Effects of the active constituents of Crocus Sativus L., crocins, in an animal model of obsessive-compulsive disorder

Neuroscience Letters

Volumn 528, Issue 1, 2012, Pages 27-30

  Georgiadou, G ^a   Tarantilis, P A ^b   Pitsikas, N ^a  

^a UNIVERSITY OF THESSALY   (Greece)

^b AGRICULTURAL UNIVERSITY OF ATHENS   (Greece)

Author keywords

Crocins; MCPP; Obsessive compulsive disorder; Rat; Self grooming

Indexed keywords

(3 CHLOROPHENYL)PIPERAZINE; CROCIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BEHAVIOR; CONTROLLED STUDY; CROCUS SATIVUS; DISEASE EXACERBATION; DRUG EFFECT; GROOMING; LOCOMOTION; MALE; NONHUMAN; OBSESSIVE COMPULSIVE DISORDER; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM;

ANIMALS; BEHAVIOR, ANIMAL; CAROTENOIDS; CROCUS; DISEASE MODELS, ANIMAL; FLOWERS; MALE; OBSESSIVE-COMPULSIVE DISORDER; PHYTOTHERAPY; PLANT EXTRACTS; RATS; RATS, WISTAR;

EID: 84866909578     PISSN: 03043940     EISSN: 18727972     Source Type: Journal    
DOI: 10.1016/j.neulet.2012.08.081     Document Type: Article

References (21)

1. Ahmad A.S., Ansari M.A., Ahmad M., Saleem S., Yousuf S., Hoda M.N., Islam F. Neuroprotection by crocetin in a hemi-parkinsonian rat model. Pharmacology Biochemistry and Behavior 2005, 81:805-813.
2. Akhondzabeh S., Fallah-Pour H., Afkham K., Jamshidi A.H., Khalighi-Cigaroudi.F. Comparison of Crocus sativus L., and imipramine in the treatment of mild to moderate depression: a pilot double-blind, randomized trial. Complementary and Alternative Medicine 2004, 4:12-16.
3. 2 receptor stimulation on excessive grooming, penile erection and plasma oxytocin concentrations. European Journal of Pharmacology 1992, 229:9-14.
4. 2c receptors. Behavioural Brain Research 2003, 142:175-179.
5. Graybiel A.M., Rauch S.L. Toward a neurobiology of obsessive-compulsive disorder. Neuron 2000, 28:343-347.
6. Graybiel A.M., Saka E. A genetic basis for obsessive grooming. Neuron 2002, 33:1-2.
7. Greer J.M., Capecchi M.R. Hoxb8 is required for normal grooming behavior in mice. Neuron 2002, 33:23-34.
8. Hosseinzadeh H., Noraei N.B. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal in mice. Phytotherapy Research 2009, 23:768-774.
9. Kanakis C.D., Daferera D.J., Tarantilis P.A., Polissiou M.G. Qualitative determination of volatile compounds and quantitative evaluation of safranal and 4-hydroxy-2,6,6-trimethyl-1-cyclohexene-1-carboxaldehyde. Journal of Agricultural and Food Chemistry 2004, 52:4515-4521.
10. Kanakis C.D., Tarantilis P.A., Tajmir-Riahi H.-A., Polissiou M.G. DNA interaction with saffron's secondary metabolites safranal, crocetin, and dimethylcrocetin. DNA and Cell Biology 2007, 26:63-70.
11. Noorbala A.A., Akhondzabeh S., Tahmacebi-Pour N., Jamshidi A.H. Hydro-alcoholic extract of Crocus sativus L., versus fluoxetine in the treatment of mild to moderate depression: a double-blind, randomized trial. Journal of Ethnopharmacology 2005, 97:281-284.
12. Papandreou M.A., Kanakis C.D., Polissiou M.G., Efthimiopoulos S., Cordopatis P., Margariti M., Lamari F.N. Inhibitory activity of amyloid-β aggregation and antioxidant properties of Crocus sativus extract and its crocins constituents. Journal of Agricultural and Food Chemistry 2006, 54:8762-8768.
13. Pitsikas N., Sakellaridis N. Crocus sativus L. extracts antagonize memory impairments in different behavioural tasks in the rat. Behavioural Brain Research 2006, 173:112-115.
14. Pitsikas N., Zisopoulou S., Tarantilis P.A., Kanakis C.D., Polissiou M.G., Sakellaridis N. Effects of the active constituents of Crocus sativus L. crocins on recognition and spatial rats' memory. Behavioural Brain Research 2007, 183:141-146.
15. Pitsikas N., Boultadakis A., Georgiadou G., Tarantilis P.A., Sakellaridis N. Effects of the active constituents of Crocus sativus L. crocins, in an animal model of anxiety. Phytomedicine 2008, 15:1135-1139.
16. 2C receptors in CHO-K1 cells. British Journal of Pharmacology 1998, 128:13-20.
17. Rios J.L., Recio M.C., Ginger R.M., Manz S. An update review of saffron and its active constituents. Phytotherapy Research 1996, 10:189-193.
18. Sugiura M., Shoyama Y., Saito H., Nishiyama N. Crocin improves the ethanol-induced impairment of learning behaviors of mice in passive avoidance tasks. Proceedings of Japanese Academy 1995, 71:319-324.
19. Tarantilis P.A., Tsoupras G., Polissiou M. Determination of saffron (Crocus sativus L.) components in crude plant extract using high-performance liquid chromatography-UV/visible photodiode-array detection-mass spectrometry. Journal of Chromatography 1995, 699:107-118.
20. Zhang Y., Shoyama Y., Sugiura M., Saito H. Effects of Crocus sativus L. on the ethanol-induced impairment of passive avoidance performance in mice. Biological and Pharmaceutical Bulletin 1994, 17:217-221.
21. Zohar J., Mueller E.A., Insel T.R., Zohar-Kadouch R.C., Murphy D.L. Serotonergic responsivity in obsessive-compulsive disorder. Comparison of patients and healthy controls. Archives of General Psychiatry 1987, 44:946-951.