Induced synthesis of P450 aromatase and 17β-estradiol by D-aspartate in frog brain

Journal of Experimental Biology

Volumn 215, Issue 20, 2012, Pages 3559-3565

  Burrone, Lavinia ^a   Santillo, Alessandra ^a   Pinelli, Claudia ^a   Baccari, Gabriella Chieffi ^a   Maddalena Di Fiore, Maria ^a  

^a SECOND UNIVERSITY OF NAPLES   (Italy)

Author keywords

17 estradiol; D aspartate; Estrogen receptor; P450 aromatase

Indexed keywords

AMPHIBIAN PROTEIN; AROMATASE; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; DEXTRO ASPARTIC ACID; ESTRADIOL; ESTROGEN RECEPTOR; MESSENGER RNA; TESTOSTERONE;

ANIMAL; ANURA; ARTICLE; BIOSYNTHESIS; BRAIN; GENETICS; MALE; METABOLISM;

AMPHIBIAN PROTEINS; ANIMALS; ANURA; AROMATASE; BRAIN; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; D-ASPARTIC ACID; ESTRADIOL; MALE; RECEPTORS, ESTROGEN; RNA, MESSENGER; TESTOSTERONE;

AMPHIBIA; ANIMALIA; ANURA; PELOPHYLAX;

EID: 84866863675     PISSN: 00220949     EISSN: None     Source Type: Journal    
DOI: 10.1242/jeb.073296     Document Type: Article

References (45)

