메뉴 건너뛰기




Volumn 9, Issue 10, 2012, Pages 1305-1317

Potentials and challenges in self-nanoemulsifying drug delivery systems

Author keywords

Bioavailability; Lipid based systems; Oral delivery; Poorly soluble drugs; Self emulsifying

Indexed keywords

AMPRENAVIR; BEXAROTENE; CALCITRIOL; CEFPODOXIME PROXETIL; CLOTRIMAZOLE; CREMOPHOR; CYCLOSPORIN A; EXCIPIENT; GLICLAZIDE; ISOTRETINOIN; KETOPROFEN; LIPID; NONSTEROID ANTIINFLAMMATORY AGENT; OCTANOIN; RETINOIC ACID; RETINOL; RITONAVIR; SAQUINAVIR; SOLVENT; SURFACTANT; TIPRANAVIR; WATER;

EID: 84866867101     PISSN: 17425247     EISSN: 17447593     Source Type: Journal    
DOI: 10.1517/17425247.2012.719870     Document Type: Review
Times cited : (110)

References (79)
  • 1
    • 34447536520 scopus 로고    scopus 로고
    • When poor solubility becomes an issue: From early stage to proof of concept
    • Stegemann S, Leveiller F, Franchi D, et al. When poor solubility becomes an issue: from early stage to proof of concept. Eur J Pharm Sci 2007;31:249-61
    • (2007) Eur J Pharm Sci , vol.31 , pp. 249-61
    • Stegemann, S.1    Leveiller, F.2    Franchi, D.3
  • 3
    • 0006421460 scopus 로고
    • The design of dosage forms
    • Pharmaceutics the science of dosage form design
    • York P. The design of dosage forms. In: Aulton ME, editor. Pharmaceutics the science of dosage form design. Churchill Livingstone; Edinburgh: 1988. p. 1-13
    • (1988) Aulton ME, Editor. Churchill Livingstone; Edinburgh , pp. 1-13
    • York, P.1
  • 5
    • 0032885450 scopus 로고    scopus 로고
    • Solid dispersion of poorly water soluble drugs: Early promises, subsequent problems and recent breakthroughs
    • Serajuddin ATM. Solid dispersion of poorly water soluble drugs: early promises, subsequent problems and recent breakthroughs. J Pharm Sci 1999;88:1058-66
    • (1999) J Pharm Sci , vol.88 , pp. 1058-66
    • Serajuddin, A.T.M.1
  • 6
    • 85047692219 scopus 로고
    • Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism
    • Aungst BJ. Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J Pharm Sci 1993;82:979-86
    • (1993) J Pharm Sci , vol.82 , pp. 979-86
    • Aungst, B.J.1
  • 7
    • 1142297630 scopus 로고    scopus 로고
    • Characterization of curcumin-PVP solid dispersion obtained by spray drying
    • Paradkar A, Ambike AA, Jadhav BK, Mahadik KR. Characterization of curcumin-PVP solid dispersion obtained by spray drying. Int J Pharm 2004;271:281-6
    • (2004) Int J Pharm , vol.271 , pp. 281-6
    • Paradkar, A.1    Ambike, A.A.2    Jadhav, B.K.3    Mahadik, K.R.4
  • 8
    • 0002890024 scopus 로고
    • Improved oral bioavailability of an HIV protease inhibitor using Gelucire 44/14 and Labrasol vehicles
    • Aungst BJ, Nguyen N, Rogers NJ, et al. Improved oral bioavailability of an HIV protease inhibitor using Gelucire 44/14 and Labrasol vehicles. B T Gattefosse 1994;87:49-54
    • (1994) B T Gattefosse , vol.87 , pp. 49-54
    • Aungst, B.J.1    Nguyen, N.2    Rogers, N.J.3
  • 9
    • 84859947948 scopus 로고    scopus 로고
    • Exploring oral nanoemulsions for bioavailability enhancement of poorly water-soluble drugs
    • Kotta S, Khan AW, Pramod K, et al. Exploring oral nanoemulsions for bioavailability enhancement of poorly water-soluble drugs. Expert Opin Drug Deliv 2012;9(5):585-98
    • (2012) Expert Opin Drug Deliv , vol.9 , Issue.5 , pp. 585-98
    • Kotta, S.1    Khan, A.W.2    Pramod, K.3
  • 10
    • 76849109564 scopus 로고    scopus 로고
    • Self-emulsifying drug delivery systems (SEDDS): Formulation development, characterization, and applications
    • Singh B, Bandopadhyay S, Kapil R, et al. Self-emulsifying drug delivery systems (SEDDS): formulation development, characterization, and applications. Crit Rev Ther Drug Carrier Syst 2009;26:427-521
    • (2009) Crit Rev Ther Drug Carrier Syst , vol.26 , pp. 427-521
    • Singh, B.1    Bandopadhyay, S.2    Kapil, R.3
  • 11
    • 77949894367 scopus 로고    scopus 로고
    • Self emulsifying drug delivery system: A review
    • Patel PA, Chaulang GM, Akolkotkar A, et al. Self emulsifying drug delivery system: a review. Res J Pharm Tech 2008;1(4):313-23
