Recognition of mesothelin by the therapeutic antibody MORAb-009: Structural and mechanistic insights

Journal of Biological Chemistry

Volumn 287, Issue 40, 2012, Pages 33123-33131

  Ma, Jichun ^a,b   Tang, Wai Kwan ^a   Esser, Lothar ^a   Pastan, Ira ^a   Xia, Di ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b JANSSEN RESEARCH AND DEVELOPMENT   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY RECOGNITION; CLINICAL TRIAL; COMPLEX FORMATIONS; CONNECTING LOOPS; DISULFIDE BONDS; HUMAN TISSUES; HUMANIZED MONOCLONAL ANTIBODY; MESOTHELIAL CELLS; N-TERMINALS; PERITONEAL CAVITY; SIDE-CHAINS; STRUCTURAL ELEMENTS; THERAPEUTIC ANTIBODIES; THERAPEUTIC EFFECTS; TUMOR METASTASIS;

CELL ADHESION; COVALENT BONDS; DISEASES; MONOCLONAL ANTIBODIES; POLYPEPTIDES; TUMORS;

ANTIGENS;

AMATUXIMAB; CA 125 ANTIGEN; EPITOPE; MESOTHELIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANTIBODY DETECTION; ANTIGEN RECOGNITION; ARTICLE; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; DISULFIDE BOND; DRUG PROTEIN BINDING; GEL PERMEATION CHROMATOGRAPHY; GLYCOSYLATION; HYDROPHOBICITY; ISOTHERMAL TITRATION CALORIMETRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; PROTEIN PURIFICATION; PROTEIN STRUCTURE; SEQUENCE ALIGNMENT;

AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIGENS, NEOPLASM; BINDING SITES; CA-125 ANTIGEN; CELL DIFFERENTIATION; CRYSTALLOGRAPHY, X-RAY; DNA, COMPLEMENTARY; EPITOPES; GPI-LINKED PROTEINS; HUMANS; IMMUNOGLOBULIN G; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR SEQUENCE DATA; MUTATION; NEOPLASM METASTASIS; PROTEIN BINDING; RECOMBINANT FUSION PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; THIOREDOXINS;

EID: 84866941433     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.381756     Document Type: Article

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