1. Assisi, L, Botte, V., D'Aniello, A. and Di Fiore, M. M. (2001). Enhancement of aromatase activity by D-aspartic acid in the ovary of the lizard Podarciss. sicula. Reproduction 121, 803-808.
2. Balthazart, J., Baillien, M., Charlier, T. D., Cornil, C. A. and Ball, G. F. (2003) Multiple mechanisms control brain aromatase activity at the genomic and non-genomic level. J. Steroid Biochem. Mol. Biol. 86, 367-379.
3. Balthazart, J., Cornil, C. A., Charlier, T. D., Taziaux, M. and Ball, G. F. (2009) Estradiol, a key endocrine signal in the sexual differentiation and activation of reproductive behavior in quail. J. Exp. Zool. A. 311, 323-345.
4. Burrone, L, Di Giovanni, M., Di Fiore, M. M., Baccari, G. C. and Santillo, A. (2010). Effects of D-aspartate treatment on D-aspartate oxidase, superoxide dismutase, and caspase 3 activities in frog (Rana esculenta) tissues. Chem. Biodivers. 7, 1459-1466.
5. Burrone, L, Raucci, F. and Di Fiore, M. M. (2012). Steroidogenic gene expression following D-aspartate treatment in frog testis. Gen. Comp. Endocrinol. 175, 109-117.
6. Chieffi, P., Colucci-D'Amato, G. L, Staibano, S., Franco, R. and Tramontano, D. (2000). Estradiol-induced mitogen-activated protein kinase (extracellular signal-regulated kinase 1 and 2) activity in the frog (Rana esculenta) testis. J. Endocrinol. 167, 77-84.
7. Cohen, R. E. and Wade, J. (2011). Aromatase mRNA in the brain of adult green anole lizards: effects of sex and season. J. Neuroendocrinol. 23, 254-260.
8. Cornil, C. A. (2009). Rapid regulation of brain oestrogen synthesis: the behavioural roles of oestrogens and their fates. J. Neuroendocrinol. 21, 217-226.
9. D'Aniello, A. (2007). D-aspartic acid: an endogenous amino acid with an important neuroendocrine role. Brain Res. Rev. 53, 215-234.
10. D'Aniello, A., Di Fiore, M. M., Fisher, G. H., Milone, A., Seleni, A., D'Aniello, S., Perna, A. F. and Ingrosso, D. (2000). Occurrence of D-aspartic acid and N-methyl-D-aspartic acid in rat neuroendocrine tissues and their role in the modulation of luteinizing hormone and growth hormone release. FASEB J. 14, 699-714.
11. D'Aniello, S., Somorjai, I., Garcia-Fernàndez, J., Topo, E. and D'Aniello, A. (2011) D-Aspartic acid is a novel endogenous neurotransmitter. FASEB J. 25, 1014-1027.
12. Di Fiore, M. M., Assisi, L, Botte, V. and D'Aniello, A. (1998). D-Aspartic acid is implicated in the control of testosterone production by the vertebrate gonad. Studies on the female green frog, Rana esculenta. J. Endocrinol. 157, 199-207.
13. Di Fiore, M. M., Lamanna, C, Assisi, L. and Botte, V. (2008). Opposing effects of D-aspartic acid and nitric oxide on tuning of testosterone production in mallard testis during the reproductive cycle. Reprod. Biol. Endocrinol. 6, 28-36.
14. Di Giovanni, M., Burrone, L, Chieffi Baccari, G., Topo, E. and Santillo, A. (2010a) Distribution of free D-aspartic acid and D-aspartate oxidase in frog Rana esculenta tissues. J. Exp. Zool. A 313, 137-143.
15. Di Giovanni, M., Topo, E., Santillo, A., D'Aniello, A. and Chieffi Baccari, G. (2010b). D-Aspartate binding sites in rat Harderian gland. Amino Acids 38, 229-235.
16. C17) in the frog brain and pituitary. J. Neurochem. 100, 251-268.
17. Do Rego, J. L, Seong, J. Y., Burel, D., Leprince, J., Luu-The, V., Tsutsui, K., Tonon, M. C, Pelletier, G. and Vaudry, H. (2009a). Neurosteroid biosynthesis: enzymatic pathways and neuroendocrine regulation by neurotransmitters and neuropeptides. Front. Neuroendocrinol. 30, 259-301.
18. Do Rego, J. L, Seong, J. Y., Burel, D., Luu-The, V., Larhammar, D., Tsutsui, K., Pelletier, G., Tonon, M. C. and Vaudry, H. (2009b). Steroid biosynthesis within the frog brain: a model of neuroendocrine regulation. Ann. N Y. Acad. Sci. 1163, 83-92.
19. Fleck, M. W., Barrionuevo, G. and Palmer, A. M. (2001). Synaptosomal and vesicular accumulation of L-glutamate, L-aspartate and D-aspartate. Neurochem. Int. 39, 217-225.
20. Forlano, P. M., Schlinger, B. A. and Bass, A. H. (2006). Brain aromatase: new lessons from non-mammalian model systems. Front. Neuroendocrinol. 27, 247-274.
21. Garcia-Segura, L. M. (2008). Aromatase in the brain: not just for reproduction anymore. J. Neuroendocrinol. 20, 705-712.
22. Gunderson, M. P., Veldhoen, N., Skirrow, R. C, Macnab, M. K., Ding, W., van Aggelen, G. and Helbing, C. C. (2011). Effect of low dose exposure to the herbicide atrazine and its metabolite on cytochrome P450 aromatase and steroidogenic factor-1 mRNA levels in the brain of premetamorphic bullfrog tadpoles (Rana catesbeiana). Aquat Toxicol. 102, 31-38.
