Pain in patients with chronic fatigue syndrome: Time for specific pain treatment?

Pain Physician

Volumn 15, Issue 5, 2012, Pages

  Nijs, Jo ^a,b,c   Crombez, Geert ^d   Meeus, Mira ^a,b   Knoop, Hans ^e   van Damme, Stefaan ^d   van Cauwenbergh, Deborah ^b   Bleijenberg, Gijs ^e  

^a VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^b Hogeschool Antwerpen   (Belgium)

^c UNIVERSITY HOSPITAL BRUSSELS   (Belgium)

^d GHENT UNIVERSITY   (Belgium)

^e RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

Catastrophizing; Central sensitization; Chronic fatigue syndrome; Chronic pain; Cognitive behavioral therapy; Exercise; Fibromyalgia

Indexed keywords

NITRIC OXIDE;

ACUPUNCTURE ANALGESIA; ANALGESIA; ANALGESIA (SENSORY DYSFUNCTION); CENTRAL NERVOUS SYSTEM SENSITIZATION; CHRONIC FATIGUE SYNDROME; CHRONIC PAIN; COGNITIVE THERAPY; EXERCISE; GENERALIZED HYPERSENSITIVITY; HUMAN; MEDICAL RESEARCH; NITRATIVE STRESS; NOCICEPTION; OXIDATIVE STRESS; PAIN BEHAVIOR; PAIN PARAMETERS; PAIN THRESHOLD; PATIENT EDUCATION; REVIEW;

DATABASES, FACTUAL; FATIGUE SYNDROME, CHRONIC; HUMANS; MULTICENTER STUDIES AS TOPIC; PAIN; PAIN MEASUREMENT;

EID: 84866989358     PISSN: 15333159     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (85)