    • (2008) Res J Pharm Tech , vol.1 , Issue.4 , pp. 313-23
    • Patel, P.A.1    Chaulang, G.M.2    Akolkotkar, A.3
  • 12
    • 0033805858 scopus 로고    scopus 로고
    • Lipid formulations for oral administration of drugs: Non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems
    • Pouton CW. Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and 'self-microemulsifying' drug delivery systems. Eur J Pharm Sci 2000;11(Suppl 2):S93-8
    • (2000) Eur J Pharm Sci , vol.11 , Issue.SUPPL. 2
    • Pouton, C.W.1
  • 13
    • 39149113817 scopus 로고    scopus 로고
    • Formulation of lipid-based delivery systems for oral administration: Materials, methods and strategies
    • Pouton CW, Porter CJ. Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv Drug Deliv Rev 2008;60:625-37
    • (2008) Adv Drug Deliv Rev , vol.60 , pp. 625-37
    • Pouton, C.W.1    Porter, C.J.2
  • 14
    • 24144464259 scopus 로고    scopus 로고
    • Structure of concentrated nanoemulsions
    • Graves S, Meleson K, Wilking J, et al. Structure of concentrated nanoemulsions. J. Chem. Phys 2005;122:134703-6
    • (2005) J. Chem. Phys , vol.122 , pp. 134703-6
    • Graves, S.1    Meleson, K.2    Wilking, J.3
  • 15
    • 67549143093 scopus 로고    scopus 로고
    • Preparation and evaluation of self-nanoemulsifying tablets of carvedilol
    • Mahmoud EA, Bendas ER, Mohamed MI. Preparation and evaluation of self-nanoemulsifying tablets of carvedilol. AAPS PharmSciTech 2009;10(1):183-92
    • (2009) AAPS PharmSciTech , vol.10 , Issue.1 , pp. 183-92
    • Mahmoud, E.A.1    Bendas, E.R.2    Mohamed, M.I.3
  • 16
    • 30344456981 scopus 로고    scopus 로고
    • Development of supersaturatable selfemulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs
    • Gao P, Morozowich W. Development of supersaturatable selfemulsifying drug delivery system formulations for improving the oral absorption of poorly soluble drugs. Expert Opin Drug Discov 2006;3:97-110
    • (2006) Expert Opin Drug Discov , vol.3 , pp. 97-110
    • Gao, P.1    Morozowich, W.2
  • 17
    • 33646383855 scopus 로고    scopus 로고
    • Controlled release of a self-emulsifying formulation formulation from a tablet dosage form: Stability assessment and optimization of some processing parameters
    • Nazzal S, Khan MA. Controlled release of a self-emulsifying formulation formulation from a tablet dosage form: stability assessment and optimization of some processing parameters. Int J Pharm 2006;315:110-21
    • (2006) Int J Pharm , vol.315 , pp. 110-21
    • Nazzal, S.1    Khan, M.A.2
  • 18
    • 0344012523 scopus 로고    scopus 로고
    • Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability
    • Gao P, Rush BD, Pfund WP. Development of a supersaturable SEDDS (S-SEDDS) formulation of paclitaxel with improved oral bioavailability. J Pharm Sci 2003;92:2386-98
    • (2003) J Pharm Sci , vol.92 , pp. 2386-98
    • Gao, P.1    Rush, B.D.2    Pfund, W.P.3
  • 19
    • 84864323714 scopus 로고    scopus 로고
    • Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems
    • Thomas N, Müllertz A, Graf A, Rades T. Influence of lipid composition and drug load on the in vitro performance of self-nanoemulsifying drug delivery systems. J Pharm Sci 2012;101:1721-31
    • (2012) J Pharm Sci , vol.101 , pp. 1721-31
    • Thomas, N.1    Müllertz, A.2    Graf, A.3    Rades, T.4
  • 20
    • 43249122851 scopus 로고    scopus 로고
    • Bioavailability of probucol from lipid and surfactant based formulations in minipigs: Influence of droplet size and dietary state
    • Nielsen FS, Petersen KB, Müllertz A. Bioavailability of probucol from lipid and surfactant based formulations in minipigs: influence of droplet size and dietary state. Eur J Pharm Biopharm 2008;69(2):553-62
    • (2008) Eur J Pharm Biopharm , vol.69 , Issue.2 , pp. 553-62
    • Nielsen, F.S.1    Petersen, K.B.2    Müllertz, A.3
  • 21
    • 34247137899 scopus 로고    scopus 로고
    • Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state
