , pp. 502-508
    • Juffermans, L.J.1    Kamp, O.2    Dijkmans, P.A.3    Visser, C.A.4    Musters, R.J.5
  • 28
    • 77953257281 scopus 로고    scopus 로고
    • Microbubble mediated sonoporation of cells in suspension: Clonogenic viability and influence of molecular size on uptake
    • Karshafian R., Samac S., Bevan P.D., Burns P.N. Microbubble mediated sonoporation of cells in suspension: Clonogenic viability and influence of molecular size on uptake. Ultrasonics 2010, 50:691-697.
    • (2010) Ultrasonics , vol.50 , pp. 691-697
    • Karshafian, R.1    Samac, S.2    Bevan, P.D.3    Burns, P.N.4
  • 29
    • 77749321427 scopus 로고    scopus 로고
    • Temperature change near microbubbles within a capillary network during focused ultrasound
    • Klotz A.R., Lindvere L., Stefanovic B., Hynynen K. Temperature change near microbubbles within a capillary network during focused ultrasound. Phys Med Biol 2010, 55:1549-1561.
    • (2010) Phys Med Biol , vol.55 , pp. 1549-1561
    • Klotz, A.R.1    Lindvere, L.2    Stefanovic, B.3    Hynynen, K.4
  • 30
    • 33846305065 scopus 로고    scopus 로고
    • Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature
    • Korpanty G., Carbon J.G., Grayburn P.A., Fleming J.B., Brekken R.A. Monitoring response to anticancer therapy by targeting microbubbles to tumor vasculature. Clin Cancer Res 2007, 13:323-330.
    • (2007) Clin Cancer Res , vol.13 , pp. 323-330
    • Korpanty, G.1    Carbon, J.G.2    Grayburn, P.A.3    Fleming, J.B.4    Brekken, R.A.5
  • 31
    • 1142263122 scopus 로고    scopus 로고
    • Presenting fats with SAPs
    • Kronenberg M. Presenting fats with SAPs. Nat Immunol 2004, 5:126-127.
    • (2004) Nat Immunol , vol.5 , pp. 126-127
    • Kronenberg, M.1
  • 32
    • 84857113870 scopus 로고    scopus 로고
    • Sonoporation-mediated anti-angiogenic gene transfer into muscle effectively regresses distant orthotopic tumors
    • Liao Z.K., Tsai K.C., Wang H.T., Tseng S.H., Deng W.P., Chen W.S., Hwang L.H. Sonoporation-mediated anti-angiogenic gene transfer into muscle effectively regresses distant orthotopic tumors. Cancer Gene Ther 2012, 19:171-180.
    • (2012) Cancer Gene Ther , vol.19 , pp. 171-180
    • Liao, Z.K.1    Tsai, K.C.2    Wang, H.T.3    Tseng, S.H.4    Deng, W.P.5    Chen, W.S.6    Hwang, L.H.7
  • 33
    • 0038725690 scopus 로고    scopus 로고
    • The ABCs of granule mediated cytotoxicity: New weapons in the arsenal
    • Lieberman J. The ABCs of granule mediated cytotoxicity: New weapons in the arsenal. Nat Rev Immunol 2003, 3:361-370.
    • (2003) Nat Rev Immunol , vol.3 , pp. 361-370
    • Lieberman, J.1
  • 34
    • 33748937705 scopus 로고    scopus 로고
    • Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits
    • McDannold N.J., Vykhodtseva N.I., Hynynen K. Microbubble contrast agent with focused ultrasound to create brain lesions at low power levels: MR imaging and histologic study in rabbits. Radiology 2006, 241:95-106.
    • (2006) Radiology , vol.241 , pp. 95-106
    • McDannold, N.J.1    Vykhodtseva, N.I.2    Hynynen, K.3
  • 35
    • 79959818292 scopus 로고    scopus 로고
    • Blood-brain barrier disruption and vascular damage induced by ultrasound bursts combined with microbubbles can be influenced by choice of anesthesia protocol
    • McDannold N., Zhang Y., Vykhodtseva N. Blood-brain barrier disruption and vascular damage induced by ultrasound bursts combined with microbubbles can be influenced by choice of anesthesia protocol. Ultrasound Med Biol 2011, 37:1259-1270.
    • (2011) Ultrasound Med Biol , vol.37 , pp. 1259-1270
    • McDannold, N.1    Zhang, Y.2    Vykhodtseva, N.3
  • 39
    • 3543114272 scopus 로고    scopus 로고
    • Biologically active Sphingolipids in cancer pathogenesis and treatment
    • Ogretmen B., Hannun Y.A. Biologically active Sphingolipids in cancer pathogenesis and treatment. Nat Rev Cancer 2004, 4:604-616.