1. Fukuda K, Straus S, Hickie I, Sharpe MC, Dobbins JG, Komaroff A. The Chronic Fatigue Syndrome: A comprehensive approach to its definition and study. Ann Intern Med 1994; 121:953-959.
2. Carruthers BM, van de Sande MI, De Meirleir KL, Klimas NG, Broderick G, Mitchell T, Staines D, Powles ACP, Speight N, Vallings R, Bateman L, Baumgarten-Austrheim B, Bell BS, Carlo-Stella N, Chia J, Darragh A, Jo D, Lewis D, Light AR, Marshall-Gradisbik S, Mena I, Mikovits JA, Miwa K, Murovska M, Pall ML, Stevens S. Myalgic encephalomyelitis: International Consensus Criteria. J Intern Med 2011; 270:327-338.
3. Jason LA, Richman JA, Rademaker AW, Jordan KM, Plioplys AV, Taylor RR, Mc-Cready W, Huang CF, Plioplys S. A community-based study of chronic fatigue syndrome. Arch Intern Med 1999; 159:2129-2137.
4. Ravindran MK, Zheng Y, Timbol C, Merck SJ, Baraniuk JN. Migraine headaches in Chronic Fatigue Syndrome (CFS): Comparison of two prospective crosssectional studies. BMC Neurol 2011; 11:30. DOI:10.1186/1471-2377-11-30.
5. Nijs J, Vaes P, McGregor N, Van Hoof E, De Meirleir K. Psychometric properties of the Dutch Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ). Phys Ther 2003; 83:444-454.
6. Nijs J, Cloostermans B, McGregor N, Vaes P, De Meirleir K. Construct validity and internal consistency of the Chronic Fatigue Syndrome Activities and Participation Questionnaire (CFS-APQ). Physiother Theory Pract 2004; 20:31-40.
7. Collin SM, Crawley E, May MT, Sterne JAC, Hollingworth W. The impact of CFS/ME on employment and productivity in the UK: A cross-sectional study based on the CFS/ME national outcomes database. BMC Health Services Res 2011; 11: DOI: 10.1186/1472-6963-11-21.
8. Meeus M, Nijs J, and Meirleir KD. Chronic musculoskeletal pain in patients with the chronic fatigue syndrome: A systematic review. Eur J Pain 2007; 11:377-386.
9. Clauw DJ, Chrousos GP. Chronic pain and fatigue syndromes: Overlapping clinical and neuroendocrine features and potential pathogenic mechanisms. Neuroimmunomodulation 1997; 4:134-153.
10. Bradley LA, McKendree-Smith NL, Alarcon GS. Pain complaints in patients with fibromyalgia versus chronic fatigue syndrome. Curr Rev Pain 2000; 4:148-157.
11. Nielsen LA, Henriksson KG. Pathophysiological mechanisms in chronic musculoskeletal pain (fibromyalgia): The role of central and peripheral sensitization and pain desinhibition. Best Pract Res Clin Rheumatol 2007; 21:465-480.
12. Vierck CJ. Mechanisms underlying development of spatial distributed chronic pain (fibromyalgia). Pain 2006; 124:242-263.
13. Wolfe F, Smythe HA, Yunus MB, Bennett RM, Bombardier C, Goldenberg DL, Tugwell P, Campbell SM, Abeles M, Clark P. The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee. Arthritis Rheum 1990; 33:160-172.
14. Wolfe F, Clauw DJ, Fitzcharles MA, Goldenberg DL, Katz RS, Mease P, Russell AS, Russell IJ, Winfield JB, Yunus MB. The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity. Arthritis Care Res 2010; 62:600-610.
15. Costa DC, Tannock C, Brostoff J. Brainstem perfusion is impaired in chronic fatigue syndrome. QJM 1995; 88:767-773.
16. Tirelli U, Chierichetti F, Tavio M, Simonelli C, Bianchin G, Zanco P, Ferlin G. Brain positron emission tomography (PET) in chronic fatigue syndrome: Preliminary data. Am J Med 1998; 105:54S-58S.
17. Mountz JM, Bradley LA, Modell JG, Alexander RW, Triana-Alexander M, Aaron LA, Stewart KE, Alarcon GS, Mountz JD. Fibromyalgia in women. Abnormalities of regional cerebral blood flow in the thalamus and the caudate nucleus are associated with low pain threshold levels. Arthritis Rheum 1995; 38:926-938.
18. Russell IJ, Orr MD, Littman B, Vipraio GA, Alboukrek D, Michalek JE, Lopez Y, MacKillip F. Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome. Arthritis Rheum 1994; 37:1593-1601.
19. Evengard B, Nilsson CG, Lindh G, Lindquist L, Eneroth P, Fredrikson S, Terenius L, Henriksson KG. Chronic fatigue syndrome differs from fibromyalgia. No evidence for elevated substance P levels in cerebrospinal fluid of patients with chronic fatigue syndrome. Pain 1998; 78:153-155.
