Functional neuroimaging demonstrates that ghrelin inhibits the central nervous system response to ingested lipid

Gut

Volumn 61, Issue 11, 2012, Pages 1543-1551

  Jones, Richard B ^a   McKie, Shane ^a   Astbury, Nerys ^a   Little, Tanya J ^a   Tivey, Stacey ^a   Lassman, Daniel J ^a   McLaughlin, John ^a   Luckman, Simon ^a   Williams, Steve R ^a   Dockray, Graham J ^b   Thompson, David G ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARBON; GHRELIN; RECOMBINANT HORMONE;

ADULT; ANATOMICAL VARIATION; ARTICLE; BLOOD SAMPLING; BOLD SIGNAL; BRAIN FUNCTION; BRAIN STEM; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; ELECTROENCEPHALOGRAM; ENZYME ACTIVATION; ENZYME INHIBITION; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HORMONE BLOOD LEVEL; HUMAN; HUMAN EXPERIMENT; HYPOTHALAMUS; IMAGE ANALYSIS; IMAGE DISPLAY; LIMBIC CORTEX; NEUROIMAGING; NORMAL HUMAN; OUTCOME ASSESSMENT; PHARMACOLOGICAL FUNCTIONAL MAGNETIC RESONANCE IMAGING; PHYSIOLOGICAL FUNCTIONAL MAGNETIC RESONANCE IMAGING; POSTPRANDIAL STATE; PRIORITY JOURNAL; SATIETY;

ADULT; BODY MASS INDEX; CENTRAL NERVOUS SYSTEM; COHORT STUDIES; DOSE-RESPONSE RELATIONSHIP, DRUG; EATING; FEMALE; FUNCTIONAL NEUROIMAGING; GASTRIC EMPTYING; GHRELIN; HUMANS; HUNGER; INFUSIONS, INTRAVENOUS; LIPID METABOLISM; LIPIDS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; POSTPRANDIAL PERIOD; REFERENCE VALUES; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84866983792     PISSN: 00175749     EISSN: 14683288     Source Type: Journal    
DOI: 10.1136/gutjnl-2011-301323     Document Type: Article

References (42)

