Correlation of C-reactive protein haplotypes with serum C-reactive protein level and response to anti-tumor necrosis factor therapy in UK rheumatoid arthritis patients: results from the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate cohort

Arthritis Research and Therapy

Volumn 14, Issue 5, 2012, Pages

  Plant, Darren ^a   Ibrahim, Ibrahim ^a   Lunt, Mark ^a   Eyre, Stephen ^a   Flynn, Edward ^a   Hyrich, Kimme L ^a   Morgan, Ann W ^b,c   Wilson, Anthony G ^d   Isaacs, John D ^e   Barton, Anne ^a,f  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b CHAPEL ALLERTON HOSPITAL   (United Kingdom)

^c ST JAMES S UNIVERSITY HOSPITAL   (United Kingdom)

^d UNIVERSITY OF SHEFFIELD   (United Kingdom)

^e NEWCASTLE UNIVERSITY   (United Kingdom)

^f MANCHESTER UNIVERSITY NHS FOUNDATION TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

C REACTIVE PROTEIN; DNA; TUMOR NECROSIS FACTOR ANTIBODY; ANTIRHEUMATIC AGENT; BIOLOGICAL PRODUCT; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE FREQUENCY; GENE LOCUS; GENETIC VARIABILITY; GENETICS; GENOTYPE; HAPLOTYPE; HUMAN; MAJOR CLINICAL STUDY; MALE; RHEUMATOID ARTHRITIS; SINGLE NUCLEOTIDE POLYMORPHISM; TREATMENT RESPONSE; AGED; ALGORITHM; ANTAGONISTS AND INHIBITORS; ARTHRITIS, RHEUMATOID; BLOOD; COHORT ANALYSIS; COMPARATIVE STUDY; ERYTHROCYTE SEDIMENTATION RATE; GENOMICS; METABOLISM; MIDDLE AGED; PHARMACOGENETICS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; UNITED KINGDOM;

AGED; ALGORITHMS; ANTIRHEUMATIC AGENTS; ARTHRITIS, RHEUMATOID; BIOLOGICAL PRODUCTS; BLOOD SEDIMENTATION; C-REACTIVE PROTEIN; COHORT STUDIES; FEMALE; GENOMICS; GREAT BRITAIN; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; PHARMACOGENETICS; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84866975986     PISSN: 14786354     EISSN: 14786362     Source Type: Journal    
DOI: 10.1186/ar4052     Document Type: Article

References (31)