    • Grove M, Müllertz A, Pedersen GP, Nielsen JL. Bioavailability of seocalcitol III. Administration of lipid-based formulations to minipigs in the fasted and fed state. Eur J Pharm Sci 2007;31(1):8-15
    • (2007) Eur J Pharm Sci , vol.31 , Issue.1 , pp. 8-15
    • Grove, M.1    Müllertz, A.2    Pedersen, G.P.3    Nielsen, J.L.4
  • 22
    • 38749146264 scopus 로고    scopus 로고
    • Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers
    • Woo JS, Song YK, Hong JY, et al. Reduced food-effect and enhanced bioavailability of a self-microemulsifying formulation of itraconazole in healthy volunteers. Eur J Pharm Sci 2008;33(2):159-65
    • (2008) Eur J Pharm Sci , vol.33 , Issue.2 , pp. 159-65
    • Woo, J.S.1    Song, Y.K.2    Hong, J.Y.3
  • 23
    • 34548094059 scopus 로고    scopus 로고
    • Bioavailability assessment of vitamin a self-nanoemulsified drug delivery systems in rats
    • Taha E, Ghorab D, Zaghloul AA. Bioavailability assessment of vitamin a self-nanoemulsified drug delivery systems in rats. A Comp Study Med Princ Pract 2007;16:355-9
    • (2007) A Comp Study Med Princ Pract , vol.16 , pp. 355-9
    • Taha, E.1    Ghorab, D.2    Zaghloul, A.A.3
  • 24
    • 67651207541 scopus 로고    scopus 로고
    • Size, Shape, and charge of salt-free catanionic microemulsion droplets: A small-angle neutron scattering and modeling study
    • Silva BFB, Marques EF, Olsson U, et al. Size, Shape, and charge of salt-free catanionic microemulsion droplets: a small-angle neutron scattering and modeling study. J Phys Chem B 2009;113:10230-9
    • (2009) J Phys Chem B , vol.113 , pp. 10230-9
    • Silva, B.F.B.1    Marques, E.F.2    Olsson, U.3
  • 25
    • 0023010568 scopus 로고
    • An experimental system designed to study the in situ intestinal lymphatic transport of lipophilic drugs in anesthetized rats
    • Charman WN, Noguchi T, Stella VJ. An experimental system designed to study the in situ intestinal lymphatic transport of lipophilic drugs in anesthetized rats. Int J Pharm 1986;33:155-64
    • (1986) Int J Pharm , vol.33 , pp. 155-64
    • Charman, W.N.1    Noguchi, T.2    Stella, V.J.3
  • 26
    • 0026593458 scopus 로고
    • Factors affecting the lymphatic transport of penclomedine (NSC-338720), a lipophilic cytotoxic drug: Comparison to DDT and hexachlorobenzene
    • Myers RA, Stella VJ. Factors affecting the lymphatic transport of penclomedine (NSC-338720), a lipophilic cytotoxic drug: comparison to DDT and hexachlorobenzene. Int J Pharm 1992;80:511-162
    • (1992) Int J Pharm , vol.80 , pp. 511-162
    • Myers, R.A.1    Stella, V.J.2
  • 27
    • 70449524336 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: Formulation and bioavailability studies
    • Zhao Y, Wang C, Chow AHL, et al. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of Zedoary essential oil: formulation and bioavailability studies. Int J Pharm 2010;383:170-7
    • (2010) Int J Pharm , vol.383 , pp. 170-7
    • Zhao, Y.1    Wang, C.2    Chow, A.H.L.3
  • 28
    • 0344514705 scopus 로고    scopus 로고
    • Lipid drug delivery and rational formulation design for lipophilic drugs with low oral bioavailability, applied to cyclosporine
    • Odeberga JM, Kaufmannb P, Kroonc KG, Hoglunda P. Lipid drug delivery and rational formulation design for lipophilic drugs with low oral bioavailability, applied to cyclosporine. Eur J Pharm Sci 2003;20:375-82
    • (2003) Eur J Pharm Sci , vol.20 , pp. 375-82
    • Odeberga, J.M.1    Kaufmannb, P.2    Kroonc, K.G.3    Hoglunda, P.4
  • 29
    • 0041311341 scopus 로고
    • Relationship between the molecular structures and emulsification properties of edible oils
    • Kimura M, Shizuki M, Miyoshi K, et al. Relationship between the molecular structures and emulsification properties of edible oils. Biosci Biotech Biochem 1994;58:1258-61
    • (1994) Biosci Biotech Biochem , vol.58 , pp. 1258-61
    • Kimura, M.1    Shizuki, M.2    Miyoshi, K.3
  • 30
    • 0031914282 scopus 로고    scopus 로고
    • Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor
    • Hauss DJ, Fogal SE, Ficorilli JV, et al. Lipid-based delivery systems for improving the bioavailability and lymphatic transport of a poorly water-soluble LTB4 inhibitor. J Pharm Sci 1998;87:164-9
