Superantigenic Activity of emm3 Streptococcus pyogenes Is Abrogated by a Conserved, Naturally Occurring smeZ Mutation

PLoS ONE

Volumn 7, Issue 10, 2012, Pages

  Turner, Claire E ^a   Sommerlad, Mary ^a   McGregor, Karen ^a   Davies, Frances J ^a   Pichon, Bruno ^b   Chong, Deborah L W ^a   Farzaneh, Leili ^a   Holden, Matthew T G ^c   Spratt, Brian G ^a   Efstratiou, Androulla ^b   Sriskandan, Shiranee ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b PUBLIC HEALTH ENGLAND   (United Kingdom)

^c WELLCOME TRUST SANGER INSTITUTE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 17; INTERLEUKIN 5; LYMPHOTOXIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BACTERIAL GENE; BACTERIAL STRAIN; BACTERIUM ISOLATE; CONTROLLED STUDY; CYTOKINE PRODUCTION; EMM3 STREPTOCOCCUS PYOGENES; FEMALE; GENE DELETION; GENE EXPRESSION; GENE MUTATION; GROUP A STREPTOCOCCAL INFECTION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; IN VIVO STUDY; MITOGENESIS; MONONUCLEAR CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN INDUCTION; SMEZ GENE; STOP CODON; STREPTOCOCCUS PYOGENES; TONSIL; TONSIL CELL;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, BACTERIAL; BACTERIAL OUTER MEMBRANE PROTEINS; BACTERIAL TOXINS; BASE SEQUENCE; CARRIER PROTEINS; EXOTOXINS; HUMANS; MICE; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION; PALATINE TONSIL; SEQUENCE ANALYSIS, DNA; SHOCK, SEPTIC; SPECIES SPECIFICITY; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; SUPERANTIGENS;

MUS; STREPTOCOCCUS PYOGENES;

EID: 84867002382     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046376     Document Type: Article

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