Synthesis and protective effect of scutellarein on focal cerebral ischemia/reperfusion in rats

Molecules

Volumn 17, Issue 9, 2012, Pages 10667-10674

  Qian, Lihua ^a   Shen, Minzhe ^a   Tang, Hao ^a   Tang, Yuping ^a   Zhang, Li ^a   Fu, Yifan ^a   Shi, Qianping ^a   Li, Nian Guang ^a  

^a NANJING UNIVERSITY OF CHINESE MEDICINE   (China)

Author keywords

Focal cerebral ischemia reperfusion; MCAO; Scutellarein; Scutellarin; Synthesis

Indexed keywords

APIGENIN; GLUCURONIC ACID; NEUROPROTECTIVE AGENT; SCUTELLAREIN; SCUTELLARIN;

ANIMAL; ARTICLE; BRAIN ISCHEMIA; CEREBRAL ARTERY DISEASE; METABOLISM; RAT; REPERFUSION INJURY; SYNTHESIS;

ANIMALS; APIGENIN; BRAIN ISCHEMIA; GLUCURONATES; INFARCTION, MIDDLE CEREBRAL ARTERY; NEUROPROTECTIVE AGENTS; RATS; REPERFUSION INJURY;

EID: 84866932808     PISSN: None     EISSN: 14203049     Source Type: Journal    
DOI: 10.3390/molecules170910667     Document Type: Article

References (21)

1. Donnan, G.A.; Fisher, M.; Macleod, M.; Davis, S.M. Stroke. Lancet 2008, 371, 1612-1623.
2. Cuzzocrea, S.; Riley, D.P.; Caputi, A.P.; Salvemini, D. Antioxidant therapy: A new pharmacological approach in shock, inflammation, and ischemia/reperfusion injury. Pharmacol. Rev. 2001, 53, 135-159.
3. Zhang, H.Y.; Ping, Q.N.; Guo, J.X.; Cao, F. Pharmacokinetics of breviscapine and its β-cyclodextrin complex in rats. Acta Pharmcol. Sin. 2005, 40, 563-567.
4. Cao, F.; Guo, J.X.; Ping, Q.N.; Shao, Y.; Liang, J. Ester prodrug of scutellarin: Synthesis, physicochemical property and degradation. Acta Pharmcol. Sin. 2006, 41, 595-602.
5. Ge, Q.H.; Zhou, Z.; Zhi, X.J.; Ma, L.L.; Chen, X.H. Pharmacokinetics and absolute bioavailability of breviscapine in beagle dogs. Chin. J. Pharm. 2003, 34, 618-632.
6. Zhang, J.L.; Che, Q.M.; Li, S.Z.; Zhou, T.H. Study on metabolism of scutellarin in rats by HPLC-MS and HPLC-NMR. J. Asian Nat. Prod. Res. 2003, 5, 249-256.
7. Che, Q.M.; Pan, L.Y.; Chen, Y.; He, H. Study on pharmacokinetics of scutellarein in rats. Chin. Pharm. J. 2007, 42, 1418-1421.
8. Ju, W.Z.; Zhang, J.; Tan, H.S.; Jiang, M.; Chen, M.; Xiong, N.N. Determination of scutellarin in human plasma by LC-MS method and its clinical pharmacokinetics in Chinese healthy volunteers. Chin. J. Clin. Pharmacol. Ther. 2005, 10, 298-301.
9. Qian, L.H.; Li, N.G.; Tang, Y.P.; Zhang, L.; Tang, H.; Wang, Z.J.; Liu, L.; Song, S.L.; Guo, J.M.; Ding, A.W. Synthesis and bio-Activity evaluation of scutellarein as a potent agent for the therapy of ischemic cerebrovascular disease. Int. J. Mol. Sci. 2011, 12, 8208-8216.
10. Song, Y.; Zhang, H.M.; Ma, J.J.; Che, Q.M.; Li, C.L. Protection of scutellarein on cerebral ischemia in rats. Chin. J. New Drug 2009, 18, 2061-2064.
11. Farkas, L.; Mezey-Vándor, G.; Nórdj, M. Die sythese des scutellarins, plantaginins, scutellarein-7-β-rutinosids und die erste herstellung des isoscutellareins. Chem. Ber. 1974, 107, 3878-3882.
12. Cui, J.M.; Fang, G.; Duan, Y.B. Total synthesis of scutellarin-7-O- glucuronide. J. Asian Nat. Prod. Res. 2005, 7, 655-660.
13. Wang, X.S.; Ruan, X.Z.; Liu, M.L. Study of erigeron on brain protection after cerebral ischemia and reperfusion in rats. Chin. Tradit. Pat. Med. 2002, 24, 947-950.
14. Pu, X.P.; Li, C.L. The revelation of cerebral ischemia cells promise on the development of new drugs. Chin. Pharm. J. 1999, 34, 579-581.
15. Chen, X.; Cui, L.; Duan, X.; Ma, B.; Zhong, D. Pharmacokinetics and metabolism of the flavonoid scutellarin in humans after a single oral administration. Drug Metab. Dispos. 2006, 34, 1345-1352.
16. Longa, E.Z.; Weinstein, P.R.; Carlson, S.; Cummins, R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke 1989, 20, 84-91.
17. Zhang, Y.; Zhang, F.G.; Meng, C.; Tian, S.Y.; Wang, Y.X.; Zhao, W.; Chen, J; Zhang, X.S.; Liang, Y.; Zhang, S.D.; et al. Inhibition of sevoflurane postconditioning against cerebral ischemia reperfusion-induced oxidative injury in rats. Molecules 2012, 17, 341-354.
18. Bederson, J.B.; Pitts, L.H.; Tsuji, M.; Nishimura, M.C.; Davis, R.L.; Bartkowski, H. Rat middle cerebral artery occlusion evaluation of the model and development of a neurologic examination. Stroke 1986, 17, 472-476.
19. Pei, H.T.; Su, X.; Zhao, L.; Li, H.Y.; Guo, Y.L.; Zhang, M.Z.; Xin, H. Primary study for the therapeutic dose and time window of picroside II in treating cerebral ischemic injury in rats. Int. J. Mol. Sci. 2012, 13, 2551-2562.
20. Li, Z.; Wang, B.S.; Kong, D.H.; Wang, L.C. The neuroprotective effect of pre-resveratrol on focal cerebral ischemia/reperfusion in rats. Chin. Pharmacol. Bull. 2010, 26, 802-806.
21. Zhou, J.; Liu, J. Protective effect of astragaloside on local cerebral ischemia in rats and its mechanism involved. J. Clin. Res. 2008, 25, 814-816.