    • (1998) J Pharm Sci , vol.87 , pp. 164-9
    • Hauss, D.J.1    Fogal, S.E.2    Ficorilli, J.V.3
  • 31
    • 84982311161 scopus 로고    scopus 로고
    • Preparation and in vitro evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) containing clotrimazole
    • Kassem AA, Marzouk MA, Ammar AA, Elosaily GH. Preparation and in vitro evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) containing clotrimazole. Drug Discov Ther 2010;4(5):373-9
    • (2010) Drug Discov Ther , vol.4 , Issue.5 , pp. 373-9
    • Kassem, A.A.1    Marzouk, M.A.2    Ammar, A.A.3    Elosaily, G.H.4
  • 32
    • 77952887062 scopus 로고    scopus 로고
    • SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: Development and optimization
    • Basalious EB, Shawky N, Badr-Eldin SM. SNEDDS containing bioenhancers for improvement of dissolution and oral absorption of lacidipine. I: development and optimization. Int J Pharm 2010;391:203-11
    • (2010) Int J Pharm , vol.391 , pp. 203-11
    • Basalious, E.B.1    Shawky, N.2    Badr-Eldin, S.M.3
  • 33
    • 84860573896 scopus 로고    scopus 로고
    • A comparative evaluation of mono-, di-and triglyceride of medium chain fatty acids by lipid/surfactant/water phase diagram, solubility determination and dispersion testing for application in pharmaceutical dosage form development
    • Prajapati HN, Dalrymple DM, Serajudin ATM. A comparative evaluation of mono-, di-and triglyceride of medium chain fatty acids by lipid/surfactant/water phase diagram, solubility determination and dispersion testing for application in pharmaceutical dosage form development. Pharm Res 2012;29:285-305
    • (2012) Pharm Res , vol.29 , pp. 285-305
    • Prajapati, H.N.1    Dalrymple, D.M.2    Serajudin, A.T.M.3
  • 34
    • 79957665321 scopus 로고    scopus 로고
    • Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system
    • Parmar N, Singla N, Amina S, Kohli K. Study of cosurfactant effect on nanoemulsifying area and development of lercanidipine loaded (SNEDDS) self nanoemulsifying drug delivery system. Colloids Surf B Biointerfaces 2011;86(2):327-38
    • (2011) Colloids Surf B Biointerfaces , vol.86 , Issue.2 , pp. 327-38
    • Parmar, N.1    Singla, N.2    Amina, S.3    Kohli, K.4
  • 37
    • 0034614208 scopus 로고    scopus 로고
    • Microemulsion based media as novel drug delivery systems
    • Lawrence MJ, Rees GD. Microemulsion based media as novel drug delivery systems. Adv Drug Deliv 2000;45:89-121
    • (2000) Adv Drug Deliv , vol.45 , pp. 89-121
    • Lawrence, M.J.1    Rees, G.D.2
  • 38
    • 0025046288 scopus 로고
    • Intestinal absorption of drugs. III. The influence of taurocholate on the disappearance kinetics of hydrophilic and lipophilic drugs from the small intestine of the rat
    • Poelma FG, Breäs R, Tukker JJ. Intestinal absorption of drugs. III. The influence of taurocholate on the disappearance kinetics of hydrophilic and lipophilic drugs from the small intestine of the rat. Pharm Res 1990;7:392-7
    • (1990) Pharm Res , vol.7 , pp. 392-7
    • Poelma, F.G.1    Breäs, R.2    Tukker, J.J.3
  • 39
    • 0037407282 scopus 로고    scopus 로고
    • Human jejunal permeability of cyclosporin A: Influence of surfactants on P-glycoprotein efflux in Caco-2 cells
    • Chiu YY, Higaki K, Neudeck BL, et al. Human jejunal permeability of cyclosporin A: influence of surfactants on P-glycoprotein efflux in Caco-2 cells. Pharm Res 2003;20:749-56
    • (2003) Pharm Res , vol.20 , pp. 749-56
    • Chiu, Y.Y.1    Higaki, K.2    Neudeck, B.L.3
  • 40
    • 79955629340 scopus 로고    scopus 로고
    • Nano-emulsions and micro-emulsions: Clarifications of the critical differences
    • Anton N, Vandamme TF. Nano-emulsions and Micro-emulsions: clarifications of the Critical Differences. Pharm Res 2011;28:978-85
    • (2011) Pharm Res , vol.28 , pp. 978-85
    • Anton, N.1    Vandamme, T.F.2
  • 41
    • 0342781953 scopus 로고
    • Microemulsion: A suitable galenical approach for the absorption enhancement of low soluble compounds?