20. Nijs J, De Meirleir K, Truyen S. Hypermobility in patients with chronic fatigue syndrome: Preliminary observations. J Musculoskel Pain 2004; 12:9-17.
21. Byrne E, Trounce I. Chronic fatigue and myalgia syndrome: Mitochondrial and glycolytic studies in skeletal muscle. J Neurol Neurosurg Psychiatry 1987; 50:743-746.
22. McCully KK, Smith S, Rajaei S, Leigh Jr. JS, Natelson BH. Muscle metabolism with blood flow restriction in chronic fatigue syndrome. J Appl Physiol 2004; 96:871-878.
23. Millan MJ. Descending control of pain. Prog Neurobiol 2002; 66:355-474.
24. Luo ZD, Cizkova D. The role of nitric oxide in nociception. Curr Rev Pain 2000; 4:459-466.
25. Woolf CJ. Central sensitization: Implications for the diagnosis and treatment of pain. Pain 2011; 152:S2-15.
26. Vikman KS, Hill RH, Backstrom E, Robertson B, Kristensson K. Interferongamma induces characteristics of central sensitization in spinal dorsal horn neurons in vitro. Pain 2003; 106:241-251.
27. Maes M, Mihaylova I, Kubera M, Bosmans E. Not in the mind but in the cell: Increased production of cyclo-oxygenase-2 and inducible NO synthase in chronic fatigue syndrome. Neuro Endocrinol Lett 2007; 28:463-469.
28. Meeus M, Roussel N, Truijen S, Nijs J. Reduced pressure pain thresholds in response to exercise in chronic fatigue syndrome but not in chronic low back pain: An experimental study. J Rehab Med 2010; 42:884-890.
29. Meeus M, van Eupen I, Hondequin J, DE Hauwere L, Kos D, Nijs J. Nitric oxide concentrations are normal and unrelated to activity level in chronic fatigue syndrome: A case-control study. In Vivo 2010; 24:865-869.
30. Viinikka L. Nitric oxide as a challenge for the clinical chemistry laboratory. Scand J Clin Lab Invest 1996; 56:577-581.
31. Lundberg JO, Weitzberg E, Gladwin MT. The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 2008; 7:156-167.
32. Kennedy G, Spence VA, McLaren M, Hill A, Underwood C, Belch JJF. Oxidative stress levels are raised in chronic fatigue syndrome and are associated with clinical symptoms. Free Radic Biol Med 2005; 39:584-589.
33. Sterling M, Jull G, Vicenzino B, Kenardy J. Characterization of acute whiplash-associated disorders. Spine 2004; 29:182-188.
34. Meeus M, Nijs J, Huybrechts S, Truijen S. Evidence for generalized hyperalgesia in chronic fatigue syndrome: A case control study. Clin Rheumatol 2010; 29:393-398.
35. Puri BK, Gunatilake KDR, Fernando KAC, Gurusinghe AI, Agour M, Treasaden IH. Increased tenderness in the left third intercostal space in adult patients with myalgic encephalomyelitis: A controlled study. J Internat Med Res 2011; 39:212-214.
36. Ullrich PM, Afari N, Jacobsen C, Goldberg J, Buchwald D. Cold pressor pain sensitivity in monozygotic twins discordant for chronic fatigue syndrome. Pain Med 2007; 8:216-222.
37. Vecchiet J, Cipollone F, Falasca K, Mezzetti A, Pizzigallo E, Bucciarelli T, De Laurentis S, Affaitati G, De Cesare D, Giamberardino MA. Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome. Neurosci Lett 2003; 335:151-154.
38. Vecchiet L, Montanari G, Pizzigallo E, Iezzi S, de Bigontina P, Dragani L, Vecchiet J, Giamberardino MA. Sensory characterization of somatic parietal tissues in humans with chronic fatigue syndrome. Neurosci Lett 1996; 208:117-120.
39. Meeus M, Nijs J, Van de Wauwer N, Toeback L, Truijen S. Diffuse noxious inhibitory control is delayed in chronic fatigue syndrome: An experimental study. Pain 2008; 139:439-448.
40. Bouhassira D, Gall O, Chitour D, Le Bars D. Dorsal horn convergent neurones: Negative feedback triggered by spatial summation of nociceptive afferents. Pain 1995; 62:195-200.
41. Marchand S, Arsenault P. Spatial summation for pain perception: Interaction of inhibitory and excitatory mechanisms. Pain 2002; 95:201-206.
42. Yamamoto S, Ouchi Y, Onoe H, Yoshikawa E, Tsukawa E, Takahashi T, Iwase M, Yamaguti K, Kuratsune H, Watanabe Y. Reduction of serotonin transporters of patients with chronic fatigue syndrome. NeuroReport 2004; 15:2571-2574.
43. Koltyn KF, Arbogast RW. Perception of pain after resistance exercise. Br J Sports Med 1998; 32:20-24.