1. Dockray GJ. Gut endocrine secretions and their relevance to satiety. Curr Opin Pharmacol 2004;4:557-60.
2. Capasso R, Izzo AA. Gastrointestinal regulation of food intake: general aspects and focus on anandamide and oleoylethanolamide. J Neuroendocrinol 2008;20(Suppl 1):39-46. (Pubitemid 351552675)
3. Gibbs J, Young RC, Smith GP. Cholecystokinin elicits satiety in rats with open gastric fistulas. Nature 1973;245:323-5.
4. Batterham RL, Cowley MA, Small CJ, et al. Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 2002;418:650-4.
5. Turton MD, O'Shea D, Gunn I, et al. A role for glucagon-like peptide-1 in the central regulation of feeding. Nature 1996;379:69-72. (Pubitemid 26008136)
6. Rodriguez DF, Navarro M, Gomez R, et al . An anorexic lipid mediator regulated by feeding. Nature 2001;414:209-12. (Pubitemid 33051235)
7. Tschop M, Smiley DL, Heiman ML. Ghrelin induces adiposity in rodents. Nature 2000;407:908-13.
8. Gomez R, Navarro M, Ferrer B, et al. A peripheral mechanism for CB1 cannabinoid receptor-dependent modulation of feeding. J Neurosci 2002;22:9612-17. (Pubitemid 35356203)
9. Grill HJ. Leptin and the systems neuroscience of meal size control. Front Neuroendocrinol 2010; 31:61-78.
10. Schwartz MW, Woods SC, Porte D Jr, et al. Central nervous system control of food intake. Nature 2000;404:661-71. (Pubitemid 30205071)
11. McLaughlin J, Grazia LM, Jones MN, et al. Fatty acid chain length determines cholecystokinin secretion and effect on human gastric motility. Gastroenterology 1999;116:46-53. (Pubitemid 29013492)
12. Raybould HE. Gut chemosensing: interactions between gut endocrine cells and visceral afferents. Auton Neurosci 2010;153:41-6.
13. Moran TH, Smith GP, Hostetler AM, et al. Transport of cholecystokinin (CCK) binding sites in subdiaphragmatic vagal branches. Brain Res 1987;415:149-52. (Pubitemid 17097385)
14. Smith GP, Jerome C, Cushin BJ, et al. Abdominal vagotomy blocks the satiety effect of cholecystokinin in the rat. Science 1981;213:1036-7.
15. Raybould HE, Tache Y. Cholecystokinin inhibits gastric motility and emptying via a capsaicin-sensitive vagal pathway in rats. Am J Physiol 1988;255:G242-6.
16. Dockray GJ. The versatility of the vagus. Physiol Behav 2009;97:531-6.
17. Kojima M, Hosoda H, Date Y, et al. Ghrelin is a growth-hormone-releasing acylated peptide from stomach. Nature 1999;402:656-60. (Pubitemid 129516334)
18. Cummings DE, Weigle DS, Frayo RS, et al. Plasma ghrelin levels after diet-induced weight loss or gastric bypass surgery. N Engl J Med 2002; 346:1623-30. (Pubitemid 34755670)
19. Wren AM, Small CJ, Ward HL, et al. The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion. Endocrinology 2000;141:4325-8.
20. Asakawa A, Inui A, Kaga T, et al. Ghrelin is an appetite-stimulatory signal from stomach with structural resemblance to motilin. Gastroenterology 2001;120:337-45. (Pubitemid 32149296)
21. Zhao TJ, Liang G, Li RL, et al. Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A 2010;107:7467-72.
22. Date Y, Murakami N, Toshinai K, et al. The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats. Gastroenterology 2002;123:1120-8.
23. Page AJ, Slattery JA, Milte C, et al. Ghrelin selectively reduces mechanosensitivity of upper gastrointestinal vagal afferents. Am J Physiol Gastrointest Liver Physiol 2007;292:G1376-84. (Pubitemid 47084656)
24. Arnold M, Mura A, Langhans W, et al. Gut vagal afferents are not necessary for the eating-stimulatory effect of intraperitoneally injected ghrelin in the rat. J Neurosci 2006;26:11052-60. (Pubitemid 44772195)
25. Date Y, Toshinai K, Koda S, et al. Peripheral interaction of ghrelin with cholecystokinin on feeding regulation. Endocrinology 2005;146:3518-25. (Pubitemid 41058123)
26. Burdyga G, Varro A, Dimaline R, et al. Ghrelin receptors in rat and human nodose ganglia: putative role in regulating CB-1 and MCH receptor abundance. Am J Physiol Gastrointest Liver Physiol 2006; 290:G1289-97. (Pubitemid 43788312)
27. Burdyga G, Varro A, Dimaline R, et al. Expression of cannabinoid CB1 receptors by vagal afferent neurons: kinetics, and role in influencing neurochemical phenotype. Am J Physiol Gastrointest Liver Physiol 2010;299:G1514-24.
28. Lassman DJ, McKie S, Gregory LJ, et al. Defining the role of cholecystokinin in the lipid-induced human brain activation matrix. Gastroenterology 2010;138:1514-24.
29. Lal S, McLaughlin J, Barlow J, et al. Cholecystokinin pathways modulate sensations induced by gastric distension in man. Am J Physiol Gastrointest Liver Physiol 2004; 287:G72-9. (Pubitemid 38802121)
30. Turner R, Howseman A, Rees GE, et al . Functional magnetic resonance imaging of the human brain: data acquisition and analysis. Exp Brain Res 1998; 123:5-12. (Pubitemid 28495290)
31. McKie S, Del-Ben C, Elliott R, et al. Neuronal effects of acute citalopram detected by pharmacoMRI. Psychopharmacology (Berl) 2005;180 :680-6. (Pubitemid 41317864)
32. Braden B, Adams S, Duan LP, et al. The [13C]acetate breath test accurately reflects gastric emptying of liquids in both liquid and semisolid test meals. Gastroenterology 1995; 108:1048-55.
33. Druce MR, Wren AM, Park AJ, et al. Ghrelin increases food intake in obese as well as lean subjects. Int J Obes (Lond) 2005;29 :1130-6. (Pubitemid 41192222)
34. Batterham RL, ffytche DH, Rosenthal JM, et al . PYY modulation of cortical and hypothalamic brain areas predicts feeding behaviour in humans. Nature 2007; 450:106-9.
35. Malik S, McGlone F, Bedrossian D, et al. Ghrelin modulates brain activity in areas that control appetitive behavior. Cell Metab 2008;7:400-9. (Pubitemid 351598026)
36. Menyhert J, Wittmann G, Hrabovszky E, et al. Distribution of ghrelin-immunoreactive neuronal networks in the human hypothalamus. Brain Res 2006; 1125:31-6. (Pubitemid 44838545)
37. Zigman JM, Jones JE, Lee CE, et al. Expression of ghrelin receptor mRNA in the rat and the mouse brain. J Comp Neurol 2006; 494:528-48. (Pubitemid 41791000)
38. Nakazato M, Murakami N, Date Y, et al . A role for ghrelin in the central regulation of feeding. Nature 2001;409:194-8. (Pubitemid 32144284)
39. Kuo YT, Parkinson JR, Chaudhri OB, et al. The temporal sequence of gut peptide CNS interactions tracked in vivo by magnetic resonance imaging. J Neurosci 2007; 27:12341-8. (Pubitemid 350085464)
40. Hewson AK, Tung LY, Connell DW, et al. The rat arcuate nucleus integrates peripheral signals provided by leptin, insulin, and a ghrelin mimetic. Diabetes 2002; 51:3412-19. (Pubitemid 35403444)
41. Kobelt P, Tebbe JJ, Tjandra I, et al. CCK inhibits the orexigenic effect of peripheral ghrelin. Am J Physiol Regul Integr Comp Physiol 2005;288:R751-8. (Pubitemid 40250589)
42. Lawrence CB, Snape AC, Baudoin FM, et al . Acute central ghrelin and GH secretagogues induce feeding and activate brain appetite centers. Endocrinology 2002; 143:155-62. (Pubitemid 34056414)