    • Meinzer A, Mueller E, Vondersher J. Microemulsion: a suitable galenical approach for the absorption enhancement of low soluble compounds? B T Gattefosse 1995;88:21-6
    • (1995) B T Gattefosse , vol.88 , pp. 21-6
    • Meinzer, A.1    Mueller, E.2    Vondersher, J.3
  • 42
    • 0028000096 scopus 로고
    • Rationale for the development of Sandimmune Neoral
    • Vonderscher J. Meinzer, A. Rationale for the development of Sandimmune Neoral. Transplant Proc 1994; 26:2925-2927A
    • (1994) Transplant Proc , vol.26
    • Vonderscher, J.1    Meinzer, A.2
  • 43
    • 33749057113 scopus 로고    scopus 로고
    • Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability
    • Ghosh PK, Majithiya RJ, Umertiia ML, Murthy RS. Design and development of microemulsion drug delivery system of acyclovir for improvement of oral bioavailability. APPS PharmSciTech 2006;7:77
    • (2006) APPS PharmSciTech , vol.7 , pp. 77
    • Ghosh, P.K.1    Majithiya, R.J.2    Umertiia, M.L.3    Murthy, R.S.4
  • 44
    • 33646547331 scopus 로고    scopus 로고
    • Microemulsion a potential drug delivery system
    • Ghosh PK, Murthy RS. Microemulsion a potential drug delivery system. Curr Drug Deliv 2006;3:167-80
    • (2006) Curr Drug Deliv , vol.3 , pp. 167-80
    • Ghosh, P.K.1    Murthy, R.S.2
  • 45
    • 0034849249 scopus 로고    scopus 로고
    • Improved oil solubilization in oil/water food grade microemulsions in the presence of polyols and ethanol
    • Garti N, Yaghmur A, Leser ME, et al. Improved oil solubilization in oil/water food grade microemulsions in the presence of polyols and ethanol. J Agric Food Chem 2001;49:2552-62
    • (2001) J Agric Food Chem , vol.49 , pp. 2552-62
    • Garti, N.1    Yaghmur, A.2    Leser, M.E.3
  • 46
    • 0000009718 scopus 로고
    • Microemulsions
    • Swarbrick J, Boylan JC, editors. Marcel Dekker; New York
    • Eccleston J. Microemulsions. In: Swarbrick J, Boylan JC, editors. Encyclopedia of pharmaceutical technology. Marcel Dekker; New York: 1994. p. 375-421
    • (1994) Encyclopedia of Pharmaceutical Technology , pp. 375-421
    • Eccleston, J.1
  • 47
    • 0011379669 scopus 로고
    • Entropy induced dispersion of bulk liquids
    • Reiss H. Entropy induced dispersion of bulk liquids. J Colloids Interface Sci 1975;53:61-70
    • (1975) J Colloids Interface Sci , vol.53 , pp. 61-70
    • Reiss, H.1
  • 48
    • 0017097531 scopus 로고
    • The self-emulsifying action of mixed surfactants in oil
    • Groves MJ, Galindez DAD. The self-emulsifying action of mixed surfactants in oil. Acta Pharma Suecica 1976;13:361-72
    • (1976) Acta Pharma Suecica , vol.13 , pp. 361-72
    • Groves, M.J.1    Galindez, D.A.D.2
  • 49
    • 0002656064 scopus 로고
    • Self-emulsification of vegetable oil-nonionic surfactant mixture: A proposed mechanism of action
    • Wakerly MG, Pouton CW, Meakin BJ, Morton FS. Self-emulsification of vegetable oil-nonionic surfactant mixture: a proposed mechanism of action. ACS Symp. Ser 1986;311:242-55
    • (1986) ACS Symp. ser , vol.311 , pp. 242-55
    • Wakerly, M.G.1    Pouton, C.W.2    Meakin, B.J.3    Morton, F.S.4
  • 50
    • 0027301116 scopus 로고
    • An investigation into the physicochemical properties of self-emulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and particle size analysis
    • Craig DQM, Lievens HSR, Pitt KG, Storey DE. An investigation into the physicochemical properties of self-emulsifying systems using low frequency dielectric spectroscopy, surface tension measurements and particle size analysis. Int J Pharm 1993;96:147-55
    • (1993) Int J Pharm , vol.96 , pp. 147-55
    • Craig, D.Q.M.1    Lievens, H.S.R.2    Pitt, K.G.3    Storey, D.E.4
  • 51
    • 0343652122 scopus 로고
    • The use of self-emulsifying systems as a means of improving drug delivery
    • Craig DQM. The use of self-emulsifying systems as a means of improving drug delivery. B.T. Gattefosse 1993;86:21-31
    • (1993) B.T. Gattefosse , vol.86 , pp. 21-31
    • Craig, D.Q.M.1
