Seeing double: A comparison of microstructure, biomechanical function, and adjacent disc health between double- and single-layer vertebral endplates

Spine

Volumn 37, Issue 21, 2012, Pages

  Fields, Aaron J ^a   Sahli, Francisco ^b   Rodriguez, Azucena G ^a   Lotz, Jeffrey C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b PONTIFICIA UNIVERSIDAD CATÓLICA DE CHILE   (Chile)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOSAMINOGLYCAN; METHYLENE BLUE;

ADULT; AGED; ARTICLE; BIOMECHANICS; BONE PLATE; BONE STRESS; CADAVER; COMPUTER ASSISTED TOMOGRAPHY; FEMALE; FINITE ELEMENT ANALYSIS; HUMAN; HUMAN TISSUE; INFORMATION; INTERVERTEBRAL DISK; INTERVERTEBRAL DISK DEGENERATION; LUMBAR SPINE; MALE; NUTRITION; POROSITY; PRIORITY JOURNAL; TRABECULAR BONE; VERTEBRA;

ADULT; AGED; AGED, 80 AND OVER; BIOMECHANICS; CADAVER; FEMALE; FINITE ELEMENT ANALYSIS; GLYCOSAMINOGLYCANS; HUMANS; INTERVERTEBRAL DISC; INTERVERTEBRAL DISC DEGENERATION; LINEAR MODELS; LUMBAR VERTEBRAE; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; X-RAY MICROTOMOGRAPHY;

EID: 84866984134     PISSN: 03622436     EISSN: 15281159     Source Type: Journal    
DOI: 10.1097/BRS.0b013e318267bcfc     Document Type: Article

References (52)