    • (2004) Nat Rev Cancer , vol.4 , pp. 604-616
    • Ogretmen, B.1    Hannun, Y.A.2
  • 40
    • 83755173017 scopus 로고    scopus 로고
    • Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma
    • Olson P., Chu G.C., Perry S.R., Nolan-Stevaux O., Hanahan D. Imaging guided trials of the angiogenesis inhibitor sunitinib in mouse models predict efficacy in pancreatic neuroendocrine but not ductal carcinoma. Proc Natl Acad Sci U S A 2011, 108:E1275-E1284.
    • (2011) Proc Natl Acad Sci U S A , vol.108
    • Olson, P.1    Chu, G.C.2    Perry, S.R.3    Nolan-Stevaux, O.4    Hanahan, D.5
  • 41
    • 78149298723 scopus 로고    scopus 로고
    • The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model
    • O'Reilly M.A., Huang Y., Hynynen K. The impact of standing wave effects on transcranial focused ultrasound disruption of the blood-brain barrier in a rat model. Phys Med Biol 2010, 55:5251-5267.
    • (2010) Phys Med Biol , vol.55 , pp. 5251-5267
    • O'Reilly, M.A.1    Huang, Y.2    Hynynen, K.3
  • 42
    • 0242317675 scopus 로고    scopus 로고
    • Experimental validation of novel and conventional approaches to quantitative real time PCR data analysis
    • Peirson S.N., Butler J.N., Foster R.G. Experimental validation of novel and conventional approaches to quantitative real time PCR data analysis. Nucleic Acids Res 2003, 31:e73.
    • (2003) Nucleic Acids Res , vol.31
    • Peirson, S.N.1    Butler, J.N.2    Foster, R.G.3
  • 43
    • 78650399787 scopus 로고    scopus 로고
    • Substrate channeling in mammalian base excision repair pathways: Passing the baton
    • Prasad R., Shock D.D., Beard W.A., Wilson S.H. Substrate channeling in mammalian base excision repair pathways: Passing the baton. J Biol Chem 2010, 285:40479-40488.
    • (2010) J Biol Chem , vol.285 , pp. 40479-40488
    • Prasad, R.1    Shock, D.D.2    Beard, W.A.3    Wilson, S.H.4
  • 44
    • 68149091582 scopus 로고    scopus 로고
    • Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer
    • Ruckhäberle E., Karn T., Rody A., Hanker L., Gätje R., Metzler D., Holtrich U., Kaufmann M. Gene expression of ceramide kinase, galactosyl ceramide synthase and ganglioside GD3 synthase is associated with prognosis in breast cancer. J Cancer Res Clin Oncol 2009, 135:1005-1013.
    • (2009) J Cancer Res Clin Oncol , vol.135 , pp. 1005-1013
    • Ruckhäberle, E.1    Karn, T.2    Rody, A.3    Hanker, L.4    Gätje, R.5    Metzler, D.6    Holtrich, U.7    Kaufmann, M.8
  • 45
    • 33750302894 scopus 로고    scopus 로고
    • Detection of acoustic cavitation in the heart with microbubble contrast agents in vivo: A mechanism for ultrasound-induced arrhythmias
    • Rota C., Raeman C.H., Child S.Z., Dalecki D. Detection of acoustic cavitation in the heart with microbubble contrast agents in vivo: A mechanism for ultrasound-induced arrhythmias. J Acoust Soc Am 2006, 120:2958-2964.
    • (2006) J Acoust Soc Am , vol.120 , pp. 2958-2964
    • Rota, C.1    Raeman, C.H.2    Child, S.Z.3    Dalecki, D.4
  • 46
    • 34848895758 scopus 로고    scopus 로고
    • Apoptosis induced by capsaicin in prostate PC3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation
    • Sánchez A.M., MalagarieCazenave S., Olea N., Vara D., Chiloeches A., DíazLaviada I. Apoptosis induced by capsaicin in prostate PC3 cells involves ceramide accumulation, neutral sphingomyelinase, and JNK activation. Apoptosis 2007, 12:2013-2024.
    • (2007) Apoptosis , vol.12 , pp. 2013-2024
    • Sánchez, A.M.1    MalagarieCazenave, S.2    Olea, N.3    Vara, D.4    Chiloeches, A.5    DíazLaviada, I.6
  • 47
    • 44949231424 scopus 로고    scopus 로고
    • Analyzing real-time PCR data by the comparative C(T) method
    • Schmittgen T.D., Livak K.J. Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc 2008, 3:1101-1108.
    • (2008) Nat Protoc , vol.3 , pp. 1101-1108
    • Schmittgen, T.D.1    Livak, K.J.2
  • 49
    • 83155191794 scopus 로고    scopus 로고
    • Microbubble-mediated ultrasonic techniques for improved chemotherapeutic delivery in cancer
    • Sorace A.G., Warram J.M., Umphrey H., Hoyt K. Microbubble-mediated ultrasonic techniques for improved chemotherapeutic delivery in cancer. J Drug Target 2012, 20:43-54.