  • 52
    • 0028949717 scopus 로고
    • An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy
    • Craig DQM, Barker SA, Banning D, Booth SW. An investigation into the mechanisms of self-emulsification using particle size analysis and low frequency dielectric spectroscopy. Int J Pharm 1995;114:103-10
    • (1995) Int J Pharm , vol.114 , pp. 103-10
    • Craig, D.Q.M.1    Barker, S.A.2    Banning, D.3    Booth, S.W.4
  • 53
    • 0035799428 scopus 로고    scopus 로고
    • Formation of nano-emulsions by low-energy emulsification methods at constant temperature
    • Forgiarini A, Esqucna J, González C, Solans C. Formation of nano-emulsions by low-energy emulsification methods at constant temperature. Langmuir 2001; 17:2076-83
    • (2001) Langmuir , vol.17 , pp. 2076-83
    • Forgiarini, A.1    Esqucna, J.2    González, C.3    Solans, C.4
  • 54
    • 0034434844 scopus 로고    scopus 로고
    • Studies of the relation between phase behavior and emulsification methods with nanoemulsion formation
    • Forgiarini A, Esqucna J, Gonzalez C, Solans C. Studies of the relation between phase behavior and emulsification methods with nanoemulsion formation. Prog Colloid Polym Sci 2000;115:36-9
    • (2000) Prog Colloid Polym Sci , vol.115 , pp. 36-9
    • Forgiarini, A.1    Esqucna, J.2    Gonzalez, C.3    Solans, C.4
  • 55
    • 84859748557 scopus 로고    scopus 로고
    • Study of nano-emulsion formation by dilution of microemulsions
    • Sole I, Solans C, Maestro A, et al. Study of nano-emulsion formation by dilution of microemulsions. J Colloid Interface Sci 2012;376:133-9
    • (2012) J Colloid Interface Sci , vol.376 , pp. 133-9
    • Sole, I.1    Solans, C.2    Maestro, A.3
  • 56
    • 0343487750 scopus 로고    scopus 로고
    • Formulation of self-emulsifying drug delivery systems
    • Pouton CW. Formulation of self-emulsifying drug delivery systems. Adv Drug Deliv Rev 1997;25:47-58
    • (1997) Adv Drug Deliv Rev , vol.25 , pp. 47-58
    • Pouton, C.W.1
  • 57
    • 33645020126 scopus 로고    scopus 로고
    • Light scattering measurements on microemulsions: Estimation of droplet sizes
    • Goddeeris C, Cuppob F, Reynaersb H, et al. Light scattering measurements on microemulsions: estimation of droplet sizes. Int J Pharm 2006;312:187-95
    • (2006) Int J Pharm , vol.312 , pp. 187-95
    • Goddeeris, C.1    Cuppob, F.2    Reynaersb, H.3
  • 58
    • 1242337284 scopus 로고    scopus 로고
    • Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors
    • Yang S, Gursoy RN, Lambert G, Benita S. Enhanced oral absorption of paclitaxel in a novel self-microemulsifying drug delivery system with or without concomitant use of P-glycoprotein inhibitors. Pharm Res 2004;21:261-70
    • (2004) Pharm Res , vol.21 , pp. 261-70
    • Yang, S.1    Gursoy, R.N.2    Lambert, G.3    Benita, S.4
  • 59
    • 57449109685 scopus 로고    scopus 로고
    • Design and optimization of a new self-nanoemulsifying drug delivery system
    • Wang L, Dong J, Chen J, et al. Design and optimization of a new self-nanoemulsifying drug delivery system. J Colloids Interface Sci 2009; 330:0443-8
    • (2009) J Colloids Interface Sci , vol.330 , pp. 0443-8
    • Wang, L.1    Dong, J.2    Chen, J.3
  • 60
    • 0344443710 scopus 로고    scopus 로고
    • Excipient effects on in vitro cytotoxicity of a novel paclitaxel self-emulsifying drug delivery system
    • Gursoy N, Garrigue JS, Razafindratsita A, et al. Excipient effects on in vitro cytotoxicity of a novel paclitaxel self-emulsifying drug delivery system. J Pharm Sci 2003;92:2411-18
    • (2003) J Pharm Sci , vol.92 , pp. 2411-18
    • Gursoy, N.1    Garrigue, J.S.2    Razafindratsita, A.3
  • 61
    • 0037139412 scopus 로고    scopus 로고
    • Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: Mechanism and progress of emulsion formation
    • Nazzal S, Smalyukh II, Lavrentovich OD, Khan MA. Preparation and in vitro characterization of a eutectic based semisolid self-nanoemulsified drug delivery system (SNEDDS) of ubiquinone: mechanism and progress of emulsion formation. Int J Pharm 2002;235:247-65
