WT1 CpG islands methylation in human lung cancer: A pilot study

Biochemical and Biophysical Research Communications

Volumn 426, Issue 3, 2012, Pages 306-309

  Bruno, Pierdonato ^a,b   Gentile, Giovanna ^a,b   Mancini, Rita ^a   de Vitis, Claudia ^a   Esposito, Maria Cristina ^a,b   Scozzi, Davide ^a,b   Mastrangelo, Mario ^a   Ricci, Alberto ^a,b   Mohsen, Ibrahim ^a,b   Ciliberto, Gennaro ^c   Simmaco, Maurizio ^a,b   Mariotta, Salvatore ^a,b  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

^b SAPIENZA UNIVERSITY OF ROME   (Italy)

^c NATIONAL CANCER INSTITUTE   (Italy)

Author keywords

Gene; Human; Lung cancer; Methylation; NSCLC; WT1

Indexed keywords

CIGARETTE SMOKE; DNA; WT1 PROTEIN;

AGED; ARTICLE; CANCER TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; CPG ISLAND; DNA EXTRACTION; DNA METHYLATION; FEMALE; HUMAN; HUMAN TISSUE; LUNG ADENOCARCINOMA; LUNG NON SMALL CELL CANCER; LUNG PARENCHYMA; LUNG SQUAMOUS CELL CARCINOMA; MALE; NUCLEOTIDE SEQUENCE; PILOT STUDY; PRIORITY JOURNAL; PYROSEQUENCING;

ADENOCARCINOMA; AGED; CARCINOMA, NON-SMALL-CELL LUNG; CELL TRANSFORMATION, NEOPLASTIC; CPG ISLANDS; DNA METHYLATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; HUMANS; LUNG; LUNG NEOPLASMS; MALE; MIDDLE AGED; PILOT PROJECTS; SMOKING; WT1 PROTEINS;

EID: 84866933726     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.08.059     Document Type: Article

References (26)

