Influence of blocking of 2,3-butanediol pathway on glycerol metabolism for 1,3-propanediol production by Klebsiella oxytoca

Applied Biochemistry and Biotechnology

Volumn 168, Issue 1, 2012, Pages 116-128

  Zhang, Gang ^a   Yang, Guang ^b   Wang, Xu ^a   Guo, Qingjuan ^a   Li, Ying ^a   Li, Jilun ^a  

^a CHINA AGRICULTURAL UNIVERSITY   (China)

^b Chinese Academy of Sciences   (China)

Author keywords

Acetolactate decarboxylase; 1,3 Propanediol; 2,3 Butanediol; Klebsiella oxytoca; Reducing equivalent

Indexed keywords

1 ,3 PROPANEDIOL; 2 ,3-BUTANEDIOL; DECARBOXYLASES; KLEBSIELLA OXYTOCA; REDUCING EQUIVALENT;

BACTERIA; BYPRODUCTS; ENZYME ACTIVITY; ETHANOL; FERMENTATION; METABOLISM; PHYSIOLOGY;

GLYCEROL;

1,3 PROPANEDIOL; 2,3 BUTANEDIOL; ACETIC ACID; ACETOLACTATE DECARBOXYLASE; ALCOHOL; CARBOXYLYASE; GLYCEROL; LACTIC ACID; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; SUCCINIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL STRAIN; BATCH FERMENTATION; CONTROLLED STUDY; DRY WEIGHT; ENZYME ACTIVITY; ENZYME METABOLISM; KLEBSIELLA OXYTOCA; OXIDATION REDUCTION STATE; PRODUCTIVITY; SIGNAL TRANSDUCTION; SOLUBILITY;

BATCH CELL CULTURE TECHNIQUES; BUTYLENE GLYCOLS; FERMENTATION; GENES, BACTERIAL; GLYCEROL; KLEBSIELLA OXYTOCA; METABOLIC NETWORKS AND PATHWAYS; METABOLOMICS; MUTATION; NUCLEOTIDES; OXIDATION-REDUCTION; PLASMIDS; POLYMERASE CHAIN REACTION; PROPYLENE GLYCOLS; TIME FACTORS;

KLEBSIELLA OXYTOCA;

EID: 84866986534     PISSN: 02732289     EISSN: 15590291     Source Type: Journal    
DOI: 10.1007/s12010-011-9363-3     Document Type: Article

References (30)