    • (2012) J Drug Target , vol.20 , pp. 43-54
    • Sorace, A.G.1    Warram, J.M.2    Umphrey, H.3    Hoyt, K.4
  • 50
    • 66449084139 scopus 로고    scopus 로고
    • Jagged gives endothelial tip cells an edge
    • Suchting S., Eichmann A. Jagged gives endothelial tip cells an edge. Cell 2009, 137:988-990.
    • (2009) Cell , vol.137 , pp. 988-990
    • Suchting, S.1    Eichmann, A.2
  • 51
    • 33847368998 scopus 로고    scopus 로고
    • Free-radical generation from collapsing microbubbles in the absence of a dynamic stimulus
    • Takahashi M., Chiba K., Li P. Free-radical generation from collapsing microbubbles in the absence of a dynamic stimulus. J Phys Chem B 2007, 111:1343-1347.
    • (2007) J Phys Chem B , vol.111 , pp. 1343-1347
    • Takahashi, M.1    Chiba, K.2    Li, P.3
  • 52
    • 0034631827 scopus 로고    scopus 로고
    • Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipids scrambling and alters cell surface morphology
    • Tepper A.D., Ruurs P., Wiedmer T., Sims P.J., Borst J., Blitterswijk W.J.V. Sphingomyelin hydrolysis to ceramide during the execution phase of apoptosis results from phospholipids scrambling and alters cell surface morphology. J Cell Biol 2000, 150:15564.
    • (2000) J Cell Biol , vol.150 , pp. 15564
    • Tepper, A.D.1    Ruurs, P.2    Wiedmer, T.3    Sims, P.J.4    Borst, J.5    Blitterswijk, W.J.V.6
  • 56
    • 43249099500 scopus 로고    scopus 로고
    • Twenty-five years of quantitative PCR for gene expression analysis
    • VanGuilder H.D., Vrana K.E., Freeman W.M. Twenty-five years of quantitative PCR for gene expression analysis. Biotechniques 2008, 44:619-626.
    • (2008) Biotechniques , vol.44 , pp. 619-626
    • VanGuilder, H.D.1    Vrana, K.E.2    Freeman, W.M.3
  • 57
    • 0038044636 scopus 로고    scopus 로고
    • Understanding the function of CD1restricted T cells
    • Vincent M.S., Gumperz J.E., Brenner M.B. Understanding the function of CD1restricted T cells. Nat Immunol 2003, 4:51723.
    • (2003) Nat Immunol , vol.4 , pp. 51723
    • Vincent, M.S.1    Gumperz, J.E.2    Brenner, M.B.3
  • 58
    • 0037364854 scopus 로고    scopus 로고
    • Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity
    • Wilson S.B., Delovitch T.L. Janus-like role of regulatory iNKT cells in autoimmune disease and tumour immunity. Nat Rev Immunol 2003, 3:211-222.
    • (2003) Nat Rev Immunol , vol.3 , pp. 211-222
    • Wilson, S.B.1    Delovitch, T.L.2
  • 59
    • 48649100658 scopus 로고    scopus 로고
    • The disruption of murine tumor neovasculature by low-intensity ultrasound-comparison between 1- and 3-MHz sonication frequencies
    • Wood A.K., Bunte R.M., Price H.E., Deitz M.S., Tsai J.H., Lee W.M., Sehgal C.M. The disruption of murine tumor neovasculature by low-intensity ultrasound-comparison between 1- and 3-MHz sonication frequencies. Acad Radiol 2008, 15:1133-1141.
    • (2008) Acad Radiol , vol.15 , pp. 1133-1141
    • Wood, A.K.1    Bunte, R.M.2    Price, H.E.3    Deitz, M.S.4    Tsai, J.H.5    Lee, W.M.6    Sehgal, C.M.7
  • 60
    • 79954630255 scopus 로고    scopus 로고
    • Therapeutic ultrasonic microbubbles carrying paclitaxel and LyP-1 peptide: Preparation, characterization and application to ultrasound-assisted chemotherapy in breast cancer cells
    • Yan F., Li X., Jin Q., Jiang C., Zhang Z., Ling T., Qiu B., Zheng H. Therapeutic ultrasonic microbubbles carrying paclitaxel and LyP-1 peptide: Preparation, characterization and application to ultrasound-assisted chemotherapy in breast cancer cells. Ultrasound Med Biol 2011, 37:768-779.
    • (2011) Ultrasound Med Biol , vol.37 , pp. 768-779
    • Yan, F.1    Li, X.2    Jin, Q.3    Jiang, C.4    Zhang, Z.5    Ling, T.6    Qiu, B.7    Zheng, H.8


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