1. Parkin D.M., Bray F., Ferlay J., Pisani P. Global cancer statistics, 2002. CA Cancer J. Clin. 2005, 55:74-108.
2. Jubb A.M., Harris A.L. Biomarkers to predict the clinical efficacy of bevacizumab in cancer. Lancet Oncol. 2010, 11:1172-1183.
3. Gadgeel S.M., Cote M.L., Schwartz A.G., Matherly L.H., Wozniak A., Bepler G. Parameters for individualizing systemic therapy in non-small cell lung cancer. Drug Resist. Updat. 2010, 13:196-204.
4. Chen Z.X., Riggs A.D. Maintenance and regulation of DNA methylation patterns in mammals. Biochem. Cell Biol. 2005, 83:438-448.
5. Zochbauer-Muller S., Fong K.M., Virmani A.K., Geradts J., Gazdar A.F., Minna J.D. Aberrant promoter methylation of multiple genes in non-small cell lung cancers. Cancer Res. 2001, 61:249-255.
6. Toyooka S., Maruyama R., Toyooka K.O., McLerran D., Feng Z., Fukuyama Y., Virmani A.K., Zochbauer-Muller S., Tsukuda K., Sugio K., Shimizu N., Shimizu K., Lee H., Chen C.Y., Fong K.M., Gilcrease M., Roth J.A., Minna J.D., Gazdar A.F. Smoke exposure, histologic type and geography-related differences in the methylation profiles of non-small cell lung cancer. Int. J. Cancer 2003, 103:153-160.
7. Yanagawa N., Tamura G., Oizumi H., Takahashi N., Shimazaki Y., Motoyama T. Promoter hypermethylation of tumor suppressor and tumor-related genes in non-small cell lung cancers. Cancer Sci. 2003, 94:589-592.
8. Franklin W.A. Premalignant evolution of lung cancer: Gilles F Filley lecture. Chest 2004, 125:90S-94S.
9. Topaloglu O., Hoque M.O., Tokumaru Y., Lee J., Ratovitski E., Sidransky D., Moon C.S. Detection of promoter hypermethylation of multiple genes in the tumor and bronchoalveolar lavage of patients with lung cancer. Clin. Cancer Res. 2004, 10:2284-2288.
10. Dammann R., Strunnikova M., Schagdarsurengin U., Rastetter M., Papritz M., Hattenhorst U.E., Hofmann H.S., Silber R.E., Burdach S., Hansen G. CpG island methylation and expression of tumour-associated genes in lung carcinoma. Eur. J. Cancer. 2005, 41:1223-1236.
11. Kim Y.T., Park S.J., Lee S.H., Kang H.J., Hahn S., Kang C.H., Sung S.W., Kim J.H. Prognostic implication of aberrant promoter hypermethylation of CpG islands in adenocarcinoma of the lung. J. Thorac. Cardiovasc. Surg. 2005, 130:1378.
12. Tessema M., Yu Y.Y., Stidley C.A., Machida E.O., Schuebel K.E., Baylin S.B., Belinsky S.A. Concomitant promoter methylation of multiple genes in lung adenocarcinomas from current, former and never smokers. Carcinogenesis 2009, 30:1132-1138.
13. Green L.M., Wagner K.J., Campbell H.A., Addison K., Roberts S.G. Dynamic interaction between WT1 and BASP1 in transcriptional regulation during differentiation. Nucleic Acids Res. 2009, 37:431-440.
14. Call K.M., Glaser T., Ito C.Y., Buckler A.J., Pelletier J., Haber D.A., Rose E.A., Kral A., Yeger H., Lewis W.H. Isolation and characterization of a zinc finger polypeptide gene at the human chromosome 11 Wilms' tumor locus. Cell 1990, 60:509-520.
15. Oji Y., Ogawa H., Tamaki H., Oka Y., Tsuboi A., Kim E.H., Soma T., Tatekawa T., Kawakami M., Asada M., Kishimoto T., Sugiyama H. Expression of the Wilms' tumor gene WT1 in solid tumors and its involvement in tumor cell growth. Jpn. J. Cancer Res. 1999, 90:194-204.
16. Vicent S., Chen R., Sayles L.C., Lin C., Walker R.G., Gillespie A.K., Subramanian A., Hinkle G., Yang X., Saif S., Root D.E., Huff V., Hahn W.C., Sweet-Cordero E.A. Wilms tumor 1 (WT1) regulates KRAS-driven oncogenesis and senescence in mouse and human models. J. Clin. Invest. 2010, 120:3940-3952.
17. Scharnhorst V., Dekker P., van der Eb A.J., Jochemsen A.G. Internal translation initiation generates novel WT1 protein isoforms with distinct biological properties. J. Biol. Chem. 1999, 274:23456-23462.
18. Krug L.M., Dao T., Brown A.B., Maslak P., Travis W., Bekele S., Korontsvit T., Zakhaleva V., Wolchok J., Yuan J., Li H., Tyson L., Scheinberg D.A. WT1 peptide vaccinations induce CD4 and CD8 T cell immune responses in patients with mesotelioma and non-small cell lung cancer. Cancer Immunol. Immunother. 2010, 59:1467-1479.
19. Damiani L.A., Yingling C.M., Leng S., Romo P.E., Nakamura J., Belinsky S.A. Carcinogen-induced gene promoter hypermethylation is mediated by DNMT1 and causal for transformation of immortalized bronchial epithelial cells. Cancer Res. 2008, 68:9005-9014.
20. Leng S., Stidley C.A., Willink R., Bernauer A., Do K., Picchi M.A., Sheng X., Frasco M.A., Van Den Berg D., Gilliland F.D., Zima C., Crowell R.E., Belinsky S.A. Double-strand break damage and associated DNA repair genes predispose smokers to gene methylation. Cancer Res. 2008, 68:3049-3056.
21. Belinsky S.A., Liechty K.C., Gentry F.D., Wolf H.J., Rogers J., Vu K., Haney J., Kennedy T.C., Hirsch F.R., Miller Y., Franklin W.A., Herman J.G., Baylin S.B., Bunn P.A., Byers T. Promoter hypermethylation of multiple genes in sputum precedes lung cancer incidence in a high-risk cohort. Cancer Res. 2006, 66:338-3344.
22. Sun S., Schiller J.H., Gazdar A.F. Lung cancer in never smokers a different disease. Nat. Rev. Cancer 2007, 7:778-790.
23. Gazdar A.F., Thun M.J. Lung cancer, smoke exposure, and sex. J. Clin. Oncol. 2007, 25:469-471.
24. INK4A, and fragile histidine triad in nonsmall cell lung carcinoma. Cancer 2006, 15(106):2190-2199.
25. Suzuki M., Shigematsu H., Iizasa T., Hiroshima K., Nakatani Y., Minna J.D., Gazdar A.F., Fujisawa T. Exclusive mutation in epidermal growth factor receptor gene, HER-2, and KRAS, and synchronous methylation of nonsmall cell lung cancer. Cancer 2006, 15(106):2200-2207.
26. Maruyama R., Sugio K., Yoshino I., Maehara Y., Gazdar A.F. Hypermethylation of FHIT as a prognostic marker in nonsmall cell lung carcinoma. Cancer 2004, 1(100):1472-1477.