Molecular structure of human GM-CSF in complex with a disease-associated anti-human GM-CSF autoantibody and its potential biological implications

Biochemical Journal

Volumn 447, Issue 2, 2012, Pages 205-215

  Blech, Michaela ^a,b   Seeliger, Daniel ^a   Kistler, Barbara ^a   Bauer, Margit M T ^a   Hafner, Mathias ^b   Hor̈er, Stefan ^a   Zeeb, Markus ^a   Nar, Herbert ^a   Park, John E ^a  

^a BOEHRINGER INGELHEIM PHARMA GMBH AND CO KG   (Germany)

^b UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

Autoantibody; Epitope mapping; Fas fragment; Granulocyte macrophage colony stimulating factor (GM CSF); Microscale thermophoresis (MST); Pulmonary alveolar proteinosis (PAP)

Indexed keywords

AUTOANTIBODY; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G1; MB 007; NEUTRALIZING ANTIBODY; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; UNCLASSIFIED DRUG;

ANTIBODY COMBINING SITE; ANTIBODY ISOLATION; ANTIGEN ANTIBODY COMPLEX; ARTICLE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DEUTERON NUCLEAR MAGNETIC RESONANCE; GERM LINE; HUMAN; HUMAN CELL; INFORMATION PROCESSING; LUNG ALVEOLUS PROTEINOSIS; MOLECULAR MODEL; NITROGEN NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL;

ANTIGEN-ANTIBODY COMPLEX; AUTOANTIBODIES; BINDING SITES, ANTIBODY; CRYSTALLIZATION; EPITOPE MAPPING; GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; HUMANS; IMMUNOGLOBULIN FAB FRAGMENTS; IMMUNOGLOBULIN G; MODELS, MOLECULAR; PULMONARY ALVEOLAR PROTEINOSIS;

EID: 84866875447     PISSN: 02646021     EISSN: 14708728     Source Type: Journal    
DOI: 10.1042/BJ20120884     Document Type: Article

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