23. Hogan, N. S., Crump, K. L., Duarte, P., Lean, D. R. and Trudeau, V. L. (2007) Hormone cross-regulation in the tadpole brain: developmental expression profiles and effect of T3 exposure on thyroid hormone-and estrogen-responsive genes in Rana pipiens. Gen. Comp. Endocrinol. 154, 5-15.
24. Iwabuchi, J., Wako, S., Tanaka, T., Ishikawa, A., Yoshida, Y. and Miyata, S. (2007) Analysis of the p450 aromatase gene expression in the Xenopus brain and gonad. J. Steroid Biochem. Mol. Biol. 107, 149-155.
25. Kuntz, S., Chesnel, A., Flament, S. and Chardard, D. (2004). Cerebral and gonadal aromatase expressions are differently affected during sex differentiation of Pleurodeles waltl. J. Mol. Endocrinol. 33, 717-727.
26. Lamanna, C, Assisi, L., Botte, V. and Di Fiore, M. M. (2006). Endogenous testicular D-aspartic acid regulates gonadal aromatase activity in boar. J. Endocrinol. Invest. 29, 141-146.
27. Lamanna, C, Assisi, L., Botte, V. and Di Fiore, M. M. (2007). Involvement of D-Asp in P450 aromatase activity and estrogen receptors in boar testis. Amino Acids 32, 45-51.
28. Metzdorf, R., Gahr, M. and Fusani, L. (1999). Distribution of aromatase, estrogen receptor, and androgen receptor mRNA in the forebrain of songbirds and nonsongbirds. J. Comp. Neurol. 407, 115-129.
29. Panzica, G. C, Viglietti-Panzica, C. and Balthazart, J. (1996). The sexually dimorphic medial preoptic nucleus of quail: a key brain area mediating steroid action on male sexual behavior. Front. Neuroendocrinol. 17, 51-125.
30. Raucci, F. and Di Fiore, M. M. (2011). D-Asp: a new player in reproductive endocrinology of the amphibian Rana esculenta. J. Chromatogr. B 879, 3268-3276.
31. Raucci, F., Assisi, L., D'Aniello, S., Spinelli, P., Botte, V. and Di Fiore, M. M. (2004). Testicular endocrine activity is upregulated by D-aspartic acid in the green frog, Rana esculenta. J. Endocrinol. 182, 365-376.
32. Raucci, F., D'Aniello, S. and Di Fiore, M. M. (2005a). Endocrine roles of D-aspartic acid in the testis of lizard Podarciss. sicula. J. Endocrinol. 187, 347-359.
33. Raucci, F., Santillo, A., D'Aniello, A., Chieffi, P. and Baccari, G. C. (2005b). D-Aspartate modulates transcriptional activity in Harderian gland of frog, Rana esculenta: Morphological and molecular evidence. J. Cell. Physiol. 204, 445-454.
34. Roselli, C. E. (2007). Brain aromatase: roles in reproduction and neuroprotection. J. Steroid Biochem. Mol. Biol. 106, 143-150.
35. Roselli, C. E. and Resko, J. A. (1997). Sex differences in androgen-regulated expression of cytochrome P450 aromatase in the rat brain. J. Steroid Biochem. Mol. Biol. 61, 365-374.
36. Roselli, C. E., Horton, L. E. and Resko, J. A. (1985). Distribution and regulation of aromatase activity in the rat hypothalamus and limbic system. Endocrinology 117, 2471-2477.
37. Saldanha, C. J., Tuerk, M. J., Kim, Y. H., Fernandes, A. O., Arnold, A. P. and Schlinger, B. A. (2000). Distribution and regulation of telencephalic aromatase expression in the zebra finch revealed with a specific antibody. J. Comp. Neurol. 423, 619-630.
38. Schlinger, B. A. and Callard, G. V. (1990). Aromatization mediates aggressive behavior in quail. Gen. Comp. Endocrinol. 79, 39-53.
39. Simpson, E. R., Mahendroo, M. S., Means, G. D., Kilgore, M. W., Hinshelwood, M. M., Graham-Lorence, S., Amarneh, B., Ito, Y., Fisher, C. R., Michael, M. D. et al. (1994). Aromatase cytochrome P450, the enzyme responsible for estrogen biosynthesis. Endocr. Rev. 15, 342-355.
40. Spinelli, P., Brown, E. R., Ferrandino, G., Branno, M., Montarolo, P. G., DAniello, E., Rastogi, R. K., DAniello, B., Baccari, G. C., Fisher, G. et al. (2006). D-Aspartic acid in the nervous system of Aplysia limacina: possible role in neurotransmission. J. Cell. Physiol. 206, 672-681.
41. Stocco, C. (2008). Aromatase expression in the ovary: hormonal and molecular regulation. Steroids 73, 473-487.
42. Topo, E., Soricelli, A., Di Maio, A., DAniello, E., Di Fiore, M. M. and DAniello, A. (2010). Evidence for the involvement of D-aspartic acid in learning and memory of rat. Amino Acids 38, 1561-1569.
43. Urbatzka, R., Lutz, I. and Kloas, W. (2007). Aromatase, steroid-5-alpha-reductase type 1 and type 2 mRNA expression in gonads and in brain of Xenopus laevis during ontogeny. Gen. Comp. Endocrinol. 153, 280-288.
44. Voigt, C., Ball, G. F. and Balthazart, J. (2007). Neuroanatomical specificity of sex differences in expression of aromatase mRNA in the quail brain. J. Chem. Neuroanat. 33, 75-86.
45. Waagepetersen, H. S., Shimamoto, K. and Schousboe, A. (2001). Comparison of effects of DL-threo-beta-benzyloxyaspartate (DL-TBOA) and L-trans-pyrrolidine-2, 4-dicarboxylate (t-2, 4-PDC) on uptake and release of [3H]D-aspartate in astrocytes and glutamatergic neurons. Neurochem. Res. 26, 661-666.