    • (2002) Int J Pharm , vol.235 , pp. 247-65
    • Nazzal, S.1    Smalyukh, I.I.2    Lavrentovich, O.D.3    Khan, M.A.4
  • 62
    • 1542358756 scopus 로고    scopus 로고
    • Evaluation of cytotoxicity of oils used in coenzyme Q10 self-emulsifying drug delivery systems (SEDDS)
    • Palamakula A, Khan MA. Evaluation of cytotoxicity of oils used in coenzyme Q10 self-emulsifying drug delivery systems (SEDDS). Int J Pharm 2004; 273:63-73
    • (2004) Int J Pharm , vol.273 , pp. 63-73
    • Palamakula, A.1    Khan, M.A.2
  • 63
    • 21644461482 scopus 로고    scopus 로고
    • Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib
    • Subramanian N, Ray S, Ghosal SK, et al. Formulation design of self-microemulsifying drug delivery systems for improved oral bioavailability of celecoxib. Biol Pharm Bull 2004;27:1993-9
    • (2004) Biol Pharm Bull , vol.27 , pp. 1993-9
    • Subramanian, N.1    Ray, S.2    Ghosal, S.K.3
  • 64
    • 0030298897 scopus 로고    scopus 로고
    • Positively charged self-emulsifying oil formulation for improving the oral bioavailability of progestrone
    • Gershanik T, Benita S. Positively charged self-emulsifying oil formulation for improving the oral bioavailability of progestrone. Pharm Dev Technol 1996;1:147-57
    • (1996) Pharm Dev Technol , vol.1 , pp. 147-57
    • Gershanik, T.1    Benita, S.2
  • 65
    • 80052269742 scopus 로고    scopus 로고
    • Uptake of phenothiazines by the harvested chylomicrons ex vivo model: Influence of self-nanoemulsifying formulation design
    • Shahnaz G, Hartl M, Barthelmes J, et al. Uptake of phenothiazines by the harvested chylomicrons ex vivo model: Influence of self-nanoemulsifying formulation design. Eur J Pharm Biopharm 2011;79(1):171-80
    • (2011) Eur J Pharm Biopharm , vol.79 , Issue.1 , pp. 171-80
    • Shahnaz, G.1    Hartl, M.2    Barthelmes, J.3
  • 66
    • 77953642243 scopus 로고    scopus 로고
    • Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein
    • Yoo JH, Shanmugam S, Thapa P, et al. Novel self-nanoemulsifying drug delivery system for enhanced solubility and dissolution of lutein. Arch Pharm Res 2010;33:417-26
    • (2010) Arch Pharm Res , vol.33 , pp. 417-26
    • Yoo, J.H.1    Shanmugam, S.2    Thapa, P.3
  • 67
    • 84866858398 scopus 로고    scopus 로고
    • Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for Gliclazide
    • Wankhade V, Tapar K, Pande S, Bobade N. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for Gliclazide. Der Pharmacia Lett 2010;2:132-43
    • (2010) Der Pharmacia Lett , vol.2 , pp. 132-43
    • Wankhade, V.1    Tapar, K.2    Pande, S.3    Bobade, N.4
  • 68
    • 23144432623 scopus 로고    scopus 로고
    • Effect of formulation variables on preparation and evaluation of gelled self-emulsifying drug delivery system (SEDDS) of Ketoprofen
    • Patil P, Joshi P, Paradkar A. Effect of formulation variables on preparation and evaluation of gelled self-emulsifying drug delivery system (SEDDS) of Ketoprofen. AAPS PharmSciTech 2004;5:E42
    • (2004) AAPS PharmSciTech , vol.5
    • Patil, P.1    Joshi, P.2    Paradkar, A.3
  • 69
    • 47149099427 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery system for enhanced bioavailability and improved hepatoprotective activity of Biphenyl Dimethyl Dicarboxylate
    • El-Laithy HM. Self-nanoemulsifying drug delivery system for enhanced bioavailability and improved hepatoprotective activity of Biphenyl Dimethyl Dicarboxylate. Curr Drug Deliv 2008;5:170-6
    • (2008) Curr Drug Deliv , vol.5 , pp. 170-6
    • El-Laithy, H.M.1
  • 70
    • 70449524336 scopus 로고    scopus 로고
    • Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of zedoary essential oil: Formulation and bioavailability studies
    • Zhao Y, Wang C, Chow AH, et al. Self-nanoemulsifying drug delivery system (SNEDDS) for oral delivery of zedoary essential oil: formulation and bioavailability studies. Int J Pharm 2010;383:170-7