1. Buckwalter JA. Aging and degeneration of the human intervertebral disc. Spine 1995; 20 : 1307-14.
2. Adams MA, Freeman BJ, Morrison HP, et al. Mechanical initiation of intervertebral disc degeneration. Spine 2000; 25 : 1625-36. (Pubitemid 30460463)
3. Urban JP, Smith S, Fairbank JC. Nutrition of the intervertebral disc. Spine 2004; 29 : 2700-9. (Pubitemid 40353256)
4. Adams MA, McNally DS, Wagstaff J, et al. Abnormal stress concentrations in lumbar intervertebral discs following damage to the vertebral bodies: a cause of disc failure? Eur Spine J 1993; 1 : 214-21. (Pubitemid 23100324)
5. Lotz JC, Chin JR. Intervertebral disc cell death is dependent on the magnitude and duration of spinal loading. Spine 2000; 25 : 1477-83. (Pubitemid 30418460)
6. Walsh AJ, Lotz JC. Biological response of the intervertebral disc to dynamic loading. J Biomech 2004; 37 : 329-37. (Pubitemid 38156081)
7. Handa T, Ishihara H, Ohshima H, et al. Effects of hydrostatic pressure on matrix synthesis and matrix metalloproteinase production in the human lumbar intervertebral disc. Spine 1997; 22 : 1085-91 (Pubitemid 27209349)
8. Ishihara H, McNally DS, Urban JP, et al. Effects of hydrostatic pressure on matrix synthesis in different regions of the intervertebral disk. J Appl Physiol 1996; 80 : 839-46. (Pubitemid 26087247)
9. Bibby SR, Urban JP. Effect of nutrient deprivation on the viability of intervertebral disc cells. Eur Spine J 2004; 13 : 695-701. (Pubitemid 40416836)
10. Horner HA, Urban JP. 2001 Volvo Award Winner in Basic Science Studies: Effect of nutrient supply on the viability of cells from the nucleus pulposus of the intervertebral disc. Spine 2001; 26 : 2543-9. (Pubitemid 33134301)
11. Ohshima H, Urban JP. The effect of lactate and pH on proteoglycan and protein synthesis rates in the intervertebral disc. Spine 1992; 17 : 1079-82.
12. Benneker LM, Heini PF, Alini M, et al. 2004 Young Investigator Award Winner: Vertebral endplate marrow contact channel occlusions and intervertebral disc degeneration. Spine 2005; 30 : 167-73. (Pubitemid 40348204)
13. Roberts S, Urban JP, Evans H, et al. Transport properties of the human cartilage endplate in relation to its composition and calcification. Spine 1996; 21 : 415-20. (Pubitemid 26067848)
14. Rajasekaran S, Babu JN, Arun R, et al. ISSLS prize winner: A study of diffusion in human lumbar discs: a serial magnetic resonance imaging study documenting the influence of the endplate on diffusion in normal and degenerate discs. Spine 2004; 29 : 2654-67. (Pubitemid 40353251)
15. Nachemson A, Lewin T, Maroudas A, et al. In vitro diffusion of dye through the end-plates and the annulus fibrosus of human lumbar inter-vertebral discs. Acta Orthop Scand 1970; 41 : 589-607.
16. Edwards WT, Zheng YG, Ferrara LA, et al. Structural features and thickness of the vertebral cortex in the thoracolumbar spine. Spine 2001; 26 : 218-25. (Pubitemid 32115615)
17. Rodriguez AG, Rodriguez-Soto AE, Burghardt AJ, et al. Morphology of the human vertebral endplate. J Orthop Res 2012; 30 : 280-7.
18. Silva MJ, Wang C, Keaveny TM, et al. Direct and computed-tomography thickness measurements of the human lumbar vertebral shell and end-plate. Bone 1994; 15 : 409-14. (Pubitemid 24168013)
19. Wang Y, Battie MC, Boyd SK, et al. The osseous endplates in lumbar vertebrae: thickness, bone mineral density and their associations with age and disk degeneration. Bone 2011; 48 : 804-9.
20. Zhao FD, Pollintine P, Hole BD, et al. Vertebral fractures usually affect the cranial endplate because it is thinner and supported by less-dense trabecular bone. Bone 2009; 44 : 372-9.
21. Vernon-Roberts B, Pirie CJ. Degenerative changes in the intervertebral discs of the lumbar spine and their sequelae. Rheumatol Rehabil 1977; 16 : 13-21. (Pubitemid 8046526)
22. Fields AJ, Lee GL, Keaveny TM. Mechanisms of initial endplate failure in the human vertebral body. J Biomech 2010; 43 : 3126-31.
23. Grant JP, Oxland TR, Dvorak MF. Mapping the structural properties of the lumbosacral vertebral endplates. Spine 2001; 26 : 889-96. (Pubitemid 32373975)
24. Rodriguez AG, Slichter CK, Acosta FL, et al. Human disc nucleus properties and vertebral endplate permeability. Spine 2011; 36 : 512-20.
25. Kim YJ, Sah RL, Doong JY, et al. Fluorometric assay of DNA in cartilage explants using Hoechst 33258. Anal Biochem 1988; 174 : 168-76. (Pubitemid 18261664)
26. Farndale RW, Buttle DJ, Barrett AJ. Improved quantitation and discrimination of sulphated glycosaminoglycans by use of dimethylmethylene blue. Biochim Biophys Acta 1986; 883 : 173-7. (Pubitemid 16027978)
27. Van Rietbergen B, Weinans H, Huiskes R, et al. A new method to determine trabecular bone elastic properties and loading using micromechanical finite-element models. J Biomech 1995; 28 : 69-81. (Pubitemid 24343733)