44. Koltyn KF. Analgesia following exercise: A review. Sports Med 2000; 29:85-98. {There cannot be 2 references for the same reference number. Each should be a separate reference number. ALL subsequent references and ALL references in the text will need to be renumbered.}
45. Ray CA, Carter JR. Central modulation of exercise-induced muscle pain in humans. J Physiol 2007; 585:287-294.
46. Millan MJ. Descending control of pain. Prog Neurobiol 2002; 66:355-474. {There cannot be 2 references for the same reference number. Each should be a separate reference number. ALL subsequent references and ALL references in the text will need to be renumbered.}
47. Whiteside A, Hansen S and Chaudhuri A. Exercise lowers pain threshold in chronic fatigue syndrome. Pain 2004; 109:497-499.
48. Van Oosterwijck J, Nijs J, Meeus M, Levefer I, Huybrechts L, Lambrecht L, Paul L. Pain inhibition and post-exertional malaise in myalgic encephalomyelitis/chronic fatigue syndrome: An experimental study. J Intern Med 2010; 268:265-278.
49. Van Oosterwijck J, Nijs J, Meeus M, Van Loo M, Paul L. Lack of endogenous pain inhibition during exercise in patients with chronic whiplash associated disorders: An experimental study. J Pain 2012:; 13:242-254.
50. Staud R, Robinson ME, Price DD: Isometric exercise has opposite effects on central pain mechanisms in fibromyalgia patients compared to normal controls. Pain 2005; 118:176-184.
51. Kosek E, Ekholm J, Hansson P. Modulation of pressure pain thresholds during and following isometric contraction in patients with fibromyalgia and in healthy controls. Pain 1996; 64:415-423.
52. Hoffman MD, Shepanski MA, Mackenzie SP, Clifford PS. Experimentally induced pain perception is acutely reduced by aerobic exercise in people with chronic low back pain. J Rehabil Res Dev 2005; 42:183-190.
53. Light AR, White AT, Hughen RW, Light KC. Moderate exercise increases expression for sensory, adrenergic, and immune genes in chronic fatigue syndrome patients but not in normal subjects. J Pain 2009; 10:1099-1112.
54. White AT, Light AR, Hughen RW, Bateman L, Martins TB, Hill HR, Light KC. Severity of symptom flare after moderate exercise is linked to cytokine activity in chronic fatigue syndrome. Psychophysiol 2010; 47:615-624.
55. Jungersten L, Ambring A, Wall B, Wennmalm A. Both physical fitness and acute exercise regulate nitric oxide formation in healthy humans. J Appl Physiol 1997; 82:760-764.
56. Suárez A, Guillamó E, Roig T, Blázquez A, Alegre J, Bermúdez J, Ventura JL, García-Quintana AM, Comella A, Segura R, Javierre C. Nitric oxide metabolite production during exercise in chronic fatigue syndrome: A case-control study. J Womens Health 2010; 19:1073-1077.
57. Vlaeyen, J.W.S., Kole-Snijders, A.M.J., Boeren, R.G.B., van Eek, H. Fear of movement/(re)injury in chronic low back pain and its relation to behavioral performance. Pain 1995; 62:363-372.
58. Nijs J, Vanherberghen K, Duquet W, De Meirleir K. Chronic fatigue syndrome: Lack of association between pain-related fear of movement and exercise capacity and disability. Phys Ther 2004; 84:696-705.
59. Sullivan MJL, Bishop SR, Pivik J. The Pain Catastrophizing Scale: Development and validation. Psychol Assess 1995; 7:524-532.
60. Nijs J, Van de Putte K, Louckx F, Truijen S, De Meirleir K. Exercise performance and chronic pain in chronic fatigue syndrome: The role of pain catastrophizing. Pain Med 2008; 9:1164-1172.
61. Meeus M, Nijs J, Van Mol E, Truijen S, De Meirleir K. Psychological determinants of chronic musculoskeletal pain and daily functioning in chronic fatigue syndrome. Clin Rheumatol 2012; 31:921-929.
62. Vercoulen JH, Swanink CM, Galama JM, Fennis JF, Jongen PJ, Hommes OR, van der Meer JW, Bleijenberg G. The persistence of fatigue in chronic fatigue syndrome and multiple sclerosis: Development of a model. J Psychosom Res 1998; 45:507-517.
63. Jackson T, Pope L, Nagasaka T, Fritch A, Iezzi T, Chen H. The impact of threatening information about pain on coping and pain tolerance. Br J Health Psychol 2005; 10:441-451.
64. Meeus M, Nijs J, Van Oosterwijck J, Van Alsenoy V, Truijen S, De Meirleir K. Pain physiology education improves pain beliefs in patients with Chronic Fatigue Syndrome compared to pacing and selfmanagement education: A double-blind randomized controlled trial. Arch Phys Med Rehabil 2010; 91:1153-1159.