    • (2010) Int J Pharm , vol.383 , pp. 170-7
    • Zhao, Y.1    Wang, C.2    Chow, A.H.3
  • 71
    • 0034665061 scopus 로고    scopus 로고
    • The formulation of halofantrine as either non-solubilising PEG 6000 or solubilising lipid based solid dispersions: Physical, stability and absolute bioavailability assessment
    • Khoo S-M, Porter CJH, Charman WN. The formulation of halofantrine as either non-solubilising PEG 6000 or solubilising lipid based solid dispersions: physical, stability and absolute bioavailability assessment. Int J Pharm 2000;205:65-78
    • (2000) Int J Pharm , vol.205 , pp. 65-78
    • Khoo, S.-M.1    Porter, C.J.H.2    Charman, W.N.3
  • 72
    • 0036212425 scopus 로고    scopus 로고
    • Preparation and characterization of coenzyme QlO-Eudragit solid dispersion
    • Nazzal S, Guven N, Reddy IK, Khan MA. Preparation and characterization of coenzyme QlO-Eudragit solid dispersion. Drug Dev Ind Pharm 2002;28:49-57
    • (2002) Drug Dev Ind Pharm , vol.28 , pp. 49-57
    • Nazzal, S.1    Guven, N.2    Reddy, I.K.3    Khan, M.A.4
  • 73
    • 0022359144 scopus 로고
    • Phase distribution studies on an oil-water emulsion based on a eutectic mixture of lidocaine and prilocaine as the dispersed phase
    • Nyqvist-Mayer AA, Brodin AF, Frank SG. Phase distribution studies on an oil-water emulsion based on a eutectic mixture of lidocaine and prilocaine as the dispersed phase. Pharm Sci 1985;74:1192-5
    • (1985) Pharm Sci , vol.74 , pp. 1192-5
    • Nyqvist-Mayer, A.A.1    Brodin, A.F.2    Frank, S.G.3
  • 74
    • 0034714866 scopus 로고    scopus 로고
    • Physicochemical studies of lidocaine-menthol binary systems for enhanced membrane transport
    • Kang LS, Jun HW, McCall JW. Physicochemical studies of lidocaine-menthol binary systems for enhanced membrane transport. Int J Pharm 2000;206:35-42
    • (2000) Int J Pharm , vol.206 , pp. 35-42
    • Kang, L.S.1    Jun, H.W.2    McCall, J.W.3
  • 75
    • 33845576641 scopus 로고    scopus 로고
    • Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil
    • Date AS, Nagarsenker MS. Design and evaluation of self-nanoemulsifying drug delivery systems (SNEDDS) for cefpodoxime proxetil. Int J Pharm 2007;329:166-72
    • (2007) Int J Pharm , vol.329 , pp. 166-72
    • Date, A.S.1    Nagarsenker, M.S.2
  • 76
    • 0342617694 scopus 로고    scopus 로고
    • Lipid based vehicles for oral delivery of poorly water soluble drugs
    • Humberstone AJ, Charman WN. Lipid based vehicles for oral delivery of poorly water soluble drugs. Adv Drug Deliv Rev 1997;25:103-28
    • (1997) Adv Drug Deliv Rev , vol.25 , pp. 103-28
    • Humberstone, A.J.1    Charman, W.N.2
  • 77
    • 37549031769 scopus 로고    scopus 로고
    • Oral bioavailability enhancement of acyclovir by self-microemulsifying drug delivery systems (SMEDDS)
    • Patel D, Sawant KK. Oral bioavailability enhancement of acyclovir by self-microemulsifying drug delivery systems (SMEDDS). Drug Dev. Ind Pharm 2007;33:1318-26
    • (2007) Drug Dev. Ind Pharm , vol.33 , pp. 1318-26
    • Patel, D.1    Sawant, K.K.2
  • 78
    • 33847394968 scopus 로고    scopus 로고
    • Lipids and lipid-based formulations: Optimizing the oral delivery of lipophilic drugs
    • Porter CJ, Trevaskis NL, Charman WN. Lipids and lipid-based formulations: optimizing the oral delivery of lipophilic drugs. Nat Rev Drug Discov 2007;6:231-48
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 231-48
    • Porter, C.J.1    Trevaskis, N.L.2    Charman, W.N.3
  • 79
    • 80054703087 scopus 로고    scopus 로고
    • Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier
    • Oh DH, Kang JH, Kim DW, et al. Comparison of solid self-microemulsifying drug delivery system (solid SMEDDS) prepared with hydrophilic and hydrophobic solid carrier. Int J Pharm 2011;420:412-18
    • (2011) Int J Pharm , vol.420 , pp. 412-18
    • Oh, D.H.1    Kang, J.H.2    Kim, D.W.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.