28. Niebur GL, Yuen JC, Hsia AC, et al. Convergence behavior of highresolution finite element models of trabecular bone. J Biomech Eng 1999; 121 : 629-35. (Pubitemid 30010729)
29. Bevill G, Eswaran SK, Farahmand F, et al. The influence of boundary conditions and loading mode on high-resolution finite element-computed trabecular tissue properties. Bone 2009; 44 : 573-8.
30. Athanasiou KA, Rosenwasser MP, Buckwalter JA, et al. Interspecies comparisons of in situ intrinsic mechanical properties of distal femoral cartilage. J Orthop Res 1991; 9 : 330-40.
31. Duncan NA, Lotz JC. Experimental validation of a porohyperelastic finite element model of the annulus fibrosus. In: Computer Methods in Biomechanics and Biomedical Engineering. New York, NY : Gordon and Breach; 1998 : 527-34.
32. Natarajan RN, Williams JR, Andersson GB. Recent advances in analytical modeling of lumbar disc degeneration. Spine 2004; 29 : 2733-41. (Pubitemid 40353259)
33. Bevill G, Easley SK, Keaveny TM. Side-artifact errors in yield strength and elastic modulus for human trabecular bone and their dependence on bone volume fraction and anatomic site. J Biomech 2007; 40 : 3381-8. (Pubitemid 47632594)
34. Adams MF, Bayraktar HH, Keaveny TM, et al. Ultrascalable implicit finite element analyses in solid mechanics with over a half a billion degrees of freedom. ACM/IEEE Proceedings of SC2004: High Performance Networking and Computing ; Pittsburgh, PA ; November 6-12, 2004.
35. Antoniou J, Steffen T, Nelson F, et al. The human lumbar intervertebral disc: evidence for changes in the biosynthesis and denaturation of the extracellular matrix with growth, maturation, ageing, and degeneration. J Clin Invest 1996; 98 : 996-1003. (Pubitemid 26293318)
36. Hulme PA, Boyd SK, Ferguson SJ. Regional variation in vertebral bone morphology and its contribution to vertebral fracture strength. Bone 2007; 41 : 946-57. (Pubitemid 350116742)
37. Brinckmann P, Frobin W, Hierholzer E, et al. Deformation of the vertebral end-plate under axial loading of the spine. Spine 1983; 8 : 851-6. (Pubitemid 14151416)
38. Yoganandan N, Maiman DJ, Pintar F, et al. Microtrauma in the lumbar spine: a cause of low back pain. Neurosurgery; 1988; 23: 162-8.
39. Feng YS, Moses F. Optimum design, redundancy, and reliability of structural systems. Comput Struct 1986; 24 : 239-51.
40. Schafer BW, Bajpai P. Stability degradation and redundancy in damaged structures. Eng Struct 2005; 27 : 1642-51. (Pubitemid 41102602)
41. Fields AJ, Nawathe S, Eswaran SK, et al. Vertebral fragility and structural redundancy. J Bone Miner Res. In press.
42. Hsu KY, Zucherman JF, Derby R, et al. Painful lumbar endplate disruptions - a significant discographic finding. Spine 1988; 13 : 76-8.
43. Crock HV, Goldwasser M. Anatomic studies of the circulation in the region of the vertebral end-plate in adult Greyhound dogs. Spine 1984; 9 : 702-6. (Pubitemid 15190619)
44. Roberts S, Menage J, Urban JP. Biochemical and structural properties of the cartilage end-plate and its relation to the intervertebral disc. Spine 1989; 14 : 166-74. (Pubitemid 19059686)
45. Maroudas A, Stockwell RA, Nachemson A, et al. Factors involved in the nutrition of the human lumbar intervertebral disc: cellularity and diffusion of glucose in vitro. J Anat 1975; 120 : 113-30.
46. Liu YJ, Huang GS, Juan CJ, et al. Intervertebral disk degeneration related to reduced vertebral marrow perfusion at dynamic contrast-enhanced MRI. AJR Am J Roentgenol 2009; 192 : 974-9.
47. Battie MC, Videman T, Gibbons LE, et al. 1995 Volvo Award in clinical sciences. Determinants of lumbar disc degeneration. A study relating lifetime exposures and magnetic resonance imaging findings in identical twins. Spine 1995; 20 : 2601-12. (Pubitemid 26011067)
48. Eswaran SK, Gupta A, Keaveny TM. Locations of bone tissue at high risk of initial failure during compressive loading of the human vertebral body. Bone 2007; 41 : 733-9. (Pubitemid 47385424)
49. Homminga J, Van-Rietbergen B, Lochmüller EM, et al. The osteoporotic vertebral structure is well adapted to the loads of daily life, but not to infrequent "error" loads. Bone 2004; 34 : 510-6. (Pubitemid 38314915)
50. Antoniou J, Goudsouzian NM, Heathfield TF, et al. The human lumbar endplate. Evidence of changes in biosynthesis and denaturation of the extracellular matrix with growth, maturation, aging, and degeneration. Spine 1996; 21 : 1153-61. (Pubitemid 26161379)
51. Iatridis JC, Weidenbaum M, Setton LA, et al. Is the nucleus pulposus a solid or a fluid? Mechanical behaviors of the nucleus pulposus of the human intervertebral disc. Spine 1996; 21 : 1174-84. (Pubitemid 26161382)
52. Pollintine P, van Tunen MS, Luo J, et al. Time-dependent compressive deformation of the ageing spine: relevance to spinal stenosis. Spine 2010; 35 : 386-94.