65. Nijs J, van Wilgen CP, Van Oosterwijck J, van Ittersum M, Meeus M. How to explain central sensitization to patients with 'unexplained' chronic musculoskeletal pain: Practice guidelines. Manual Ther 2011; 16:413-418.
66. Louw A, Diener I, Butler DS, Puentedura EJ. The effect of neuroscience education on pain, disability, anxiety, and stress in chronic musculoskeletal pain. Arch Phys Med Rehabil 2011; 92:2041-2056.
67. Price JR, Mitchell E, Tidy E, Hunot V. Cognitive behaviour therapy for chronic fatigue syndrome in adults. Cochrane Database Syst Rev 2008; 3:CD001027.
68. Prins JB, Bleijenberg G, Bazelmans E, Elving LD, de Boo TM, Severens JL, van der Wilt GJ, Spinhoven P, van der Meer JW. Cognitive behaviour therapy for chronic fatigue syndrome: A multicentre randomised controlled trial. Lancet 2001; 357:841-847.
69. Knoop H, Bleijenberg G, Gielissen MF, van der Meer JW, White PD. Is full recovery possible after cognitive behavioural therapy for chronic fatigue syndrome? Psychother Psychosom 2007; 76:171-176.
70. National Institute for Health and Clinical Excellence. Chronic fatigue syndrome/myalgic encephalomyelitis (or encephalopathy): Diagnosis and management of CFS/ME in adults and children. 2007. www.nice.org.uk/CG053
71. Knoop H, Stulemeijer M, Prins JB, van der Meer JWM, Bleijenberg G. Is cognitive behaviour therapy for chronic fatigue syndrome also effective for pain symptoms? Behav Res Ther 2007; 45:2034-2043
72. Cella M, Chalder T, White PD. Does the heterogeneity of chronic fatigue syndrome moderate the response to cognitive behaviour therapy? An exploratory study. Psychother Psychosom 2011; 80:353-358.
73. Marshall R, Paul L, Wood L. The search for pain relief in chronic fatigue syndrome: A descriptive study. Physiother Theory Pract 2011; 27:373-383.
74. Nijs J, Meeus M, Van Oosterwijck J, Ickmans K, Moorkens G, Hans G, De Clerck LS. In the mind or in the brain? Scientific evidence for central sensitization in chronic fatigue syndrome. Eur J Clin Invest 2012; 42:203-212.
75. Zusman, M. Forebrain-mediated sensitization of central pain pathways: 'Nonspecific' pain and a new image for MT. Manual Ther 2002; 7:80-88.
76. Brosschot, J. F. Cognitive-emotional sensitization and somatic health complaints. Scand J Psychol 2002; 43:113-121.
77. Van Den Eede F, Moorkens G, Van Houdenhove B, Cosyns P, Claes SJ. Hypothalamic-pituitary-adrenal axis function in chronic fatigue syndrome. Neuropsychobiol 2007; 55:112-120.
78. Torres-Harding S, Sorenson M, Jason L, Reynolds N, Brown M, Maher K, Fletcher MA. The associations between basal salivary cortisol and illness symptomatology in chronic fatigue syndrome. J Appl Biobehavior Res 2008; 13:157-180.
79. Van Damme S, Crombez G, Van Houdenhove B, Mariman A, Michielsen W. Well-being in patients with chronic fatigue syndrome: The role of acceptance. J Psychosom Res 2006; 61:595-599.
80. Brooks SK, Rimes KA, Chalder T. The role of acceptance in chronic fatigue syndrome. J Psychosom Res 2011; 71:411-415.
81. Wetherell JL, Afari N, Rutledge T, Sorrell JT, Stoddard JA, Petkus AJ, Solomon BC, Lehman DH, Liu L, Lang AJ, Atkinson JH. A randomized, controlled trial of acceptance and commitment therapy and cognitive-behavioral therapy for chronic pain. Pain 2011; 152:2098-2107.
82. Crombez G, Eccleston C, Van Damme S, Vlaeyen JWS, Karoly P. Fear avoidance model of chronic pain. The next generation. Clin J Pain 2012: in press.
83. Cousins MJ, Lynch ME. The Declaration Montreal: Access to pain management is a fundamental human right. Pain 2011; 152:2673-2674.
84. Ang DC, Chakr R, Mazzuca S, France CR, Steiner J, Stump T. Cognitive-behavioral therapy attenuates nociceptive responding in patients with fibromyalgia: A pilot study. Arthr Care Res 2010; 62:618-623.
85. Wiborg JF, Knoop H, Prins JB, Bleijenberg G. Does a decrease in avoidance behavior and focusing on fatigue mediate the effect of cognitive behavior therapy for chronic fatigue syndrome? J Psychosom Res 2011; 70:306-310.