Detection of the presence of gold nanoparticles in organs by transmission electron microscopy

Materials

Volumn 3, Issue 9, 2010, Pages 4681-4694

  De Jong, Wim H ^a   Burger, Marina C ^a   Verheijen, Marcel A ^b   Geertsma, Robert E ^a  

^a NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

^b PHILIPS RESEARCH LABORATORIES   (Netherlands)

Author keywords

Gold nanoparticles; Tissue distribution; Transmission electron microscopy

Indexed keywords

ENERGY DISPERSIVE X-RAY; GLOBULAR STRUCTURE; GOLD NANOPARTICLES; NANOSIZED STRUCTURES; NUMBER OF SAMPLES; PHAGOCYTIC CELLS; TISSUE DISTRIBUTIONS; TISSUE SECTIONS;

BLOOD VESSELS; ENDOTHELIAL CELLS; METAL NANOPARTICLES; NANOSTRUCTURED MATERIALS; TISSUE; TRANSMISSION ELECTRON MICROSCOPY;

GOLD;

EID: 84866881373     PISSN: None     EISSN: 19961944     Source Type: Journal    
DOI: 10.3390/ma3094681     Document Type: Article

References (10)

1. De Jong, W.H.; Hagens, W.I.; Krystek, P.; Burger, M.C.; Sips, A.J.A.M.; Geertsma, R.E. Particle size-dependent organ distribution of gold nanoparticles after intravenous administration. Biomaterials 2008, 29, 1912-1919.
2. Cedervall, T.; Lynch, I.; Foy, M.; Berggard, T.; Donelly, S.C.; Cagney, G, Linse, S.; Dawson, K.A. Detailed identification of plasma proteins adsorbed on copolymer nanoparticles. Angew. Chem. Int. Ed. 2007, 46, 5754-5756.
3. Niidome, T.; Yamagata, M.; Okamoto, Y.; Akayima, Y.;Takahashi, H.; kawano, T.; Katayama, Y.; Niidome, Y. PEG-modified gold nanorods with a stealth character for in vivo applications. J. Control. Rel. 2006, 114, 343-347.
4. Akiyama, Y.; Mori, T.; Katayama Y.; Niidome, T. The effects of PEG grafting level and injection dose on gold nanorods biodistriobution in tumopr bearing mice. J. Control. Rel. 2009, 139, 81-84.
5. Bazile, D.; Prud'Homme, C.; Bassoullet, M-T.; Marlard, M.; Spenlehauer, G.; Veillard, M. Stealth Me.PEG-PLA nanoparticles avoid uptake by the mononuclear phagocytes system. J. Pharm. Sci. 1995, 84, 493-498.
6. Peracchia, M.T.; Harnisch, H.; Pinto-Alphandry, H.; Gulik, A.; Dedieu, J.C.; Desmaële, D.; D'Angelo, J.; Müller, R.H.; Couvreur, P. Visualization of in vitro protein-rejecting properties of PEGylated stealth polycyanoacrylate nanoparticles. Biomaterials 1999, 20, 1269-1275.
7. Sadauskas, E.; Danscher, G.; Stoltenberg, M.; Vogel, U.; Larsen, A.; Wallin, H. Protracted elimination of gold nanoparticles from mouse liver. Nanomedicine: Nanotechnol. Biol. Med. 2009, 5, 162-169.
8. Sadauskas, E.; Wallin, H.; Stoltenberg, M.; Vogel, U.; Doering, P.; Larsen, A.; Danscher, G. Kupffer cells are central in the removal of nanoparticles from the organism. Part Fiber Toxicol. 2007, 4, doi:10.1186/1743-8977-4-10.
9. Geiser, M.; Rothen-Rutishauser, B.; Kapp, N.; Schurch, S.; Kreyling, W.G.; Schulz, H.; Semmler, M.; Im Hof, V.; Heyder, J.; Gehr, P. Ultrafine particles cross cellular membranes by nonphagocytic mechanisms in lungs and in cultured cells. Environ. Health Perspect. 2005, 113, 1555-1560.
10. Rothen-Rutishauser, B.M.; Schurch, S.; Haenni, B.; Kapp, N.; Gehr, P. Interaction of fine particles and nanoparticles with red blood cells visualized with advanced microscopic techniques. Environ. Sci. Technol. 2006, 40, 4353-4359.