1. Scott DL, Wolfe F, Huizinga TW. Rheumatoid arthritis. Lancet 2010, 376:1094-1108. 10.1016/S0140-6736(10)60826-4, 20870100.
2. Firestein GS. Evolving concepts of rheumatoid arthritis. Nature 2003, 423:356-361. 10.1038/nature01661, 12748655.
3. Feldmann M, Maini RN. Anti-TNFalpha therapy of rheumatoid arthritis: what have we learned?. Annu Rev Immunol 2001, 19:163-196. 10.1146/annurev.immunol.19.1.163, 11244034.
4. Taylor PC, Feldmann M. Anti-TNF biologic agents: still the therapy of choice for rheumatoid arthritis. Nat Rev Rheumatol 2009, 5:578-582. 10.1038/nrrheum.2009.181, 19798034.
5. National Institute for Health and Clinical Excellence. , http://www.nice.org.uk/
6. Prevoo M, Van 'T Hof M, Kuper H, Van Leeuwen M, Van de Putte L, Van Riel P. Modified disease activity scores that include twenty-eight-joint counts: development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995, 38:44-48. 10.1002/art.1780380107, 7818570.
7. DAS-SCORE.NL. , http://www.das-score.nl/
8. Kushner I. C-reactive protein in rheumatology. Arthritis Rheum 1991, 35:982-984.
9. Wolfe F. Comparative usefulness of C-reactive protein and erythrocyte sedimentation rate in patients with rheumatoid arthritis. J Rheumatol 1997, 24:1477-1485.
10. D'Aiuto F, Casas JP, Shah T, Humphries SE, Hingorani AD, Tonetti MS. C-reactive protein (+1444C > T) polymorphism influences CRP response following a moderate inflammatory stimulus. Atherosclerosis 2005, 179:413-417. 10.1016/j.atherosclerosis.2004.10.036, 15777561.
11. Motoyama S, Miura M, Hinai Y, Maruyama K, Usami S, Nakatsu T, Saito H, Minamiya Y, Suzuki T, Ogawa J. C-reactive protein 1059 g > c genetic polymorphism influences serum C-reactive protein levels after esophagectomy in patients with thoracic esophageal cancer. J Am Coll Surg 2009, 209:477-483. 10.1016/j.jamcollsurg.2009.06.365, 19801321.
12. Perry T, Muehlschlegel J, Liu KY, Fox A, Collard C, Body S, Shernan S, . the CABG Genomics Investigators C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery. BMC Med Genet 2009, 10:38. 2686694, 19426506, the CABG Genomics Investigators.
13. Suk HJ, Ridker PM, Cook NR, Zee RYL. Relation of polymorphism within the C-reactive protein gene and plasma CRP levels. Atherosclerosis 2005, 178:139-145. 10.1016/j.atherosclerosis.2004.07.033, 15585211.
14. Brull DJ, Serrano N, Zito F, Jones L, Montgomery HE, Rumley A, Sharma P, Lowe GDO, World MJ, Humphries SE, Hingorani AD. Human CRP gene polymorphism influences CRP levels. Arterioscler Thromb Vasc Biol 2003, 23:2063-2069. 10.1161/01.ATV.0000084640.21712.9C, 12842840.
15. Rhodes B, Furnrohr BG, Vyse TJ. C-reactive protein in rheumatology: biology and genetics. Nat Rev Rheumatol 2011, 7:282-289. 10.1038/nrrheum.2011.37, 21468143.
16. Rhodes B, Merriman ME, Harrison A, Nissen MJ, Smith M, Stamp L, Steer S, Merriman TR, Vyse TJ. A genetic association study of serum acute-phase C-reactive protein levels in rheumatoid arthritis: implications for clinical interpretation. PLoS Med 2010, 7:e1000341. 10.1371/journal.pmed.1000341, 2943443, 20877716.
17. Hyrich KL, Watson KD, Isenberg DA, Symmons DPM. The British Society for Rheumatology Biologics Register: 6 years on. Rheumatology 2008, 47:1441-1443. 10.1093/rheumatology/ken242, 18596052.
18. Potter C, Hyrich KL, Tracey A, Lunt M, Plant D, Symmons DPM, Thomson W, Worthington J, Emery P, Morgan AW, Wilson AG, Isaacs J, Barton A, . BRAGGSS Association of rheumatoid factor and anti-cyclic citrullinated peptide positivity, but not carriage of shared epitope or PTPN22 susceptibility variants, with anti-tumour necrosis factor response in rheumatoid arthritis. Ann Rheum Dis 2009, 68:69-74. 2596303, 18375541, BRAGGSS.
19. Silman A, Symmons D, Scott DGI, Griffiths I. British Society for Rheumatology Biologics Register. Ann Rheum Dis 2003, 62:ii28-ii29. 1766752, 14532144.
20. Potter C, Cordell HJ, Barton A, Daly AK, Hyrich KL, Mann DA, Morgan AW, Wilson AG, , Isaacs JD. the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS) Association between anti-tumour necrosis factor treatment response and genetic variants within the TLR and NFκB signalling pathways. Ann Rheum Dis 2010, 69:1315-1320. 10.1136/ard.2009.117309, 20448286, the Biologics in Rheumatoid Arthritis Genetics and Genomics Study Syndicate (BRAGGSS).
21. Tan RJL, Gibbons LJ, Potter C, Hyrich KL, Morgan AW, Wilson AG, Isaacs JD, Barton A. Investigation of rheumatoid arthritis susceptibility genes identifies association of AFF3 and CD226 variants with response to anti-tumour necrosis factor treatment. Ann Rheum Dis 2010, 69:1029-1035. 10.1136/ard.2009.118406, 2930850, 20444755.
22. Sequenom. , http://www.sequenom.com
23. Morita A, Nakayama T, Doba N, Hinohara S, Mizutani T, Soma M. Genotyping of triallelic SNPs using TaqMan® PCR. Mol Cell Probes 2007, 21:171-176. 10.1016/j.mcp.2006.10.005, 17161935.
24. Applied Biosystems. , http://www.appliedbiosystems.com
25. Bioconductor. , http://www.bioconductor.org
26. STATA. , http://www.stata.com
27. Gene × Environment, Gene × Gene Interaction Home page. , http://hydra.usc.edu/gxe
28. Suk Danik J, Chasman DI, Cannon CP, Miller DT, Zee RYL, Kozlowski P, Kwiatkowski DJ, Ridker PM. Influence of genetic variation in the C-reactive protein gene on the inflammatory response during and after acute coronary ischemia. Ann Human Genet 2006, 70:705-716.
29. Dehghan A, Dupuis J, Barbalic M, Bis JC, Eiriksdottir G, Lu C, Pellikka N, Wallaschofski H, Kettunen J, Henneman P, Baumert J, Strachan DP, Fuchsberger C, Vitart V, Wilson JF, Pare G, Naitza S, Rudock ME, Surakka I, de Geus EJC, Alizadeh BZ, Guralnik J, Shuldiner A, Tanaka T, Zee RYL, Schnabel RB, Nambi V, Kavousi M, Ripatti S, Nauck M, et al. Meta-analysis of genome-wide association studies in > 80 000 subjects identifies multiple loci for C-reactive protein levels: clinical perspective. Circulation 2011, 123:731-738. 10.1161/CIRCULATIONAHA.110.948570, 3147232, 21300955.
30. Kuiper S, van Gestel AM, Swinkels HL, de Boo TM, da Silva JA, van Riel PL. Influence of sex, age, and menopausal state on the course of early rheumatoid arthritis. J Rheumatol 2001, 28:1809-1816.
31. Iikuni N, Sato E, Hoshi M, Inoue E, Taniguchi A, Hara M, Tomastu T, Kamatani N, Yamanaka H. The influence of sex on patients with rheumatoid arthritis in a large observational cohort. J Rheumatol 2009, 36:508-511. 10.3899/jrheum.080724, 19208610.