Application of linear discriminant analysis in performance evaluation of extractable nuclear antigen immunoassay systems in the screening and diagnosis of systemic autoimmune rheumatic diseases

American Journal of Clinical Pathology

Volumn 138, Issue 4, 2012, Pages 596-603

  Pi, David ^a,b   De Badyn, Monika Hudoba ^a,b   Nimmo, Mike ^a,b   White, Rick ^a   Pal, Jason ^b   Wong, Patrick ^a   Phoon, Carmen ^b   O'Connor, Deidre ^a   Pi, Steven ^a   Shojania, Kam ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b VANCOUVER GENERAL HOSPITAL   (Canada)

Author keywords

Diagnostic algorithm; Discriminant analysis; Immunopathology; Systemic autoimmune rheumatic disease

Indexed keywords

AUTOANTIBODY;

ACUTE LEUKEMIA; ANTIBODY DETECTION; ANTIPHOSPHOLIPID SYNDROME; AREA UNDER THE CURVE; ARTHRALGIA; ARTHRITIS; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNE HEPATITIS; AUTOIMMUNE THROMBOCYTOPENIA; AUTOIMMUNE THYROIDITIS; BRAIN DISEASE; CELIAC DISEASE; CYTOPENIA; DERMATOMYOSITIS; DRUG HYPERSENSITIVITY; ENTEROCOLITIS; ENZYME LINKED IMMUNOSORBENT ASSAY; HEPATITIS; HUMAN; IMMUNOASSAY; IMMUNOCHEMISTRY; INTERMETHOD COMPARISON; KIDNEY DISEASE; LIVER CIRRHOSIS; LYMPHOPROLIFERATIVE DISEASE; MAJOR CLINICAL STUDY; MIXED CONNECTIVE TISSUE DISEASE; MULTIPLE SCLEROSIS; MULTIPLEX BEAD BASED IMMUNOASSAY; MYASTHENIA; PLASMA CELL DYSCRASIA; POLYMYOSITIS; POLYNEUROPATHY; PRIORITY JOURNAL; PYREXIA IDIOPATHICA; RAYNAUD PHENOMENON; RHEUMATIC DISEASE; RHEUMATOID ARTHRITIS; SARCOIDOSIS; SCLERODERMA; SENSITIVITY AND SPECIFICITY; SEPTICEMIA; SJOEGREN SYNDROME; SKIN DISEASE; SYSTEMIC AUTOIMMUNE RHEUMATIC DISEASE; SYSTEMIC LUPUS ERYTHEMATOSUS; SYSTEMIC VASCULITIS; ULCERATIVE COLITIS; VIRUS INFECTION; WILSON DISEASE;

ANTIGENS, NUCLEAR; AUTOANTIBODIES; AUTOIMMUNE DISEASES; DISCRIMINANT ANALYSIS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; IMMUNOASSAY; MASS SCREENING; MICROSPHERES; REAGENT KITS, DIAGNOSTIC; RHEUMATIC DISEASES; SENSITIVITY AND SPECIFICITY; TERTIARY CARE CENTERS;

EID: 84866976027     PISSN: 00029173     EISSN: 19437722     Source Type: Journal    
DOI: 10.1309/AJCPX1SQXKI3MWNN     Document Type: Article

References (18)

1. Stinton LM, Fritzler MJ. A clinical approach to autoantibody testing in systemic autoimmune rheumatic disorders. Autoimmun Rev. 2007;7:77-84. (Pubitemid 47633394)
2. Tozzoli R, Bizzaro N, Tonutti E, et al. Guidelines for the laboratory use of autoantibody tests in the diagnosis and monitoring of autoimmune rheumatic disease. Am J Clin Pathol. 2002;117:316-324. (Pubitemid 34823674)
3. Solomon DH, Kavanaugh AJ, Schur PH, et al. Evidence-based guidelines for the use of immunologic tests: antinuclear antibody testing. Arthritis Rheum. 2002;47:434-444. (Pubitemid 34856134)
4. Froelich CJ, Wallman J, Skosey JL, et al. Clinical value of an integrated ELISA system for the detection of 6 autoantibodies (ssDNA, dsDNA, Sm, RNP/Sm, SSA, and SSB). J Rheumatol. 1990;17:192-200. (Pubitemid 20108222)
5. Lopez-Hoyos M, Rodriguez-Valverde V, Martinez-Taboada V. Performance of antinuclear antibody connective tissue disease screen. Ann NY Acad Sci. 2007;1109:322-329. (Pubitemid 47511375)
6. Bonilla E, Francis L, Allam F, et al. Immunofluorescence microscopy is superior to fluorescent beads for detection of antinuclear antibody reactivity in systemic lupus erythematosus patients. Clin Immunol. 2007;124:18-21. (Pubitemid 46951036)
7. Gonzalez C, Martin T, Arroyo T, et al. Comparison and variation of different methodologies for the detection of autoantibodies to nuclear antigens (ANA). J Clin Lab Anal. 1997;11:388-392. (Pubitemid 27513675)
8. Hanly JG, Thompson K, McCurdy G, et al. Measurement of autoantibodies using multiplex methodology in patients with systemic lupus erythematosus. J Immunol Meth. 2009;352:147-152.
9. Avaniss-Aghajani E, Berzon S, Sarkissian A. Clinical value of multiplexed bead-based immunoassays for detection of autoantibodies to nuclear antigens. Clin Vaccine Immunol. 2007;14:505-509.
10. Nifli AP, Notas G, Mamoulaki M, et al. Comparison of a multiplex, bead-based fluorescent assay and immunofluorescence methods for the detection of ANA and ANCA autoantibodies in human serum. J Immunol Meth. 2006;311:189-197.
11. Meroni PL, Schur PH. ANA screening: an old test with new recommendations. Ann Rheum Dis. 2010;69:1420-1422.
12. McLachlan GJ. Selection of feature variables in discriminant analysis. Discriminant Analysis and Statistical Pattern Recognition. 2nd ed. Hoboken, NJ: John Wiley & Sons; 2004:398-400.
13. Kurien BT, Scofield RH. Autoantibody determination in the diagnosis of systemic lupus erythematosus. Scand J Immunol. 2006;64:227-235. (Pubitemid 44215112)
14. Verstegen G, Duyck MC, Meeus P, et al. Detection and identification of anti-nuclear antibodies (ANA) in a large community hospital. Acta Clin Belg. 2009;64:317-323.
15. Kang I, Siperstein R, Quan T, et al. Utility of age, gender, ANA titer and pattern as predictors of anti-ENA and -dsDNA antibodies. Clin Rheumatol. 2004;23:509-515. (Pubitemid 39562257)
16. Dellavance A, Viana VST, Leon EP, et al. The clinical spectrum of antinuclear antibodies associated with the nuclear dense fine speckled immunofluorescence pattern. J Rheumatol. 2005;32:2144-2149. (Pubitemid 41587858)
17. ARUP Laboratories. Connective tissue disease testing algorithm. Available at www.arupconsult.com/Algorithms/ ConnectiveTissueDz.pdf. Accessed May 10, 2012.
18. Mayo Medical Laboratories. Connective tissue disease cascade (CTDC) test-ordering algorithm. Available at www.mayomedicallaboratories.com/test- catalog/ Clinical+and+Interpretive/9026. Accessed May 10, 2012.