The recreational tryptamine 5-MeO-DALT (N,N-diallyl-5-methoxytryptamine): A brief review

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 39, Issue 2, 2012, Pages 259-262

  Corkery, John M ^a,c   Durkin, Emma ^b   Elliott, Simon ^b   Schifano, Fabrizio ^a,c   Ghodse, A Hamid ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

^b Inverness Medical Innovations   (United States)

^c UNIVERSITY OF HERTFORDSHIRE   (United Kingdom)

Author keywords

5 MeO DALT; Death; N,N diallyl 5 methoxytryptamine; Poisoning; United Kingdom (UK)

Indexed keywords

5 METHOXYTRYPTAMINE; N,N DIALLYL 5 METHOXYTRYPTAMINE; UNCLASSIFIED DRUG;

ARTICLE; AUTOPSY; DRUG ABUSE; DRUG CONTROL; DRUG EFFECT; DRUG FATALITY; DRUG MECHANISM; FORENSIC TOXICOLOGY; HUMAN; INTOXICATION;

5-METHOXYTRYPTAMINE; ALLYL COMPOUNDS; ANIMALS; DRUG ADMINISTRATION ROUTES; DRUG AND NARCOTIC CONTROL; HUMANS; STREET DRUGS; TRYPTAMINES;

EID: 84866996017     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2012.05.022     Document Type: Article

References (25)

1. Bluelight The Big & Dandy 5-MeO-DALT thread [Available at:, Accessed on 31 March 2011]. http://webcache.googleusercontent.com/search?q=cache:dssR-VuQdCsJ:www.bluelight.ru/vb/showthread.php%3Ft%3D146249%26page%3D10+5-MeO-Dalt+batches&cd=7&hl=en&ct=clnk&gl=uk&source=www.google.co.uk.
2. Boland D.M., Andollow W., Hine G.W., Hearn W.L. Fatality due to acute alpha-methyltryptamine intoxication. J Anal Toxicol 2005, 29(5):394-398.
3. Drugs Forum 5-MeO-DALT [Available at:, Accessed on 22 April 2012]. http://www.drugs-forum.com/forum/showwiki.php?title=5-MeO-DALT.
4. EDND 5-MeO-DALT. European Database on New Drugs 2011, (November). [Available at: ednd.emcdda.europa.eu. Accessed on 22 April 2012].
5. Erowid Erowid 5-MeO-DALT vault [Available at:, Accessed on 22 April 2012]. http://www.erowid.org/chemicals/5meo_dalt/5meo_dalt.shtml.
6. Erowid E., Spoon What drug is in my drug?. Chemical analysis of 5-MeO-DALT and discussion of inconsistent RCs in the 2010 market 2010, 4 November. Erowid.org. [Available at: http://www.erowid.org/chemicals/5meo_dalt/5meo_dalt_article1.shtml. Accessed on 22 April 2012].
7. Fantegrossi W.E., Harrington A.W., Kiessel C.L., Eckler J.R., Rabin R.A., Winter J.C., et al. Hallucinogen-like actions of 5-methoxy-N,N-diisopropyltryptamine in mice and rats. Pharmacol Biochem Behav 2006, 83(1):122-129.
8. Ghodse H., Corkery J., Ahmed K., Naidoo V., Oyefeso A., Schifano F. Drug-related deaths in the UK: annual report 2010. Drug-related deaths reported by Coroners in England, Wales, Northern Ireland, Guernsey, Jersey and the Isle of Man; police forces in Scotland; & the Northern Ireland Statistics and Research Agency - annual report January-December 2009 2010, International Centre for Drug Policy, St George's University of London, London, 24 August 2010. Available at: http://www.sgul.ac.uk/research/projects/icdp/pdf/np-sad-11th-annual-report-2010-finalcopy.pdf. Accessed on 22 April 2012.
9. Gibbons S. 'Legal highs' - novel and emerging psychoactive drugs: a chemical overview for the toxicologist. Clin Toxicol 2012, 50(1):15-24.
10. Jones R.S. Tryptamine: a neuromodulator or neurotransmitter in mammalian brain?. Prog Neurobiol 1982, 19(1-2):117-139.
11. Kamata T., Katagi M., Tsuchihashi H. Metabolism and toxicological analyses of hallucinogenic tryptamine analogues being abused in Japan. Forensic Toxicol 2010, 28(1):1-8.
12. Makey J. Family's vow over 'legal high' drugs danger 2010, 29 October. cambridge-news.co.uk. [Available at: http://www.cambridge-news.co.uk/Home/Familys-vow-over-legal-high-drugs-danger.htm. Accessed on 22 April 2012].
13. Nagai F., Nonaka R., Kamimura K.S.H. The effects of non-medically used psychoactive drugs on monoamine neurotransmission in rat brain. Eur J Pharmacol 2007, 559(2-3):132-137.
14. Nichols D.E. Hallucinogens. Pharmacol Ther 2004, 101(2):131-181.
15. 35S]GTPγS binding in rat brain membranes. Biol Pharm Bull 2007, 30(12):2328-2333.
16. Peden N.R., Macaulay K.E.C., Bisset A.F., Crooks J., Pelosi A.J. Clinical toxicology of 'magic mushrooms' ingestion. Postgrad Med J 1981, 57(671):543-545.
17. Rogawski M.A., Aghajanian G.K. Serotonin autoreceptors in dorsal raphe neurons: structure-activity relationships of tryptamine analogs. J Neurosci 1981, 1(10):1148-1154.
18. Schifano F., Deluca P., Baldacchino A., Peltoniemi T., Scherbaum N., Torrens M., et al. Drugs on the web; the Psychonaut 2002 EU project. Prog Neuropsychopharmacol Biol Psychiatry 2006, 30(4):640-646.
19. Shimazu S., Miklya I. Pharmacological studies with endogeneous enhancer substances: β-phenethylamine, tryptamine, and their synthetic derivatives. Prog Neuropsychopharmacol Biol Psychiatry 2004, 28(3):421-427.
20. Shulgin A., Shulgin A. Book II of TiHKAL: the continuation. Isomerdesign 2010, [Available at: http://isomerdesign.com/PiHKAL/read.php?domain=tk&id=56. Accessed on 22 April 2012].
21. Sogawa C., Sogawa N., Tagawa J., Fujino A., Ohyama K., Asanuma M., et al. 5-Methoxy-N, N-diisopropyltryptamine (Foxy), a selective and high affinity inhibitor of serotonin transporter. Toxicol Lett 2007, 170(1):75-82.
22. Sullivan J.P., McDonnell L., Hardiman O.M., Farrell M.A., Phillips J.P., Tipton K.F. The oxidation of tryptamine by the two forms of monoamine oxidase in human tissues. Biochem Pharmacol 1986, 35(19):3255-3260.
23. Tanaka E., Kamata T., Katagi M., Tsuchihashi H., Honda K. A fatal poisoning with 5-methoxy-N, N-diisopropyltryptamine, Foxy. Forensic Sci Int 2006, 163(1-2):152-154.
24. Wilson J.M., McGeorge F., Smolinske S., Meatherall R. A foxy intoxication. Forensic Sci Int 2005, 148(1):31-36.
25. Wölfel R., Graefe K.H. Evidence for various tryptamines and related compounds acting as substrates of the platelet 5-hydroxytryptamine transporter. Naunyn Schmiedebergs Arch Pharmacol 1992, 345(2):129-136.