MAML1 Acts Cooperatively with EGR1 to Activate EGR1-Regulated Promoters: Implications for Nephrogenesis and the Development of Renal Cancer

PLoS ONE

Volumn 7, Issue 9, 2012, Pages

  Hansson, Magnus L ^a   Behmer, Stefanie ^a   Ceder, Rebecca ^a   Mohammadi, Sadollah ^a   Preta, Giulio ^a   Grafström, Roland C ^a   Fadeel, Bengt ^a   Wallberg, Annika E ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

E1A ASSOCIATED P300 PROTEIN; EARLY GROWTH RESPONSE FACTOR 1; MESSENGER RNA; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR MAML1; UNCLASSIFIED DRUG;

ACETYLATION; ARTICLE; BIOINFORMATICS; CANCER PATIENT; CARCINOGENESIS; CONTROLLED STUDY; COPY NUMBER VARIATION; CORRELATION ANALYSIS; EGR1 GENE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME REGULATION; GENE TARGETING; GENETIC ASSOCIATION; HUMAN; HUMAN CELL; KIDNEY CARCINOMA; KIDNEY CELL; KIDNEY DEVELOPMENT; MAJOR CLINICAL STUDY; MAML1 GENE; ONCOGENE; P300 GENE; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RNA TRANSCRIPTION;

ACETYLATION; CELL LINE; DNA-BINDING PROTEINS; EARLY GROWTH RESPONSE PROTEIN 1; GENE DOSAGE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENOMICS; HCT116 CELLS; HEK293 CELLS; HUMANS; KIDNEY NEOPLASMS; P300-CBP TRANSCRIPTION FACTORS; PROMOTER REGIONS, GENETIC; PROTEIN INTERACTION MAPPING; RNA, MESSENGER; TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

EID: 84866910871     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0046001     Document Type: Article

References (27)

1. Kitagawa M, Oyama T, Kawashima T, Yedvobnick B, Kumar A, et al. (2001) A human protein with sequence similarity to Drosophila mastermind coordinates the nuclear form of notch and a CSL protein to build a transcriptional activator complex on target promoters. Mol Cell Biol 21: 4337-4346.
2. Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, et al. (2000) MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. Nat Genet 26: 484-489.
3. Kurooka H, Honjo T, (2000) Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. J Biol Chem 275: 17211-17220.
4. Oswald F, Tauber B, Dobner T, Bourteele S, Kostezka U, et al. (2001) p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol 21: 7761-7774.
5. Shen H, McElhinny AS, Cao Y, Gao P, Liu J, et al. (2006) The Notch coactivator, MAML1, functions as a novel coactivator for MEF2C-mediated transcription and is required for normal myogenesis. Genes Dev 20: 675-688.
6. Zhao Y, Katzman RB, Delmolino LM, Bhat I, Zhang Y, et al. (2007) The notch regulator MAML1 interacts with p53 and functions as a coactivator. J Biol Chem 282: 11969-11981.
7. Alves-Guerra MC, Ronchini C, Capobianco AJ, (2007) Mastermind-like 1 Is a specific coactivator of beta-catenin transcription activation and is essential for colon carcinoma cell survival. Cancer Res 67: 8690-8698.
8. Fryer CJ, Lamar E, Turbachova I, Kintner C, Jones KA, (2002) Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex. Genes Dev 16: 1397-1411.
9. Saint Just Ribeiro M, Hansson ML, Wallberg AE, (2007) A proline repeat domain in the Notch co-activator MAML1 is important for the p300-mediated acetylation of MAML1. Biochem J 404: 289-298.
10. Wallberg AE, Pedersen K, Lendahl U, Roeder RG, (2002) p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol 22: 7812-7819.
11. Hansson ML, Popko-Scibor AE, Saint Just Ribeiro M, Dancy BM, Lindberg MJ, et al. (2009) The transcriptional coactivator MAML1 regulates p300 autoacetylation and HAT activity. Nucleic Acids Res 37: 2996-3006.
12. Popko-Scibor AE, Lindberg MJ, Hansson ML, Holmlund T, Wallberg AE, (2011) Ubiquitination of Notch1 is regulated by MAML1-mediated p300 acetylation of Notch1. Biochem Biophys Res Commun 416: 300-306.
13. Saint Just Ribeiro M, Hansson ML, Lindberg MJ, Popko-Scibor AE, Wallberg AE, (2009) GSK3beta is a negative regulator of the transcriptional coactivator MAML1. Nucleic Acids Res 37: 6691-6700.
14. Lindberg MJ, Popko-Scibor AE, Hansson ML, Wallberg AE, (2010) SUMO modification regulates the transcriptional activity of MAML1. FASEB J 24: 2396-2404.
15. Gitenay D, Baron VT, (2009) Is EGR1 a potential target for prostate cancer therapy? Future Oncol 5: 993-1003.
16. Liu C, Rangnekar VM, Adamson E, Mercola D, (1998) Suppression of growth and transformation and induction of apoptosis by EGR-1. Cancer Gene Ther 5: 3-28.
17. Yu J, Baron V, Mercola D, Mustelin T, Adamson ED, (2007) A network of p73, p53 and Egr1 is required for efficient apoptosis in tumor cells. Cell Death Differ 14: 436-446.
18. Yu J, de Belle I, Liang H, Adamson ED, (2004) Coactivating factors p300 and CBP are transcriptionally crossregulated by Egr1 in prostate cells, leading to divergent responses. Mol Cell 15: 83-94.
19. Rackley RR, Kessler PM, Campbell C, Williams BR, (1995) In situ expression of the early growth response gene-1 during murine nephrogenesis. J Urol 154: 700-705.
20. Pode-Shakked N, Dekel B, (2011) Wilms tumor-a renal stem cell malignancy? Pediatr Nephrol 26: 1535-1543.
21. Scharnhorst V, Menke AL, Attema J, Haneveld JK, Riteco N, et al. (2000) EGR-1 enhances tumor growth and modulates the effect of the Wilms' tumor 1 gene products on tumorigenicity. Oncogene 19: 791-800.
22. Strefford JC, Stasevich I, Lane TM, Lu YJ, Oliver T, et al. (2005) A combination of molecular cytogenetic analyses reveals complex genetic alterations in conventional renal cell carcinoma. Cancer Genet Cytogenet 159: 1-9.
23. Beroukhim R, Getz G, Nghiemphu L, Barretina J, Hsueh T, et al. (2007) Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proc Natl Acad Sci U S A 104: 20007-20012.
24. Saint Just Ribeiro M, Wallberg AE, (2009) Transcriptional mechanisms by the coregulator MAML1. Curr Protein Pept Sci 10: 570-576.
25. McElhinny AS, Li JL, Wu L, (2008) Mastermind-like transcriptional co-activators: emerging roles in regulating cross talk among multiple signaling pathways. Oncogene 27: 5138-5147.
26. Silverman ES, Collins T, (1999) Pathways of Egr-1-mediated gene transcription in vascular biology. Am J Pathol 154: 665-670.
27. Lee KK, Workman JL, (2007) Histone acetyltransferase complexes: one size doesn't fit all. Nat Rev Mol Cell Biol 8: 284-295.