1. Celińska, C. (2010). Debottlenecking the 1,3-propanediol pathway by metabolic engineering. Biotechnology Advances, 28, 519-530.
2. Da Silva, G. P.; Mack, M.; & Contiero, J. (2009). Glycerol: a promising and abundant carbon source for industrial microbiology. Biotechnology Advances, 27, 30-39.
3. Zeng, A. P.; & Biebl, H. (2002). Bulk chemicals from biotechnology: the case of 1,3-propanediol production and the new trends. Advances in Biochemical Engineering/Biotechnology, 74, 239-259.
4. Homann, T.; Tag, C.; Biebl, H.; & Dechwer, W. D. (1990). Fermentation of glycerol to 1,3-propanediol by Klebsiella and Citrobacter strains. Applied Microbiology and Biotechnology, 33, 121-126.
5. Biebl, H.; Menzel, K.; Zeng, A. P.; & Deckwer, W. D. (1999). Microbial production of 1,3-propanediol. Applied Microbiology and Biotechnology, 52, 289-297.
6. Zeng, A. P.; Biebl, H.; Schlieker, H.; & Deckwer, W. D. (1993). Pathway analysis of glycerol fermentation by Klebsiella pneumoniae: regulation of reducing equivalent balance and product formation. Enzyme and Microbial Technology, 15, 770-779.
7. Ahrens, K.; Menzel, K.; Zeng, A. P.; & Deckwer, W. D. (1998). Kinetic, dynamic, and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuoous culture: III, Enzymes and fluxes of glycerol dissimilation and 1,3-propanediol formation. Biotechnology and Bioengineeing, 59, 544-552.
8. Yang, G.; Tian, J. S.; & Li, J. L. (2007). Fermentation of 1,3-propanediol by a lactate deficient mutant of Klebsiella oxytoca under microaerobic conditions. Applied Microbiology and Biotechnology, 73, 1017-1024.
9. Xu, Y. Z.; Guo, N. N.; Zheng, Z. M.; Ou, X. J.; Liu, H. J.; & Liu, D. H. (2009). Metabolism in 1,3-propanediol fed-batch fermentation by d-lactate deficient mutant of Klebsiella pneumoniae. Biotechnology and Bioengineering, 104(5), 1-8.
10. Zhang, Y. P.; Li, Y.; Du, C. Y.; Liu, M.; & Cao, Z. A. (2006). Inactivation of aldehyde dehydrogenase: a key factor for engineering 1,3-propanediol by Klebsiella pneumoniae. Metabolic Engineering, 8, 578-586.
11. Horng, Y. T.; Chang, K. C.; Chou, T. C.; Yu, C. J.; Chien, C. C.; Wei, Y. H.; et al. (2010). Inactivation of dhaD and dhaK abolishes by-product accumulation during 1,3-propanediol production in Klebsiella pneumoniae. Journal of Industrial Microbiology and Biotechnology, 37(7), 707-716.
12. Seo, M. Y.; Seo, J. W.; Heo, S. Y.; Baek, J. O.; Rairakhwada, D.; Oh, B. R.; et al. (2009). Elimination of by-product formation during production of 1,3-propanediol in Klebsiella pneumoniae by inactivation of glycerol oxidative pathway. Applied Microbiology and Biotechnology, 84, 527-534.
13. Xiu, Z. L.; & Zeng, A. P. (2008). Present state and perspective of downstream processing of biologically produced 1,3-propanediol and 2,3-butanediol. Applied Microbiology and Biotechnology, 78, 917-926.
14. Blomqvist, K.; Nikkola, M.; Lehtovaara, P.; Suihko, M. L.; Airaksinen, U.; Straby, K. B.; et al. (1993). Characterization of the genes of the 2,3-BD operons from Klebsiella terrigena and Enterobacter aerogenes. Journal of Bacteriology, 175(5), 1392-1404.
15. Wood, B. E.; Yomano, L. P.; York, S. W.; & Ingram, L. O. (2005). Development of industrial-medium-required elimination of the 2,3-BD fermentation pathway to maintain ethanol yield in an ethanologenic strain of Klebsiella oxytoca. Biotechnology Progress, 21, 1366-1372.
16. Ohta, K.; Beall, D. S.; Mejia, J. P.; Shanmugam, K. T.; & Ingram, L. O. (1991). Metabolic engineering of Klebsiella oxytoca M5al for ethanol production from xylose and glucose. Applied and Evironmental Microbiology, 157, 1810-1815.
17. 3. Applied Microbiology and Biotechnology, 36, 289-295.
18. Schweizer, H. D. (1993). Small broad-host-range gentamycin resistance gene cassettes for site-specific insertion and deletion mutagenesis. BioTechniques, 15(5), 831-834.
19. Zhao, D. H.; & Li, J. L. (2004). Construction and characterization of double mutants in nitrogenase of Klebsiella pneumoniae. Chinese Science Bulletin, 49, 1807-1713.
20. Miller, V. L.; & Mekalanos, J. J. (1988). A novel suicide vector and its use in construction of insertion mutation: osmoregulation of outer membrane proteins and virulence determinants in Vibrio Cholerae requires toxR. Journal of Bacteriology, 170, 2572-2583.
21. Zheng, Z. M.; Xu, Y. Z.; Liu, H. J.; Guo, N. N.; Cai, Z. Z.; & Liu, D. H. (2008). Physiologic mechanisms of sequential products synthesis in 1,3-propanediol fed-batch fermentation by Klebsiella pneumoniae. Biotechnology and Bioengineering, 100(5), 923-932.
22. Olsen, F.; & K, Aunstrup. December 1984. Denmark patent, EP 0128714.
23. Phalip, V.; Monnet, C.; Schmitt, P.; Renault, P.; Godon, J. J.; & Diviès, C. (1994). Purification and properties of the α-actolactate debocarboxylase from Lactococcus lactis subsp. lactis NCDO 2118. FEBS Letters, 351, 95-99.
24. Bradford, M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72, 248-254.
25. Du, C. Y.; Zhang, Y. P.; Li, Y.; & Cao, Z. A. (2007). Novel redox potential-based screening strategy for rapid isolation of Klebsiella pneumoniae mutants with enhanced 1,3-propanediol-producing capability. Applied and Environmental Microbiology, 73(14), 4515-4521.
26. Menzel, K.; Ahrens, K.; Zeng, A. P.; & Deckwer, W. D. (1998). Kinetic, dynamic, and pathway studies of glycerol metabolism by Klebsiella pneumoniae in anaerobic continuous culture: IV. Enzyme and fluxes of pyruvate metabolism. Biotechnology and Bioengineering, 60(5), 617-626.
27. Ma, B. B.; Xu, X. L.; Zhang, G. L.; Wang, L. W.; Wu, M.; & Li, C. (2009). Microbial production of 1,3-propanediol by Klebsiella pneumoniae XJPD-Li under different aeration strategies. Applied Biochemistry and Biotechnology, 152, 127-134.
28. Zhao, L.; Zheng, Y.; Ma, X. Y.; & Wei, D. Z. (2009). Effects of overexpression of glycerol dehydrogenase and 1,3-propanediol oxidoreductase on bioconversion of glycerol into 1,3-propanediol by Klebsiella pneumoniae under microaerobic conditions. Bioprocess and Biosystems Engineering, 32, 313-320.
29. Hao, J.; Wang, W.; Tian, J. S.; Li, J. L.; & Liu, D. H. (2008). Decrease of 3-hydroxypropionaldehyde accumulation in 1,3-propanediol production by over-expressing dhaT gene in Klebsiella pneunoniae TUAC01. Journal of Industrial Microbiology and Biotechnology, 35, 735-741.
30. Zhang, Y. P.; Huang, Z. H.; Du, C. Y.; Li, Y.; & Cao, Z. A. (2009). Introduction of an NADH regeneration system into Klebsiella oxytoca leads to an enhanced oxidative and reductive metabolism of glycerol. Metabolic Engineering, 11, 101-106.